Josephine Heine
@josephineheine.bsky.social
Neuroscientist (PhD), postdoc at Charité Berlin🔸️I study human brain function through the lens of neuroimaging, plasticity, cognition & patient perspectives🔸️memory🔸️fatigue🔸️MS🔸️long COVID🔸️encephalitis🔸️NMOSD🔸️women's neurology🔸️health equity
Pinned
📣 New publication 📣
Our latest review article explores the role sex differences play in neuroimaging, disease progression and clinical outcomes of #multiplesclerosis and related diseases.
- with @jelenabrasanac.bsky.social and Claudia Chien
doi.org/10.1159/0005...
🧵 #ms #nmosd #womenshealth
Our latest review article explores the role sex differences play in neuroimaging, disease progression and clinical outcomes of #multiplesclerosis and related diseases.
- with @jelenabrasanac.bsky.social and Claudia Chien
doi.org/10.1159/0005...
🧵 #ms #nmosd #womenshealth
Reposted by Josephine Heine
Why do women often have more severe strokes than men? 🧠
Dr. Farida Sohrabji joins Dr. @liisagalea.bsky.social on Women’s Health Interrupted to unpack sex differences, estrogens, & gut health in stroke.
ow.ly/zFSJ50XjGLT
#WomensHealthInterrupted #Stroke
Dr. Farida Sohrabji joins Dr. @liisagalea.bsky.social on Women’s Health Interrupted to unpack sex differences, estrogens, & gut health in stroke.
ow.ly/zFSJ50XjGLT
#WomensHealthInterrupted #Stroke
October 29, 2025 at 5:37 PM
Why do women often have more severe strokes than men? 🧠
Dr. Farida Sohrabji joins Dr. @liisagalea.bsky.social on Women’s Health Interrupted to unpack sex differences, estrogens, & gut health in stroke.
ow.ly/zFSJ50XjGLT
#WomensHealthInterrupted #Stroke
Dr. Farida Sohrabji joins Dr. @liisagalea.bsky.social on Women’s Health Interrupted to unpack sex differences, estrogens, & gut health in stroke.
ow.ly/zFSJ50XjGLT
#WomensHealthInterrupted #Stroke
Reposted by Josephine Heine
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types.
ja.ma/4pAC3zi
ja.ma/4pAC3zi
September 24, 2025 at 4:00 PM
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types.
ja.ma/4pAC3zi
ja.ma/4pAC3zi
Reposted by Josephine Heine
ICYMI: New online! Advancing multiple sclerosis management in older adults
Advancing multiple sclerosis management in older adults
Nature Reviews Neurology, Published online: 23 July 2025; doi:10.1038/s41582-025-01115-5Approximately half of the people currently with multiple sclerosis (MS) are ≥50 years of age, yet guidelines for management of MS in older age are lacking. This Consensus statement presents the outcomes of an International Advisory Committee on Clinical Trials (IACCT) in MS workshop on ageing and MS, including recommendations for advancing research, care and awareness.
bit.ly
July 29, 2025 at 12:29 PM
ICYMI: New online! Advancing multiple sclerosis management in older adults
Reposted by Josephine Heine
Discrete sites in the human insular cortex showed changes of ac vity that predicted later memory recall, while others responded to emo onal content. Smula on of memoryrelated sites showed direct influence over the hippocampus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Direct interactions between the human insula and hippocampus during memory encoding - Nature Neuroscience
The hippocampus and insula communicate when processing emotional memories. Discrete sites in the human insular cortex showed changes that predicted later memory recall, while others responded to emoti...
www.nature.com
July 16, 2025 at 7:40 PM
Discrete sites in the human insular cortex showed changes of ac vity that predicted later memory recall, while others responded to emo onal content. Smula on of memoryrelated sites showed direct influence over the hippocampus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Josephine Heine
An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Benchmarking methods for mapping functional connectivity in the brain - Nature Methods
In this Analysis, Liu et al. benchmark more than 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure–function coupling and behavio...
www.nature.com
June 6, 2025 at 3:51 PM
An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Josephine Heine
RELEASE THE KRAKEN(CODER)!
