RSC Medicinal Chemistry
@rscmedchem.rsc.org
The journal for research and review articles in medicinal chemistry and related drug discovery science.
Published by @rsc.org 🌐 Website: rsc.li/rscmedchem
Take a look at recent work by Jhuma Bhadra, Santanu Bhattacharya and colleagues where they present a promising therapeutic strategy for treating persistent infections caused by both Gram-positive and Gram-negative pathogens, including co-infective scenarios👏
pubs.rsc.org/en/content/a...
📍IACS 🧪
pubs.rsc.org/en/content/a...
📍IACS 🧪
An innovative strategy to treat pathogenic biofilm-associated infections in vitro and in vivo using guanidinium-linked neomycin lipidation
To overcome neomycin's limited efficacy against complex Gram-positive and Gram-negative co-infections, we have developed a novel guanidinium-linked neomycin–lipid conjugate (guanidino Neo-lipid).…
pubs.rsc.org
December 24, 2025 at 9:45 AM
Take a look at recent work by Jhuma Bhadra, Santanu Bhattacharya and colleagues where they present a promising therapeutic strategy for treating persistent infections caused by both Gram-positive and Gram-negative pathogens, including co-infective scenarios👏
pubs.rsc.org/en/content/a...
📍IACS 🧪
pubs.rsc.org/en/content/a...
📍IACS 🧪
🔓Don't miss this #OpenAccess work by Moustafa T. Gabr & co on the discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library screening⬇️
pubs.rsc.org/en/content/a...
📍 @weillcornell.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @weillcornell.bsky.social 🧪
Discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library (DEL) screening
The SLIT2/ROBO1 signaling axis plays a critical role in neural development, immune regulation, and tumor progression, including glioblastoma. However, small molecule inhibitors targeting this…
pubs.rsc.org
December 22, 2025 at 2:03 PM
🔓Don't miss this #OpenAccess work by Moustafa T. Gabr & co on the discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library screening⬇️
pubs.rsc.org/en/content/a...
📍 @weillcornell.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @weillcornell.bsky.social 🧪
🔓Don't miss this #OpenAccess article by @gerhardecker.bsky.social and colleagues, using KNIME and ChEMBL data to show how common bioisosteric swaps predictably shift off‑target potencies 👇
pubs.rsc.org/en/content/a...
📍 @univie.ac.at 🧪
pubs.rsc.org/en/content/a...
📍 @univie.ac.at 🧪
Data-driven assessment of bioisosteric replacements and their influence on off-target activity profiles
Bioisosterism, a fundamental concept in medicinal chemistry, involves the substitution of chemical groups with structural analogs that preserve similar physicochemical properties while potentially…
pubs.rsc.org
December 19, 2025 at 10:15 AM
🔓Don't miss this #OpenAccess article by @gerhardecker.bsky.social and colleagues, using KNIME and ChEMBL data to show how common bioisosteric swaps predictably shift off‑target potencies 👇
pubs.rsc.org/en/content/a...
📍 @univie.ac.at 🧪
pubs.rsc.org/en/content/a...
📍 @univie.ac.at 🧪
Explore this Review by Jialin Guo, Chun Hu, Junhai Xiao & co discussing the recent progress in finding inhibitors targeting clathrin-mediated endocytosis👏
pubs.rsc.org/en/content/a...
📍State Key Laboratory of National Security Specially Needed Medicines & Shenyang Pharmaceutical University 🧪
pubs.rsc.org/en/content/a...
📍State Key Laboratory of National Security Specially Needed Medicines & Shenyang Pharmaceutical University 🧪
Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects
Clathrin-mediated endocytosis (CME) is a critical pathway for cellular uptake of metabolites, hormones, and pathogens, including viruses. Recent advances in understanding CME mechanisms and…
pubs.rsc.org
December 17, 2025 at 9:01 AM
Explore this Review by Jialin Guo, Chun Hu, Junhai Xiao & co discussing the recent progress in finding inhibitors targeting clathrin-mediated endocytosis👏
pubs.rsc.org/en/content/a...
📍State Key Laboratory of National Security Specially Needed Medicines & Shenyang Pharmaceutical University 🧪
pubs.rsc.org/en/content/a...
📍State Key Laboratory of National Security Specially Needed Medicines & Shenyang Pharmaceutical University 🧪
🔓Read this #OpenAccess Opinion article by Prabir Kumar Gharai & co on how the use of peptoid-based hydrogels could progress neuroregenerative therapies💡
pubs.rsc.org/en/content/a...
