Joshua Sharp
@joshuasharp.bsky.social
Triplett-Behrakis Professor of Pharmacology, University of Mississippi School of Pharmacy. Director, Glycoscience Center of Research Excellence. CTO, GenNext Technologies. Analytical and physical biochemist. Posting on BlueSky is not my job.
Reposted by Joshua Sharp
Tell me you don’t understand risk pools without telling me you don’t understand risk pools
November 10, 2025 at 3:02 PM
Tell me you don’t understand risk pools without telling me you don’t understand risk pools
Seriously...what are the betting odds that one juror threw a sandwich at a hold-out, they all laughed about it and voted not guilty?
According to a person familiar with jury lunches
November 6, 2025 at 10:06 PM
Seriously...what are the betting odds that one juror threw a sandwich at a hold-out, they all laughed about it and voted not guilty?
Reports like this make me want to abandon index funds...
Crowd goes wild as Elon Musk's trillion dollar pay package is approved with over 75% of the vote
November 6, 2025 at 10:04 PM
Reports like this make me want to abandon index funds...
135,000,000,000 lbs
342,784,500 Americans
__________________________
...
These guys really ARE trying to kill us.
342,784,500 Americans
__________________________
...
These guys really ARE trying to kill us.
Oz: We thought it was 125 million pounds. Our estimate is Americans will lose 135 billion pounds by the midterms
November 6, 2025 at 9:19 PM
135,000,000,000 lbs
342,784,500 Americans
__________________________
...
These guys really ARE trying to kill us.
342,784,500 Americans
__________________________
...
These guys really ARE trying to kill us.
If your T&P committees aren't factoring in the funding mess that we're going through into their decisions, your committees are making a big mistake.
And if you're not willing to take it into account in your external T&P review letters, please decline requests to review.
And if you're not willing to take it into account in your external T&P review letters, please decline requests to review.
and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.
2025
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
November 5, 2025 at 9:14 PM
If your T&P committees aren't factoring in the funding mess that we're going through into their decisions, your committees are making a big mistake.
And if you're not willing to take it into account in your external T&P review letters, please decline requests to review.
And if you're not willing to take it into account in your external T&P review letters, please decline requests to review.
There's a good chance that you have a local coffee shop that makes better stuff anyway. Here's a good excuse to try it out.
I don't drink coffee so not crossing this picket line won't be difficult for me, but the rest of you should probably be prepared to caffeinate in an alternate fashion
BREAKING: After months of stonewalling by Starbucks, unionized baristas just voted 92% to authorize a ULP strike unless Starbucks finalizes fair contracts & stops union busting.
If forced, our baristas will strike in dozens of cities on November 13 – the company's busiest sales day of the year.
If forced, our baristas will strike in dozens of cities on November 13 – the company's busiest sales day of the year.
November 5, 2025 at 8:21 PM
There's a good chance that you have a local coffee shop that makes better stuff anyway. Here's a good excuse to try it out.
Reposted by Joshua Sharp
I don't drink coffee so not crossing this picket line won't be difficult for me, but the rest of you should probably be prepared to caffeinate in an alternate fashion
BREAKING: After months of stonewalling by Starbucks, unionized baristas just voted 92% to authorize a ULP strike unless Starbucks finalizes fair contracts & stops union busting.
If forced, our baristas will strike in dozens of cities on November 13 – the company's busiest sales day of the year.
If forced, our baristas will strike in dozens of cities on November 13 – the company's busiest sales day of the year.
Starbucks unionized workers say they'll strike on Nov. 13 if coffee giant doesn't finalize contract
Union members say they are ready to strike on the chain's Red Cup Day if Starbucks doesn't finalize a contract with their union by then.
www.cbsnews.com
November 5, 2025 at 8:16 PM
I don't drink coffee so not crossing this picket line won't be difficult for me, but the rest of you should probably be prepared to caffeinate in an alternate fashion
If you're on the UMiss campus tomorrow, join our Glycoscience Student Advocates group for their upcoming seminar!
#glycoscience #researchseminar #studentadvocates #biomolecularsciences #graduatestudents #stemcommunity #glycobiology #umiss #olemissresearch #sciencetalks | Glycoscience Center of Research Excellence
🧬 Discover the future of glycoscience! Join us as Dr. Lei Li (Georgia State University) shares innovative chemoenzymatic strategies for expanding the synthetic glycome.
📅 Nov. 6 | 11 a.m.–12 p.m. | ...
www.linkedin.com
November 5, 2025 at 8:17 PM
If you're on the UMiss campus tomorrow, join our Glycoscience Student Advocates group for their upcoming seminar!
I haven't looked into this enough to comment on the merits.
But I do know that I don't trust Marty Makary and Vinay Prasad, and think they're both in way over their heads but too arrogant or stupid to realize it.
