Kyuha Choi
@kyuhachoi.bsky.social
Plant Genomic Recombination Laboratory at POSTECH
Pinned
Kyuha Choi
@kyuhachoi.bsky.social
· Apr 4
Thrilled to announce our study on the histone variant H2A.W & pericentromeric crossovers is now out in PNAS! We show that loss/knockdown of H2A.Ws boosts meiotic crossovers in Arabidopsis pericentromeric regions: www.pnas.org/doi/10.1073/...
Our study on COmapper using nanopore long-read sequencing is now published online! (see New Phytologist: nph.onlinelibrary.wiley.com/doi/10.1111/...) Congratulations to lead author Dohwan Byun, soon-to-be Dr. Namil Son, and the co-authors!
phytologistnph.onlinelibrary.wiley.com
June 20, 2025 at 12:22 AM
Our study on COmapper using nanopore long-read sequencing is now published online! (see New Phytologist: nph.onlinelibrary.wiley.com/doi/10.1111/...) Congratulations to lead author Dohwan Byun, soon-to-be Dr. Namil Son, and the co-authors!
Reposted by Kyuha Choi
Paper alert! #Meiosis4Ever
Maximizing meiotic crossover rates reveals the map of Crossover Potential
Juli Jing, Qiachao Lian and Stephanie Durand
www.nature.com/articles/s41...
We pushed meiotic crossover as much has we could, and had some surprises
A thread 👇
Maximizing meiotic crossover rates reveals the map of Crossover Potential
Juli Jing, Qiachao Lian and Stephanie Durand
www.nature.com/articles/s41...
We pushed meiotic crossover as much has we could, and had some surprises
A thread 👇
Maximizing meiotic crossover rates reveals the map of Crossover Potential - Nature Communications
Meiotic crossovers enhance genetic diversity in sexually reproducing organisms. Here, the authors propose that the higher-order spatial organization of the meiotic chromosomes shapes sexual dimorphism...
www.nature.com
June 12, 2025 at 2:53 PM
Paper alert! #Meiosis4Ever
Maximizing meiotic crossover rates reveals the map of Crossover Potential
Juli Jing, Qiachao Lian and Stephanie Durand
www.nature.com/articles/s41...
We pushed meiotic crossover as much has we could, and had some surprises
A thread 👇
Maximizing meiotic crossover rates reveals the map of Crossover Potential
Juli Jing, Qiachao Lian and Stephanie Durand
www.nature.com/articles/s41...
We pushed meiotic crossover as much has we could, and had some surprises
A thread 👇
Reposted by Kyuha Choi
"Haploid induction in sweet potato by activating the
AP2/ERF family transcription factor IbBBM"
From: onlinelibrary.wiley.com/doi/full/10....
Since sweet potato is hexaploid, the corresponding haploid is actually triploid then?
AP2/ERF family transcription factor IbBBM"
From: onlinelibrary.wiley.com/doi/full/10....
Since sweet potato is hexaploid, the corresponding haploid is actually triploid then?
Haploid induction in sweet potato by activating the AP2/ERF family transcription factor IbBBM
Click on the article title to read more.
onlinelibrary.wiley.com
June 1, 2025 at 12:46 PM
"Haploid induction in sweet potato by activating the
AP2/ERF family transcription factor IbBBM"
From: onlinelibrary.wiley.com/doi/full/10....
Since sweet potato is hexaploid, the corresponding haploid is actually triploid then?
AP2/ERF family transcription factor IbBBM"
From: onlinelibrary.wiley.com/doi/full/10....
Since sweet potato is hexaploid, the corresponding haploid is actually triploid then?
Excited to share that our COmapper preprint on bioRxiv has been updated following two rounds of major revision—thanks to insightful peer reviews! biorxiv.org/content/10.1...
COmapper is now even better—check it out on GitHub: github.com/KyuhaChoi-La...
Journal version coming soon!
COmapper is now even better—check it out on GitHub: github.com/KyuhaChoi-La...
Journal version coming soon!
