kevinbolding.bsky.social
@kevinbolding.bsky.social
Memory / olfaction PI at Monell Chemical Senses Center in Philly
boldinglab.org
kevinbolding@neuromatch.social
boldinglab.org
kevinbolding@neuromatch.social
Anyone know where to find an example of an inhibitory cross-correlogram produced by a somatostatin interneuron? #neuroskyence
July 15, 2025 at 1:26 AM
Anyone know where to find an example of an inhibitory cross-correlogram produced by a somatostatin interneuron? #neuroskyence
Reposted by kevinbolding.bsky.social
Neuropixels and Optogenetics are delighted to announce the birth of
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
February 7, 2025 at 9:16 AM
Neuropixels and Optogenetics are delighted to announce the birth of
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
Reposted by kevinbolding.bsky.social
This year we ran another meme contest as part of my ML4CCN lecture series. Student submissions were fantastic.
Guess the paper...
Guess the paper...
February 6, 2025 at 7:26 PM
This year we ran another meme contest as part of my ML4CCN lecture series. Student submissions were fantastic.
Guess the paper...
Guess the paper...
Reposted by kevinbolding.bsky.social
Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's @ivychanchiwai.bsky.social findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body
Neural representations of sensory stimuli serve multiple distinct purposes, from the rapid recognition of familiar environments, to the precise identification of individual salient cues. In the insect...
www.biorxiv.org
January 27, 2025 at 2:17 PM
Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's @ivychanchiwai.bsky.social findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by kevinbolding.bsky.social
John Cohen, Painter/Collage Artist/Graphic Designer Robert Rauschenberg Preparing for a Show at the Tanager Gallery, 10th St, New York City, 1959.
February 2, 2025 at 4:38 PM
John Cohen, Painter/Collage Artist/Graphic Designer Robert Rauschenberg Preparing for a Show at the Tanager Gallery, 10th St, New York City, 1959.
Reposted by kevinbolding.bsky.social
NSF’s cash management service is now back up and running.
Seems like they responded to the court order.
new.nsf.gov/executive-or...
Seems like they responded to the court order.
new.nsf.gov/executive-or...
NSF Implementation of Recent Executive Orders
Information for the NSF community regarding executive orders.
new.nsf.gov
February 2, 2025 at 5:13 PM
NSF’s cash management service is now back up and running.
Seems like they responded to the court order.
new.nsf.gov/executive-or...
Seems like they responded to the court order.
new.nsf.gov/executive-or...
Reposted by kevinbolding.bsky.social
Here's the speech if you haven't heard it. 13 minutes of your time. Share it with your American friends and neighbours, because they won't see it otherwise. Circulate it in Mexico and Denmark, France and the UK, Panama and Germany, Poland and Estonia, and especially -- especially -- Ukraine.
Trudeau: Canada will retaliate with 25% tariffs on $155B of U.S. goods
YouTube video by CBC News
youtu.be
February 2, 2025 at 4:38 AM
Here's the speech if you haven't heard it. 13 minutes of your time. Share it with your American friends and neighbours, because they won't see it otherwise. Circulate it in Mexico and Denmark, France and the UK, Panama and Germany, Poland and Estonia, and especially -- especially -- Ukraine.
Reposted by kevinbolding.bsky.social
Really proud to see my postdoc work out!!
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
Touch-evoked traveling waves establish a translaminar spacetime code
Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.
www.science.org
January 31, 2025 at 10:54 PM
Really proud to see my postdoc work out!!
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
Reposted by kevinbolding.bsky.social
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!
The time course and organization of hippocampal replay
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...
www.science.org
January 31, 2025 at 9:14 PM
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!
Reposted by kevinbolding.bsky.social
Someone needs to be reaching out to these philanthropies to make it VERY CLEAR that the return on investment from their donations will TANK with NIH and NSF being affected, and that THEIR GOOD MONEY and investment is being being WASTED by these inexcusable (from a business angle) actions.
January 31, 2025 at 5:09 PM
Someone needs to be reaching out to these philanthropies to make it VERY CLEAR that the return on investment from their donations will TANK with NIH and NSF being affected, and that THEIR GOOD MONEY and investment is being being WASTED by these inexcusable (from a business angle) actions.
Reposted by kevinbolding.bsky.social
Sources of philanthropic giving to biomedical science and training programs (graduate and medical school programs, etc.) are NOT going to backstop the loss of NIH, NSF Funding. They aren't able to do so, and many of them may not want attention.
BUT they have sway, and have money in the game.
BUT they have sway, and have money in the game.
