John Janetzko
@jjanetzko.bsky.social
Asst. Prof. Univ of Colorado. Chemist. Sometimes structural biologist. Molecular microscopist 🔬. Usually found thinking about PTMs, GPCRs and protein dynamics. Bike racer 🚴🏼♂️.👦 & 🐶 dad, 🇨🇦, 🎓 Stanford/Harvard/UToronto.
Reposted by John Janetzko
Now out at @cellpress.bsky.social Cell Genomics, we characterized the genetic architecture of the murine red blood cell proteome using omics profiling in 350 genetically diverse mice.
The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/n
The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/n
Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance
Keele et al. uncover the genetic architecture of the proteome of fresh and stored
red blood cells using a multi-omics analysis of 350 genetically diverse mice. Their
work reveals how a hemoglobin redo...
www.cell.com
November 19, 2025 at 8:24 PM
Now out at @cellpress.bsky.social Cell Genomics, we characterized the genetic architecture of the murine red blood cell proteome using omics profiling in 350 genetically diverse mice.
The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/n
The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/n
Reposted by John Janetzko
From my perspective, there are many potential problems with this decision.
It is likely to disadvantage applications from early stage investigators and for certain classes of proposals.
More on this later...
2/13
It is likely to disadvantage applications from early stage investigators and for certain classes of proposals.
More on this later...
2/13
November 14, 2025 at 3:31 PM
From my perspective, there are many potential problems with this decision.
It is likely to disadvantage applications from early stage investigators and for certain classes of proposals.
More on this later...
2/13
It is likely to disadvantage applications from early stage investigators and for certain classes of proposals.
More on this later...
2/13
Happy Halloween from the Janetzko lab 🎃 👻
October 31, 2025 at 8:06 PM
Happy Halloween from the Janetzko lab 🎃 👻
I’m crushed. She was such a great human being who stood up for their principles like few others. She will be deeply missed 😢
Zara Weinberg was a brilliant, loving, and beautiful woman. She inspired everyone who she interacted with, and always strived to make the world a better place for everyone. Tho the world is a little less bright today without her, her memory will always be a blessing.
She was truly one of the best.
She was truly one of the best.
October 31, 2025 at 3:10 AM
I’m crushed. She was such a great human being who stood up for their principles like few others. She will be deeply missed 😢
The issue of Molecular Pharmacology edited by @nicoleperryhauser.bsky.social and me is finally finished!
As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩
Check it out 👇
www.sciencedirect.com/science/arti...
As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩
Check it out 👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com
October 13, 2025 at 1:17 PM
The issue of Molecular Pharmacology edited by @nicoleperryhauser.bsky.social and me is finally finished!
As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩
Check it out 👇
www.sciencedirect.com/science/arti...
As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩
Check it out 👇
www.sciencedirect.com/science/arti...
Reposted by John Janetzko
A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Emerging Voices in GPCR Biology
www.sciencedirect.com
October 13, 2025 at 10:24 AM
A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by John Janetzko
Thanking the reviewers
October 4, 2025 at 7:14 PM
Thanking the reviewers
A lab that collects data together stays together. Feeling like the luckiest PI to work with such great folks 🤩🔬 @cuanschutz.bsky.social @cu-bmg.bsky.social
September 6, 2025 at 9:22 PM
A lab that collects data together stays together. Feeling like the luckiest PI to work with such great folks 🤩🔬 @cuanschutz.bsky.social @cu-bmg.bsky.social
Reposted by John Janetzko
We have new members! Welcome to the CU Cancer Center! 👏
August 17, 2025 at 12:58 AM
We have new members! Welcome to the CU Cancer Center! 👏
Reposted by John Janetzko
The acknowledgements section speaks to considerable privilege. Without a senior author, he and his classmate were provided with lab space, purified protein, and technical help. Their paper was communicated to PNAS. I doubt many undergraduate researchers have received comparable support.
31/n
31/n
August 3, 2025 at 11:21 PM
The acknowledgements section speaks to considerable privilege. Without a senior author, he and his classmate were provided with lab space, purified protein, and technical help. Their paper was communicated to PNAS. I doubt many undergraduate researchers have received comparable support.
