RubeCo
@justbiotechthings.bsky.social
Things overheard or imagined in the world of biotech, or techbio if you're feeling like giving up on the idea of ever producing something.
Wow, amazing Time cover showing all of the tangible achievements that AI CEOs have produced. Truly remarkable to encapsulate all that we've achieved in such a short time! Rubeco aspires to achieve the same for techbio!
December 11, 2025 at 1:49 PM
Wow, amazing Time cover showing all of the tangible achievements that AI CEOs have produced. Truly remarkable to encapsulate all that we've achieved in such a short time! Rubeco aspires to achieve the same for techbio!
How did he get ahold of our org chart?
December 4, 2025 at 2:01 AM
How did he get ahold of our org chart?
Techbio must be bold like our fellow tech-ecosystem brethren and follow their example in saying the quiet part out loud.
December 1, 2025 at 3:34 AM
Techbio must be bold like our fellow tech-ecosystem brethren and follow their example in saying the quiet part out loud.
Brb turning this Epstein email into a killer pitch
November 13, 2025 at 6:21 PM
Brb turning this Epstein email into a killer pitch
They've mastered word salad. God help us if we get AGI and they learn to lie. They will replace biotech founders! We can't lose OUR jobs!!!!
bsky.app/profile/phil...
bsky.app/profile/phil...
It seems this can't be emphasized enough. Chatbots and LLMs do not make mistakes (excepting any bugs in the code). They do not lie. They do not blackmail or cheat. They follow statistics. When the people who build these systems don't tell you this, they are either deluded or trying to mislead.
When a chatbot gets something wrong, it’s not because it made an error. It’s because on that roll of the dice, it happened to string together a group of words that, when read by a human, represents something false. But it was working entirely as designed. It was supposed to make a sentence & it did.
November 6, 2025 at 11:53 AM
They've mastered word salad. God help us if we get AGI and they learn to lie. They will replace biotech founders! We can't lose OUR jobs!!!!
bsky.app/profile/phil...
bsky.app/profile/phil...
They did it! They finally did it! Machine Learning has finally enabled the development of micromolar AKT inhibitors of unknown selectivity!
Rejoice, AGI is upon us!
www.nature.com/articles/s42...
Rejoice, AGI is upon us!
www.nature.com/articles/s42...
September 19, 2025 at 12:39 PM
They did it! They finally did it! Machine Learning has finally enabled the development of micromolar AKT inhibitors of unknown selectivity!
Rejoice, AGI is upon us!
www.nature.com/articles/s42...
Rejoice, AGI is upon us!
www.nature.com/articles/s42...
Rice accelerator? My instant pot makes it in minutes!
July 23, 2025 at 3:05 PM
Rice accelerator? My instant pot makes it in minutes!
Real techbio trailblazers know the skepticism we face from traditionalists and luddites. It's basically discrimination!
July 23, 2025 at 1:51 PM
Real techbio trailblazers know the skepticism we face from traditionalists and luddites. It's basically discrimination!
Look, it's true that none of the All In guys have any real experience with this technology, and that's what makes it so impressive that they are as equally delusional about the technology as the leadership of most AI-first drug discovery companies like RubeCo.
Hats off to the GOATs.
Hats off to the GOATs.
![Travis Kalanick, the founder of Uber who no longer works at the company, appeared on All-In to talk with hosts Jason Calacanis and Chamath Palihapitiya about the future of technology. When the topic turned to AI, Kalanick discussed how he uses xAI’s Grok, which went haywire last week, praising Adolf Hitler and advocating for a second Holocaust against Jews.
“I’ll go down this thread with [Chat]GPT or Grok and I’ll start to get to the edge of what’s known in quantum physics and then I’m doing the equivalent of vibe coding, except it’s vibe physics,” Kalanick explained. “And we’re approaching what’s known. And I’m trying to poke and see if there’s breakthroughs to be had. And I’ve gotten pretty damn close to some interesting breakthroughs just doing that.”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:qlnirjwff4ibiw3wchmleszo/bafkreiac2szurc5dnw6klquhpjmo7iafg4n6fwmrqyred7jrrph6h6mptq@jpeg)
July 16, 2025 at 10:55 PM
Look, it's true that none of the All In guys have any real experience with this technology, and that's what makes it so impressive that they are as equally delusional about the technology as the leadership of most AI-first drug discovery companies like RubeCo.