📍 @okstate.edu 🧪
pubs.rsc.org/en/content/a...
📍 @okstate.edu 🧪
Sequence-controlled peptoid hydrogels for neuronal trans-differentiation: a synthetic biomaterials approach in future neuroregenerative research
Peptide-based hydrogels stimulate stem cell differentiation into neurons, improve neuroprotection, and aid in spinal cord/brain injury repair by moderating inflammatory responses and activating…
pubs.rsc.org
December 15, 2025 at 10:00 AM
🔓Read this #OpenAccess Opinion article by Prabir Kumar Gharai & co on how the use of peptoid-based hydrogels could progress neuroregenerative therapies💡
pubs.rsc.org/en/content/a...
📍 @okstate.edu 🧪
pubs.rsc.org/en/content/a...
📍 @okstate.edu 🧪
Our inside front cover is work by Renato J. S. Oliveira, Dennis Russowsky & co on synthesising fluorescent dihydropyridine–dihydropyrimidinone hybrids and their inhibition of protein kinases for anticancer applications, take a look⬇️
pubs.rsc.org/en/content/a...
📍UFRGS and Barretos Cancer Hospital🧪
pubs.rsc.org/en/content/a...
📍UFRGS and Barretos Cancer Hospital🧪
December 12, 2025 at 2:01 PM
Our inside front cover is work by Renato J. S. Oliveira, Dennis Russowsky & co on synthesising fluorescent dihydropyridine–dihydropyrimidinone hybrids and their inhibition of protein kinases for anticancer applications, take a look⬇️
pubs.rsc.org/en/content/a...
📍UFRGS and Barretos Cancer Hospital🧪
pubs.rsc.org/en/content/a...
📍UFRGS and Barretos Cancer Hospital🧪
This month's front cover showcases a Review article by Paul Groundwater & co discussing structural qualities of β-lactamase enzymes and the efficacy of emerging β-lactamase inhibitors against clinically significant carbapenemases, read it here👀
pubs.rsc.org/en/content/a...
📍 @sydney.edu.au 🧪
pubs.rsc.org/en/content/a...
📍 @sydney.edu.au 🧪
December 12, 2025 at 10:00 AM
This month's front cover showcases a Review article by Paul Groundwater & co discussing structural qualities of β-lactamase enzymes and the efficacy of emerging β-lactamase inhibitors against clinically significant carbapenemases, read it here👀
pubs.rsc.org/en/content/a...
📍 @sydney.edu.au 🧪
pubs.rsc.org/en/content/a...
📍 @sydney.edu.au 🧪
December 11, 2025 at 1:32 PM
Recently added to the RSC Medicinal Chemistry Editor's Choice collection are Hayley Binch's chosen articles!
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/25/editors-choice-collection-hayley-binch
And scan the QR code to see our collection as it grows👀 🧪
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/25/editors-choice-collection-hayley-binch
And scan the QR code to see our collection as it grows👀 🧪
December 9, 2025 at 12:17 PM
Recently added to the RSC Medicinal Chemistry Editor's Choice collection are Hayley Binch's chosen articles!
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/25/editors-choice-collection-hayley-binch
And scan the QR code to see our collection as it grows👀 🧪
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/25/editors-choice-collection-hayley-binch
And scan the QR code to see our collection as it grows👀 🧪
Reposted by RSC Medicinal Chemistry
We are pleased to sponsor Poster Prizes at the 34th GP2A Medicinal Chemistry Conference with @rscmedchem.rsc.org & @rscpharmaceutics.rsc.org
📅26-28 Aug 2026
📍Department of Chemistry and Molecular Biology, University of Gothenburg
👉Visit gp2a.org/index.php/gp...
#GP2A #MedChem @omc-gu.bsky.social
📅26-28 Aug 2026
📍Department of Chemistry and Molecular Biology, University of Gothenburg
👉Visit gp2a.org/index.php/gp...
#GP2A #MedChem @omc-gu.bsky.social
December 5, 2025 at 11:53 AM
We are pleased to sponsor Poster Prizes at the 34th GP2A Medicinal Chemistry Conference with @rscmedchem.rsc.org & @rscpharmaceutics.rsc.org
📅26-28 Aug 2026
📍Department of Chemistry and Molecular Biology, University of Gothenburg
👉Visit gp2a.org/index.php/gp...
