@laurakuijpers.bsky.social
Reposted
ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL
Absorption takes drug into blood from GI,
Vd spreads drug out to where bug calls home.
And after bacteria are doomed to die,
The drug’s eliminated on the porcelain throne
In the Land of Notion where this table doth lie…
#idSky #microsky #pharmsky #medsky
Absorption takes drug into blood from GI,
Vd spreads drug out to where bug calls home.
And after bacteria are doomed to die,
The drug’s eliminated on the porcelain throne
In the Land of Notion where this table doth lie…
#idSky #microsky #pharmsky #medsky
January 26, 2025 at 7:48 PM
Reposted
David Paterson and the ADVANCE-ID team are doing a lot of work for us summarizing recent literature on bacterial & fungal infections & therapies. If you aren't already receiving their bimonthly newsletters, you should! ad-id.co/subscribe
#IDSky #Clinmicro
#IDSky #Clinmicro
October 15, 2025 at 4:42 AM
David Paterson and the ADVANCE-ID team are doing a lot of work for us summarizing recent literature on bacterial & fungal infections & therapies. If you aren't already receiving their bimonthly newsletters, you should! ad-id.co/subscribe
#IDSky #Clinmicro
#IDSky #Clinmicro
Reposted
In a sample of thousands of Covid survivors from Rwanda, 34% suffered from #LongCovid symptoms for a study period of up to three years (LC WHO case definition)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Prevalence and characterization of post-acute sequelae of SARS-CoV-2 infection (PASC) in Rwanda
Reliable, population-level estimates of post-acute sequelae of SARS-CoV-2 infection (PASC) remain scarce for sub-Saharan Africa. We aimed to quantify …
www.sciencedirect.com
September 27, 2025 at 6:21 PM
In a sample of thousands of Covid survivors from Rwanda, 34% suffered from #LongCovid symptoms for a study period of up to three years (LC WHO case definition)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
Host-directed therapies for infectious disease are here & coming!
Simple equation proposed to consider best interventions:
⭐ Microorganism + immune response = clinical presentation/status ⭐
Will require futuristic-sounding real-time diagnostics = exciting!
#IDSky #MedSky #ImmunoSky #TBSky
Simple equation proposed to consider best interventions:
⭐ Microorganism + immune response = clinical presentation/status ⭐
Will require futuristic-sounding real-time diagnostics = exciting!
#IDSky #MedSky #ImmunoSky #TBSky
The Changing Paradigm in Infectious Diseases - Host-Directed Medicine: Implications for the Next Generation of ID Physicians
academic.oup.com
October 1, 2025 at 8:43 AM
Host-directed therapies for infectious disease are here & coming!
Simple equation proposed to consider best interventions:
⭐ Microorganism + immune response = clinical presentation/status ⭐
Will require futuristic-sounding real-time diagnostics = exciting!
#IDSky #MedSky #ImmunoSky #TBSky
Simple equation proposed to consider best interventions:
⭐ Microorganism + immune response = clinical presentation/status ⭐
Will require futuristic-sounding real-time diagnostics = exciting!
#IDSky #MedSky #ImmunoSky #TBSky
Reposted
Among over 77,000 flights, incidence of in-flight medical events was 39 per 1 million enplanements, with aircraft diversion in 1.7% of cases, most often for neurologic and cardiac emergencies. ja.ma/46wnDZD
October 1, 2025 at 8:30 PM
Among over 77,000 flights, incidence of in-flight medical events was 39 per 1 million enplanements, with aircraft diversion in 1.7% of cases, most often for neurologic and cardiac emergencies. ja.ma/46wnDZD
Reposted
Reposted
Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study
Olorofim showed efficacy and good tolerability in patients with IFD with few or no
treatment options. Further studies will be needed to fully delineate the role of this
new antifungal agent.
