Joshua Shapiro
@josh.shapiro.foo
not ‘Eureka’ but ‘That’s funny…’
Current projects: Biological data and Childhood cancer at http://ccdatalab.org, part of https://alexslemonade.org
Not governor.
Current projects: Biological data and Childhood cancer at http://ccdatalab.org, part of https://alexslemonade.org
Not governor.
Reposted by Joshua Shapiro
He’s on a mission from God.
What's from Chicago, hates Illinois Nazis, and is holy as fuck?
It's the Pope in 1982.
It's the Pope in 1982.
November 13, 2025 at 2:32 AM
He’s on a mission from God.
I just discovered that the feature where AirPods automatically mute when you start talking is not triggered if you are singing along to music. So cool.
Apologies to those who hear me singing.
Apologies to those who hear me singing.
November 7, 2025 at 12:53 PM
I just discovered that the feature where AirPods automatically mute when you start talking is not triggered if you are singing along to music. So cool.
Apologies to those who hear me singing.
Apologies to those who hear me singing.
Reposted by Joshua Shapiro
“STOP”
I've been... busy.
October 29, 2025 at 11:29 PM
“STOP”
And if you are writing a widely used (or not) library, don’t set the random seed somewhere deep in your code to a fixed number that will override the user’s seed (an R problem, to be sure). Looking at you Seurat. Maybe this has been fixed, but 🤦
We need to have a conversation about random seeds. Don't use 42.
blog.genesmindsmachines.com/p/if-your-ra...
blog.genesmindsmachines.com/p/if-your-ra...
If your random seed is 42 I will come to your office and set your computer on fire🔥
Figuratively. More likely you'll get a stern talking to.
blog.genesmindsmachines.com
October 22, 2025 at 3:13 PM
And if you are writing a widely used (or not) library, don’t set the random seed somewhere deep in your code to a fixed number that will override the user’s seed (an R problem, to be sure). Looking at you Seurat. Maybe this has been fixed, but 🤦
A warning: Costco has TimTams now. This is very dangerous.
October 21, 2025 at 11:48 PM
A warning: Costco has TimTams now. This is very dangerous.
Reposted by Joshua Shapiro
Before it was illegally destroyed by Musk and co., USAID had a budget of $35 billion (in 2024)
Treasury Secretary Scott Bessent says the bailout for Argentina, now doubled to $40 billion, is part of an effort to swing Latin America to the right
@jacobbogage.bsky.social @davidjlynch.bsky.social David Feliba report
www.washingtonpost.com/business/202...
@jacobbogage.bsky.social @davidjlynch.bsky.social David Feliba report
www.washingtonpost.com/business/202...
Bessent says bailout for Argentina will double to boost U.S. influence in region
The Trump administration is working to arrange private sector financing for Argentina that would double the total U.S. financial lifeline for the embattled Latin nation.
www.washingtonpost.com
October 15, 2025 at 10:39 PM
Before it was illegally destroyed by Musk and co., USAID had a budget of $35 billion (in 2024)
I often get questions about how federal cuts affect my work at ALSF. The short answer is that we don’t get federal money, so my own work is largely insulated. The longer answer is more complex and difficult. We’ll keep trying to support researchers as best we can.
share.inquirer.com/24oSYR
share.inquirer.com/24oSYR
Alex’s Lemonade Stand Foundation worries about federal cuts to childhood cancer research
The childhood cancer charity, based in Bala Cynwyd, is pushing "extra hard" to raise money this year in hopes of offsetting some of the losses in federal funding. But it's not enough to fill the gaps.
share.inquirer.com
October 15, 2025 at 10:02 PM
I often get questions about how federal cuts affect my work at ALSF. The short answer is that we don’t get federal money, so my own work is largely insulated. The longer answer is more complex and difficult. We’ll keep trying to support researchers as best we can.
share.inquirer.com/24oSYR
share.inquirer.com/24oSYR
Reposted by Joshua Shapiro
Ever want a live code review of your #bioinformatics code?
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
October 14, 2025 at 10:10 PM
Ever want a live code review of your #bioinformatics code?