#GP2A #MedChem @omc-gu.bsky.social
📅26-28 Aug 2026
📍Department of Chemistry and Molecular Biology, University of Gothenburg
👉Visit gp2a.org/index.php/gp...
#GP2A #MedChem @omc-gu.bsky.social
Reposted by RSC Medicinal Chemistry
Happy to share our latest paper in @rscmedchem.rsc.org as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/a...
Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein (OSBP)
Schweinfurthins (SWs) are natural products isolated from the plant genus Macaranga which display a unique cytotoxicity profile in human cancer cell lines with low nanomolar potency. Their known target...
pubs.rsc.org
December 2, 2025 at 1:17 PM
Happy to share our latest paper in @rscmedchem.rsc.org as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/a...
2025 marks our journal's 5th Anniversary🎉
To celebrate, we have launched a collection aimed to highlight key advances in medicinal chemistry and drug discovery research in the last 5 years, as well as current breakthroughs and future prospects.
Read it here👉 pubs.rsc.org/en/journals/...
#chemsky🧪
To celebrate, we have launched a collection aimed to highlight key advances in medicinal chemistry and drug discovery research in the last 5 years, as well as current breakthroughs and future prospects.
Read it here👉 pubs.rsc.org/en/journals/...
#chemsky🧪
December 2, 2025 at 11:05 AM
2025 marks our journal's 5th Anniversary🎉
To celebrate, we have launched a collection aimed to highlight key advances in medicinal chemistry and drug discovery research in the last 5 years, as well as current breakthroughs and future prospects.
Read it here👉 pubs.rsc.org/en/journals/...
#chemsky🧪
To celebrate, we have launched a collection aimed to highlight key advances in medicinal chemistry and drug discovery research in the last 5 years, as well as current breakthroughs and future prospects.
Read it here👉 pubs.rsc.org/en/journals/...
#chemsky🧪
🔓Read #OpenAccess work by Vipul Navinchandra Panchal, @ruthbrenk.bsky.social & co where they demonstrate the effective use of biolayer interferometry to investigate RNA–small molecule interactions using three different riboswitches💡
pubs.rsc.org/en/content/a...
📍 @unibergen.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @unibergen.bsky.social 🧪
Discovery of RNA-binding fragments using biolayer interferometry
Structured RNAs are increasingly explored as novel pharmacological targets for a range of diseases. Therefore, evaluating methods for RNA-focused hit discovery is crucial. Biolayer Interferometry…
pubs.rsc.org
November 26, 2025 at 9:45 AM
🔓Read #OpenAccess work by Vipul Navinchandra Panchal, @ruthbrenk.bsky.social & co where they demonstrate the effective use of biolayer interferometry to investigate RNA–small molecule interactions using three different riboswitches💡
pubs.rsc.org/en/content/a...
📍 @unibergen.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @unibergen.bsky.social 🧪
Don't miss recent work by Yeong-Jiunn Jang, Yang-Chang Wu & co on the synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241⬇️
pubs.rsc.org/en/content/a...
📍China Medical University 🧪
pubs.rsc.org/en/content/a...
📍China Medical University 🧪
Synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241
Natural products are an important source for developing anti-cancer agents. Previously, we identified the anti-cancer flavonoid protoapigenone from Thelypteris torresiana (Gaud.) and synthesized its…
pubs.rsc.org
November 24, 2025 at 10:01 AM
Don't miss recent work by Yeong-Jiunn Jang, Yang-Chang Wu & co on the synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241⬇️
pubs.rsc.org/en/content/a...
📍China Medical University 🧪
pubs.rsc.org/en/content/a...
📍China Medical University 🧪
Be sure to read the latest Review by Zahoor Ahmad & co discussing ultrashort cationic β-peptides as promising antimicrobial therapeutics👏
pubs.rsc.org/en/content/a...
📍CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) 🧪
pubs.rsc.org/en/content/a...
📍CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) 🧪
The rise of ultrashort cationic β-peptides as promising antimicrobial therapeutics
Antimicrobial resistance (AMR) is a mounting global health crisis demanding novel, sustainable therapeutic strategies beyond traditional antibiotics. Ultra-short cationic β-peptides have emerged as a…
pubs.rsc.org
November 21, 2025 at 10:00 AM
Be sure to read the latest Review by Zahoor Ahmad & co discussing ultrashort cationic β-peptides as promising antimicrobial therapeutics👏
pubs.rsc.org/en/content/a...
📍CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) 🧪
pubs.rsc.org/en/content/a...
