@jie-immunology.bsky.social
Harrison professor of medicine at UVA. We study respiratory immunity and immunopathology. Working on COVID, Influenza, Aging, T cells, macrophages, lung regeneration and tumorigenesis. https://www.immunology.virginia.edu/Sun/publications.php
Pinned
Respiratory viral infections prime accelerated lung cancer growth
The COVID-19 pandemic has highlighted long-term health concerns of viral pneumonia, yet its potential impact on cancer development and growth remains poorly understood. Here, we demonstrate that prior...
doi.org
Excited to share our new findings: Severe respiratory viral infections like COVID-19 and flu can accelerate lung cancer development. Our study establishes a direct causal link, highlighting the urgent need for long-term cancer surveillance in COVID-19 survivors.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Couldn’t be prouder of this team! We are excited to welcome new members and celebrate big career milestones of lab colleagues!
November 15, 2025 at 4:22 PM
Couldn’t be prouder of this team! We are excited to welcome new members and celebrate big career milestones of lab colleagues!
Reposted
TCF4 regulates alveolar macrophage stemness and is a promising therapeutic target in long COVID and related chronic lung diseases @jie-immunology.bsky.social @biorxivpreprint.bsky.social @uvaimmunology.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:07 PM
TCF4 regulates alveolar macrophage stemness and is a promising therapeutic target in long COVID and related chronic lung diseases @jie-immunology.bsky.social @biorxivpreprint.bsky.social @uvaimmunology.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Jinyi Tang, PhD, received an NIHK99/R00 grant! The award was issued for Jinyi's work developing mucosal vaccines, which he and the @jie-immunology.bsky.social lab have shown to offer additional protection against COVID-19.
Read more: immunology.virginia.edu/jtang_k99/
Read more: immunology.virginia.edu/jtang_k99/
September 25, 2025 at 7:03 PM
Jinyi Tang, PhD, received an NIHK99/R00 grant! The award was issued for Jinyi's work developing mucosal vaccines, which he and the @jie-immunology.bsky.social lab have shown to offer additional protection against COVID-19.
Read more: immunology.virginia.edu/jtang_k99/
Read more: immunology.virginia.edu/jtang_k99/
Excited to share our new findings: Severe respiratory viral infections like COVID-19 and flu can accelerate lung cancer development. Our study establishes a direct causal link, highlighting the urgent need for long-term cancer surveillance in COVID-19 survivors.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Respiratory viral infections prime accelerated lung cancer growth
The COVID-19 pandemic has highlighted long-term health concerns of viral pneumonia, yet its potential impact on cancer development and growth remains poorly understood. Here, we demonstrate that prior...
doi.org
September 4, 2025 at 6:54 AM
Excited to share our new findings: Severe respiratory viral infections like COVID-19 and flu can accelerate lung cancer development. Our study establishes a direct causal link, highlighting the urgent need for long-term cancer surveillance in COVID-19 survivors.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted
HHS Secretary Robert F. Kennedy Jr. threatened to bar government scientists from publishing in major medical journals, saying on a podcast that three top journals were “corrupt” and influenced by pharmaceutical companies.
RFK Jr. threatens to bar government scientists from publishing in leading medical journals
The health secretary said the New England Journal of Medicine, the Journal of the American Medical Association, and The Lancet are in bed with pharma.
www.politico.com
May 27, 2025 at 7:24 PM
HHS Secretary Robert F. Kennedy Jr. threatened to bar government scientists from publishing in major medical journals, saying on a podcast that three top journals were “corrupt” and influenced by pharmaceutical companies.
SIS 2025 registration ends next Monday. We still have a few seats available. Please join us! @uvaimmunology.bsky.social
Abstract submission due in 1 week on April. 21st. #SIS2025. Please join Drs. Merad, Mathis and Kipnis and many more on the beautiful UVA campus.
www.immunology.virginia.edu/sis2025/
www.immunology.virginia.edu/sis2025/
May 3, 2025 at 9:02 PM
SIS 2025 registration ends next Monday. We still have a few seats available. Please join us! @uvaimmunology.bsky.social
SIS 2025 early registration and abstract due today. Please join us! @uvaimmunology.bsky.social
Abstract submission due in 1 week on April. 21st. #SIS2025. Please join Drs. Merad, Mathis and Kipnis and many more on the beautiful UVA campus.
www.immunology.virginia.edu/sis2025/
www.immunology.virginia.edu/sis2025/
April 21, 2025 at 3:23 PM
SIS 2025 early registration and abstract due today. Please join us! @uvaimmunology.bsky.social
Abstract submission due in 1 week on April. 21st. #SIS2025. Please join Drs. Merad, Mathis and Kipnis and many more on the beautiful UVA campus.