Hats off to the GOATs.
Hats off to the GOATs.
Acquiring and dismantling excellent companies is also RubeCo's other central mission.
My glorious beloved Roomba is about to die for forever this time .
I know the brand was acquired by Amazon and practically dismantled.
So any alternative brand around $200-300 is fine. Vacuum cleaner only, no floor cleaner. Thanks in advance if u answer
I know the brand was acquired by Amazon and practically dismantled.
So any alternative brand around $200-300 is fine. Vacuum cleaner only, no floor cleaner. Thanks in advance if u answer
July 16, 2025 at 10:51 PM
Acquiring and dismantling excellent companies is also RubeCo's other central mission.
This is the true test of our industry and innovation and I think RubeCo can do this bigger in every way than anyone else out there!
This whole "Let's use computers to do everything badly in the most expensive and unethical possible way" thing is really testing me.
July 16, 2025 at 10:50 PM
This is the true test of our industry and innovation and I think RubeCo can do this bigger in every way than anyone else out there!
Uh, I believe they gave a nobel in fundraising for this which means it is in fact very solved.
AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...
clauswilke.substack.com/p/no-alphafo...
No, AlphaFold has not completely solved protein folding
Biology is hard. Yes, even for AI.
clauswilke.substack.com
July 14, 2025 at 2:53 AM
Uh, I believe they gave a nobel in fundraising for this which means it is in fact very solved.
We at RubeCo are not just focused on the 100-1000. Not even 0-1! We are solidly committed to the 0 stage: our science, our runway, and our investor returns!
People say “look we automated science” then show you a machine that does a 30-year-old method efficiently
That’s cool! But to me, the heart of science is the 0-to-1 moment. You automated the 100-to-1000 stage
That’s cool! But to me, the heart of science is the 0-to-1 moment. You automated the 100-to-1000 stage
July 13, 2025 at 3:59 PM
We at RubeCo are not just focused on the 100-1000. Not even 0-1! We are solidly committed to the 0 stage: our science, our runway, and our investor returns!
Reposted by RubeCo
Although I am very pro-automation, I often roll my eyes when I see people talk about “automating science” in biotech
Any serious conversation here needs to consider the way new methods are invented and scaled
Any serious conversation here needs to consider the way new methods are invented and scaled
July 13, 2025 at 3:51 PM
Although I am very pro-automation, I often roll my eyes when I see people talk about “automating science” in biotech
Any serious conversation here needs to consider the way new methods are invented and scaled
Any serious conversation here needs to consider the way new methods are invented and scaled
We are proud to announce our latest innovation: Virtual Sells!
We will sell our last shred of integrity and pride for virtually anything in order to hop on the next AI/Multimodal jargon bandwagon.
#virtualcells #ai #ml #biotech #techbio
We will sell our last shred of integrity and pride for virtually anything in order to hop on the next AI/Multimodal jargon bandwagon.
#virtualcells #ai #ml #biotech #techbio
July 13, 2025 at 7:53 AM
We are proud to announce our latest innovation: Virtual Sells!
We will sell our last shred of integrity and pride for virtually anything in order to hop on the next AI/Multimodal jargon bandwagon.
#virtualcells #ai #ml #biotech #techbio
We will sell our last shred of integrity and pride for virtually anything in order to hop on the next AI/Multimodal jargon bandwagon.
#virtualcells #ai #ml #biotech #techbio
In response to escalating research integrity concerns, RubeCo are disrupting the loop with our new proprietary adhesive wellness patches.
Applying these "stickers" to your team's mouths can produce up to a 100% reduction in reported "obvious flaws" and "ethical concerns."
The future is quiet!
Applying these "stickers" to your team's mouths can produce up to a 100% reduction in reported "obvious flaws" and "ethical concerns."
The future is quiet!
July 9, 2025 at 4:53 PM
In response to escalating research integrity concerns, RubeCo are disrupting the loop with our new proprietary adhesive wellness patches.
Applying these "stickers" to your team's mouths can produce up to a 100% reduction in reported "obvious flaws" and "ethical concerns."
The future is quiet!
Applying these "stickers" to your team's mouths can produce up to a 100% reduction in reported "obvious flaws" and "ethical concerns."
