Kyle MacQuarrie MD PhD
@kylemacquarrie.bsky.social
Pediatric oncologist and physician-scientist in Chicago, Asst Prof, big ol’ science nerd, 🏳️🌈, views my own, etc etc
Reposted by Kyle MacQuarrie MD PhD
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
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November 18, 2025 at 11:02 AM
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
Reposted by Kyle MacQuarrie MD PhD
Just as saving for retirement starts early, so should protecting your heart. A new study led by Sadiya Khan introduces a first-of-its-kind online calculator that to help younger adults forecast and understand their risk of a heart event over the next 30 years — bit.ly/4i8g13F
November 17, 2025 at 4:02 PM
Just as saving for retirement starts early, so should protecting your heart. A new study led by Sadiya Khan introduces a first-of-its-kind online calculator that to help younger adults forecast and understand their risk of a heart event over the next 30 years — bit.ly/4i8g13F
Mishearing of my first name has reached never before seen heights today.
November 17, 2025 at 2:58 PM
Mishearing of my first name has reached never before seen heights today.
Reposted by Kyle MacQuarrie MD PhD
as a physician, patient, and human, I can say that relieving pain is not “useless”
November 13, 2025 at 4:50 PM
as a physician, patient, and human, I can say that relieving pain is not “useless”
Would like to know who I register a complaint with about this much snow before Thanksgiving.
November 10, 2025 at 3:40 PM
Would like to know who I register a complaint with about this much snow before Thanksgiving.
So grateful that technology tells me the sort of thing that really matters at 11 PM for me and my airport uber driver - like where the nearest Sunglass Hut is.
November 7, 2025 at 1:45 PM
So grateful that technology tells me the sort of thing that really matters at 11 PM for me and my airport uber driver - like where the nearest Sunglass Hut is.
All right, Philly, I’ll concede you make some compelling points on a beautiful fall day.
November 4, 2025 at 8:41 PM
All right, Philly, I’ll concede you make some compelling points on a beautiful fall day.
Co-pilot kept pushing to have me let it ‘analyze’ some data I put in a spreadsheet and generate a pathway diagram for me.
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
November 4, 2025 at 4:15 PM
Co-pilot kept pushing to have me let it ‘analyze’ some data I put in a spreadsheet and generate a pathway diagram for me.
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
Reposted by Kyle MacQuarrie MD PhD
Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
Life Is Geometry
In 2025, we’ve got DNA all figured out, right? It’s been over fifty years since Crick and Watson (and Franklin) discovered the double helix…
kimbellard.medium.com
November 3, 2025 at 10:09 PM
Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
Reposted by Kyle MacQuarrie MD PhD
Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
November 3, 2025 at 2:05 PM
Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Putting on my trick or treating game face (/horns).
October 31, 2025 at 9:37 PM
Putting on my trick or treating game face (/horns).
Signs that Halloween is intense in your neighborhood: when you organize the 500+ pieces of candy you’ll hand out tonight before you even leave for work this morning.
October 31, 2025 at 12:41 PM
Signs that Halloween is intense in your neighborhood: when you organize the 500+ pieces of candy you’ll hand out tonight before you even leave for work this morning.
Reposted by Kyle MacQuarrie MD PhD
New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers.
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
From Sequence to Shape: Scientists Discover the Possible Geometric Blueprint of Complex Life
New research from Professors Vadim Backman and Igal Szleifer reveals the language that stores cell memory -- written in the shape of the genome itself.
www.mccormick.northwestern.edu
October 29, 2025 at 6:15 PM
New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers.
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
Early access for our paper is now live!
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome - Almassalha - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
This study introduces a new hypothesis: exons, introns, and intergenic segments are non-random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented...
advanced.onlinelibrary.wiley.com
October 27, 2025 at 10:00 PM
Early access for our paper is now live!
Now I have to be on the lookout for iPSC tags.
October 26, 2025 at 6:29 PM
Now I have to be on the lookout for iPSC tags.
Reposted by Kyle MacQuarrie MD PhD
An editorial in @thelancetrheum.bsky.social about prioritizing diversity in rheumatology - whether it's in clinical trials, in other research, in clinical practice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 23, 2025 at 12:56 PM
An editorial in @thelancetrheum.bsky.social about prioritizing diversity in rheumatology - whether it's in clinical trials, in other research, in clinical practice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyle MacQuarrie MD PhD
NEWS: ICE arrests Chicago man whose teenage daughter is fighting cancer: “He belongs with her.” I spent yesterday afternoon with Ofelia Torres and her mother, Sandibell, talking about Ruben Torres. Here’s the story www.chicagotribune.com/2025/10/21/i...
