Jolien Perneel
@jolienperneel.bsky.social
Postdoctoral Researcher | Neurodegeneration, Lysosomes & FTD | Rosa Rademakers Lab, VIB-UAntwerp Center for Molecular Neurology
And that’s a wrap - I successfully defended my PhD last week!
Grateful for everyone who made this journey possible (- and meaningful). It feels a bit strange and surreal, yet incredibly rewarding to close such an important chapter of my life. Excited to see what comes next!
Grateful for everyone who made this journey possible (- and meaningful). It feels a bit strange and surreal, yet incredibly rewarding to close such an important chapter of my life. Excited to see what comes next!
October 22, 2025 at 9:31 AM
And that’s a wrap - I successfully defended my PhD last week!
Grateful for everyone who made this journey possible (- and meaningful). It feels a bit strange and surreal, yet incredibly rewarding to close such an important chapter of my life. Excited to see what comes next!
Grateful for everyone who made this journey possible (- and meaningful). It feels a bit strange and surreal, yet incredibly rewarding to close such an important chapter of my life. Excited to see what comes next!
Almost there! 🎓
Excited (and a bit surreal) to be defending my PhD soon!
Welcome to join the defense 👇
Excited (and a bit surreal) to be defending my PhD soon!
Welcome to join the defense 👇
October 11, 2025 at 6:47 AM
Almost there! 🎓
Excited (and a bit surreal) to be defending my PhD soon!
Welcome to join the defense 👇
Excited (and a bit surreal) to be defending my PhD soon!
Welcome to join the defense 👇
Reposted by Jolien Perneel
'The role of #endolysosomal #progranulin and #TMEM106B in neurodegenerative diseases'
Hideyuki Takahashi & Stephen M. Strittmatter
molecularneurodegeneration.biomedcentral.com/articles/10....
Hideyuki Takahashi & Stephen M. Strittmatter
molecularneurodegeneration.biomedcentral.com/articles/10....
The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases - Molecular Neurodegeneration
Although different neurodegenerative diseases are defined by distinct pathological proteins, they share many common features including protein aggregation. Despite this commonality, most current thera...
molecularneurodegeneration.biomedcentral.com
July 27, 2025 at 3:27 AM
'The role of #endolysosomal #progranulin and #TMEM106B in neurodegenerative diseases'
Hideyuki Takahashi & Stephen M. Strittmatter
molecularneurodegeneration.biomedcentral.com/articles/10....
Hideyuki Takahashi & Stephen M. Strittmatter
molecularneurodegeneration.biomedcentral.com/articles/10....
Reposted by Jolien Perneel
Prevail Tx/Lilly's investigational AAV gene therapy PR006 that delivers progranulin into brains of patients w/ rare form of dementia/FTD has shown promise in an early safety trial. Nature Biotech story says 6 companies are pursuing the progranulin pathway to potentially treat frontotemporal dementia
February 26, 2025 at 8:12 PM
Prevail Tx/Lilly's investigational AAV gene therapy PR006 that delivers progranulin into brains of patients w/ rare form of dementia/FTD has shown promise in an early safety trial. Nature Biotech story says 6 companies are pursuing the progranulin pathway to potentially treat frontotemporal dementia
Reposted by Jolien Perneel
I am so very proud announce my lab's first preprint!!
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
www.biorxiv.org
April 24, 2025 at 9:24 PM
I am so very proud announce my lab's first preprint!!
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
Reposted by Jolien Perneel
🧠 Can we defeat dementia?
This week, BNA President @tspiresjones.bsky.social took the TEDx stage to explore the powerful neuroscience that could help us do just that.
🎥 Watch her talk here: youtu.be/hJMEAd9ODis
#TEDx #Neuroscience #Dementia #BNA
This week, BNA President @tspiresjones.bsky.social took the TEDx stage to explore the powerful neuroscience that could help us do just that.
🎥 Watch her talk here: youtu.be/hJMEAd9ODis
#TEDx #Neuroscience #Dementia #BNA
The neuroscience of defeating dementia | Prof Tara Spires-Jones | TEDxUniversityofStAndrews
YouTube video by TEDx Talks
youtu.be
April 24, 2025 at 8:30 AM
🧠 Can we defeat dementia?
