Jean-Philippe Nougayrede
jpnoug.bsky.social
Jean-Philippe Nougayrede
@jpnoug.bsky.social
Reposted by Jean-Philippe Nougayrede
Hydrogen sulfide production distinguishes Salmonella from close relatives, but its biological significance remains obscure. This study uncovers the secret: Salmonella uses hydrogen sulfide production as a weapon to outcompete E. coli and gain a foothold in the gut.
www.pnas.org/doi/10.1073/...
September 13, 2025 at 6:32 PM
Reposted by Jean-Philippe Nougayrede
How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky)
doi.org/10.1098/rstb...
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....
doi.org
September 4, 2025 at 4:02 PM
Reposted by Jean-Philippe Nougayrede
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reposted by Jean-Philippe Nougayrede
Reposted by Jean-Philippe Nougayrede
🚨 PhD opportunity in Toulouse!
Join a dynamic team to study membrane proteins & transporters of therapeutic interest using cryo-EM, enzymology & biophysics.

📅 Deadline: June 19, 2025
🔗 Funded by @frm-officiel.bsky.social

#StructuralBiology #MicroSky

More details 👇
shorturl.at/OaVMI
PhD position in structural biology and infectious diseases - IPBS-Toulouse
We are currently looking for highly motivated PhD student with a strong interest in structural[…]
shorturl.at
May 17, 2025 at 6:21 AM
Reposted by Jean-Philippe Nougayrede
New preprint led by @brunoluviano.bsky.social & Fernando Santos.

We show that filamentation enhances bacterial survival under toxic stress — not as collateral damage, but as a regulated morphological response.

TL;DR: Filamentation isn’t a symptom, it’s a strategy!
www.biorxiv.org/content/10.1...
May 15, 2025 at 5:23 PM
A nice review with the latest advances and views on our favourite genotoxin !
🔬 New review out in Trends in Microbiology!
Together with @MaudeJans , we explore the physiological factors driving pks+ E. coli expansion and colibactin exposure in colorectal cancer.
read the full story:
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

#ColorectalCancer #Ecoli #Genotoxins
kwnsfk27.r.eu-west-1.awstrack.me
May 7, 2025 at 1:56 PM
Reposted by Jean-Philippe Nougayrede
🔬 New review out in Trends in Microbiology!
Together with @MaudeJans , we explore the physiological factors driving pks+ E. coli expansion and colibactin exposure in colorectal cancer.
read the full story:
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

#ColorectalCancer #Ecoli #Genotoxins
kwnsfk27.r.eu-west-1.awstrack.me
May 6, 2025 at 1:38 PM
Reposted by Jean-Philippe Nougayrede
Happy to share Saurabh's latest review on the bacterial exometabolome and its role in virulence and pathogenesis, just out in @cp-trendsmicrobiol.bsky.social — and it’s open access! 😉

👏 @saurabhchugh09.bsky.social

www.cell.com/trends/micro...
The exometabolome as a hidden driver of bacterial virulence and pathogenesis
The traditional view of metabolism as merely supplying energy and biosynthetic precursors is undergoing a paradigm shift. Metabolic dynamics not only regulates gene expression but also orchestrates ce...
www.cell.com
May 6, 2025 at 4:19 PM
Reposted by Jean-Philippe Nougayrede
Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩
Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭!
Please visit my lab's webpage for details about the position and how to formally apply.
April 25, 2025 at 4:15 PM
Reposted by Jean-Philippe Nougayrede
If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio
www.sciencedirect.com/science/arti...
Chemical strategies for targeting lipid pathways in bacterial pathogens
Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…
www.sciencedirect.com
April 19, 2025 at 10:22 PM
Reposted by Jean-Philippe Nougayrede
We are looking for a PhD candidate starting on the 01-10-2025. The project aims to understand how the host cells use copper and oxidative species to fight Salmonella infection and how this pathogen evades this antimicrobial response.

SHORT DEADLINE ! 20-04-2025
jobs.inrae.fr/en/ot-25517
March 27, 2025 at 9:20 AM
Reposted by Jean-Philippe Nougayrede
You want to learn about microbiology from a fantastic lineup of speakers on a beautiful Greek island? PhD students apply now for the @EMBO | @FEBSnews Lecture Course The New Microbiology!
Registration: 1 Apr 2025
Course: 03 – 11 Sep 2025 | Spetses, Greece
meetings.embo.org/event/25-new...
December 16, 2024 at 8:43 AM
Reposted by Jean-Philippe Nougayrede
1. For the past thirty years I've had the best job in the world.


I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.
March 19, 2025 at 7:32 PM