Kaiwen Chen
@kaiwenchen-lab.bsky.social
Assistant Professor in NUS Singapore. Cell death, innate immunity and host-pathogen interaction.
Pinned
Kaiwen Chen
@kaiwenchen-lab.bsky.social
· Mar 24
A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection | The EMBO Journal
imageimageHost cells activate cell death pathways in response to bacterial manipulation of innate
immune signalling, but the molecular mechanisms underlying this interplay are not
fully understood. Th...
www.embopress.org
I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats @michelleyeaphw.bsky.social and all co-authors! 🥳
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats @michelleyeaphw.bsky.social and all co-authors! 🥳
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection | The EMBO Journal
imageimageHost cells activate cell death pathways in response to bacterial manipulation of innate
immune signalling, but the molecular mechanisms underlying this interplay are not
fully understood. Th...
www.embopress.org
March 24, 2025 at 12:06 PM
I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats @michelleyeaphw.bsky.social and all co-authors! 🥳
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Kaiwen Chen
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
March 7, 2025 at 8:49 PM
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8
and GSDMD activation in murine macrophages; however, how macrophages defend against
Yersinia when caspase-8 or YopJ ...
www.cell.com
January 16, 2025 at 11:09 PM
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Reposted by Kaiwen Chen
We just posted a preprint about a death mechanism that we find truly surprising.
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
Pol II degradation activates cell death independently from the loss of transcription
Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...
www.biorxiv.org
December 13, 2024 at 2:17 PM
We just posted a preprint about a death mechanism that we find truly surprising.
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
Reposted by Kaiwen Chen
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
December 6, 2024 at 10:38 PM
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
Reposted by Kaiwen Chen
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Reposted by Kaiwen Chen
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
www.nature.com
December 5, 2024 at 4:55 PM
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Reposted by Kaiwen Chen
Thrilled to share our new paper out today in #ScienceImmunology!
It’s been a long time coming and I’m so excited to be able to share it.
Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!
#ImmunoSky #RNASky
It’s been a long time coming and I’m so excited to be able to share it.
Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!
#ImmunoSky #RNASky
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 22, 2024 at 8:06 PM
Thrilled to share our new paper out today in #ScienceImmunology!
It’s been a long time coming and I’m so excited to be able to share it.
Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!
#ImmunoSky #RNASky
It’s been a long time coming and I’m so excited to be able to share it.
Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!
#ImmunoSky #RNASky