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
I know he’s talking about calculus, but this is really the state of the art for single-cell.
Integration by vibes is the best technique
October 14, 2025 at 4:13 PM
I know he’s talking about calculus, but this is really the state of the art for single-cell.
Reposted by Joshua Shapiro
Integration by vibes is the best technique
October 13, 2025 at 4:10 PM
Integration by vibes is the best technique
Reposted by Joshua Shapiro
Bumi the 1-year-old rockhopper penguin played during a bubble enrichment activity at the Saint Louis Zoo.
Southern rockhopper penguins, like Bumi, are listed as a vulnerable species by the World Wildlife Fund.
Southern rockhopper penguins, like Bumi, are listed as a vulnerable species by the World Wildlife Fund.
October 10, 2025 at 12:00 AM
Bumi the 1-year-old rockhopper penguin played during a bubble enrichment activity at the Saint Louis Zoo.
Southern rockhopper penguins, like Bumi, are listed as a vulnerable species by the World Wildlife Fund.
Southern rockhopper penguins, like Bumi, are listed as a vulnerable species by the World Wildlife Fund.
I don't want to sell anything, buy anything, or process anything by AI. I don't want to sell anything bought or processed with AI, or buy anything sold or processed with AI, or process anything sold, bought, or processed by AI, or repair anything sold, bought, or processed by AI.
I don’t want to generate or receive an email, document, manuscript, PowerPoint deck, post it note, grocery list, novel, film, or hit list that has been generated with AI.
I write because I love writing. I love writing even when I'm struggling with a writing problem that is killing me. Finding a way through that problem is both intensely rewarding and also helps me become a better writer. There is no reason for me to ever outsource that.
October 9, 2025 at 11:09 PM
I don't want to sell anything, buy anything, or process anything by AI. I don't want to sell anything bought or processed with AI, or buy anything sold or processed with AI, or process anything sold, bought, or processed by AI, or repair anything sold, bought, or processed by AI.
Reposted by Joshua Shapiro
i desperately want everyone involved in the destruction of USAID to have to, st the very least, answer to the american people for the suffering and misery they have caused apnews.com/article/myan...
Starving children screaming for food as US aid cuts unleash devastation and death across Myanmar
U.S. Secretary of State Marco Rubio has repeatedly said “no one has died" because of his government’s decision to gut its foreign aid program.
apnews.com
October 8, 2025 at 2:59 PM
i desperately want everyone involved in the destruction of USAID to have to, st the very least, answer to the american people for the suffering and misery they have caused apnews.com/article/myan...
On the train back from the @theaacr.bsky.social pediatric cancer meeting in Boston. What a great meeting. Learned a lot, met some great people.
Already looking forward to the next one, but sad I won’t be able to take a train to it.
Already looking forward to the next one, but sad I won’t be able to take a train to it.
September 28, 2025 at 7:38 PM
On the train back from the @theaacr.bsky.social pediatric cancer meeting in Boston. What a great meeting. Learned a lot, met some great people.
Already looking forward to the next one, but sad I won’t be able to take a train to it.
Already looking forward to the next one, but sad I won’t be able to take a train to it.
Reposted by Joshua Shapiro
This remarkable therapy uses an approach the Trump administration just cancelled funding for.
September 24, 2025 at 12:29 PM
This remarkable therapy uses an approach the Trump administration just cancelled funding for.
Reposted by Joshua Shapiro
Critical part of the President's new $100,000 charge for H1-B visas: The Administration can also offer a $100,000 discount to any person, company, or industry that it wants. Replacing rules with arbitrary discretion.
Want visas? You know who to call and who to flatter.
Want visas? You know who to call and who to flatter.
September 20, 2025 at 1:40 PM
Critical part of the President's new $100,000 charge for H1-B visas: The Administration can also offer a $100,000 discount to any person, company, or industry that it wants. Replacing rules with arbitrary discretion.
Want visas? You know who to call and who to flatter.
Want visas? You know who to call and who to flatter.