Ever struggle deciding which connectome pipeline to use or want to map between structure and function? Our multi-modal connectome mapping and fusion tool-the Krakencoder-can help! Brilliant Keith Jamison led this work, code available! www.nature.com/articles/s41...
Ever struggle deciding which connectome pipeline to use or want to map between structure and function? Our multi-modal connectome mapping and fusion tool-the Krakencoder-can help! Brilliant Keith Jamison led this work, code available! www.nature.com/articles/s41...
June 5, 2025 at 1:55 PM
RELEASE THE KRAKEN(CODER)!
Ever struggle deciding which connectome pipeline to use or want to map between structure and function? Our multi-modal connectome mapping and fusion tool-the Krakencoder-can help! Brilliant Keith Jamison led this work, code available! www.nature.com/articles/s41...
Ever struggle deciding which connectome pipeline to use or want to map between structure and function? Our multi-modal connectome mapping and fusion tool-the Krakencoder-can help! Brilliant Keith Jamison led this work, code available! www.nature.com/articles/s41...
Reposted by Josephine Heine
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉
www.nature.com/articles/s41...
🧵1👇
www.nature.com/articles/s41...
🧵1👇
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data
Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
www.nature.com
June 4, 2025 at 6:30 PM
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉
www.nature.com/articles/s41...
🧵1👇
www.nature.com/articles/s41...
🧵1👇
Reposted by Josephine Heine
Thalamic atrophy in multiple sclerosis is associated with tract disconnection and altered microglia link.springer.com/article/10.1...
Thalamic atrophy in multiple sclerosis is associated with tract disconnection and altered microglia - Acta Neuropathologica
Thalamic atrophy already occurs in the early stages of multiple sclerosis (MS) and continues progressively throughout the disease. Demyelination is one of the main pathological hallmarks of MS and yet...
link.springer.com
May 29, 2025 at 8:49 AM
Thalamic atrophy in multiple sclerosis is associated with tract disconnection and altered microglia link.springer.com/article/10.1...
Reposted by Josephine Heine
ICYMI: New online! Synapse vulnerability and resilience across the clinical spectrum of dementias
Synapse vulnerability and resilience across the clinical spectrum of dementias
Nature Reviews Neurology, Published online: 22 May 2025; doi:10.1038/s41582-025-01094-7In this Review, Taddei and Duff consider the concepts of synapse vulnerability and resilience, and how an understanding of the mechanisms that underlie these states could identify novel strategies to mitigate the cognitive dysfunction associated with dementias.
bit.ly
May 28, 2025 at 7:56 PM
ICYMI: New online! Synapse vulnerability and resilience across the clinical spectrum of dementias
Reposted by Josephine Heine
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
The history and future of resting-state functional magnetic resonance imaging - Nature
This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...
www.nature.com
May 28, 2025 at 3:52 PM
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
Reposted by Josephine Heine
⭐ preprint ⭐
In-vivo evidence for increased tau deposition in temporal lobe epilepsy
➡️ Using [¹⁸F]MK-6240 PET, we show increased tau in young and middle aged TLE
➡️ Tau aggregation potential mechanism of disease progression & cognitive decline
➡️ pdf bit.ly/4mmlTYH
by Raul Cruces & a super team
In-vivo evidence for increased tau deposition in temporal lobe epilepsy
➡️ Using [¹⁸F]MK-6240 PET, we show increased tau in young and middle aged TLE
➡️ Tau aggregation potential mechanism of disease progression & cognitive decline
➡️ pdf bit.ly/4mmlTYH
by Raul Cruces & a super team
May 19, 2025 at 12:31 PM
⭐ preprint ⭐
In-vivo evidence for increased tau deposition in temporal lobe epilepsy
➡️ Using [¹⁸F]MK-6240 PET, we show increased tau in young and middle aged TLE
➡️ Tau aggregation potential mechanism of disease progression & cognitive decline
➡️ pdf bit.ly/4mmlTYH
by Raul Cruces & a super team
In-vivo evidence for increased tau deposition in temporal lobe epilepsy
➡️ Using [¹⁸F]MK-6240 PET, we show increased tau in young and middle aged TLE
➡️ Tau aggregation potential mechanism of disease progression & cognitive decline
➡️ pdf bit.ly/4mmlTYH
by Raul Cruces & a super team
Reposted by Josephine Heine
Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
May 15, 2025 at 6:49 PM
Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
📣 New publication 📣
Our latest review article explores the role sex differences play in neuroimaging, disease progression and clinical outcomes of #multiplesclerosis and related diseases.
