Jay Hesselberth
jayhesselberth.bsky.social
Jay Hesselberth
@jayhesselberth.bsky.social
RNA technologies. hesselberthlab.org
Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class.

www.cell.com/cell-reports...
Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences
Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...
www.cell.com
June 20, 2025 at 12:22 AM
Just released an update of an R data package for NIH funding data from 1985-2024.

github.com/rnabioco/nih...
GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data
An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.
github.com
February 9, 2025 at 12:55 PM
Here for my first post. Our new approach to study tRNA aminoacylation by nanopore sequencing. Started as a napkin sketch ~1 year ago! This was a fun one, congrats to @laurakwhite.bsky.social and Aleks.

www.biorxiv.org/content/10.1...
Nanopore sequencing of intact aminoacylated tRNAs
Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of ...
www.biorxiv.org
November 19, 2024 at 3:07 AM