Killian Hurley
@killianhurley.bsky.social
Physician-scientist and pulmonary fibrosis doc developing new treatments for #IPF.🧪 🫁 European Research Council grant awardee.
#CureIPF #iPSC #Telomeres #CleanAir #SciSky #MedSky
Interested in #running, #sailing & #nature.
LivingLungLab.com
#CureIPF #iPSC #Telomeres #CleanAir #SciSky #MedSky
Interested in #running, #sailing & #nature.
LivingLungLab.com
Reposted by Killian Hurley
I am calling upon the people of Ireland to immediately begin construction of a thread on this site about how you or someone you know was roasted for a fashion choice. We need it.
All roasts must have come from Irish people *only*. Please respect this important rule, it makes a difference.
Tanks
All roasts must have come from Irish people *only*. Please respect this important rule, it makes a difference.
Tanks
November 12, 2025 at 5:45 AM
I am calling upon the people of Ireland to immediately begin construction of a thread on this site about how you or someone you know was roasted for a fashion choice. We need it.
All roasts must have come from Irish people *only*. Please respect this important rule, it makes a difference.
Tanks
All roasts must have come from Irish people *only*. Please respect this important rule, it makes a difference.
Tanks
Reposted by Killian Hurley
EMBL scientists have created a more sensitive single-cell sequencing tool for genomic variants and RNA in the same single cell.
Known as SDR-seq, the tool has unprecedented scale, precision, and speed to characterise variants and link them to functions and disease.
www.embl.org/news/science...
Known as SDR-seq, the tool has unprecedented scale, precision, and speed to characterise variants and link them to functions and disease.
www.embl.org/news/science...
New tool offers single-cell study of specific genetic variants | EMBL
Scientists developed a more sensitive single-cell sequencing tool linking genomic variants & RNA in the same cell uncover links to disease.
www.embl.org
October 10, 2025 at 10:23 AM
EMBL scientists have created a more sensitive single-cell sequencing tool for genomic variants and RNA in the same single cell.
Known as SDR-seq, the tool has unprecedented scale, precision, and speed to characterise variants and link them to functions and disease.
www.embl.org/news/science...
Known as SDR-seq, the tool has unprecedented scale, precision, and speed to characterise variants and link them to functions and disease.
www.embl.org/news/science...
Reposted by Killian Hurley
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
October 11, 2025 at 8:22 AM
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Fascinating work on the regulation of telomere length - molecular clocks we all have in our cells controlling aging and disease.
Emerging evidence of their role pulmonary fibrosis.
#CureIPF
#Telomeres
@elife.bsky.social
@rcsi.bsky.social
@kaminskimed.bsky.social
Emerging evidence of their role pulmonary fibrosis.
#CureIPF
#Telomeres
@elife.bsky.social
@rcsi.bsky.social
@kaminskimed.bsky.social
Your chromosomes have protective ends called telomeres. As they shorten, your cells age. This study reveals how a protein, TRF2, directly regulates telomerase activity to keep telomeres in check.
Keeping telomeres at the right length
The key telomere protein TRF2 helps regulate telomere length by interacting with the telomerase gene TERT in a length-dependent manner.
buff.ly
October 4, 2025 at 4:33 PM
Fascinating work on the regulation of telomere length - molecular clocks we all have in our cells controlling aging and disease.
Emerging evidence of their role pulmonary fibrosis.
#CureIPF
#Telomeres
@elife.bsky.social
@rcsi.bsky.social
@kaminskimed.bsky.social
Emerging evidence of their role pulmonary fibrosis.
#CureIPF
#Telomeres
@elife.bsky.social
@rcsi.bsky.social
@kaminskimed.bsky.social
Great work by Dr Aoife Carolan from our group at @rcsi.bsky.social
RCSI showing data from our familial pulmonary fibrosis clinic.
- 1 in 5 patients have a family memeber with lung fibrosis.
- 1 in 5 of these patients have a single suspected gene.
#CureIPF
@europeanrespsoc.bsky.social
RCSI showing data from our familial pulmonary fibrosis clinic.
- 1 in 5 patients have a family memeber with lung fibrosis.
- 1 in 5 of these patients have a single suspected gene.
#CureIPF
@europeanrespsoc.bsky.social
September 29, 2025 at 6:07 AM
Great work by Dr Aoife Carolan from our group at @rcsi.bsky.social
RCSI showing data from our familial pulmonary fibrosis clinic.
- 1 in 5 patients have a family memeber with lung fibrosis.
- 1 in 5 of these patients have a single suspected gene.