📍CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) 🧪
🔓Read this #OpenAccess Opinion article by Louise Sternicki and our Associate Editor, Sally-Ann Poulsen, where they discuss the role of native mass spectrometry (nMS) to gain important insights to guide drug discovery and development👇
pubs.rsc.org/en/content/a...
📍 @griffith.edu.au 🧪
pubs.rsc.org/en/content/a...
📍 @griffith.edu.au 🧪
Toward routine utilisation of native mass spectrometry as an enabler of contemporary drug development
As therapeutic modalities increasingly diversify, the need for biophysical tools for routine characterisation of the underlying biomolecular targets and their noncovalent interactions is growing. In…
pubs.rsc.org
November 19, 2025 at 9:30 AM
🔓Read this #OpenAccess Opinion article by Louise Sternicki and our Associate Editor, Sally-Ann Poulsen, where they discuss the role of native mass spectrometry (nMS) to gain important insights to guide drug discovery and development👇
pubs.rsc.org/en/content/a...
📍 @griffith.edu.au 🧪
pubs.rsc.org/en/content/a...
📍 @griffith.edu.au 🧪
Our 2025 Emerging Investigator Lectureship winner, Michael Bollong, will be presenting his lecture at the upcoming @rscbmcs.bsky.social Mastering MedChem Symposium in March 2026!
Be sure to register for this fantastic event👇
www.rscbmcs.org/events/maste...
#chemsky 🧪
Be sure to register for this fantastic event👇
www.rscbmcs.org/events/maste...
#chemsky 🧪
📣 New confirmed speaker for Mastering MedChem X!
We’re excited to welcome Dr Michael Bollong (The Scripps Research Institute), who will present: “Chemical Approaches to Regenerative Organ Repair”
📆 13 March 2026
📍 Burlington House, London
Register: www.eventsforce.net/hg3/338/regi...
We’re excited to welcome Dr Michael Bollong (The Scripps Research Institute), who will present: “Chemical Approaches to Regenerative Organ Repair”
📆 13 March 2026
📍 Burlington House, London
Register: www.eventsforce.net/hg3/338/regi...
November 17, 2025 at 1:47 PM
Our 2025 Emerging Investigator Lectureship winner, Michael Bollong, will be presenting his lecture at the upcoming @rscbmcs.bsky.social Mastering MedChem Symposium in March 2026!
Be sure to register for this fantastic event👇
www.rscbmcs.org/events/maste...
#chemsky 🧪
Be sure to register for this fantastic event👇
www.rscbmcs.org/events/maste...
#chemsky 🧪
🔓On the inside front cover is #OpenAccess work by Oleg Mediannikov & Philipp Tsvetkov exploring the potential of repurposing FDA-approved microtubule-targeting agents (MTAs) in anti-amoebic therapy, take a look👀
pubs.rsc.org/en/content/a...
📍 @ird-fr.bsky.social, @univ-amu.fr 🧪
pubs.rsc.org/en/content/a...
📍 @ird-fr.bsky.social, @univ-amu.fr 🧪
November 17, 2025 at 10:01 AM
🔓On the inside front cover is #OpenAccess work by Oleg Mediannikov & Philipp Tsvetkov exploring the potential of repurposing FDA-approved microtubule-targeting agents (MTAs) in anti-amoebic therapy, take a look👀
pubs.rsc.org/en/content/a...
📍 @ird-fr.bsky.social, @univ-amu.fr 🧪
pubs.rsc.org/en/content/a...
📍 @ird-fr.bsky.social, @univ-amu.fr 🧪
🔓This month's front cover features an #OpenAccess Review article by David Morales-Morales and colleagues which discusses the antitumor properties of cyclometalated compounds containing metals from groups 8, 9, and 10, read it here⬇️
pubs.rsc.org/en/content/a...
📍UNAM, Mexico 🧪
pubs.rsc.org/en/content/a...
📍UNAM, Mexico 🧪
November 14, 2025 at 10:00 AM
🔓This month's front cover features an #OpenAccess Review article by David Morales-Morales and colleagues which discusses the antitumor properties of cyclometalated compounds containing metals from groups 8, 9, and 10, read it here⬇️
pubs.rsc.org/en/content/a...
📍UNAM, Mexico 🧪
pubs.rsc.org/en/content/a...
📍UNAM, Mexico 🧪
November 13, 2025 at 2:55 PM
Next up in the RSC Medicinal Chemistry Editor's Choice collection are Sally-Ann Poulsen's chosen articles!