www.thelancet.com
July 1, 2025 at 10:20 AM
Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Reposted
A bit similar to the way fosfomycin can be used, as in in this RCT by @marcbonten.bsky.social
(2/2)
#IDSky #UTISky
(2/2)
#IDSky #UTISky
Fosfomycin Vs Ciprofloxacin as Oral Step-Down Treatment for Escherichia coli Febrile Urinary Tract Infections in Women: A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial
Fosfomycin is noninferior to ciprofloxacin regarding clinical cure as a targeted oral step-down treatment for Escherichia colifebrile urinary tract infecti
academic.oup.com
June 30, 2025 at 7:59 AM
A bit similar to the way fosfomycin can be used, as in in this RCT by @marcbonten.bsky.social
(2/2)
#IDSky #UTISky
(2/2)
#IDSky #UTISky
Reposted
Pivmecillinam role in treating uncomplicated UTI is established (esp for many AmpC/ ESBL bacteria).
I wonder if it also has a place in pyelonephritis care. Perhaps as an oral step down once bacillary burden has fallen?
(1/2)
#IDSky #UTISky #MedSky #AMR
I wonder if it also has a place in pyelonephritis care. Perhaps as an oral step down once bacillary burden has fallen?
(1/2)
#IDSky #UTISky #MedSky #AMR
Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infection: New Efficacy Analysis
This reanalysis of data from historical randomized, controlled trials, according to criteria published by the US Food and Drug Administration in 2019, conf
academic.oup.com
June 30, 2025 at 7:59 AM
Reposted
As measles outbreaks continue, all healthcare professionals should have a better understanding of the disease. NEJM just published a review.
www.nejm.org/doi/full/10....
#IDSky #PharmSky
www.nejm.org/doi/full/10....
#IDSky #PharmSky
Measles 2025 | NEJM
In this article on measles, the authors review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies.
www.nejm.org
June 30, 2025 at 2:38 PM
As measles outbreaks continue, all healthcare professionals should have a better understanding of the disease. NEJM just published a review.
www.nejm.org/doi/full/10....
#IDSky #PharmSky
www.nejm.org/doi/full/10....
#IDSky #PharmSky
Reposted
I don’t usually post around this time—unless something 🔥 drops. Time zones don’t matter when it’s this good
Worth breaking the pattern #IDsky #EMIMCC
Worth breaking the pattern #IDsky #EMIMCC
🆕🔥 State of the art review article @cmicomms.bsky.social
Approach to Clostridioides difficile Diarrheal Infection ( CDI)
Excellent discussions about the management of CDI #IDsky #mustread
www.sciencedirect.com/science/arti...
Approach to Clostridioides difficile Diarrheal Infection ( CDI)
Excellent discussions about the management of CDI #IDsky #mustread
www.sciencedirect.com/science/arti...
May 1, 2025 at 3:34 AM
Reposted
🆕💫 Narrative review in ICM
How to approach a patient hospitalized for pneumonia who is not responding to treatment? #idsky #EMIMCC
link.springer.com/article/10.1...
How to approach a patient hospitalized for pneumonia who is not responding to treatment? #idsky #EMIMCC
link.springer.com/article/10.1...
May 24, 2025 at 8:08 PM
🆕💫 Narrative review in ICM
How to approach a patient hospitalized for pneumonia who is not responding to treatment? #idsky #EMIMCC
link.springer.com/article/10.1...
How to approach a patient hospitalized for pneumonia who is not responding to treatment? #idsky #EMIMCC
link.springer.com/article/10.1...
