Kristi T.
@katgrrl73.bsky.social
👍: drawing, painting, reading, nature, the PNW. Slow food and a cuppa hot tea. History. Research, critical thinking skills, and a Renaissance mind.
👎: Angry, selfish, judgmental, fake people. Religious cults. American fascism-#saynotoProject2025.
👎: Angry, selfish, judgmental, fake people. Religious cults. American fascism-#saynotoProject2025.
Reposted by Kristi T.
Reposted by Kristi T.
Reposted by Kristi T.
Love this. Superbly done. Please send this far and wide. @donwinslow.bsky.social
October 6, 2025 at 11:00 PM
Love this. Superbly done. Please send this far and wide. @donwinslow.bsky.social
Reposted by Kristi T.
LOOK AT ALL THE PEOPLE DESPERATELY RUNNING 26 MILES, 385 YARDS TO ESCAPE A WAR ZONE
It was a beautiful Sunday in Portland. Farmer’s markets, the Portland Marathon, peaceful protests, and some views of Mt. Hood. This city is vibrant, peaceful, and resilient. We do not need a federal occupation, and we sure as hell don’t want one.
October 7, 2025 at 3:52 AM
LOOK AT ALL THE PEOPLE DESPERATELY RUNNING 26 MILES, 385 YARDS TO ESCAPE A WAR ZONE
Reposted by Kristi T.
Same with this gem
October 3, 2025 at 12:36 PM
Same with this gem
Reposted by Kristi T.
Reposted by Kristi T.
Even in the world where Trump is somehow right and Epstein was an elaborate blackmail operation by the U.S. government to ensnare every prominent American political aspirant over the last 40 years… I would like to know that. That is also bad. It would be good information to have.
July 12, 2025 at 11:44 PM
Even in the world where Trump is somehow right and Epstein was an elaborate blackmail operation by the U.S. government to ensnare every prominent American political aspirant over the last 40 years… I would like to know that. That is also bad. It would be good information to have.
Reposted by Kristi T.
The censorship algorithm on Twitter reduced our audience by roughly 95%, and seriously, who does that to a wildlife biology & advocacy group ?
So we moved 😇 over here to BlueSky
If you could, please help us regain our following
Follow
Retweet and
Repeat ;-)
Together we can change the world.
So we moved 😇 over here to BlueSky
If you could, please help us regain our following
Follow
Retweet and
Repeat ;-)
Together we can change the world.
January 4, 2025 at 5:56 PM
The censorship algorithm on Twitter reduced our audience by roughly 95%, and seriously, who does that to a wildlife biology & advocacy group ?
So we moved 😇 over here to BlueSky
If you could, please help us regain our following
Follow
Retweet and
Repeat ;-)
Together we can change the world.
So we moved 😇 over here to BlueSky
If you could, please help us regain our following
Follow
Retweet and
Repeat ;-)
Together we can change the world.
Reposted by Kristi T.
“I am directing the Bureau of Prisons to use all 850 Joann locations to house America’s most ruthless and violent Offenders,” Trump wrote in a post on Truth Social
theonion.com/trump-v...
theonion.com/trump-v...
Trump Vows To Reopen Joann Fabrics As Prison
WASHINGTON—Vowing to restore and revitalize the facilities as a symbol of law, order, and justice, President Donald Trump ordered the U.S. government Monday to reopen Joann Fabrics and Crafts stores as federal prisons. “I am directing the Bureau of Prisons to use all 850 Joann locations to house America’s most ruthless and violent Offenders,” Trump wrote […]
theonion.com
May 6, 2025 at 11:30 PM
“I am directing the Bureau of Prisons to use all 850 Joann locations to house America’s most ruthless and violent Offenders,” Trump wrote in a post on Truth Social
theonion.com/trump-v...
theonion.com/trump-v...
Reposted by Kristi T.
Study in Greece (2020–2023, 10M people) found COVID-19 linked to rises in rheumatoid arthritis (+20%), lupus, psoriatic arthritis, ankylosing spondylitis, and systemic sclerosis.
SARS-CoV-2 may trigger autoimmunity.
link.springer.com/article/10.1...
SARS-CoV-2 may trigger autoimmunity.
link.springer.com/article/10.1...