January 31, 2025 at 5:09 PM
Sources of philanthropic giving to biomedical science and training programs (graduate and medical school programs, etc.) are NOT going to backstop the loss of NIH, NSF Funding. They aren't able to do so, and many of them may not want attention.
BUT they have sway, and have money in the game.
BUT they have sway, and have money in the game.
Reposted by kevinbolding.bsky.social
My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)
Opinion | The Devastating Legacy of Lies in Alzheimer’s Science
Fraud in research needs to end.
nam12.safelinks.protection.outlook.com
January 30, 2025 at 9:37 PM
My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)
Reposted by kevinbolding.bsky.social
Tetanus on demand! (not for bioweapons, but for neuroscience research)
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
January 30, 2025 at 2:30 PM
Tetanus on demand! (not for bioweapons, but for neuroscience research)
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
Reposted by kevinbolding.bsky.social
Reposted by kevinbolding.bsky.social
🚨Important paper alert (a bit late, but see below)
Guo et al show that while place cells may not initially form a manifold reflecting the environment's topology, the topology is learned across days, during sleep.
www.cell.com/cell-reports...
Another story to tell about this paper 👇
1/5
Guo et al show that while place cells may not initially form a manifold reflecting the environment's topology, the topology is learned across days, during sleep.
www.cell.com/cell-reports...
Another story to tell about this paper 👇
1/5
Latent learning drives sleep-dependent plasticity in distinct CA1 subpopulations
Guo et al. find that when mice repeatedly explore a novel environment, a distinct
subset of neurons in the CA1 region of the hippocampus, which initially exhibits weak
spatial selectivity, gradually d...
www.cell.com
January 28, 2025 at 3:45 PM
🚨Important paper alert (a bit late, but see below)
Guo et al show that while place cells may not initially form a manifold reflecting the environment's topology, the topology is learned across days, during sleep.
www.cell.com/cell-reports...
Another story to tell about this paper 👇
1/5
Guo et al show that while place cells may not initially form a manifold reflecting the environment's topology, the topology is learned across days, during sleep.
www.cell.com/cell-reports...
Another story to tell about this paper 👇
1/5
Reposted by kevinbolding.bsky.social
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
Apply by: February 16th!
January 14, 2025 at 4:58 AM
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
Apply by: February 16th!
Reposted by kevinbolding.bsky.social
Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here.
From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."
From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."
The Effect of Olfactory Disorder (and Other Chemosensory Disorders) on Perception, Acceptance, and Consumption of Food
People with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...
link.springer.com
January 26, 2025 at 3:31 PM
Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here.
From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."
From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."
The reveal of what she created here (the strings, the screamed chorus) had me crying laughing. Truly bonkers.
youtu.be/DwhbnN9hCtI
youtu.be/DwhbnN9hCtI
I Made Good Luck Babe By Chappell Roan Without Hearing It
YouTube video by Dev Limes
youtu.be
January 26, 2025 at 3:21 AM
The reveal of what she created here (the strings, the screamed chorus) had me crying laughing. Truly bonkers.
youtu.be/DwhbnN9hCtI
youtu.be/DwhbnN9hCtI
Reposted by kevinbolding.bsky.social
Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence
#neuroskyence
January 22, 2025 at 6:27 PM
Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence
#neuroskyence
Reposted by kevinbolding.bsky.social
Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Experience-dependent dopamine modulation of male aggression - Nature
Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.
www.nature.com
January 22, 2025 at 7:38 PM
Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by kevinbolding.bsky.social
New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal - Nature Communications
Hernandez-Trejo, Ciuparu, and Garcia da Silva et al. report that the piriform-to-olfactory bulb feedback in the mouse carries multimodal identity and reward contingency signals, which are re-formatted...
doi.org
January 23, 2025 at 11:27 AM
New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence
#neuroskyence
January 22, 2025 at 6:27 PM
Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence
#neuroskyence
Reposted by kevinbolding.bsky.social
Alison's work is always worth a look! SST interneurons provide precise inputs to the various dendritic branches of pyramidal cells, as well as providing strong interneuron regulation. Go take a look at this review of their role in cognition and learning!
Neocortical somatostatin neuron diversity in cognition and learning: doi.org/10.1016/j.ti...
"In this review, we discuss and synthesize recent advances in understanding the diversity, circuit integration, and functional properties of this important group of GABAergic neurons."
"In this review, we discuss and synthesize recent advances in understanding the diversity, circuit integration, and functional properties of this important group of GABAergic neurons."
January 19, 2025 at 9:02 PM
Alison's work is always worth a look! SST interneurons provide precise inputs to the various dendritic branches of pyramidal cells, as well as providing strong interneuron regulation. Go take a look at this review of their role in cognition and learning!