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physgencenter.bsky.social
@PhysGenCenter
@physgencenter.bsky.social
790 followers 3.9K following 110 posts
The mission of the Center for Physical Genomics and Engineering at Northwestern University’s McCormick School of Engineering is to create new strategies for the treatment of disease and the reversible manipulation of living systems
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physgencenter.bsky.social
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"

Registration is free. Join us!

tinyurl.com/f9njvnyu

#chromatin #genomics #northwestern #biology #dna
November 11, 2025 at 6:55 PM
Reposted by @PhysGenCenter
kimbbellard.bsky.social
Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲

H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social

kimbellard.medium.com/life-is-geom...
Life Is Geometry
In 2025, we’ve got DNA all figured out, right? It’s been over fifty years since Crick and Watson (and Franklin) discovered the double helix…
kimbellard.medium.com
November 3, 2025 at 10:09 PM
physgencenter.bsky.social
New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers.

#chromatin #dna

www.mccormick.northwestern.edu/news/article...
From Sequence to Shape: Scientists Discover the Possible Geometric Blueprint of Complex Life
New research from Professors Vadim Backman and Igal Szleifer reveals the language that stores cell memory -- written in the shape of the genome itself.
www.mccormick.northwestern.edu
October 29, 2025 at 6:15 PM
physgencenter.bsky.social
This Friday @ 12pm CT, Prof. Anja Groth of the University of Copenhagen presents the Monthly Seminar on Physical Genomics: "Epigenetic Cell Memory - How Cells Copy Their Epigenome", live on Zoom!

Registration is free at tinyurl.com/5t59y8kj

#northwestern #chromatin #genomics #biology #dna #bio
September 22, 2025 at 10:56 PM
physgencenter.bsky.social
Friday Sept. 26 @ 12pm CT Prof. Anja Groth of the University of Copenhagen presents the Monthly Seminar on Physical Genomics: "Epigenetic Cell Memory - How Cells Copy Their Epigenome", live on Zoom!

Registration is free at tinyurl.com/5t59y8kj

#northwestern #chromatin #genomics #biology #dna #bio
September 15, 2025 at 3:46 PM
physgencenter.bsky.social
The fascinating August Seminar on Physical Genomics by Travis Craddock, PhD can now be watched on YouTube: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

#quantum #biophysics #chromatin #genomics #biology #dna

youtu.be/ZA2j_0PqPXQ
Travis Craddock, PhD: Quantum Spin Dynamics in Biology
YouTube video by Center for Physical Genomics and Engineering
youtu.be
August 30, 2025 at 7:42 PM
physgencenter.bsky.social
Coming up at 12pm CT today! Travis Craddock gives the Monthly Seminar on Physical Genomics live on Zoom: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

Free registration at: tinyurl.com/3mhyseyr

#quantum #biology #chromatin #dna
August 29, 2025 at 3:33 PM
physgencenter.bsky.social
This Friday August 29 @ 12pm CT! Travis Craddock presents the Monthly Seminar on Physical Genomics live on Zoom: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

Registration is free at: tinyurl.com/3mhyseyr

#chromatin #dna #quantum
August 27, 2025 at 6:53 PM
physgencenter.bsky.social
Friday August 29 @ 12pm CT, Travis Craddock presents the Monthly Seminar on Physical Genomics live on Zoom: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

Registration is free at: tinyurl.com/3mhyseyr

#chromatin #dna #quantum
August 19, 2025 at 3:23 PM
physgencenter.bsky.social
The 2025 Physical Genomics Training Program Research Showcase is now on YouTube! Check out 3 short talks by outstanding program participants and learn about the cutting-edge convergent science happening at CPGE.

#cpge #chromatin #biophysics #AI #cancer #nih #genomics

youtu.be/JTCXlXA8D4M?...
2025 Physical Genomics Training Program Research Showcase
YouTube video by Center for Physical Genomics and Engineering
youtu.be
July 28, 2025 at 9:28 PM
physgencenter.bsky.social
Coming up at 12pm CT today, the Physical Genomics Training Program Research Showcase live on Zoom! Three of our PhD trainees will discuss their exciting research projects - join us and experience the breakthrough science happening at CPGE!

Registration is free at: tinyurl.com/yj5v8y85
July 25, 2025 at 4:07 PM
physgencenter.bsky.social
CPGE in Northwestern News: New strategy doubles chemo effectiveness in treatment-resistant cancer: restoring cellular memory prevents cancer cells’ ability to adapt to evade treatment

#cancer #chemo #chromatin #chemotherapy #northwestern #genomics

news.northwestern.edu/stories/2025...
July 23, 2025 at 7:47 PM
physgencenter.bsky.social
New CPGE research out today in PNAS: "Leveraging chromatin packing domains to target chemoevasion in vivo"

On the role of chromatin in cellular adaptation to cytotoxic stress, and a framework for enhancing cancer therapies with broad potential across multiple cancers.

www.pnas.org/doi/10.1073/...
Leveraging chromatin packing domains to target chemoevasion in vivo | PNAS
Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin...
www.pnas.org
July 22, 2025 at 5:18 PM
physgencenter.bsky.social
The Physical Genomics Training Program Research Showcase is going live on Zoom this Friday, July 25 at 12pm CT. Three of our PhD trainees will discuss their exciting research projects - join us and experience the breakthrough science happening at CPGE!