Reposted by Joshua Shapiro
The Executive Order does not appear to exempt professors (who are exempt from various other working visa conditions) from the 100,000 USD fee. That means that no university will hire foreign professors. American academia is toasted.
September 20, 2025 at 7:29 AM
The Executive Order does not appear to exempt professors (who are exempt from various other working visa conditions) from the 100,000 USD fee. That means that no university will hire foreign professors. American academia is toasted.
Definitely a good day to rewatch Sneakers. Not that any day is a bad day for that.
September 16, 2025 at 3:24 PM
Definitely a good day to rewatch Sneakers. Not that any day is a bad day for that.
@reckless.bsky.social Was that a WhatsApp ad featuring a party speaker during the Emmys? I expect deep analysis when you get back.
September 15, 2025 at 12:23 AM
@reckless.bsky.social Was that a WhatsApp ad featuring a party speaker during the Emmys? I expect deep analysis when you get back.
Reposted by Joshua Shapiro
My thoughts on this dark day.
1/ The beating heart of a free society is the ability for citizens to engage in political life with no fear of violence. Once we lose this freedom, few will step forward, and our entire democratic experiment unwinds into chaos and recrimination.
1/ The beating heart of a free society is the ability for citizens to engage in political life with no fear of violence. Once we lose this freedom, few will step forward, and our entire democratic experiment unwinds into chaos and recrimination.
September 10, 2025 at 10:09 PM
My thoughts on this dark day.
1/ The beating heart of a free society is the ability for citizens to engage in political life with no fear of violence. Once we lose this freedom, few will step forward, and our entire democratic experiment unwinds into chaos and recrimination.
1/ The beating heart of a free society is the ability for citizens to engage in political life with no fear of violence. Once we lose this freedom, few will step forward, and our entire democratic experiment unwinds into chaos and recrimination.
Such a fun mix of science and complete bullshit. www.nytimes.com/interactive/...
Your Zodiac Sign Is 2,000 Years Out of Date (Gift Article)
Over millennia, our view of the stars has shifted, because of Earth’s wobble. It may be time to rethink your sign.
www.nytimes.com
September 9, 2025 at 12:56 AM
Such a fun mix of science and complete bullshit. www.nytimes.com/interactive/...
I want to emphasize that do not speak for my employer when I say: What a bunch of fucking ghouls.
Pediatric Brain Cancer Group to Lose Federal Funding www.nytimes.com/2025/08/28/w...
Pediatric Brain Cancer Group to Lose Federal Funding www.nytimes.com/2025/08/28/w...
Pediatric Brain Cancer Group to Lose Federal Funding
www.nytimes.com
August 30, 2025 at 1:40 PM
I want to emphasize that do not speak for my employer when I say: What a bunch of fucking ghouls.
Pediatric Brain Cancer Group to Lose Federal Funding www.nytimes.com/2025/08/28/w...
Pediatric Brain Cancer Group to Lose Federal Funding www.nytimes.com/2025/08/28/w...
Reposted by Joshua Shapiro
All together now:
DUMP RFK Jr.
DUMP RFK Jr.
August 28, 2025 at 12:54 AM
All together now:
DUMP RFK Jr.
DUMP RFK Jr.
Reposted by Joshua Shapiro
I had serious doubts about CDC Director Monarez’s willingness to stand up against RFK Jr.’s personal mission to destroy public health in America—I’m glad that I was wrong.
If there are any adults left in the White House: we cannot let RFK Jr. burn what's left of CDC. FIRE HIM.
If there are any adults left in the White House: we cannot let RFK Jr. burn what's left of CDC. FIRE HIM.
New C.D.C. Director Resists Ouster as Other Officials Resign
www.nytimes.com
August 28, 2025 at 12:52 AM
I had serious doubts about CDC Director Monarez’s willingness to stand up against RFK Jr.’s personal mission to destroy public health in America—I’m glad that I was wrong.
If there are any adults left in the White House: we cannot let RFK Jr. burn what's left of CDC. FIRE HIM.
If there are any adults left in the White House: we cannot let RFK Jr. burn what's left of CDC. FIRE HIM.