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/1...
And scan the QR code to see our collection as it grows👀
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/1...
And scan the QR code to see our collection as it grows👀
November 11, 2025 at 11:01 AM
Next up in the RSC Medicinal Chemistry Editor's Choice collection are Sally-Ann Poulsen's chosen articles!
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/1...
And scan the QR code to see our collection as it grows👀
Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/1...
And scan the QR code to see our collection as it grows👀
Reposted by RSC Medicinal Chemistry
Thrilled to see our work on β-lactams and SARS-CoV-2 Mpro published in @rscmedchem.rsc.org! It’s been a pleasure contributing the computational modelling to this collaboration, which highlights how subtle chemical modifications can shift inhibition mechanisms.
doi.org/10.1039/D5MD...
doi.org/10.1039/D5MD...
C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease
Inhibition of the SARS-CoV-2 main protease (Mpro) by small-molecules is a validated strategy for COVID-19 treatment. There is a need for improved Mpro inhibitors, including because Mpro mutations can ...
doi.org
November 9, 2025 at 3:32 PM
Thrilled to see our work on β-lactams and SARS-CoV-2 Mpro published in @rscmedchem.rsc.org! It’s been a pleasure contributing the computational modelling to this collaboration, which highlights how subtle chemical modifications can shift inhibition mechanisms.
doi.org/10.1039/D5MD...
doi.org/10.1039/D5MD...
🔓Don't miss recent #OpenAccess work by Andrew G. Jamieson & co which reports the first lysine-targeting covalent inhibitors for malaria, showing promise for antimalarial drugs, as seen in our Kinases collection💡
pubs.rsc.org/en/content/a...
📍 @uofglasgow.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @uofglasgow.bsky.social 🧪
Lysine targeting covalent inhibitors of malarial kinase PfCLK3
Malaria continues to devastate tropical regions of the world, with resistance to frontline drugs on the rise. Kinase inhibition has emerged as a promising novel mechanism of action in the fight…
pubs.rsc.org
November 4, 2025 at 10:01 AM
🔓Don't miss recent #OpenAccess work by Andrew G. Jamieson & co which reports the first lysine-targeting covalent inhibitors for malaria, showing promise for antimalarial drugs, as seen in our Kinases collection💡
pubs.rsc.org/en/content/a...
📍 @uofglasgow.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @uofglasgow.bsky.social 🧪
As seen in our Kinases collection: Work by Partha Chakrabarti, Arindam Talukdar & co introducing a novel PROTAC-based strategy for the selective degradation of apoptosis signal-regulating kinase 1 (ASK1), a key mediator of MASH pathology. Read more here👇
pubs.rsc.org/en/content/a...
📍CSIR- IICB 🧪
pubs.rsc.org/en/content/a...
📍CSIR- IICB 🧪
Rational design and discovery of potent PROTAC degraders of ASK1: a targeted therapy in MASH
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease marked by hepatic steatosis, inflammation, and fibrosis, with limited therapeutic options. This study introduces…
pubs.rsc.org
November 3, 2025 at 10:01 AM
As seen in our Kinases collection: Work by Partha Chakrabarti, Arindam Talukdar & co introducing a novel PROTAC-based strategy for the selective degradation of apoptosis signal-regulating kinase 1 (ASK1), a key mediator of MASH pathology. Read more here👇
pubs.rsc.org/en/content/a...
📍CSIR- IICB 🧪
pubs.rsc.org/en/content/a...
📍CSIR- IICB 🧪
Be sure to read this Review article by Selina Koch and Jürgen Bajorath which identifies and evaluates understudied protein kinases using biological and chemical criteria, featured in our Kinases themed collection⬇️
pubs.rsc.org/en/content/a...
📍 @unibonn.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @unibonn.bsky.social 🧪
Identifying and evaluating understudied protein kinases using biological and chemical criteria
Protein kinases (PKs) play a central role in cellular signaling. Uncontrolled signaling by deregulated PKs is implicated in a variety of diseases. As a consequence, PKs are among the most popular…
pubs.rsc.org
October 31, 2025 at 2:05 PM
Be sure to read this Review article by Selina Koch and Jürgen Bajorath which identifies and evaluates understudied protein kinases using biological and chemical criteria, featured in our Kinases themed collection⬇️
pubs.rsc.org/en/content/a...
📍 @unibonn.bsky.social 🧪
pubs.rsc.org/en/content/a...
📍 @unibonn.bsky.social 🧪