Registration is free at: tinyurl.com/yj5v8y85
July 22, 2025 at 3:20 PM
physgencenter.bsky.social
Join us live on Zoom Friday, July 25 at 12pm CT for the Physical Genomics Training Program Research Showcase! Three of our PhD trainees will discuss their research projects and the exciting convergent science happening at CPGE

Registration is free at: tinyurl.com/yj5v8y85

#chromatin #genomics
July 16, 2025 at 4:47 PM
physgencenter.bsky.social
Collaborative research between CPGE and the Center for Advanced Regenerative Engineering at Northwestern published in Nature Communications: "Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome"

www.nature.com/articles/s41...
Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome - Nature Communications
Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promotin...
www.nature.com
July 14, 2025 at 5:59 PM
physgencenter.bsky.social
New CPGE research published in ACS Photonics: "Multiplexed Chromatin Analysis Using Optical Spectroscopic Statistical Nanosensing", highlighting the capacity of PWS microscopy to sense chromatin ultrastructure

#chromatin #imaging #northwestern #genomics #photonics

pubs.acs.org/doi/full/10....
Multiplexed Chromatin Analysis Using Optical Spectroscopic Statistical Nanosensing
In single cells, chromatin packs into organized structures to perform biological functions, such as RNA transcription regulation. Characterizing such structural behaviors, including packing density an...
pubs.acs.org
July 10, 2025 at 4:45 PM
physgencenter.bsky.social
Prof. Dawn Chen's lecture for the June Seminar on Physical Genomics, "Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain", can now be viewed at CPGE's YouTube channel:

youtu.be/BqhpxuoQevw

#microscopy #biology #AI #northwestern #biophotonics #cpge
Xi (Dawn) Chen - Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain
YouTube video by Center for Physical Genomics and Engineering
youtu.be
July 2, 2025 at 2:15 AM
physgencenter.bsky.social
CPGE's research has been featured by the National Science Foundation's "Science Matters" series - give it a read!

#genomics #cpge #dna #biophysics #chromatin #microscopy

www.nsf.gov/science-matt...
From structure to function: Unpacking how genome organization shapes cell behavior
www.nsf.gov
June 27, 2025 at 8:54 PM
physgencenter.bsky.social
Today at 12 noon CT, Dawn Chen, PhD presents the Monthly Seminar on Physical Genomics: Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain

Live on Zoom, register at tinyurl.com/mr2smffd

#imaging #northwestern #biology #AI #microscopy
June 27, 2025 at 3:54 PM
physgencenter.bsky.social
Tomorrow! June 27 @ 12pm CT, Xi (Dawn) Chen presents the Monthly Seminar on Physical Genomics: Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain

Live on Zoom, register at tinyurl.com/mr2smffd

#imaging #northwestern #biology #AI #microscopy #biophotonics #research
June 26, 2025 at 3:23 PM
physgencenter.bsky.social
This Friday June 27 @ 12pm CT, Xi (Dawn) Chen presents the Monthly Seminar on Physical Genomics: Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain

Live on Zoom, register at tinyurl.com/mr2smffd

#photonics #imaging #cpge #northwestern #biology #AI #microscopy
June 23, 2025 at 5:40 PM
physgencenter.bsky.social
Friday June 27 @ 12pm CT, Xi (Dawn) Chen presents the Monthly Seminar on Physical Genomics: Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain

Live on Zoom, register at tinyurl.com/mr2smffd

#photonics #imaging #cpge #northwestern #biology #research #AI #microscopy
June 17, 2025 at 5:24 PM
physgencenter.bsky.social
Prof. Kristy Stengel's talk for the May Monthly Seminar on Physical Genomics, "Rapid Transcription Factor Degradation Reveals Mechanisms of Gene Regulation", can now be viewed on the CPGE YouTube channel.

#chromatin #transcription #genomics #biophysics #biology #northwestern

youtu.be/_ujAdmvi0a4
Kristy Stengel - Rapid Transcription Factor Degradation Reveals Mechanisms of Gene Regulation
YouTube video by Center for Physical Genomics and Engineering
youtu.be
May 30, 2025 at 9:39 PM
Reposted by @PhysGenCenter
almassalha.bsky.social
Excited to share our latest preprint on #chromatin #epigenetics. We present a hypothesis that the nanoscale packing of the human genome has positional encoding. This needs some context on the implications.
www.biorxiv.org/content/10.1...
Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome
Human tissues require a mechanism to generate durable, yet modifiable, transcriptional memories to sustain cell function across a lifetime. Previously, we demonstrated that nanoscale packing domains c...
www.biorxiv.org
May 30, 2025 at 2:05 PM