#CureIPF
@europeanrespsoc.bsky.social
RCSI showing data from our familial pulmonary fibrosis clinic.
- 1 in 5 patients have a family memeber with lung fibrosis.
- 1 in 5 of these patients have a single suspected gene.
#CureIPF
@europeanrespsoc.bsky.social
Gene variants such as MUC5B can increase the risk for lung fibrosis/IPF.
We found a strong correlation with high frequency of the variant per county and hospital admissions for lung fibrosis/IPF.
This method could be used for future geographical healthcare planning.
doi.org/10.1183/2312...
We found a strong correlation with high frequency of the variant per county and hospital admissions for lung fibrosis/IPF.
This method could be used for future geographical healthcare planning.
doi.org/10.1183/2312...
Fine-scale regional frequency of the MUC5B promoter variant correlates with healthcare burden of idiopathic pulmonary fibrosis
ExtractThe gain-of-function MUC5B promoter variant n.661G>T (rs35705950) is a well-established common genetic risk factor for idiopathic pulmonary fibrosis (IPF) [1] and is present in over 50% of European-like ancestry patients with IPF. It also confers risk for other types of interstitial lung diseases (ILDs) with usual interstitial pneumonia pattern, including chronic hypersensitivity pneumonitis [2], asbestosis [3] and rheumatoid arthritis-associated ILD [4].
doi.org
September 24, 2025 at 12:21 PM
Gene variants such as MUC5B can increase the risk for lung fibrosis/IPF.
We found a strong correlation with high frequency of the variant per county and hospital admissions for lung fibrosis/IPF.
This method could be used for future geographical healthcare planning.
doi.org/10.1183/2312...
We found a strong correlation with high frequency of the variant per county and hospital admissions for lung fibrosis/IPF.
This method could be used for future geographical healthcare planning.
doi.org/10.1183/2312...
I totally agree.
Summaries may be fine for some forms of science communications but scientists need the detail to make up their minds on the veracity of claims in papers.
Summaries may be fine for some forms of science communications but scientists need the detail to make up their minds on the veracity of claims in papers.
Reading papers is a basic skill (and dare I say duty?) of scientists, and I include medical doctors in that group. Keeping abreast of the literature is a foundational part of our professions. There aren’t good shortcuts. In any case, reading papers regularly is fun.
arstechnica.com/ai/2025/09/s...
arstechnica.com/ai/2025/09/s...
Science journalists find ChatGPT is bad at summarizing scientific papers
LLM “tended to sacrifice accuracy for simplicity” when writing news briefs.
arstechnica.com
September 21, 2025 at 9:59 AM
I totally agree.
Summaries may be fine for some forms of science communications but scientists need the detail to make up their minds on the veracity of claims in papers.
Summaries may be fine for some forms of science communications but scientists need the detail to make up their minds on the veracity of claims in papers.
Reposted by Killian Hurley
It is grossly irresponsible of Reform to platform such dangerous pseudoscience in the name of ‘free speech’.
Reform criticised over doctor's Covid jab claims at conference www.bbc.com/news/article...
Reform criticised over doctor's Covid jab claims at conference www.bbc.com/news/article...
Reform distances itself from doctor who made Covid claims at conference
A speaker at the Reform UK conference claimed it was "highly likely" that the jab was linked to the King and Princess of Wales' cancers.
www.bbc.com
September 7, 2025 at 4:15 AM
It is grossly irresponsible of Reform to platform such dangerous pseudoscience in the name of ‘free speech’.
Reform criticised over doctor's Covid jab claims at conference www.bbc.com/news/article...
Reform criticised over doctor's Covid jab claims at conference www.bbc.com/news/article...
Reposted by Killian Hurley
Reposted by Killian Hurley
9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health
www.nytimes.com
September 1, 2025 at 11:23 AM
9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
Reposted by Killian Hurley
Really cool: "Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma "
Kudos Drs Kay and Gomez and team!!!
#DemistifyAsthma
www.atsjournals.org/doi/10.1165/...
@ajrcmb.bsky.social @yalepccsm.bsky.social
Kudos Drs Kay and Gomez and team!!!
#DemistifyAsthma
www.atsjournals.org/doi/10.1165/...
@ajrcmb.bsky.social @yalepccsm.bsky.social
August 30, 2025 at 10:58 AM
Really cool: "Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma "
Kudos Drs Kay and Gomez and team!!!
#DemistifyAsthma
www.atsjournals.org/doi/10.1165/...