COmapper: High-resolution mapping of meiotic crossovers by long-read sequencing in Arabidopsis
Meiotic crossovers rearrange existing genetic variation between homologous chromosomes, profoundly affecting genomic diversity. Crossovers are typically constrained to 1-3 events per chromosome pair, ...
biorxiv.org
May 31, 2025 at 2:14 AM
Excited to share that our COmapper preprint on bioRxiv has been updated following two rounds of major revision—thanks to insightful peer reviews! biorxiv.org/content/10.1...
COmapper is now even better—check it out on GitHub: github.com/KyuhaChoi-La...
Journal version coming soon!
COmapper is now even better—check it out on GitHub: github.com/KyuhaChoi-La...
Journal version coming soon!
Reposted by Kyuha Choi
It is sad that even basic research needs to be defended with utility. For me, basic research is in the same category as art: civilized societies can't do without it, because we all want to know who we are and what our place in the natural world is -- questions that only science can answer.
May 9, 2025 at 9:09 PM
It is sad that even basic research needs to be defended with utility. For me, basic research is in the same category as art: civilized societies can't do without it, because we all want to know who we are and what our place in the natural world is -- questions that only science can answer.
Reposted by Kyuha Choi
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
May 5, 2025 at 7:22 AM
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
Reposted by Kyuha Choi
We have a complete program !
meiosis.cornell.edu/mayosis2025/...
The #Mayosis25 seminar series will open with a tribute to Scott Hawley by @jeffsekelsky.bsky.social.
Congrats to all the selected speakers and we look forward to hearing about your fantastic science !
#Meiosis4ever
meiosis.cornell.edu/mayosis2025/...
The #Mayosis25 seminar series will open with a tribute to Scott Hawley by @jeffsekelsky.bsky.social.
Congrats to all the selected speakers and we look forward to hearing about your fantastic science !
#Meiosis4ever
MAYosis 2025
meiosis.cornell.edu
April 7, 2025 at 8:54 AM
We have a complete program !
meiosis.cornell.edu/mayosis2025/...
The #Mayosis25 seminar series will open with a tribute to Scott Hawley by @jeffsekelsky.bsky.social.
Congrats to all the selected speakers and we look forward to hearing about your fantastic science !
#Meiosis4ever
meiosis.cornell.edu/mayosis2025/...
The #Mayosis25 seminar series will open with a tribute to Scott Hawley by @jeffsekelsky.bsky.social.
Congrats to all the selected speakers and we look forward to hearing about your fantastic science !
#Meiosis4ever
Reposted by Kyuha Choi
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Kyuha Choi
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
April 11, 2025 at 8:35 AM
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
Thrilled to announce our study on the histone variant H2A.W & pericentromeric crossovers is now out in PNAS! We show that loss/knockdown of H2A.Ws boosts meiotic crossovers in Arabidopsis pericentromeric regions: www.pnas.org/doi/10.1073/...
April 4, 2025 at 6:37 PM
Thrilled to announce our study on the histone variant H2A.W & pericentromeric crossovers is now out in PNAS! We show that loss/knockdown of H2A.Ws boosts meiotic crossovers in Arabidopsis pericentromeric regions: www.pnas.org/doi/10.1073/...
Reposted by Kyuha Choi
Nature research paper: Haploid facultative parthenogenesis in sunflower sexual reproduction
https://go.nature.com/4hYpSY3
https://go.nature.com/4hYpSY3
Haploid facultative parthenogenesis in sunflower sexual reproduction - Nature
Spontaneous parthenogenesis in sunflower has been used to develop a scalable doubled haploid breeding system.
go.nature.com
April 3, 2025 at 2:14 PM
Nature research paper: Haploid facultative parthenogenesis in sunflower sexual reproduction
https://go.nature.com/4hYpSY3
https://go.nature.com/4hYpSY3
Reposted by Kyuha Choi
New Perspective: "The future of genome editing in plants" rdcu.be/ef8aa
Genome editing will mimic the natural evolutionary processes that shape genomes; will be used to reshape genomes in a manner that could have happened naturally, but more precisely and more rapidly.
