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kalindi.bsky.social
@kalindi.bsky.social
Accidentally made mint-earl grey tea instead of mint-green tea and am pleasantly surprised.
December 10, 2025 at 2:24 AM
Reposted
In the latest episode of Inflection Point, we travel back in time to relive three historical moments that ultimately led to our current understanding of antibiotic resistance. cen.acs.org/pharmaceutic... #chemsky 🧪
Podcast: The ancient, ‘juicy’ origins of antibiotic resistance
Hosts David and Gina endure environmental extremes to understand how resistance emerged—and how we’re fighting it
cen.acs.org
December 9, 2025 at 7:45 PM
Reposted
Chemists have found that attaching a small quinoline group to vancomycin lets it slip inside the bacteria and reach its target. cen.acs.org/pharmaceutic... #chemsky 🧪
Quinoline tag helps vancomycin breach gram-negative defenses
The work reveals how tiny structural shifts can deliver outsize biological effects
cen.acs.org
December 9, 2025 at 8:35 PM
Reposted
I wrote a piece for Marginalia Review of Books, based on a talk earlier this year, about the role of narratives in science - something that I think deserves more attention than it gets.
www.marginaliareviewofbooks.com/post/theory-...
Theory, Metaphor, Narrative: How Science Creates the Stories it Tells
PHILIP BALL | Science is often not a competition between theories but a process of narrative creation in which the paradigm tends to be set by the most persuasive narrative
www.marginaliareviewofbooks.com
December 8, 2025 at 9:52 PM
Reposted
So I found a snickedoodle recipe that looks like mine. For the goddamn holiday part, put more cinnamon in the dough and then roll in green or red sugar.

If anyone starts about standard measurements or weird ingredients, so help me. #Recipe

www.modernhoney.com/the-best-sni...
The Best Snickerdoodle Cookie Recipe
Soft and Chewy Snickerdoodle Cookies. The popular cinnamon-sugar soft and chewy sugar cookie recipe. Tips and tricks for making the best snickerdoodle cookie recipe that always receives rave reviews. ...
www.modernhoney.com
December 9, 2025 at 3:02 AM
Reposted
Love and compassion are forms of resistance- David Byrne

Pic of the day

#photography
December 6, 2025 at 12:57 PM
Reposted
Hongkongers wrote handwritten notes and fold paper cranes during a memorial earlier this week to mark the traditional seventh day ritual for the 159 people who died in the massive fire at Wang Fuk Court: buff.ly/PGTV3ry Video: AFP. In full: buff.ly/iQPZDTM
December 7, 2025 at 8:30 AM
Reposted
100% THIS!!!!
December 6, 2025 at 8:02 PM
Just found a 20 yr old flash drive filled with a bunch of music mp3s a friend gave me.

Feeling deeply nostalgic for that brief moment in time. The Internet was everywhere, imbued with hope.

Subscriptions were nowhere. Music was traded as tokens of friendship not playlists filling greedy pockets
December 7, 2025 at 6:27 AM
Reposted
Each time,
the found world surprises
- that is its nature.

Jane Hirshfield
December 6, 2025 at 3:50 AM
Reposted
The Nobel Prize committee should announce the World Cup winner tomorrow
December 6, 2025 at 4:29 AM
Reposted
Another huge issue, and I don't think people even know this is a thing, is that just about everything is done with smart phones now. And many (most?) seniors literally cannot work their phones. Signing things, texting, dealing with spam and fraud or even using the basic functions? They're often lost
December 5, 2025 at 1:41 PM
Reposted
🔓Don't miss in our latest issue this #OpenAccess review by @maximilianfrey.bsky.social & co. @ipbhalle.bsky.social, @unihalle.bsky.social & @mpi-ce.bsky.social looking at the biosynthesis of biologically active terpenoids in the mint family #naturalproducts #secmet
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)
Covering: 2000 to 2025 The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including…
pubs.rsc.org
December 4, 2025 at 12:52 PM
Reposted
Good night
NGC 346
NASA/Chandra Observatory
December 3, 2025 at 5:26 AM
Reposted
You’ll Be OK
December 3, 2025 at 5:41 PM
Reposted
Here’s my Spotify Wrapped 🎵✨
December 3, 2025 at 4:51 PM
Ok, nothing has made me feel like time is moving rapidly as to realizing the Wii came out almost 20 years ago.
December 3, 2025 at 2:59 AM
Reposted
You were just thinking - you know what we need? one more hot take on the Canada Alberta climate and energy hot take. Well we at @energyvsclimate.bsky.social have got you covered with a quick run down, and at the end some bonus takes from the EvC community www.energyvsclimate.com/hot-take-can...
HOT TAKE: Canada-Alberta Memorandum of Understanding (MOU)
There are many takes on the big Carney-Smith energy agreement – we thought you could use one more. The new Canada–Alberta MOU unveiled last Thursday is already generating more chatter than a pipeline...
www.energyvsclimate.com
December 2, 2025 at 3:40 PM
Reposted
“Moments before her Nov. 20 flight, she was told there was a problem with her boarding pass. On the way to customer service, she was surrounded, handcuffed and ‘dragged out of the airport,’ Pomerleau says.” people.com/college-fres...
College Freshman 'Dragged Out' of Boston Airport and Deported While Trying to Fly Home to Surprise Family for Thanksgiving
College student Any Lucía López Belloza was detained at Boston Logan International Airport on Nov. 20 and deported to Honduras two days later.
people.com
December 2, 2025 at 3:41 PM
Reposted
no relation
Tetra Pak just launched a heat-pump-based pasteurization system that can cut energy use by up to 77%.

