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lbcpufmg.bsky.social
LBCP - UFMG
@lbcpufmg.bsky.social
23 followers 82 following 5 posts
Protein Computational Biology Lab @ UFMG
We use and develop computational and biophysical methods to study protein structure, function and evolution.
P.I.: Lucas Bleicher
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lbcpufmg.bsky.social
LBCP - UFMG @lbcpufmg.bsky.social · Aug 22
We are a research group in Belo Horizonte, Brazil, studying protein structure, function and evolution using computational and biophysical methods.

P.I.: Lucas Bleicher, Biochemistry and Immunology Department, Biological Sciences Institute, UFMG.
Protein Computational Biology Group at UFMG, 2025
Reposted by LBCP - UFMG
post-doc-club.bsky.social
Great news!
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month

www.jstor.org/action/showL...
September 29, 2025 at 3:27 PM
Reposted by LBCP - UFMG
philipcball.bsky.social
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...
The simple machine that visualised atomic orbitals
In 1931, Harvey Elliott White developed a device that traced out the shapes of electron clouds by approximating solutions to the Schrödinger equation
www.chemistryworld.com
September 18, 2025 at 9:37 AM
Reposted by LBCP - UFMG
luckytran.com
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 19, 2025 at 9:48 PM
Reposted by LBCP - UFMG
rcsbpdb.bsky.social
Watch the Webinar: Searching the PDB for high-quality ligand-bound structures
Learn how to search the PDB for the best examples of ligands using text, chemical drawing, and APIs
PDB101: Searching the PDB for High-Quality Ligand-Bound Structures
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
November 11, 2025 at 5:55 PM
lbcpufmg.bsky.social
After our study on transthyretin and HIUase ancestral reconstruction, I wrote this personal account on how TTRs were present in key moments in my career and on tackling this interesting case of neofunctionalization using crystallography and calorimetry

communities.springernature.com/posts/evolut...
Evolution meets biophysics in the early history of transthyretins
Transthyretin, the primary thyroxine carrier in the cerebrospinal fluid, has been known since the forties, but the discovery of homologs in C. elegans and several microorganisms in 2000 revealed an in...
communities.springernature.com
November 11, 2025 at 5:00 PM
Reposted by LBCP - UFMG
deborahleao.bsky.social
imigração é um direito. fronteiras são inventadas. bichos migram, os seres humanos sempre mudaram de lugar.
nisreenalwan.bsky.social Prof Nisreen Alwan @nisreenalwan.bsky.social · Nov 4
I think this constant push for immigrants to feel & act ‘grateful’ is so insidious. Let’s change the narrative. Migration is a normal part of human behaviour, not a charity case. If you’re doing your best to do your best, you don’t need to do even more to be accepted. It’s your right to be accepted.
November 5, 2025 at 7:20 AM
Reposted by LBCP - UFMG
adolfont.github.io
(The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥)

www.linkedin.com/posts/monett...
The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥 | Dagmar Monett
The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥
www.linkedin.com
October 21, 2025 at 11:20 PM
lbcpufmg.bsky.social
Very interesting recollection from interviews and the literature on alchemical free-energy methods.

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"THE DAWN OF ALCHEMICAL FREE-ENERGY METHODS IN BIOMOLECULAR SIMULATIONS" (Daniele Macuglia, Giovanni Ciccotti, Benoît Roux)
arxiv.org/pdf/2510.04917
arxiv.org
October 9, 2025 at 1:38 PM
lbcpufmg.bsky.social
Journal of Molecular Evolution tem artigos tão maravilhosos que fico triste que não exista mais versão impressa, queria tirar um dia por mês pra ir numa biblioteca e ler a última edição.
September 23, 2025 at 2:35 PM
Reposted by LBCP - UFMG
rcsbpdb.bsky.social
Players match protein targets with drugs in this game developed by RCSB PDB and @ccdc.cam.ac.uk
PDB101: Learn: Other Resources: Bound! Protein-drug matching game
Bound! is a card game for students 12 and up, where players compete to match the most drugs to their protein targets.
pdb101.rcsb.org
September 11, 2025 at 11:26 PM
Reposted by LBCP - UFMG
olivia.science
Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia:
doi.org/10.5281/zeno...

We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
Abstract: Under the banner of progress, products have been uncritically adopted or even imposed on users — in past centuries with tobacco and combustion engines, and in the 21st with social media. For these collective blunders, we now regret our involvement or apathy as scientists, and society struggles to put the genie back in the bottle. Currently, we are similarly entangled with artificial intelligence (AI) technology. For example, software updates are rolled out seamlessly and non-consensually, Microsoft Office is bundled with chatbots, and we, our students, and our employers have had no say, as it is not considered a valid position to reject AI technologies in our teaching and research. This is why in June 2025, we co-authored an Open Letter calling on our employers to reverse and rethink their stance on uncritically adopting AI technologies. In this position piece, we expound on why universities must take their role seriously toa) counter the technology industry’s marketing, hype, and harm; and to b) safeguard higher education, critical thinking, expertise, academic freedom, and scientific integrity. We include pointers to relevant work to further inform our colleagues. Figure 1. A cartoon set theoretic view on various terms (see Table 1) used when discussing the superset AI (black outline, hatched background): LLMs are in orange; ANNs are in magenta; generative models are in blue; and finally, chatbots are in green. Where these intersect, the colours reflect that, e.g. generative adversarial network (GAN) and Boltzmann machine (BM) models are in the purple subset because they are both generative and ANNs. In the case of proprietary closed source models, e.g. OpenAI’s ChatGPT and Apple’s Siri, we cannot verify their implementation and so academics can only make educated guesses (cf. Dingemanse 2025). Undefined terms used above: BERT (Devlin et al. 2019); AlexNet (Krizhevsky et al. 2017); A.L.I.C.E. (Wallace 2009); ELIZA (Weizenbaum 1966); Jabberwacky (Twist 2003); linear discriminant analysis (LDA); quadratic discriminant analysis (QDA). Table 1. Below some of the typical terminological disarray is untangled. Importantly, none of these terms are orthogonal nor do they exclusively pick out the types of products we may wish to critique or proscribe. Protecting the Ecosystem of Human Knowledge: Five Principles
September 6, 2025 at 8:13 AM
Reposted by LBCP - UFMG
oldschoolgentl1.bsky.social
Science is real
August 31, 2025 at 3:12 PM
Reposted by LBCP - UFMG
rcsbpdb.bsky.social
Cases of Dengue have been rising in California, Florida, and Texas
Learn more about the virus (and build paper models) at PDB-101
PDB101: Learn: Paper Models: Dengue Virus
Atomic structures of dengue virus are giving new hope for creation of a vaccine
pdb101.rcsb.org
August 26, 2025 at 5:11 PM
lbcpufmg.bsky.social
We are a research group in Belo Horizonte, Brazil, studying protein structure, function and evolution using computational and biophysical methods.

P.I.: Lucas Bleicher, Biochemistry and Immunology Department, Biological Sciences Institute, UFMG.
Protein Computational Biology Group at UFMG, 2025
August 22, 2025 at 4:59 PM
Reposted by LBCP - UFMG
nurdankuru.bsky.social
Our new algorithm PHACE: Phylogeny-Aware Detection of Molecular Coevolution, by me and Ogün Adebali (@compgenomics.bsky.social), is now published in Molecular Biology and Evolution.

Many thanks to @nehircanozdemir.bsky.social for the beautiful illustration of PHACE!
molbioevol.bsky.social Molecular Biology and Evolution @molbioevol.bsky.social · Jul 18
@nurdankuru.bsky.social & Adebali present PHACE, a phylogeny-aware coevolution algorithm that maps amino acid substitutions onto a phylogenetic tree to detect molecular coevolution.

🔗 doi.org/10.1093/molbev/msaf150

#evobio #molbio #phylogenetics
July 18, 2025 at 3:10 PM
Reposted by LBCP - UFMG
sberry.bsky.social
Lovely article from our colleague Kseniia Petrova, who has been wrongfully imprisoned for months: www.nytimes.com/2025/05/13/o...
Opinion | The Science I Would Be Doing if I Weren’t in ICE Detention
www.nytimes.com
May 13, 2025 at 12:33 PM
lbcpufmg.bsky.social
Millena Fernandes M.Sc. defense

By analyzing conservation and coevolution patterns in voltage-gated sodium channels, point mutants in the cardiac channel Nav1.5 were proposed, and she assessed their effect in activation and inactivation using patch clamp techniques.
August 20, 2025 at 5:08 PM