COVID-19 is a trigger of autoimmune rheumatic diseases: a hypothesis tested over time - Rheumatology International
We discuss the paper recently published in Rheumatology Internationa. This article reflects on the prevalence of autoimmune rheumatic diseases (ARD) during the COVID-19 pandemic (2020–2023) and compar...
link.springer.com
December 29, 2024 at 3:00 PM
Study in Greece (2020–2023, 10M people) found COVID-19 linked to rises in rheumatoid arthritis (+20%), lupus, psoriatic arthritis, ankylosing spondylitis, and systemic sclerosis.
SARS-CoV-2 may trigger autoimmunity.
link.springer.com/article/10.1...
SARS-CoV-2 may trigger autoimmunity.
link.springer.com/article/10.1...
Reposted by Kristi T.
📃Scientific paper: PAPILLARY THYROID CARCINOMA FOLLOWING ADALIMUMAB TREATMENT IN ANKYLOSING SPONDYLITIS: A CAUSAL OR CO...
➡️ Continued on ES/IODE
➡️ Continued on ES/IODE
September 4, 2024 at 7:17 PM
📃Scientific paper: PAPILLARY THYROID CARCINOMA FOLLOWING ADALIMUMAB TREATMENT IN ANKYLOSING SPONDYLITIS: A CAUSAL OR CO...
➡️ Continued on ES/IODE
➡️ Continued on ES/IODE
Reposted by Kristi T.
Deciphering Metabolic Pathways and Protein-Protein Interaction Networks in Ankylosing Spondylitis through Single-Cell RNA Sequencing https://www.biorxiv.org/content/10.1101/2024.10.21.619465v1
Deciphering Metabolic Pathways and Protein-Protein Interaction Networks in Ankylosing Spondylitis through Single-Cell RNA Sequencing https://www.biorxiv.org/content/10.1101/2024.10.21.619465v1
Ankylosing Spondylitis (AS) is a common autoimmune disease affecting spinal joints and causing chron
www.biorxiv.org
October 24, 2024 at 10:04 PM
Deciphering Metabolic Pathways and Protein-Protein Interaction Networks in Ankylosing Spondylitis through Single-Cell RNA Sequencing https://www.biorxiv.org/content/10.1101/2024.10.21.619465v1
Reposted by Kristi T.
Ankylosing spondylitis
You stand until it hurts so you sit
You sit until it hurts so you lie down
You lie down until it hurts so you stand.
Wash and repeat.
You stand until it hurts so you sit
You sit until it hurts so you lie down
You lie down until it hurts so you stand.
Wash and repeat.
January 25, 2025 at 6:18 PM
Ankylosing spondylitis
You stand until it hurts so you sit
You sit until it hurts so you lie down
You lie down until it hurts so you stand.
Wash and repeat.
You stand until it hurts so you sit
You sit until it hurts so you lie down
You lie down until it hurts so you stand.
Wash and repeat.
Reposted by Kristi T.
Extracellular Vesicles Derived from Ligament Tissue Transport Interleukin‐17A to Mediate Ligament‐To‐Bone Crosstalk in Ankylosing Spondylitis
Extracellular Vesicles Derived from Ligament Tissue Transport Interleukin‐17A to Mediate Ligament‐To‐Bone Crosstalk in Ankylosing Spondylitis
Extracellular vesicles (EVs) derived from ligament tissue mediate inter-tissue communication between ligament and bone in ankylosing spondylitis (AS). EVs carrying interleukin-17A promote osteogenic differentiation of AS mesenchymal stem cells by altering the cellular cytoskeleton and mechanical signaling. This study provides the first evidence of tissue EVs contributing to pathological ossification in AS, offering potential avenues for targeted therapies.
Abstract
Pathological new bone formation is a critical feature of the progression of ankylosing spondylitis (AS), and spine ankylosis is a distinctive feature of this condition. Ligaments are the primary regions of pathological new bone formation in AS. Here, it is demonstrated that ligament tissue-derived extracellular vesicles (EVs) and their interleukin-17A (IL-17A) cargo mediate the communication between the tissue and other cells. The investigation revealed that IL-17A in EVs can activate the JAK-STAT3 pathway, thereby stimulating the expression of MMP14 in AS ligament. Overexpression of MMP14 can lead to changes in the cytoskeleton and mechanical signaling of mesenchymal stem cells and other cells. These alterations in cellular cytoskeleton and mechanical signaling at ligament sites in patients with AS or in stem cells treated with EVs can result in pathological new bone formation. Finally, inhibiting IL-17A activity and EV endocytosis effectively controlled inflammation and pathological new bone formation. Overall, these data suggest that ligament-derived EVs and the enclosed IL-17A have a potential role in driving pathological new bone formation in AS, and targeting EVs may therefore emerge as a novel approach to delaying ectopic ossification in AS.
