James Seddon
@jaseddon.bsky.social
Paediatric Infectious Diseases doctor and TBologist
Reposted by James Seddon
New comment:
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
www.thelancet.com/journals/lan...
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
www.thelancet.com/journals/lan...
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the
risk of people developing tuberculosis disease and of poor outcomes in those who do.1
Each year, WHO publishes estima...
www.thelancet.com
October 28, 2025 at 10:01 AM
New comment:
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
www.thelancet.com/journals/lan...
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
www.thelancet.com/journals/lan...
Reposted by James Seddon
Great to see this published after the hard work in Stockholm and Cape Town! How should we think about aerosol detection of #tuberculosis? Is it a diagnostic test? Could it help us prioritize prevention activities? Much more work to do, but exciting nonetheless @climeresearchgroup.bsky.social @ki.se
Detection of aerosolized Mycobacterium tuberculosis DNA from adults being investigated for pulmonary tuberculosis using an electrostatic sampler in a South African primary care setting
✅ Just Accepted
#IDSky
🔗 https://bit.ly/474fRq0
✅ Just Accepted
#IDSky
🔗 https://bit.ly/474fRq0
October 8, 2025 at 11:33 AM
Great to see this published after the hard work in Stockholm and Cape Town! How should we think about aerosol detection of #tuberculosis? Is it a diagnostic test? Could it help us prioritize prevention activities? Much more work to do, but exciting nonetheless @climeresearchgroup.bsky.social @ki.se
Reposted by James Seddon
So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Background Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modifiable risk factors such as undernutrit...
doi.org
September 10, 2025 at 4:11 AM
So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)
Reposted by James Seddon
Although several AI algorithms can interpret chest x-rays for TB, we still do not have validated or approved CAD products for children. With @jaseddon.bsky.social and colleagues, we shared our thoughts on how to advance CAD for #pediatricTB:
www.thelancet.com/journals/lan...
#tbsky #idsky
www.thelancet.com/journals/lan...
#tbsky #idsky
Computer-aided reading of chest radiographs for paediatric tuberculosis: current status and future directions
Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs)
have been developed and approved for tuberculosis triage in adults but not in children.
However, CXR is frequently t...
www.thelancet.com
September 2, 2025 at 5:25 PM
Although several AI algorithms can interpret chest x-rays for TB, we still do not have validated or approved CAD products for children. With @jaseddon.bsky.social and colleagues, we shared our thoughts on how to advance CAD for #pediatricTB:
www.thelancet.com/journals/lan...
#tbsky #idsky
www.thelancet.com/journals/lan...
#tbsky #idsky
Reposted by James Seddon
A clinical practice guideline for tuberculous meningitis
Tuberculous Meningitis International Research Consortium
www.thelancet.com/journals/lan... 🔒
Tuberculous Meningitis International Research Consortium
www.thelancet.com/journals/lan... 🔒
A clinical practice guideline for tuberculous meningitis
Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability
in around half of those affected. There are no up-to-date international guidelines
defining its optimal mana...
www.thelancet.com
August 19, 2025 at 1:15 PM
A clinical practice guideline for tuberculous meningitis
Tuberculous Meningitis International Research Consortium
www.thelancet.com/journals/lan... 🔒
Tuberculous Meningitis International Research Consortium
www.thelancet.com/journals/lan... 🔒
Reposted by James Seddon
Meet the antivax whisperer trying to turnaround Britain's child vaccine slump one family at a time. How does she do it? What does she say?
Interview with Professor Elizabeth Whittaker:
www.thetimes.com/article/26a8...
Interview with Professor Elizabeth Whittaker:
www.thetimes.com/article/26a8...
Meet the antivax whisperer fighting the vaccine slump
Professor Elizabeth Whittaker convinces reluctant parents to get their children jabbed — and has seen the horrors that unchecked diseases like measles inflict
www.thetimes.com
June 15, 2025 at 9:08 AM
Meet the antivax whisperer trying to turnaround Britain's child vaccine slump one family at a time. How does she do it? What does she say?
Interview with Professor Elizabeth Whittaker:
www.thetimes.com/article/26a8...
Interview with Professor Elizabeth Whittaker:
www.thetimes.com/article/26a8...
Reposted by James Seddon
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents
As individuals progress through adolescence, their risk of tuberculosis (TB) increases and the type of disease that develops changes, with increasing cavitary formation and parenchymal tissue destruction.
doi.org
June 8, 2025 at 2:44 PM
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Loads of amazing colleagues have contributed to this review of the management of individuals exposed to MDR/RR-TB. www.thelancet.com/journals/lan...
Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis
Individuals exposed to a person with infectious multidrug-resistant or rifampicin-resistant
(MDR-RR) tuberculosis are at risk of developing tuberculosis disease. Historically,
insufficient empirical e...
www.thelancet.com
June 6, 2025 at 3:45 PM
Loads of amazing colleagues have contributed to this review of the management of individuals exposed to MDR/RR-TB. www.thelancet.com/journals/lan...
TB seems to comprehensively disrupt the normal physiological progression of puberty.
academic.oup.com/jid/advance-...
academic.oup.com/jid/advance-...
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents
AbstractBackground. As individuals progress through adolescence, their risk of tuberculosis (TB) increases and the type of disease that develops changes, w
academic.oup.com
June 3, 2025 at 5:21 AM
TB seems to comprehensively disrupt the normal physiological progression of puberty.
academic.oup.com/jid/advance-...
academic.oup.com/jid/advance-...
Reposted by James Seddon
Risk of tuberculosis infection in young children exposed to multidrug-resistant tuberculosis in the TB-CHAMP multi-site randomised controlled trial
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Risk of tuberculosis infection in young children exposed to multidrug-resistant tuberculosis in the TB-CHAMP multi-site randomised controlled trial
Young children have a high risk of developing tuberculosis (TB) disease following infection with Mycobacterium tuberculosis in the absence of preventive treatment.
doi.org
May 30, 2025 at 8:07 PM
Risk of tuberculosis infection in young children exposed to multidrug-resistant tuberculosis in the TB-CHAMP multi-site randomised controlled trial
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by James Seddon
Brilliant work by @cfmcquaid.bsky.social and Matt Saunders!
Their updated analysis— a MOUNTAIN of work— shows that an increase in 1 unit of BMI reduces TB risk by 12.3%.
@theunion-tblh.bsky.social @jasonandrews.bsky.social @madhupai.bsky.social
Link: papers.ssrn.com/sol3/papers....
Their updated analysis— a MOUNTAIN of work— shows that an increase in 1 unit of BMI reduces TB risk by 12.3%.
@theunion-tblh.bsky.social @jasonandrews.bsky.social @madhupai.bsky.social
Link: papers.ssrn.com/sol3/papers....
Tuberculosis Incidence and Body Mass Index – An Updated Systematic Literature Review and Global Analysis
Background: Undernutrition is the leading population-level determinant of tuberculosis, but the relationship between tuberculosis and nutritional status remains
papers.ssrn.com
February 17, 2025 at 11:20 AM
Brilliant work by @cfmcquaid.bsky.social and Matt Saunders!
Their updated analysis— a MOUNTAIN of work— shows that an increase in 1 unit of BMI reduces TB risk by 12.3%.
@theunion-tblh.bsky.social @jasonandrews.bsky.social @madhupai.bsky.social
Link: papers.ssrn.com/sol3/papers....
Their updated analysis— a MOUNTAIN of work— shows that an increase in 1 unit of BMI reduces TB risk by 12.3%.
@theunion-tblh.bsky.social @jasonandrews.bsky.social @madhupai.bsky.social
Link: papers.ssrn.com/sol3/papers....
Reposted by James Seddon
In the endTB trial, researchers assessed the efficacy and safety of five 9-month, all-oral treatment regimens, as compared with the evolving standard of care, in participants with rifampin-resistant, fluoroquinolone-susceptible tuberculosis. nej.md/3WFFJTv
#MedSky #IDSky
#MedSky #IDSky
February 5, 2025 at 5:14 PM
In the endTB trial, researchers assessed the efficacy and safety of five 9-month, all-oral treatment regimens, as compared with the evolving standard of care, in participants with rifampin-resistant, fluoroquinolone-susceptible tuberculosis. nej.md/3WFFJTv
#MedSky #IDSky
#MedSky #IDSky
Reposted by James Seddon
Interesting paper published today in Chest, led by Cheng Chen and Leo Martinez. High frequency of reversions observed when serial QTF is performed. Reversion rates decreased with time from exposure and at older ages. Data from 4 different countries
@chest
linkinghub.elsevier.com/retrieve/pii...
@chest
linkinghub.elsevier.com/retrieve/pii...
Redirecting
linkinghub.elsevier.com
February 6, 2025 at 3:55 PM
Interesting paper published today in Chest, led by Cheng Chen and Leo Martinez. High frequency of reversions observed when serial QTF is performed. Reversion rates decreased with time from exposure and at older ages. Data from 4 different countries
@chest
linkinghub.elsevier.com/retrieve/pii...