@ajrcmb.bsky.social @yalepccsm.bsky.social
Kudos Drs Kay and Gomez and team!!!
#DemistifyAsthma
www.atsjournals.org/doi/10.1165/...
@ajrcmb.bsky.social @yalepccsm.bsky.social
Looks like telomere dysfunction is complex in mice and people
- needs more investigation and great science.
#Telomeres
#CureIPF
🧪
🧬
- needs more investigation and great science.
#Telomeres
#CureIPF
🧪
🧬
According to dogma mammalian telomeres shorten with age.
This paper shows that mouse telomeres do not shorten with age. Should we revisit the paradigm?
Kudos Drs Smoom, Tzfati & team!!!
#ScienceMattets
academic.oup.com/nar/article/...
This paper shows that mouse telomeres do not shorten with age. Should we revisit the paradigm?
Kudos Drs Smoom, Tzfati & team!!!
#ScienceMattets
academic.oup.com/nar/article/...
The house mouse maintains constant telomere length throughout life
Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length
academic.oup.com
August 31, 2025 at 4:58 PM
Looks like telomere dysfunction is complex in mice and people
- needs more investigation and great science.
#Telomeres
#CureIPF
🧪
🧬
- needs more investigation and great science.
#Telomeres
#CureIPF
🧪
🧬
Reposted by Killian Hurley
🫁 Listen up LUNG people! 🫁
Get your colleagues over here to #medsky and start posting and engaging! These breathing problems aren’t gonna fix themselves - we need engagement, knowledge sharing, and discussion! 🤩
Get your colleagues over here to #medsky and start posting and engaging! These breathing problems aren’t gonna fix themselves - we need engagement, knowledge sharing, and discussion! 🤩
Here is a full list of all #Medsky accounts by specialty:
Ophtho: 231
Geri: 310
Derm: 330
Rheum: 393
Urology: 432
Anesthesia: 493
Ob/Gyn: 505
Heme: 505
IM: 588
Neph: 878
Palliative: 882
Rads: 918
ID: 969
FM/PC: 1,102
Cards: 1,177
Surgery: 2,340
Psych: 2,441
Onc: 2,815
Immuno: 2,988
Peds: 2,999
Ophtho: 231
Geri: 310
Derm: 330
Rheum: 393
Urology: 432
Anesthesia: 493
Ob/Gyn: 505
Heme: 505
IM: 588
Neph: 878
Palliative: 882
Rads: 918
ID: 969
FM/PC: 1,102
Cards: 1,177
Surgery: 2,340
Psych: 2,441
Onc: 2,815
Immuno: 2,988
Peds: 2,999
August 27, 2025 at 4:25 AM
🫁 Listen up LUNG people! 🫁
Get your colleagues over here to #medsky and start posting and engaging! These breathing problems aren’t gonna fix themselves - we need engagement, knowledge sharing, and discussion! 🤩
Get your colleagues over here to #medsky and start posting and engaging! These breathing problems aren’t gonna fix themselves - we need engagement, knowledge sharing, and discussion! 🤩
Reposted by Killian Hurley
A new study reveals a shocking link between oil & gas air pollution and the health of our children. It's time to demand cleaner air for our families. #CleanAir #ClimateAction #ProtectOurKids #momsky
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Air pollution from oil and gas causes 90,000 premature US deaths each year, says new study
Study analyzed health impacts of fossil fuels from exploration to end use, and found communities of color bear brunt of harm
www.theguardian.com
August 24, 2025 at 5:46 PM
A new study reveals a shocking link between oil & gas air pollution and the health of our children. It's time to demand cleaner air for our families. #CleanAir #ClimateAction #ProtectOurKids #momsky
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Reposted by Killian Hurley
The nicotine addiction industry always wants new victims. Why else sell bubblegum flavoured vapes?
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Third of UK teenagers who vape will go on to start smoking, research shows
Findings suggest e-cigarettes increasingly act as ‘gateway’ to nicotine for children, undermining earlier falling rates
www.theguardian.com
July 30, 2025 at 5:26 AM
The nicotine addiction industry always wants new victims. Why else sell bubblegum flavoured vapes?
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Reposted by Killian Hurley
The air we breathe at work shouldn’t put our health at risk.
That’s why we propose new exposure limits for hazardous chemicals like cobalt, PAHs, 1,4-dioxane & welding fumes.
These measures could save €1.16B in healthcare costs & protect workers’ lives ↓
europa.eu/!mCQd69
That’s why we propose new exposure limits for hazardous chemicals like cobalt, PAHs, 1,4-dioxane & welding fumes.
