Benedikt Kessler
@kesslerbenedikt001.bsky.social
Professor of Biochemistry and Life Science Mass Spectrometry. Ubiquitin & Protease Biology. Sings in the Witchert Chorale.
Many congratulations Emma for your Ph.D.📜 Remarkable contribution to the NLRP3 inflammasome field 👩🔬
Delighted to announce I passed my PhD viva yesterday! Many thanks to my examiners @kesslerbenedikt001.bsky.social and @gunnarns.bsky.social for the fantastic discussion and feedback. Thanks as well to my incredible supervisors Ben Collins and @colllab.bsky.social, and everyone in the labs!
October 1, 2025 at 7:06 PM
Many congratulations Emma for your Ph.D.📜 Remarkable contribution to the NLRP3 inflammasome field 👩🔬
Reposted by Benedikt Kessler
So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊
October 1, 2025 at 2:07 PM
So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊
Reposted by Benedikt Kessler
#ChronicPain is considered one of the leading causes of disability worldwide. But for the first time, researchers at @CMD.ox.ac.uk and others have discovered a new genetic link to pain, offering a promising target for treating chronic pain 🧬
Find out more 👉 www.ndm.ox.ac.uk/news/chronic...
Find out more 👉 www.ndm.ox.ac.uk/news/chronic...
August 21, 2025 at 11:00 AM
#ChronicPain is considered one of the leading causes of disability worldwide. But for the first time, researchers at @CMD.ox.ac.uk and others have discovered a new genetic link to pain, offering a promising target for treating chronic pain 🧬
Find out more 👉 www.ndm.ox.ac.uk/news/chronic...
Find out more 👉 www.ndm.ox.ac.uk/news/chronic...
Reposted by Benedikt Kessler
Our review is out now in Molecular & Cellular Proteomics! We discuss the latest advances in #HDX mass spectrometry to aid neurotherapeutic design & development in #Alzheimers, #Parkinsons and #ALS, providing molecular insights into protein aggregation pathways and therapeutic antibodies 🧠
Driving Therapeutic Innovation in Neurodegenerative Disease with Hydrogen Deuterium eXchange Mass Spectrometry
Human neurodegenerative conditions such as Parkinson’s and Alzheimer’s Disease are
characterized by the formation and deposition of toxic protein species which exacerbate
neuronal dysfunction, impacti...
www.mcponline.org
June 23, 2025 at 8:43 AM
Our review is out now in Molecular & Cellular Proteomics! We discuss the latest advances in #HDX mass spectrometry to aid neurotherapeutic design & development in #Alzheimers, #Parkinsons and #ALS, providing molecular insights into protein aggregation pathways and therapeutic antibodies 🧠
Reposted by Benedikt Kessler
🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
May 19, 2025 at 8:20 AM
🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
Reposted by Benedikt Kessler
My time in his lab - which only stretched 6-7 months - has had a lasting impact on my career. It was there, that I fell in love with proteases, I met my later post-doc advisor @mbogyo.bsky.social, performed my first cell culture under guidance of @kesslerbenedikt001.bsky.social, and learned a lot!
May 23, 2025 at 9:54 PM
My time in his lab - which only stretched 6-7 months - has had a lasting impact on my career. It was there, that I fell in love with proteases, I met my later post-doc advisor @mbogyo.bsky.social, performed my first cell culture under guidance of @kesslerbenedikt001.bsky.social, and learned a lot!
Reposted by Benedikt Kessler
Last Saturday, I attended - unfortunately not live, but hybrid - the retirement symposium of Prof. Hidde Ploegh. I enjoyed presentations of @kesslerbenedikt001.bsky.social @mbogyo.bsky.social, Domenic Tortorella, various other alumni of the lab, and of course of Hidde himself
May 23, 2025 at 9:54 PM
Last Saturday, I attended - unfortunately not live, but hybrid - the retirement symposium of Prof. Hidde Ploegh. I enjoyed presentations of @kesslerbenedikt001.bsky.social @mbogyo.bsky.social, Domenic Tortorella, various other alumni of the lab, and of course of Hidde himself
Integrative proximal-ubiquitomics profiling for deubiquitinase (DUB) substrate discovery applied to USP30: www.cell.com/cell-chemica...