onlinelibrary.wiley.com
September 23, 2024 at 9:10 AM
Extracellular Vesicles Derived from Ligament Tissue Transport Interleukin‐17A to Mediate Ligament‐To‐Bone Crosstalk in Ankylosing Spondylitis
Reposted by Kristi T.
Multi-Omics Uncover New Targets for Ankylosing Spondylitis Treatment
Genetically Supported Drug Targets Shine Through Integrative Analysis
onixonpoint.substack.com/p/multi-omic...
Genetically Supported Drug Targets Shine Through Integrative Analysis
onixonpoint.substack.com/p/multi-omic...
March 13, 2025 at 11:43 AM
Multi-Omics Uncover New Targets for Ankylosing Spondylitis Treatment
Genetically Supported Drug Targets Shine Through Integrative Analysis
onixonpoint.substack.com/p/multi-omic...
Genetically Supported Drug Targets Shine Through Integrative Analysis
onixonpoint.substack.com/p/multi-omic...
Reposted by Kristi T.
Exploring the mechanisms and potential therapeutic targets of Ferroptosis Related Genes in ankylosing spondylitis https://www.biorxiv.org/content/10.1101/2023.09.19.558184v1
Exploring the mechanisms and potential therapeutic targets of Ferroptosis Related Genes in ankylosing spondylitis https://www.biorxiv.org/content/10.1101/2023.09.19.558184v1
Background: Ferroptosis is a novel type of regulated cell death, and there is growing evidence that
www.biorxiv.org
September 22, 2023 at 10:48 AM
Exploring the mechanisms and potential therapeutic targets of Ferroptosis Related Genes in ankylosing spondylitis https://www.biorxiv.org/content/10.1101/2023.09.19.558184v1
Reposted by Kristi T.
The pain of Ankylosing Spondylitis is equivalent to the pain of childbirth.. only difference is my pain lasts forever.. #Spoonie #ChronicPain #Disability
www.tiktok.com/t/ZT2XGb6xf/
www.tiktok.com/t/ZT2XGb6xf/
The pain associated with Ankylosing Spondylitis is equivalent with the pain of childbirth. Except it lasts forever.. #chronicillness #spoonie #trending #fyp #chronicpain #ankylosingspondylitis
TikTok video by Jed Finley
www.tiktok.com
March 10, 2025 at 1:41 AM
The pain of Ankylosing Spondylitis is equivalent to the pain of childbirth.. only difference is my pain lasts forever.. #Spoonie #ChronicPain #Disability
www.tiktok.com/t/ZT2XGb6xf/
www.tiktok.com/t/ZT2XGb6xf/
Reposted by Kristi T.
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
March 15, 2025 at 5:32 PM
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
Reposted by Kristi T.
A reminder in dark times: kindness, mercy, decency, and respect towards the least of us enrages Trumpists. It burns them. It’s like a mirror that shows them how they fall short of humanity.
Kindness and decency towards the people Trumpists hate is not just right; it torments Trumpists.
Kindness and decency towards the people Trumpists hate is not just right; it torments Trumpists.
March 16, 2025 at 2:34 AM
A reminder in dark times: kindness, mercy, decency, and respect towards the least of us enrages Trumpists. It burns them. It’s like a mirror that shows them how they fall short of humanity.
Kindness and decency towards the people Trumpists hate is not just right; it torments Trumpists.
Kindness and decency towards the people Trumpists hate is not just right; it torments Trumpists.
Reposted by Kristi T.
Exactly right
Crockett: "Down in Alabama, who's broke. Down in Louisiana, who's broke. I can go through pretty much the entire south and tell you that they're broke and rely on a lot of welfare from the government. To be perfectly honest, it is tax dollars from these big blue states...we're in the find out phase"
February 20, 2025 at 2:07 PM
Exactly right
Reposted by Kristi T.