These measures could save €1.16B in healthcare costs & protect workers’ lives ↓
europa.eu/!mCQd69
July 18, 2025 at 12:01 PM
The air we breathe at work shouldn’t put our health at risk.
That’s why we propose new exposure limits for hazardous chemicals like cobalt, PAHs, 1,4-dioxane & welding fumes.
These measures could save €1.16B in healthcare costs & protect workers’ lives ↓
europa.eu/!mCQd69
That’s why we propose new exposure limits for hazardous chemicals like cobalt, PAHs, 1,4-dioxane & welding fumes.
These measures could save €1.16B in healthcare costs & protect workers’ lives ↓
europa.eu/!mCQd69
Reposted by Killian Hurley
We are delighted that RCSI is featured on the Sunday Times Ireland Best Places to Work 2025 list.
Organisations must have excellent scores across a six-step framework, including reward and recognition, well-being and job satisfaction.
🔗 www.thetimes.com/world/irelan... #BestPlacestoWork2025
Organisations must have excellent scores across a six-step framework, including reward and recognition, well-being and job satisfaction.
🔗 www.thetimes.com/world/irelan... #BestPlacestoWork2025
July 14, 2025 at 9:35 AM
We are delighted that RCSI is featured on the Sunday Times Ireland Best Places to Work 2025 list.
Organisations must have excellent scores across a six-step framework, including reward and recognition, well-being and job satisfaction.
🔗 www.thetimes.com/world/irelan... #BestPlacestoWork2025
Organisations must have excellent scores across a six-step framework, including reward and recognition, well-being and job satisfaction.
🔗 www.thetimes.com/world/irelan... #BestPlacestoWork2025
Delighted to give a talk at the Vermont Lung Stem Cell Conference last week.
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
July 14, 2025 at 5:30 PM
Delighted to give a talk at the Vermont Lung Stem Cell Conference last week.
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
Reposted by Killian Hurley
Incidence, Prevalence, and Mortality of Interstitial Lung Diseases in Alberta, Canada: A Population-based Study
www.atsjournals.org/doi/suppl/10...
🧵👇
📣 TL:DR Incidence stable, prevalence rising, improved survival for ILD & IPF over 10 years.
Numbers much higher than prior reports for ILD & IPF.
www.atsjournals.org/doi/suppl/10...
🧵👇
📣 TL:DR Incidence stable, prevalence rising, improved survival for ILD & IPF over 10 years.
Numbers much higher than prior reports for ILD & IPF.
July 4, 2025 at 2:35 PM
Incidence, Prevalence, and Mortality of Interstitial Lung Diseases in Alberta, Canada: A Population-based Study
www.atsjournals.org/doi/suppl/10...
🧵👇
📣 TL:DR Incidence stable, prevalence rising, improved survival for ILD & IPF over 10 years.
Numbers much higher than prior reports for ILD & IPF.
www.atsjournals.org/doi/suppl/10...
🧵👇
📣 TL:DR Incidence stable, prevalence rising, improved survival for ILD & IPF over 10 years.
Numbers much higher than prior reports for ILD & IPF.
Dirty air is killing more than 500 people a week in the UK according to a Royal College of Physicians report.
This is a public health issue and not just an environmental one.
@royalcollege.bsky.social
@irishthoracicsoc.bsky.social
@ilfa-ireland.bsky.social
www.theguardian.com/environment/...
This is a public health issue and not just an environmental one.
@royalcollege.bsky.social
@irishthoracicsoc.bsky.social
@ilfa-ireland.bsky.social
www.theguardian.com/environment/...
UK air pollution killing more than 500 people a week, doctors say
Royal College of Physicians also says poor air quality costs country more than £500m a week
www.theguardian.com
June 29, 2025 at 10:20 AM
Dirty air is killing more than 500 people a week in the UK according to a Royal College of Physicians report.
This is a public health issue and not just an environmental one.
@royalcollege.bsky.social
@irishthoracicsoc.bsky.social
@ilfa-ireland.bsky.social
www.theguardian.com/environment/...
This is a public health issue and not just an environmental one.
@royalcollege.bsky.social
@irishthoracicsoc.bsky.social
@ilfa-ireland.bsky.social
www.theguardian.com/environment/...
A wet but spirited performance from Neil Young and the Chrome Hearts in Malahide Castle Dublin.
Well worth the rain. ☔️
@neilyoungarchives.bsky.social
Well worth the rain. ☔️
@neilyoungarchives.bsky.social
June 28, 2025 at 9:02 AM
A wet but spirited performance from Neil Young and the Chrome Hearts in Malahide Castle Dublin.
Well worth the rain. ☔️
@neilyoungarchives.bsky.social
Well worth the rain. ☔️
@neilyoungarchives.bsky.social
Reposted by Killian Hurley
Agreed, impressive!
Involved significant immunosuppression: ATG then sirolimus/tacrolimus
2 deaths: 1 related to preexisting neurological disorder, the other cryptococcal meningitis related to sinus surgery + high-dose systemic steroids prohibited by the protocol
www.nejm.org/doi/full/10....
Involved significant immunosuppression: ATG then sirolimus/tacrolimus
2 deaths: 1 related to preexisting neurological disorder, the other cryptococcal meningitis related to sinus surgery + high-dose systemic steroids prohibited by the protocol
www.nejm.org/doi/full/10....
June 21, 2025 at 5:14 AM
Agreed, impressive!
Involved significant immunosuppression: ATG then sirolimus/tacrolimus
2 deaths: 1 related to preexisting neurological disorder, the other cryptococcal meningitis related to sinus surgery + high-dose systemic steroids prohibited by the protocol
www.nejm.org/doi/full/10....
Involved significant immunosuppression: ATG then sirolimus/tacrolimus
2 deaths: 1 related to preexisting neurological disorder, the other cryptococcal meningitis related to sinus surgery + high-dose systemic steroids prohibited by the protocol
www.nejm.org/doi/full/10....
Reposted by Killian Hurley
Finally out! The first AI regenerative model applied to IPF & PCLS single nuclear sequencing data is out & it works!!
See 🧵 below
and paper here
www.nature.com/articles/s41...
#CureIPF
#ScienceMatters
See 🧵 below
and paper here
www.nature.com/articles/s41...
#CureIPF
#ScienceMatters
June 20, 2025 at 9:26 PM
Finally out! The first AI regenerative model applied to IPF & PCLS single nuclear sequencing data is out & it works!!
See 🧵 below
and paper here
www.nature.com/articles/s41...
#CureIPF
#ScienceMatters
See 🧵 below
and paper here
www.nature.com/articles/s41...
#CureIPF
#ScienceMatters
Another piece in the puzzle of telomere biology disorders and pulmonary fibrosis - well done to the Tzfati and @kaminskimed.bsky.social teams.
Beautiful paper!
#CureIPF
#MedSky
#SciSky
Beautiful paper!
#CureIPF
#MedSky
#SciSky
Wow!!
Mice inserted with RTEL1 point mutation causal of human Hoyeraal-Hreidarsson syndrome (HHS), display ⬆️ telomere DNA damage & fragility, aberrant hematopoiesis & pre-fibrotic changes in the lung.
Kudos Drs Smoom, Kaestner, Tzfati & team💪🏼
#ScienceMatters
academic.oup.com/nar/article/...
Mice inserted with RTEL1 point mutation causal of human Hoyeraal-Hreidarsson syndrome (HHS), display ⬆️ telomere DNA damage & fragility, aberrant hematopoiesis & pre-fibrotic changes in the lung.
Kudos Drs Smoom, Kaestner, Tzfati & team💪🏼
#ScienceMatters
academic.oup.com/nar/article/...
Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1
Abstract. RTEL1 is an essential DNA helicase that plays multiple roles in genome stability and telomere length regulation. The ultra-long telomeres of the
academic.oup.com
June 18, 2025 at 8:02 PM
Another piece in the puzzle of telomere biology disorders and pulmonary fibrosis - well done to the Tzfati and @kaminskimed.bsky.social teams.
Beautiful paper!
#CureIPF
#MedSky
#SciSky
Beautiful paper!
#CureIPF
#MedSky
#SciSky
Reposted by Killian Hurley
It that JIF time of year again and here they are. Some surprising movement which leaves me & I’m sure other wondering a) what does it mean & b) will journals adjust strategy or process as a result!
No change at the top:
@lancetrespirmed.bsky.social 32.1
However coming in at number 2 🥁🥁
No change at the top:
@lancetrespirmed.bsky.social 32.1
However coming in at number 2 🥁🥁
June 18, 2025 at 1:01 PM
It that JIF time of year again and here they are. Some surprising movement which leaves me & I’m sure other wondering a) what does it mean & b) will journals adjust strategy or process as a result!
No change at the top:
@lancetrespirmed.bsky.social 32.1
However coming in at number 2 🥁🥁
No change at the top:
@lancetrespirmed.bsky.social 32.1
However coming in at number 2 🥁🥁