ICE arrests Chicago man whose teenage daughter is fighting cancer: ‘He belongs with her’
Ofelia Torres has spent almost every day of the past month at Lurie Children’s Hospital, where the 16-year-old Lake View High School student is fighting cancer.
www.chicagotribune.com
October 21, 2025 at 7:02 PM
NEWS: ICE arrests Chicago man whose teenage daughter is fighting cancer: “He belongs with her.” I spent yesterday afternoon with Ofelia Torres and her mother, Sandibell, talking about Ruben Torres. Here’s the story www.chicagotribune.com/2025/10/21/i...
‘Oh! I know what movie we should watch tonight!’ says my husband for inscrutable reasons.
October 13, 2025 at 12:10 AM
‘Oh! I know what movie we should watch tonight!’ says my husband for inscrutable reasons.
Reposted by Kyle MacQuarrie MD PhD
Breaking new data:
83% of Americans still trust their doctor -- even as faith in agencies like the CDC drops (now ~50%).
Trust in the AAP stays strong (69%). Most reject false Tylenol–autism claims, but politicization of public health remains a threat. #MedSky
www.kff.org/public-opini...
83% of Americans still trust their doctor -- even as faith in agencies like the CDC drops (now ~50%).
Trust in the AAP stays strong (69%). Most reject false Tylenol–autism claims, but politicization of public health remains a threat. #MedSky
www.kff.org/public-opini...
KFF Tracking Poll on Health Information and Trust: Tylenol-Autism Link and Vaccine Policies | KFF
Following the Trump administration’s warning last month that using acetaminophen – the active ingredient in Tylenol – during pregnancy can increase the risk of autism in children, very few adults say ...
www.kff.org
October 9, 2025 at 3:56 PM
Breaking new data:
83% of Americans still trust their doctor -- even as faith in agencies like the CDC drops (now ~50%).
Trust in the AAP stays strong (69%). Most reject false Tylenol–autism claims, but politicization of public health remains a threat. #MedSky
www.kff.org/public-opini...
83% of Americans still trust their doctor -- even as faith in agencies like the CDC drops (now ~50%).
Trust in the AAP stays strong (69%). Most reject false Tylenol–autism claims, but politicization of public health remains a threat. #MedSky
www.kff.org/public-opini...
An ominous start to your commute home: when the subway conductor comes on the intercom right after you get on the train and goes ‘ATTENTION: THIS TRAIN IS DEFECTIVE.’
September 30, 2025 at 10:32 PM
An ominous start to your commute home: when the subway conductor comes on the intercom right after you get on the train and goes ‘ATTENTION: THIS TRAIN IS DEFECTIVE.’
21 minutes total between entering our vet and leaving - with a history, physical, vaccines, bloodwork, billing, and discussions of followup all done - makes me wonder if they’re available to coach me on efficiency.
September 29, 2025 at 1:52 PM
21 minutes total between entering our vet and leaving - with a history, physical, vaccines, bloodwork, billing, and discussions of followup all done - makes me wonder if they’re available to coach me on efficiency.
Reposted by Kyle MacQuarrie MD PhD
Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 3:31 PM
Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social
Reposted by Kyle MacQuarrie MD PhD
Jon’s working in the children’s ER today: “Already 2nd family asked if Tylenol is safe FOR THEIR KIDS.”
September 24, 2025 at 6:00 PM
Jon’s working in the children’s ER today: “Already 2nd family asked if Tylenol is safe FOR THEIR KIDS.”
Reposted by Kyle MacQuarrie MD PhD
This is what vaccines do.
Advances Drive ‘Stunning’ Drop in Infant RSV Hospitalizations
2023 marked the debut of groundbreaking innovations to prevent severe RSV infections in infants. Now protected babies are way less likely to develop severe infections or to end up in the ICU
www.scientificamerican.com/article/new-...
2023 marked the debut of groundbreaking innovations to prevent severe RSV infections in infants. Now protected babies are way less likely to develop severe infections or to end up in the ICU
www.scientificamerican.com/article/new-...
A Turning Point in Infant Health—How 2023 Changed the Fight Against RSV
The year 2023 marked the debut of groundbreaking innovations to prevent severe RSV infections in infants. Now protected babies are way less likely to develop severe infections or to end up in the ICU
www.scientificamerican.com
September 24, 2025 at 12:46 AM
This is what vaccines do.