The total estimated savings when using Cost Plus Drugs compared to Medicare was $462,375,491.53 and $618,833,850.34 for 30- and 90-count pricing, respectively. The price of a 42.5-gram tube of vaginal estrogen cream was $22.48 on Cost Plus Drugs, compared to $293.66 through Medicare Part D.
#econsky
#econsky
We are ready to help pave a path for lower medication and healthcare costs for taxpayers
journals.lww.com/fpmrs/fullte...
journals.lww.com/fpmrs/fullte...
The Mark Cuban Cost Plus Drug Company Effect on... : Urogynecology
imated $1.29 billion reduction in 2020 costs if they replaced the Medicare prices.
Objectives
We sought to investigate the savings for all drugs commonly used in urogynecology.
Study Design
We r...
journals.lww.com
January 30, 2025 at 1:48 AM
The total estimated savings when using Cost Plus Drugs compared to Medicare was $462,375,491.53 and $618,833,850.34 for 30- and 90-count pricing, respectively. The price of a 42.5-gram tube of vaginal estrogen cream was $22.48 on Cost Plus Drugs, compared to $293.66 through Medicare Part D.
#econsky
#econsky
Musk Signals Willingness To Bid More Than $97 Billion To Acquire Respect — theonion.com/musk-signals...
Musk Signals Willingness To Bid More Than $97 Billion To Acquire Respect
WASHINGTON—Stressing that he was open to going far higher to close the deal, Tesla CEO Elon Musk announced Wednesday that he had made an unsolicited $97.4 billion offer to acquire respect. “This is a ...
theonion.com
February 14, 2025 at 2:55 PM
Musk Signals Willingness To Bid More Than $97 Billion To Acquire Respect — theonion.com/musk-signals...
Reposted by Kristi T.
FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States
FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States
WASHINGTON—Putting the nation on alert against what it has described as a “highly credible terrorist threat,” the FBI announced today that it has uncovered a plot by members of al-Qaeda to sit back an...
theonion.com
February 5, 2025 at 6:31 PM
FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States
Reposted by Kristi T.
These are the good guys supporting DEI. Reward them with your business.
Costco
Meijer
Kroger
Giant Grocery
Ben & Jerry’s
Ulta, Macy’s
Old Navy
Nordstrom’s
TJ Maxx
GoTo Foods ( Moe’s Southwest Grill, Mcalister’s, Auntie Anne’s, Jamba, Cinnabon…)
Dollar Tree
Walgreens
Wegmans
Costco
Meijer
Kroger
Giant Grocery
Ben & Jerry’s
Ulta, Macy’s
Old Navy
Nordstrom’s
TJ Maxx
GoTo Foods ( Moe’s Southwest Grill, Mcalister’s, Auntie Anne’s, Jamba, Cinnabon…)
Dollar Tree
Walgreens
Wegmans
January 26, 2025 at 12:07 AM
These are the good guys supporting DEI. Reward them with your business.
Costco
Meijer
Kroger
Giant Grocery
Ben & Jerry’s
Ulta, Macy’s
Old Navy
Nordstrom’s
TJ Maxx
GoTo Foods ( Moe’s Southwest Grill, Mcalister’s, Auntie Anne’s, Jamba, Cinnabon…)
Dollar Tree
Walgreens
Wegmans
Costco
Meijer
Kroger
Giant Grocery
Ben & Jerry’s
Ulta, Macy’s
Old Navy
Nordstrom’s
TJ Maxx
GoTo Foods ( Moe’s Southwest Grill, Mcalister’s, Auntie Anne’s, Jamba, Cinnabon…)
Dollar Tree
Walgreens
Wegmans
Reposted by Kristi T.
The most common question I receive is how everyday citizens can help in the fight for democracy. My advice, take the first step, start with something small and see what works for you. Here are ten things all of us can do. www.democracydocket.com/opinion/10-t...
Ten Things We Can All Do to Protect Democracy
From Marc | The most common question I receive is how everyday citizens can help in the fight for democracy.
www.democracydocket.com
January 25, 2025 at 2:59 PM
The most common question I receive is how everyday citizens can help in the fight for democracy. My advice, take the first step, start with something small and see what works for you. Here are ten things all of us can do. www.democracydocket.com/opinion/10-t...