www.immunology.virginia.edu/sis2025/
www.immunology.virginia.edu/sis2025/
April 15, 2025 at 11:41 AM
Abstract submission due in 1 week on April. 21st. #SIS2025. Please join Drs. Merad, Mathis and Kipnis and many more on the beautiful UVA campus.
www.immunology.virginia.edu/sis2025/
www.immunology.virginia.edu/sis2025/
Reposted
How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
HHS starts layoffs of thousands of workers across its agencies
Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.
www.statnews.com
April 1, 2025 at 2:44 PM
How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
Reposted
By attacking science:
We are less safe because science informs national security and medical care.
We are less prosperous because science drives innovation and economic benefit.
We are less free because science and democracy depend on the liberty to ask questions, and seek and share knowledge.
We are less safe because science informs national security and medical care.
We are less prosperous because science drives innovation and economic benefit.
We are less free because science and democracy depend on the liberty to ask questions, and seek and share knowledge.
March 19, 2025 at 2:21 PM
By attacking science:
We are less safe because science informs national security and medical care.
We are less prosperous because science drives innovation and economic benefit.
We are less free because science and democracy depend on the liberty to ask questions, and seek and share knowledge.
We are less safe because science informs national security and medical care.
We are less prosperous because science drives innovation and economic benefit.
We are less free because science and democracy depend on the liberty to ask questions, and seek and share knowledge.
Reposted
We are glad to make to the round of 16 #STATMadness2025. Our work has discovered an aberrant immune-epithelial niche underlying severe long COVID. www.nature.com/articles/s41...
Please keep supporting us by voting for the University of Virginia team.
Please keep supporting us by voting for the University of Virginia team.
March 17, 2025 at 10:52 AM
We are glad to make to the round of 16 #STATMadness2025. Our work has discovered an aberrant immune-epithelial niche underlying severe long COVID. www.nature.com/articles/s41...
Please keep supporting us by voting for the University of Virginia team.
Please keep supporting us by voting for the University of Virginia team.
Join us on the topic of an aberrant immune-epithelial niche driving respiratory long COVID at the ATS online journal club. Please register below here. site.thoracic.org/events/an-ab...
American Thoracic Society | An Aberrant Immune–Epithelial Progenitor…
The American Thoracic Society is the world's leading medical society dedicated to accelerating the advancement of global respiratory health through…
site.thoracic.org
March 20, 2025 at 12:59 AM
Join us on the topic of an aberrant immune-epithelial niche driving respiratory long COVID at the ATS online journal club. Please register below here. site.thoracic.org/events/an-ab...
We are glad to make to the round of 16 #STATMadness2025. Our work has discovered an aberrant immune-epithelial niche underlying severe long COVID. www.nature.com/articles/s41...
Please keep supporting us by voting for the University of Virginia team.
Please keep supporting us by voting for the University of Virginia team.
March 17, 2025 at 10:52 AM
We are glad to make to the round of 16 #STATMadness2025. Our work has discovered an aberrant immune-epithelial niche underlying severe long COVID. www.nature.com/articles/s41...
Please keep supporting us by voting for the University of Virginia team.
Please keep supporting us by voting for the University of Virginia team.
Join us with Drs. Mathis, Kipnis and Merad for #SIS2025 at the beautiful UVA campus in Charlottesville! It’s an affordable meeting with an outstanding speaker lineup. Enjoy the superb local history, food, wineries, events, and scenic views. immunology.virginia.edu/sis2025/
March 16, 2025 at 3:43 PM
Join us with Drs. Mathis, Kipnis and Merad for #SIS2025 at the beautiful UVA campus in Charlottesville! It’s an affordable meeting with an outstanding speaker lineup. Enjoy the superb local history, food, wineries, events, and scenic views. immunology.virginia.edu/sis2025/
Reposted
Five years ago on March 11, the World Health Organization officially declared COVID-19 a pandemic.
UVA Health talks new discovery on COVID-19 anniversary
Five years ago on March 11, the World Health Organization officially declared COVID-19 a pandemic.
www.29news.com
March 11, 2025 at 11:00 PM
Five years ago on March 11, the World Health Organization officially declared COVID-19 a pandemic.