But I do know that I don't trust Marty Makary and Vinay Prasad, and think they're both in way over their heads but too arrogant or stupid to realize it.
This is horrible. And WSJ is having a fit. www.wsj.com/opinion/fda-...
Opinion | The Spin Doctors at the FDA
Makary and Prasad duck responsibility for killing a melanoma drug.
www.wsj.com
October 28, 2025 at 8:55 PM
I haven't looked into this enough to comment on the merits.
But I do know that I don't trust Marty Makary and Vinay Prasad, and think they're both in way over their heads but too arrogant or stupid to realize it.
But I do know that I don't trust Marty Makary and Vinay Prasad, and think they're both in way over their heads but too arrogant or stupid to realize it.
Reposted by Joshua Sharp
B SKY DOT APP YOU GOTTA UNBAN THE STATE OF MISSISSIPPI, THE PEOPLE ARE MISSING OUT ON MONKEY NEWS
October 28, 2025 at 8:39 PM
B SKY DOT APP YOU GOTTA UNBAN THE STATE OF MISSISSIPPI, THE PEOPLE ARE MISSING OUT ON MONKEY NEWS
I was on a state-mandated Bluesky blackout when it happened, so I never got to announce: new publication from the Sharp Lab!
Grad student Quadrat Yusuph published her first paper, which just so happens to be the first method for carbohydrate footprinting! Check it out in Analytical Chemistry.
Grad student Quadrat Yusuph published her first paper, which just so happens to be the first method for carbohydrate footprinting! Check it out in Analytical Chemistry.
Hydroxyl and Trifluoromethyl Radical Carbohydrate Footprinting for Probing Protein Binding Components of Oligosaccharides
Carbohydrates are found in various forms in living organisms, both as free-standing glycans as well as glycoconjugates including glycoproteins, glycolipids, and glycosaminoglycans. These structures pl...
pubs.acs.org
October 28, 2025 at 8:28 PM
I was on a state-mandated Bluesky blackout when it happened, so I never got to announce: new publication from the Sharp Lab!
Grad student Quadrat Yusuph published her first paper, which just so happens to be the first method for carbohydrate footprinting! Check it out in Analytical Chemistry.
Grad student Quadrat Yusuph published her first paper, which just so happens to be the first method for carbohydrate footprinting! Check it out in Analytical Chemistry.
No wonder they're highly aggressive toward humans!!!
October 28, 2025 at 8:17 PM
No wonder they're highly aggressive toward humans!!!
Reposted by Joshua Sharp
New from me:
Elite law firms, multiple media outlets, the D.C. attorney general, and a group of parents accused a teacher of molesting 15 kids. They were wrong.
This piece is two-and-a-half years in the making. And as you'll see, it took some incredible turns, even as I was reporting it.
Elite law firms, multiple media outlets, the D.C. attorney general, and a group of parents accused a teacher of molesting 15 kids. They were wrong.
This piece is two-and-a-half years in the making. And as you'll see, it took some incredible turns, even as I was reporting it.
Accusing Jordan Silverman
A D.C. teaching assistant was accused of molesting up to 15 kids. Multiple law enforcement agencies cleared him. But his nightmare was just beginning.
radleybalko.substack.com
October 27, 2025 at 12:55 PM
New from me:
Elite law firms, multiple media outlets, the D.C. attorney general, and a group of parents accused a teacher of molesting 15 kids. They were wrong.
This piece is two-and-a-half years in the making. And as you'll see, it took some incredible turns, even as I was reporting it.
Elite law firms, multiple media outlets, the D.C. attorney general, and a group of parents accused a teacher of molesting 15 kids. They were wrong.
This piece is two-and-a-half years in the making. And as you'll see, it took some incredible turns, even as I was reporting it.
Today's experiment definitely supports my previous hypothesis:
Chocolate chip >>> oatmeal raisin > sugar
Chocolate chip >>> oatmeal raisin > sugar
October 24, 2025 at 6:40 PM
Today's experiment definitely supports my previous hypothesis:
Chocolate chip >>> oatmeal raisin > sugar
Chocolate chip >>> oatmeal raisin > sugar
Reposted by Joshua Sharp
Via @berkeleyside.org: Another view of the officer firing a likely "pepper-spray round" directly into the Rev. Jorge Bautista in the face.
Their full story here: www.berkeleyside.org/2025/10/23/l...
Their full story here: www.berkeleyside.org/2025/10/23/l...
October 24, 2025 at 2:38 PM
Via @berkeleyside.org: Another view of the officer firing a likely "pepper-spray round" directly into the Rev. Jorge Bautista in the face.
Their full story here: www.berkeleyside.org/2025/10/23/l...
Their full story here: www.berkeleyside.org/2025/10/23/l...
Reposted by Joshua Sharp
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
a dog is sitting on a rug in front of a brick wall and a plant .