May 20, 2025 at 5:17 PM
Integrative proximal-ubiquitomics profiling for deubiquitinase (DUB) substrate discovery applied to USP30: www.cell.com/cell-chemica...
ABPP reveals novel ubiquitin pathway enzymes in Plasmodium. PLOS Pathogens 21(4): e1013032. doi.org/10.1371/jour...
& Katerina Artanavis-Tsakonas’ lab
& Katerina Artanavis-Tsakonas’ lab
Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium
Author summary Malaria parasites, like all living organisms, need to regulate their proteins carefully to survive and grow. One important way they do this is through a process called ubiquitination, w...
doi.org
April 21, 2025 at 1:55 PM
ABPP reveals novel ubiquitin pathway enzymes in Plasmodium. PLOS Pathogens 21(4): e1013032. doi.org/10.1371/jour...
& Katerina Artanavis-Tsakonas’ lab
& Katerina Artanavis-Tsakonas’ lab
Reposted by Benedikt Kessler
Also see the associated News & Views by Tim Clausen for a quick summary: www.nature.com/articles/d41...
Protein waste turned into antibiotics as a defence strategy of human cells
Proteasome cleavage changes during infection to generate antibiotics.
www.nature.com
March 6, 2025 at 6:36 AM
Also see the associated News & Views by Tim Clausen for a quick summary: www.nature.com/articles/d41...
Reposted by Benedikt Kessler
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!
👉 go.nature.com/43k1a0H
👉 go.nature.com/43k1a0H
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 6:36 AM
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!
👉 go.nature.com/43k1a0H
👉 go.nature.com/43k1a0H
Reposted by Benedikt Kessler
DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...
A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode
Many intracellular bacteria secrete deubiquitinase (DUB) effectors into eukaryotic host cells to keep the bacterial surface or the enclosing vesicle m…
www.sciencedirect.com
March 4, 2025 at 8:40 AM
DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...
Profiling E2-specific substrates reveals tyrosine ubiquitination rdcu.be/eax1F News & Views rdcu.be/eaw41
Tracking E2-specific substrates
Nature Chemical Biology - Advanced E2-modified ubiquitin probes enable investigation of E2-selective ubiquitination in cells and the discovery of tyrosine ubiquitination as a modification occurring...
rdcu.be
February 20, 2025 at 8:37 AM
Profiling E2-specific substrates reveals tyrosine ubiquitination rdcu.be/eax1F News & Views rdcu.be/eaw41
Reposted by Benedikt Kessler
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
Reposted by Benedikt Kessler
Interesting talk by Hannah Jones at #EFMCISBC25. She talked at the development of a chemoproteomic assay with data-independent acquisition to profile deubiquitinase binders at 100 samples per day with a coverage of 35-40 DUBs. www.mdpi.com/1422-0067/23...
January 31, 2025 at 2:13 PM
Interesting talk by Hannah Jones at #EFMCISBC25. She talked at the development of a chemoproteomic assay with data-independent acquisition to profile deubiquitinase binders at 100 samples per day with a coverage of 35-40 DUBs. www.mdpi.com/1422-0067/23...
Reposted by Benedikt Kessler
A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology
Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...
www.nature.com
January 10, 2025 at 3:07 PM
A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From the Kessler Lab & STAMP @darraghobrien.bsky.social: Structural Dynamics of the Ubiquitin Specific Protease USP30-Inhibitor Complex revealed by HDX-MS @cmd.ox.ac.uk shorturl.at/GeImS
February 8, 2025 at 11:23 AM
From the Kessler Lab & STAMP @darraghobrien.bsky.social: Structural Dynamics of the Ubiquitin Specific Protease USP30-Inhibitor Complex revealed by HDX-MS @cmd.ox.ac.uk shorturl.at/GeImS
Reposted by Benedikt Kessler
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
November 15, 2024 at 7:38 PM
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn