We use and develop computational and biophysical methods to study protein structure, function and evolution.
P.I.: Lucas Bleicher
P.I.: Lucas Bleicher, Biochemistry and Immunology Department, Biological Sciences Institute, UFMG.
P.I.: Lucas Bleicher, Biochemistry and Immunology Department, Biological Sciences Institute, UFMG.
By analyzing conservation and coevolution patterns in voltage-gated sodium channels, point mutants in the cardiac channel Nav1.5 were proposed, and she assessed their effect in activation and inactivation using patch clamp techniques.
By analyzing conservation and coevolution patterns in voltage-gated sodium channels, point mutants in the cardiac channel Nav1.5 were proposed, and she assessed their effect in activation and inactivation using patch clamp techniques.