ALT: a dog is sitting on a rug in front of a brick wall and a plant .
media.tenor.com
October 16, 2025 at 12:25 AM
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Reposted by Joshua Sharp
Administrators at Indiana University baselessly fired the student media director and ordered the student paper to cease its print edition, so it'd sure be a shame if this excellent digital front page were to be widely shared today
issuu.com/idsnews/docs...
issuu.com/idsnews/docs...
October 17, 2025 at 1:31 PM
Administrators at Indiana University baselessly fired the student media director and ordered the student paper to cease its print edition, so it'd sure be a shame if this excellent digital front page were to be widely shared today
issuu.com/idsnews/docs...
issuu.com/idsnews/docs...
Lol that explains it!
Trump didn't take 10% of Intel. He bought it. With government money. Then lied about it.
Trump didn't take 10% of Intel. He bought it. With government money. Then lied about it.
So happy to see we finally have a socialist president willing to nationalize key industries for the benefit of all comrades!
www.cnn.com/2025/08/22/t...
www.cnn.com/2025/08/22/t...
The US takes a 10% stake in Intel as part of Trump’s big tech push | CNN Business
The United States government is making an $8.9 billion investment in Intel common stock, giving the Trump administration a roughly 10% stake in the struggling chipmaker, Intel and the president announ...
www.cnn.com
August 23, 2025 at 11:59 PM
Lol that explains it!
Trump didn't take 10% of Intel. He bought it. With government money. Then lied about it.
Trump didn't take 10% of Intel. He bought it. With government money. Then lied about it.
Reposted by Joshua Sharp
Kicking off now: A faith-led protest in DC’s Columbus Heights neighborhood against Trump’s effort to federalize the DC police force and deploy the national guard.
August 22, 2025 at 9:02 PM
Kicking off now: A faith-led protest in DC’s Columbus Heights neighborhood against Trump’s effort to federalize the DC police force and deploy the national guard.
Republications: "Seize 10% of the means of production!"
So weird how the folks freaking about "socialism" are just totally okay with government market controls and state ownership of corporations when Republicans are the ones doing it
www.cnbc.com/2025/08/22/i...
www.cnbc.com/2025/08/22/i...
U.S. officially takes 10% stake in Intel
Commerce Secretary Howard Lutnick said that the U.S. government has taken a 10% stake in chipmaker Intel.
www.cnbc.com
August 22, 2025 at 8:57 PM
Republications: "Seize 10% of the means of production!"
So did this dilute existing shareholders?
I'm confused.
I'm confused.
So weird how the folks freaking about "socialism" are just totally okay with government market controls and state ownership of corporations when Republicans are the ones doing it
www.cnbc.com/2025/08/22/i...
www.cnbc.com/2025/08/22/i...
U.S. officially takes 10% stake in Intel
Commerce Secretary Howard Lutnick said that the U.S. government has taken a 10% stake in chipmaker Intel.
www.cnbc.com
August 22, 2025 at 8:54 PM
So did this dilute existing shareholders?
I'm confused.
I'm confused.
This is just outstanding work done for free.
Ok - so I'm going to do a real context+write up but for now, here's what some of these things look like.
To start my data reference is DCinbox which is ~208,000 official e-newsletters over the past 15 years.
To start my data reference is DCinbox which is ~208,000 official e-newsletters over the past 15 years.
August 22, 2025 at 8:36 PM
This is just outstanding work done for free.
Well shit.
Unfortunately, Bluesky is unavailable in Mississippi right now, due to a new state law that requires age verification for all users.
While intended for child safety, we think this law poses broader challenges & creates significant barriers that limit free speech & harm smaller platforms like ours.
While intended for child safety, we think this law poses broader challenges & creates significant barriers that limit free speech & harm smaller platforms like ours.
August 22, 2025 at 8:18 PM
Well shit.
I am happy (and relieved) to share that the Glycoscience Center of Research Excellence has received its Phase 2 funding from NIGMS.
So, if you're a scientist (especially in the Mid-South) who's come across a glycoscience problem in your research, we're here to help!
olemiss.edu/glycore/
So, if you're a scientist (especially in the Mid-South) who's come across a glycoscience problem in your research, we're here to help!
olemiss.edu/glycore/
Glycoscience Center of Research Excellence | Ole Miss
olemiss.edu
August 22, 2025 at 6:43 PM
I am happy (and relieved) to share that the Glycoscience Center of Research Excellence has received its Phase 2 funding from NIGMS.
So, if you're a scientist (especially in the Mid-South) who's come across a glycoscience problem in your research, we're here to help!
olemiss.edu/glycore/
So, if you're a scientist (especially in the Mid-South) who's come across a glycoscience problem in your research, we're here to help!
olemiss.edu/glycore/