Reposted
Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infections: Beyond Safety and Tolerability, More Clinical and Diagnostic Questions Remain Unanswered
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infections: Beyond Safety and Tolerability, More Clinical and Diagnostic Questions Remain Unanswered
doi.org
May 22, 2025 at 6:58 PM
Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infections: Beyond Safety and Tolerability, More Clinical and Diagnostic Questions Remain Unanswered
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted
🧪A fatal case of #Oropouche fever in Brazil sheds light on the evolving pathogenic potential of this emerging arbovirus. Our study in @thelancetinfdis.bsky.social investigates viral, histopathological, and immune mechanisms behind this severe outcome.
doi.org/10.1016/S1473-3099(25)00341-X
doi.org/10.1016/S1473-3099(25)00341-X
May 20, 2025 at 1:03 AM
🧪A fatal case of #Oropouche fever in Brazil sheds light on the evolving pathogenic potential of this emerging arbovirus. Our study in @thelancetinfdis.bsky.social investigates viral, histopathological, and immune mechanisms behind this severe outcome.
doi.org/10.1016/S1473-3099(25)00341-X
doi.org/10.1016/S1473-3099(25)00341-X
Reposted
“you can think of measles cases as a probe for whether we are paying attention…While measles is often first, it is a harbinger of problems to come.”
Highly recommend ‘Booster Shots’ by @adamratnermd.bsky.social. Crucial for understanding the history of measles and what the future likely holds.
Highly recommend ‘Booster Shots’ by @adamratnermd.bsky.social. Crucial for understanding the history of measles and what the future likely holds.
April 25, 2025 at 3:26 AM
“you can think of measles cases as a probe for whether we are paying attention…While measles is often first, it is a harbinger of problems to come.”
Highly recommend ‘Booster Shots’ by @adamratnermd.bsky.social. Crucial for understanding the history of measles and what the future likely holds.
Highly recommend ‘Booster Shots’ by @adamratnermd.bsky.social. Crucial for understanding the history of measles and what the future likely holds.
Reposted
Cryptococcal Meningitis Treatment Beyond HIV: Recognizing the need for Individualized Immune-Based Strategies
Hyunah Yoon, Liise-anne Pirofsky, @drboulware.bsky.social
In non-HIV-associated CM, ⬇️ing immunosuppression --> ⬆️ inflammation --> 🧠 damage.
academic.oup.com/cid/advance-... #TxID #IDSky
Hyunah Yoon, Liise-anne Pirofsky, @drboulware.bsky.social
In non-HIV-associated CM, ⬇️ing immunosuppression --> ⬆️ inflammation --> 🧠 damage.
academic.oup.com/cid/advance-... #TxID #IDSky
April 26, 2025 at 12:47 AM
Cryptococcal Meningitis Treatment Beyond HIV: Recognizing the need for Individualized Immune-Based Strategies
Hyunah Yoon, Liise-anne Pirofsky, @drboulware.bsky.social
In non-HIV-associated CM, ⬇️ing immunosuppression --> ⬆️ inflammation --> 🧠 damage.
academic.oup.com/cid/advance-... #TxID #IDSky
Hyunah Yoon, Liise-anne Pirofsky, @drboulware.bsky.social
In non-HIV-associated CM, ⬇️ing immunosuppression --> ⬆️ inflammation --> 🧠 damage.
academic.oup.com/cid/advance-... #TxID #IDSky
Reposted
On IDSA’s & HIVMA’s Science Speaks blog: Five years since the start of the COVID-19 pandemic, long COVID remains a concern. Luis Del Carpio-Orantes, MD, provides an update on research efforts to find therapies.
Therapeutic updates on long COVID: Where things stand 5 years later
Five years since the start of the COVID-19 pandemic, long COVID remains a concern. However, despite ongoing research efforts, there is still no specific treatment.
buff.ly
April 13, 2025 at 4:03 PM
On IDSA’s & HIVMA’s Science Speaks blog: Five years since the start of the COVID-19 pandemic, long COVID remains a concern. Luis Del Carpio-Orantes, MD, provides an update on research efforts to find therapies.
Reposted
New review article on management of S. aureus bacteraemia: jamanetwork.com/journals/jam...
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
Staphylococcus aureus Bacteremia: A Review
This narrative review summarizes current evidence on the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of Staphylococcus aureus bacteremia.
jamanetwork.com
April 7, 2025 at 3:52 PM
New review article on management of S. aureus bacteraemia: jamanetwork.com/journals/jam...
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)