Reposted
Our 100th episode is out! 🎊
Nobel Laureate Dr. Peter Doherty (@pcdoherty.bsky.social) discusses his career, from studying sheep as a veterinarian to discovering the mechanisms of #Tcell antigen recognition. 🐑
Listen now: bit.ly/3FxLX1X
Nobel Laureate Dr. Peter Doherty (@pcdoherty.bsky.social) discusses his career, from studying sheep as a veterinarian to discovering the mechanisms of #Tcell antigen recognition. 🐑
Listen now: bit.ly/3FxLX1X
March 12, 2025 at 1:16 AM
Our 100th episode is out! 🎊
Nobel Laureate Dr. Peter Doherty (@pcdoherty.bsky.social) discusses his career, from studying sheep as a veterinarian to discovering the mechanisms of #Tcell antigen recognition. 🐑
Listen now: bit.ly/3FxLX1X
Nobel Laureate Dr. Peter Doherty (@pcdoherty.bsky.social) discusses his career, from studying sheep as a veterinarian to discovering the mechanisms of #Tcell antigen recognition. 🐑
Listen now: bit.ly/3FxLX1X
To vote, please select the “University of Virginia” team. We need your vote daily 😊 🙏.
We made it to the Round 2 🎉. Please keep supporting us 🙏.
We are excited that our paper on the immune mechanisms of long COVID is selected for the #STATMadness @statnews. Help us to go to round 2! 🙏
statnews.com/feature/stat-madness/bracket-voting-now-open
statnews.com/feature/stat-madness/bracket-voting-now-open
March 10, 2025 at 4:23 PM
To vote, please select the “University of Virginia” team. We need your vote daily 😊 🙏.
We made it to the Round 2 🎉. Please keep supporting us 🙏.
We are excited that our paper on the immune mechanisms of long COVID is selected for the #STATMadness @statnews. Help us to go to round 2! 🙏
statnews.com/feature/stat-madness/bracket-voting-now-open
statnews.com/feature/stat-madness/bracket-voting-now-open
2025 STAT Madness
2025 bracket Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Explore groundbreaking innovations from
statnews.com
March 10, 2025 at 1:03 PM
We made it to the Round 2 🎉. Please keep supporting us 🙏.
Reposted
Using a comparative analyses of human and mice PASCs, Xiaoqin Wei and Jie Sun’s group report that severe COVID-19 causes disruption of peroxisomes in macs, which are essential for lung repair, regulation of inflam and chronic fibrosis @jie-immunology.bsky.social [3/n] www.science.org/doi/10.1126/...
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...
www.science.org
March 8, 2025 at 6:30 PM
Using a comparative analyses of human and mice PASCs, Xiaoqin Wei and Jie Sun’s group report that severe COVID-19 causes disruption of peroxisomes in macs, which are essential for lung repair, regulation of inflam and chronic fibrosis @jie-immunology.bsky.social [3/n] www.science.org/doi/10.1126/...
Reposted
On Friday, we Stand Up for Science in locations Nationwide (& internationally!) to support science as a public good that benefits everyone.
Join us! Visit www.standupforscience2025.org for more information & other ways to get involved ☀️
Join us! Visit www.standupforscience2025.org for more information & other ways to get involved ☀️
March 4, 2025 at 12:36 PM
On Friday, we Stand Up for Science in locations Nationwide (& internationally!) to support science as a public good that benefits everyone.
Join us! Visit www.standupforscience2025.org for more information & other ways to get involved ☀️
Join us! Visit www.standupforscience2025.org for more information & other ways to get involved ☀️
Reposted
So happy to share our latest paper on #AlveolarMacrophage responses to low-dose #LPS led by @pamelialim.bsky.social!AM #innate responses are enhanced by IFN-beta due to low c-Maf and IL-10 expression, with implications for AM responses to respiratory infections and environmental exposure. #ImmunoSky
Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages
Abstract. Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can
academic.oup.com
March 4, 2025 at 2:21 PM
So happy to share our latest paper on #AlveolarMacrophage responses to low-dose #LPS led by @pamelialim.bsky.social!AM #innate responses are enhanced by IFN-beta due to low c-Maf and IL-10 expression, with implications for AM responses to respiratory infections and environmental exposure. #ImmunoSky
Reposted
Increasing evidence for the central role of peroxisomes in antiviral immunity. A new study provides in vivo evidence to support a role for peroxisomes in SARS-COV-2 infection. Kudos to the authors on this important study.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral ...
www.science.org
March 6, 2025 at 8:20 PM
Increasing evidence for the central role of peroxisomes in antiviral immunity. A new study provides in vivo evidence to support a role for peroxisomes in SARS-COV-2 infection. Kudos to the authors on this important study.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...