Genome editing will mimic the natural evolutionary processes that shape genomes; will be used to reshape genomes in a manner that could have happened naturally, but more precisely and more rapidly.
April 2, 2025 at 12:17 PM
New Perspective: "The future of genome editing in plants" rdcu.be/ef8aa
Genome editing will mimic the natural evolutionary processes that shape genomes; will be used to reshape genomes in a manner that could have happened naturally, but more precisely and more rapidly.
Genome editing will mimic the natural evolutionary processes that shape genomes; will be used to reshape genomes in a manner that could have happened naturally, but more precisely and more rapidly.
Reposted by Kyuha Choi
Paper "Triploid bridges enable gene flow in mixed-ploidy populations of Cardamine amara" published in Molecular Ecology! doi.org/10.1111/mec....
The study reveals how rare triploids help overcome ploidy barriers and mediate gene flow between diploid and tetraploid populations.
The study reveals how rare triploids help overcome ploidy barriers and mediate gene flow between diploid and tetraploid populations.
March 25, 2025 at 1:44 PM
Paper "Triploid bridges enable gene flow in mixed-ploidy populations of Cardamine amara" published in Molecular Ecology! doi.org/10.1111/mec....
The study reveals how rare triploids help overcome ploidy barriers and mediate gene flow between diploid and tetraploid populations.
The study reveals how rare triploids help overcome ploidy barriers and mediate gene flow between diploid and tetraploid populations.
Reposted by Kyuha Choi
Uncalled4: a toolkit for nanopore signal alignment, analysis and visualization of DNA and RNA modifications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 28, 2025 at 5:23 PM
Uncalled4: a toolkit for nanopore signal alignment, analysis and visualization of DNA and RNA modifications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyuha Choi
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted by Kyuha Choi
We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
March 7, 2025 at 7:18 AM
We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
Reposted by Kyuha Choi
Our new review article “To infinity and beyond: recent progress, bottlenecks, and potential of clonal seeds by apomixis” is now published open access in @theplantjournal.bsky.social
dx.doi.org/10.1111/tpj.... @ribesresearch.bsky.social
dx.doi.org/10.1111/tpj.... @ribesresearch.bsky.social
February 21, 2025 at 12:50 PM
Our new review article “To infinity and beyond: recent progress, bottlenecks, and potential of clonal seeds by apomixis” is now published open access in @theplantjournal.bsky.social
dx.doi.org/10.1111/tpj.... @ribesresearch.bsky.social
dx.doi.org/10.1111/tpj.... @ribesresearch.bsky.social
Reposted by Kyuha Choi
I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg!
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
February 21, 2025 at 9:17 AM
I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg!
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
Reposted by Kyuha Choi
Do you love meiosis? Have a cool story to share? Join us for the XVth British Meiosis Meeting 26-27 of March in Liverpool! docs.google.com/forms/d/e/1F... You only have till Sunday to submit an abstract for a talk! ECRs are prioritised for speaking slots so the odds are in your favour 😁 #meiosis4eva
February 19, 2025 at 11:30 AM
Do you love meiosis? Have a cool story to share? Join us for the XVth British Meiosis Meeting 26-27 of March in Liverpool! docs.google.com/forms/d/e/1F... You only have till Sunday to submit an abstract for a talk! ECRs are prioritised for speaking slots so the odds are in your favour 😁 #meiosis4eva
Reposted by Kyuha Choi
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro - Nature
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently atta...
www.nature.com
February 19, 2025 at 4:52 PM
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyuha Choi
Looking forward to an exciting conference at POSTECH - Korean Society of Plant Biologists. Thank you to @kyuhachoi.bsky.social for the invitation.
February 14, 2025 at 5:08 AM
Looking forward to an exciting conference at POSTECH - Korean Society of Plant Biologists. Thank you to @kyuhachoi.bsky.social for the invitation.