@chest
linkinghub.elsevier.com/retrieve/pii...
Reposted by James Seddon
Proud to see the endTB trial, work of a huge team, led by @partnersinhealth.bsky.social, @msf.org, IRD & supported by @unitaid.bsky.social, published in @nejm.org today. Safe, effective, shortened treatments for drug-resistant TB can be available to all. #TBSky #ForeignAid tinyurl.com/NEJM-endTB
Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis | NEJM
For decades, poor treatment options and low-quality evidence plagued care for patients
with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis
and enhanced funding now p...
tinyurl.com
January 30, 2025 at 2:28 AM
Proud to see the endTB trial, work of a huge team, led by @partnersinhealth.bsky.social, @msf.org, IRD & supported by @unitaid.bsky.social, published in @nejm.org today. Safe, effective, shortened treatments for drug-resistant TB can be available to all. #TBSky #ForeignAid tinyurl.com/NEJM-endTB
Reposted by James Seddon
Happy to have been part of the mammoth team effort reviewing and modelling the burden of TBM in children #TBsky www.sciencedirect.com/science/arti...
Global burden of tuberculous meningitis in children aged 0–14 years in 2019: a mathematical modelling study
Tuberculous meningitis is fatal if untreated and can lead to lifelong neurological sequelae. However, to our knowledge, there are no data on the numbe…
www.sciencedirect.com
December 19, 2024 at 1:20 PM
Happy to have been part of the mammoth team effort reviewing and modelling the burden of TBM in children #TBsky www.sciencedirect.com/science/arti...
Reposted by James Seddon
Nice to see VQUIN and TB-CHAMP finally out. Both studies evaluated levofloxacin (compared w/placebo) as preventive treatment for MDR TB contacts.
Meta-analysis showed 60% reduction: evidence.nejm.org/doi/full/10....
Each study:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Meta-analysis showed 60% reduction: evidence.nejm.org/doi/full/10....
Each study:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis
Data from randomized trials evaluating the effectiveness of tuberculosis (TB) preventive
treatment for contacts of multidrug-resistant (MDR)-TB are lacking. Two recently published
randomized trials...
evidence.nejm.org
December 19, 2024 at 4:59 PM
Nice to see VQUIN and TB-CHAMP finally out. Both studies evaluated levofloxacin (compared w/placebo) as preventive treatment for MDR TB contacts.
Meta-analysis showed 60% reduction: evidence.nejm.org/doi/full/10....
Each study:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Meta-analysis showed 60% reduction: evidence.nejm.org/doi/full/10....
Each study:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
And finally the meta-analysis of the two trials in NEJM Evidence with a nice article on the world's weird obsession with P values.
evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....
December 19, 2024 at 6:55 AM
And finally the meta-analysis of the two trials in NEJM Evidence with a nice article on the world's weird obsession with P values.
evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....
Also out in this issue of NEJM. Results from the VQUIN trial. www.nejm.org/doi/full/10....
December 19, 2024 at 6:52 AM
Also out in this issue of NEJM. Results from the VQUIN trial. www.nejm.org/doi/full/10....
This journey began for me in 2009. Beyond excited to see this now out in print. Thank you to everyone (a very large cast) who made this happen. www.nejm.org/doi/full/10....
December 19, 2024 at 6:50 AM
This journey began for me in 2009. Beyond excited to see this now out in print. Thank you to everyone (a very large cast) who made this happen. www.nejm.org/doi/full/10....
Reposted by James Seddon
A reminder on #WorldChildrensDay that 1.3million children fell ill with #tuberculosis in 2023, causing 200,000 paediatric deaths from a disease that's curable & preventable.
Govts & funders must urgently prioritise children in research funding & program implementation. msfaccess.org/tactic-test-...
Govts & funders must urgently prioritise children in research funding & program implementation. msfaccess.org/tactic-test-...
TACTIC: Test, Avoid, Cure TB in Children
Survey of adoption of WHO paediatric TB guidelines into national policy frameworks in 14 countries
msfaccess.org
November 20, 2024 at 7:45 PM
A reminder on #WorldChildrensDay that 1.3million children fell ill with #tuberculosis in 2023, causing 200,000 paediatric deaths from a disease that's curable & preventable.
Govts & funders must urgently prioritise children in research funding & program implementation. msfaccess.org/tactic-test-...
Govts & funders must urgently prioritise children in research funding & program implementation. msfaccess.org/tactic-test-...