31/n
31/n
Reposted by John Janetzko
With news that NIH grant success rates are now below 5%, consider the effort that goes into one of these grants (apart from you, who submitted 60 AI-written grants)- why would you put in that much effort knowing your chances are only slightly better than winning a lottery? 1/
July 29, 2025 at 3:47 PM
With news that NIH grant success rates are now below 5%, consider the effort that goes into one of these grants (apart from you, who submitted 60 AI-written grants)- why would you put in that much effort knowing your chances are only slightly better than winning a lottery? 1/
Reposted by John Janetzko
No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org
July 22, 2025 at 8:58 PM
No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org
Reposted by John Janetzko
We are going to hear a lot in the near future about how University brass “has to make hard decisions”. Twill be interesting to see who those hard decisions land upon.
July 20, 2025 at 2:15 AM
We are going to hear a lot in the near future about how University brass “has to make hard decisions”. Twill be interesting to see who those hard decisions land upon.
Reposted by John Janetzko
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
July 6, 2025 at 3:13 PM
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by John Janetzko
A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.
The importance of feeling responsibility and taking pride in doing the best job you can
The importance of feeling responsibility and taking pride in doing the best job you can
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
July 6, 2025 at 11:28 AM
A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.
The importance of feeling responsibility and taking pride in doing the best job you can
The importance of feeling responsibility and taking pride in doing the best job you can
Reposted by John Janetzko
Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences
Rao et al. identified thousands of previously unknown 2A peptides across both viruses
and eukaryotes using an HMMER analysis. The authors further identified a unique class
of 2A peptides, class B, who...
www.cell.com
June 20, 2025 at 12:22 AM
Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
The world is in chaos, but we still need to rally with our people!
Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉
@cu-bmg.bsky.social
Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉
@cu-bmg.bsky.social
June 14, 2025 at 9:24 PM
The world is in chaos, but we still need to rally with our people!
Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉
@cu-bmg.bsky.social
Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉
@cu-bmg.bsky.social
Reposted by John Janetzko
In America, we have no kings.
June 14, 2025 at 1:23 PM
In America, we have no kings.
Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement
Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP...
www.biorxiv.org
June 10, 2025 at 12:41 AM
Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Sometimes this job can feel like a lot. But sometimes it’s the best job you could imagine. Your whole lab tells you they want to come in on Saturday to finish an experiment we’ve worked up to and you get to see the look of amazement on your tech’s face when her first negative stain works 😍
June 7, 2025 at 10:37 PM
Sometimes this job can feel like a lot. But sometimes it’s the best job you could imagine. Your whole lab tells you they want to come in on Saturday to finish an experiment we’ve worked up to and you get to see the look of amazement on your tech’s face when her first negative stain works 😍
Reposted by John Janetzko
Federal funding to Harvard is primarily for basic research labs, a government-university partnership that has been US policy for 80 years since the end of WWII. International undergraduate student tuition is not federally funded. Anyone trying to confuse these two things is trying to play you.
May 26, 2025 at 1:21 PM
Federal funding to Harvard is primarily for basic research labs, a government-university partnership that has been US policy for 80 years since the end of WWII. International undergraduate student tuition is not federally funded. Anyone trying to confuse these two things is trying to play you.
Reposted by John Janetzko
So: In 2017, Congress made this happen:
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
April 18, 2025 at 6:59 PM
So: In 2017, Congress made this happen:
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
Reposted by John Janetzko
![[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreid7lnvd7afmasx3nxi6anxmyhbatpaw54za3kiw3eaoclrf722faq@jpeg)
Reposted by John Janetzko
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 22, 2025 at 12:42 PM
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
Reposted by John Janetzko
Oh FFS! This government is self sabotaging the decades long edge America had in recruiting the most talented people from across the world.
They're terminating OPT.
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Skilled immigration on the chopping block? Effects of eliminating "Optional Practical Training" in the US
The White House has taken numerous steps to sharply reduce the number of immigrant workers, with or without legal status, in the US economy. These policies, so far, typically target immigrants with le...
www.piie.com
May 22, 2025 at 2:48 AM
Oh FFS! This government is self sabotaging the decades long edge America had in recruiting the most talented people from across the world.