- with @jelenabrasanac.bsky.social and Claudia Chien
doi.org/10.1159/0005...
🧵 #ms #nmosd #womenshealth
Our latest review article explores the role sex differences play in neuroimaging, disease progression and clinical outcomes of #multiplesclerosis and related diseases.
- with @jelenabrasanac.bsky.social and Claudia Chien
doi.org/10.1159/0005...
🧵 #ms #nmosd #womenshealth
May 13, 2025 at 9:25 AM
📣 New publication 📣
Our latest review article explores the role sex differences play in neuroimaging, disease progression and clinical outcomes of #multiplesclerosis and related diseases.
- with @jelenabrasanac.bsky.social and Claudia Chien
doi.org/10.1159/0005...
🧵 #ms #nmosd #womenshealth
Our latest review article explores the role sex differences play in neuroimaging, disease progression and clinical outcomes of #multiplesclerosis and related diseases.
- with @jelenabrasanac.bsky.social and Claudia Chien
doi.org/10.1159/0005...
🧵 #ms #nmosd #womenshealth
Reposted by Josephine Heine
🎨🧑🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊
anniegbryant.github.io/subcortex_vi...
anniegbryant.github.io/subcortex_vi...
May 4, 2025 at 10:13 AM
🎨🧑🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊
anniegbryant.github.io/subcortex_vi...
anniegbryant.github.io/subcortex_vi...
Reposted by Josephine Heine
Task-free functional and structural magnetic resonance imaging data from 33,250 individuals at 32 weeks of postmenstrual age to 80 years from 132 global sites 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human lifespan changes in the brain’s functional connectome - Nature Neuroscience
Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative...
www.nature.com
April 8, 2025 at 2:42 PM
Task-free functional and structural magnetic resonance imaging data from 33,250 individuals at 32 weeks of postmenstrual age to 80 years from 132 global sites 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Josephine Heine
Very excited to share our new preprint that shows the increased neuroinflammatory activity on the white matter (WM) tracts disrupted by the paramagnetic rim lesions (PRLs) in people with multiple sclerosis (MS). shorturl.at/CXrWQ (1/8)
TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis
Objective: To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation in PRL-disrupted WM tracts is associated ...
shorturl.at
January 7, 2025 at 3:50 AM
Very excited to share our new preprint that shows the increased neuroinflammatory activity on the white matter (WM) tracts disrupted by the paramagnetic rim lesions (PRLs) in people with multiple sclerosis (MS). shorturl.at/CXrWQ (1/8)
Reposted by Josephine Heine
Awesome new preprint combining PET and our WM disconnectome tool NeMo to explore inflammation patterns in MS!
Very excited to share our new preprint that shows the increased neuroinflammatory activity on the white matter (WM) tracts disrupted by the paramagnetic rim lesions (PRLs) in people with multiple sclerosis (MS). shorturl.at/CXrWQ (1/8)
TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis
Objective: To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation in PRL-disrupted WM tracts is associated ...
shorturl.at
January 7, 2025 at 2:01 PM
Awesome new preprint combining PET and our WM disconnectome tool NeMo to explore inflammation patterns in MS!