Electrification + heat recovery = massive efficiency gains. This is the kind of behind-the-scenes innovation that quietly transforms entire sectors.

www.foodtechbiz.com/business-upd...
Tetra Pak launches integrated heat pump system to electrify pasteurization and cut energy use by up to 77%
Tetra Pak announces the expansion of its Factory Sustainable Solutions portfolio with its new Tetra Pak Integrated Heat Pump system for pasteurizers, designed t
www.foodtechbiz.com
December 2, 2025 at 8:25 AM
Reposted
2025 marks our journal's 5th Anniversary🎉

To celebrate, we have launched a collection aimed to highlight key advances in medicinal chemistry and drug discovery research in the last 5 years, as well as current breakthroughs and future prospects.

Read it here👉 pubs.rsc.org/en/journals/...
#chemsky🧪
December 2, 2025 at 11:05 AM
Nothing quite like getting a brand new super powerful computer that I can't actually do anything with because our IT services has decided faculty are too stupid to have local admin control on a computer, even though IT has full Intune control.

Gotta love it.
December 2, 2025 at 3:28 AM
Reposted
This is the first in a series of posts about chemical bonding. Written for the chemnovice, or even the chemcynic. Very basic, this one is focused on the role of electrons. Think of it as the first tiny bite.
#chemsky #chemistry #IteachChemistry
Electrons are the Beating Heart of Chemistry
No matter the substance, these tiny particles are involved in a big way.
open.substack.com
December 1, 2025 at 6:14 PM
Reposted
The Nguyen lab has recently published a study in JACS Au, collaborating with Prof. Steve Varga at St. Jude Research Hospital, focused on the development of novel vaccine adjuvants, designed to enhance immune responses. #wsuchemistry #chembio #ChemSky #immunology

doi.org/10.1021/jacs...
Protonated Phenanthroline Catalyzed Stereoselective Glycosylation: Synthesis and Evaluation of Saponin Adjuvant Lablaboside F and Variants Leading to Simplified Vaccine Adjuvants
Vaccine adjuvants are substances that are coadministered with antigens to enhance the immune response. Lablaboside F, a triterpene oleanolic acid β-linked to two trisaccharide chains on its eastern and western sides, emerged as a promising adjuvant candidate due to exhibiting robust adjuvanticity and low toxicity . We developed a β-stereoselective glycosylation method using a [PhenH]+[BF4]− catalyst to glycosylate oleanolic acid with C2-branched oligosaccharides, synthesizing lablaboside F and structural derivatives (S1–S8) as a result of constructing the target oligosaccharide. This approach simplifies the synthetic process when varying sugars are used and provides a platform for structure–activity relationship studies. Lablaboside F and S1–S8 were tested in vivo and in vitro for adjuvant activity, toxicity, and cytokine production. The entire branched trisaccharide on the western side of lablaboside F is not essential for adjuvant activity. Six derivatives showed low toxicity, while four increased pro-inflammatory cytokine levels. Notably, compound S5, composed of oleanolic acid and the eastern trisaccharide, demonstrated a favorable safety profile in vitro and higher antigen-specific total IgG levels than lablaboside F in vivo, without eliciting IgE production that can lead to allergic reactions. These findings advance our understanding of saponin structure–function relationships and provide a pathway for developing nontoxic adjuvants.
doi.org
December 1, 2025 at 6:43 PM