This week, BNA President @tspiresjones.bsky.social took the TEDx stage to explore the powerful neuroscience that could help us do just that.
🎥 Watch her talk here: youtu.be/hJMEAd9ODis
#TEDx #Neuroscience #Dementia #BNA
This week, BNA President @tspiresjones.bsky.social took the TEDx stage to explore the powerful neuroscience that could help us do just that.
🎥 Watch her talk here: youtu.be/hJMEAd9ODis
#TEDx #Neuroscience #Dementia #BNA
Reposted by Jolien Perneel
Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study #RareDisease #Genetics academic.oup.com/brain/advanc...
Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study
Mirza et al. show that a variant in the TMEM106B gene confers protection against frontotemporal dementia (FTD) by modifying the effects of FTD mutations—in
academic.oup.com
April 24, 2025 at 7:25 PM
Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study #RareDisease #Genetics academic.oup.com/brain/advanc...
I'm happy to share that our paper describing our novel TMEM106B overexpression mouse model is now out in Molecular Neurodegeneration 🧠📝.
It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.
It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.
'Increased #TMEM106B levels lead to #lysosomal dysfunction which affects synaptic signaling and neuronal health'
@jolienperneel.bsky.social @mirandalastraosua.bsky.social Sara Alidadiani... Xiaolai Zhou & Rosa Rademakers @cmn-vib.bsky.social @uantwerpen.be
bit.ly/4lG76ro
@jolienperneel.bsky.social @mirandalastraosua.bsky.social Sara Alidadiani... Xiaolai Zhou & Rosa Rademakers @cmn-vib.bsky.social @uantwerpen.be
bit.ly/4lG76ro
Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health - Molecular Neurodegeneration
Background Genetic variation in Transmembrane protein 106B (TMEM106B) is known to influence the risk and presentation in several neurodegenerative diseases and modifies healthy aging. While evidence f...
bit.ly
April 24, 2025 at 7:43 AM
I'm happy to share that our paper describing our novel TMEM106B overexpression mouse model is now out in Molecular Neurodegeneration 🧠📝.
It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.
It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.
📣 Exciting new paper!
The Da Cruz lab created a novel TDP-43 model by seeding TDP-43 fragments, recapitulating both cytoplasmic aggregation and nuclear clearance — key hallmarks of the pathology.
www.cell.com/neuron/fullt...
The Da Cruz lab created a novel TDP-43 model by seeding TDP-43 fragments, recapitulating both cytoplasmic aggregation and nuclear clearance — key hallmarks of the pathology.
www.cell.com/neuron/fullt...
TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43
Rummens et al. demonstrate that amyloid-like fibrils trigger TDP-43 aggregation and
nuclear depletion, key hallmarks of neurodegenerative disorders. This provokes a unique
transcriptomic signature wit...
www.cell.com
March 31, 2025 at 7:57 AM
📣 Exciting new paper!
The Da Cruz lab created a novel TDP-43 model by seeding TDP-43 fragments, recapitulating both cytoplasmic aggregation and nuclear clearance — key hallmarks of the pathology.
www.cell.com/neuron/fullt...
The Da Cruz lab created a novel TDP-43 model by seeding TDP-43 fragments, recapitulating both cytoplasmic aggregation and nuclear clearance — key hallmarks of the pathology.
www.cell.com/neuron/fullt...
Reposted by Jolien Perneel
A genetic medicine that delivers progranulin into the brains of patients with a rare form of dementia has shown promise in an early safety trial. At least six companies are pursuing the progranulin pathway to treat frontotemporal dementia www.nature.com/articles/s41...
rdcu.be/eboPa
rdcu.be/eboPa
Gains in early-onset dementia with progranulin open new paths for drug discovery - Nature Biotechnology
The first clinical results in patients with a genetic form of frontotemporal dementia (FTD) show that enhancing progranulin in the brain may halt disease progression. If successful, this potentially d...
www.nature.com
February 26, 2025 at 7:00 PM
A genetic medicine that delivers progranulin into the brains of patients with a rare form of dementia has shown promise in an early safety trial. At least six companies are pursuing the progranulin pathway to treat frontotemporal dementia www.nature.com/articles/s41...
rdcu.be/eboPa
rdcu.be/eboPa