The future is quiet!
Reposted by RubeCo
At RubeCo we have generated our own encoding for chemical structures to combat the issues with SMILES and LLMs: "Futilely Rendering Organic Wreckage Now Simplified" or FROWNS.
Using FROWNS with LLMs produces at least the same performance as SMILES so far. To convert to FROWNS simply invert SMILES
Using FROWNS with LLMs produces at least the same performance as SMILES so far. To convert to FROWNS simply invert SMILES
July 8, 2025 at 7:43 PM
At RubeCo we have generated our own encoding for chemical structures to combat the issues with SMILES and LLMs: "Futilely Rendering Organic Wreckage Now Simplified" or FROWNS.
Using FROWNS with LLMs produces at least the same performance as SMILES so far. To convert to FROWNS simply invert SMILES
Using FROWNS with LLMs produces at least the same performance as SMILES so far. To convert to FROWNS simply invert SMILES
Ernie is built on BERT architecture, which is a power move. However they should give up as we advance with our newest model: Enhanced Language Model Ontology.
ELMO is an advanced chatbot that is a true agent, fully automated! It requires no user interacting with it. It will simply not shut up!
ELMO is an advanced chatbot that is a true agent, fully automated! It requires no user interacting with it. It will simply not shut up!
Baidu officially open-sourced its Ernie 4.5 large language model yesterday, marking one of China's biggest AI moves since DeepSeek shook global markets. The release includes 10 different models, ranging from 0.3B to 424B parameters, all available under the Apache License 2.0 for commercial use.
July 2, 2025 at 1:32 PM
Ernie is built on BERT architecture, which is a power move. However they should give up as we advance with our newest model: Enhanced Language Model Ontology.
ELMO is an advanced chatbot that is a true agent, fully automated! It requires no user interacting with it. It will simply not shut up!
ELMO is an advanced chatbot that is a true agent, fully automated! It requires no user interacting with it. It will simply not shut up!
Nonsense! We all know to make an omelet you have to break a few eggs, and there are no eggs broken here! How is she going to get a 250M.series D followed by an IPO and then 10 years of dilution if she doesn't break those eggs?
It's like they don't know investor cash is revenue if you're selling!
It's like they don't know investor cash is revenue if you're selling!
Humans can get so good at weird manual dexterity shit this why biotech R&D is hard to automate
July 2, 2025 at 1:27 PM
Nonsense! We all know to make an omelet you have to break a few eggs, and there are no eggs broken here! How is she going to get a 250M.series D followed by an IPO and then 10 years of dilution if she doesn't break those eggs?
It's like they don't know investor cash is revenue if you're selling!
It's like they don't know investor cash is revenue if you're selling!
How did you get our business plan???
tech 2025 in a nutshell: products which don’t work, based on use cases no one has, intended to solve problems that don’t exist, designed by people who are never required to actually justify any of it
this is more like zuckerberg 2025 telling metaverse zuckerberg 2021 to hold his beer, these are in no way realistic objectives no matter how much talent or money they throw at it
July 1, 2025 at 2:30 PM
How did you get our business plan???
Reposted by RubeCo
CEO’s Skill Set Transferable To Any Job That Requires Dumbass To Receive Big Salary theonion.com/ceo-s-s...
June 21, 2025 at 7:00 PM
CEO’s Skill Set Transferable To Any Job That Requires Dumbass To Receive Big Salary theonion.com/ceo-s-s...
These are petty and rehashed ambitions. Demis should dream bigger! fortune.com/2025/06/06/g...
Top Google exec says AI will rival humans in just 5 years and predicts we’ll 'colonize the galaxy' in 2030—but he draws the line at robot nurses
2030 will be “an era of maximum human flourishing, where we travel to the stars and colonize the galaxy,” Google DeepMind CEO says. Bill Gates and Marc Benioff have shared similar predictions.
fortune.com
June 10, 2025 at 3:33 AM
These are petty and rehashed ambitions. Demis should dream bigger! fortune.com/2025/06/06/g...
Reposted by RubeCo
Another one, again a bit on the nose, on the definition of #MachineLearning, #ArtificialIntelligence and variants of the above.
June 4, 2025 at 11:11 AM
Another one, again a bit on the nose, on the definition of #MachineLearning, #ArtificialIntelligence and variants of the above.