Devan Jaganath, MD MPH
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djaganath.bsky.social
Devan Jaganath, MD MPH
@djaganath.bsky.social
100 followers 27 following 13 posts
Pediatric Infectious Diseases at UCSF. TB researcher, Lead of UCSF Maternal-Childhood TB Initiative. Views are my own.
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Reposted by Devan Jaganath, MD MPH
ucjointcph.bsky.social
This Wed, @djaganath.bsky.social MD delivers the CPH seminar on TB biomarkers, and moving from discovery to practice. Join us! Oct 22 1-2 PT Via Zoom. @ucsfchildrens.bsky.social Register here: buff.ly/7OsMIyY
October 20, 2025 at 9:00 PM
djaganath.bsky.social
Adolescents may particularly be interested in digital adherence technologies (DATs) to support TB treatment. We performed the first analysis of DATs for adolescent TB, and found high uptake, higher treatment success and lower loss to follow up: www.ingentaconnect.com/content/iuat...

#tbsky
September 3, 2025 at 7:55 PM
djaganath.bsky.social
Although several AI algorithms can interpret chest x-rays for TB, we still do not have validated or approved CAD products for children. With @jaseddon.bsky.social and colleagues, we shared our thoughts on how to advance CAD for #pediatricTB:

www.thelancet.com/journals/lan...

#tbsky #idsky
Computer-aided reading of chest radiographs for paediatric tuberculosis: current status and future directions
Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently t...
www.thelancet.com
September 2, 2025 at 5:25 PM
djaganath.bsky.social
Enjoyed working with the CA TB controllers association to develop a simple aid to guide #TBprevention in children, please check it out here and share: ctca.org/wp-content/u...

@citc-tb.bsky.social #tuberculosis #LTBI
ctca.org
August 26, 2025 at 11:37 PM
djaganath.bsky.social
Check out our new paper!
August 24, 2025 at 2:26 AM
Reposted by Devan Jaganath, MD MPH
natcomms.nature.com
In this work, the authors use #proteomics to identify plasma protein signatures as biomarkers of #tuberculosis disease in children

@afossati.bsky.social @djaganath.bsky.social @dlswaney.bsky.social
Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications
In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.
bit.ly
August 7, 2025 at 4:16 PM
djaganath.bsky.social
We need new biomarkers to improve TB diagnosis in children. In the COMBO study, we performed a comprehensive plasma proteomic analysis across 4 countries and found several protein signatures that met the WHO target accuracy for a TB screening test: www.nature.com/articles/s41...

#tbsky #idsky
Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications
In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.
www.nature.com
July 21, 2025 at 4:24 PM
Reposted by Devan Jaganath, MD MPH
alundh.bsky.social
Happy to be involved in these two TB diagnostic reviews
www.cochranelibrary.com/cdsr/doi/10....
www.cochranelibrary.com/cdsr/doi/10....
Great team lead by Stephanie Bjerrum, Laura Olbrich, Maunank Shah and @djaganath.bsky.social, with methodologists @yangbd.bsky.social and @tweis.bsky.social
Parallel use of low‐complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV - Bjerrum, S - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
www.cochranelibrary.com
June 13, 2025 at 12:17 PM
djaganath.bsky.social
New Publication: We conducted a multi-country prospective comparison of 3 methods for stool processing for Xpert Ultra testing for childhood TB, and found they performed similarly and were usable and acceptable by lab workers: academic.oup.com/cid/advance-.... @cidjournal.bsky.social #tbsky #idsky
Stool processing methods for Xpert Ultra testing in childhood tuberculosis: A prospective, multi-country accuracy study
AbstractBackground. Centrifuge-free processing methods support stool Xpert Ultra testing for childhood tuberculosis (TB), but there are limited data on the
academic.oup.com
June 6, 2025 at 6:45 PM
Reposted by Devan Jaganath, MD MPH
citc-tb.bsky.social
The recording is now available for the University of California, San Francisco Grand Rounds: Advances and Local Strategies in Pediatric TB presented by Dr. Ann Loeffler

youtu.be/RiOt70vekHI?...

#Tuberculosis #PediatricTB #GrandRounds #IDSky #TBSky
May 19, 2025 at 4:56 PM
djaganath.bsky.social
We need new ways to classify TB severity in children. Our new paper in @jpidsociety.bsky.social shows a 3 gene signature that only requires a finger prick could be helpful for children with confirmed TB: doi.org/10.1093/jpid...

#tuberculosis @ucsf-ctb.bsky.social @tb-innovation.bsky.social
A prospective evaluation of a three-gene host response signature to classify tuberculosis severity in children
AbstractBackground. Children with non-severe TB may benefit from short-course treatment, but point-of-care tools are needed to stratify disease severity. W
doi.org
May 8, 2025 at 4:43 PM
Reposted by Devan Jaganath, MD MPH
citc-tb.bsky.social
Upcoming UCSF Grand Rounds: Advances and Local Strategies in Pediatric TB

Presented by Dr. Ann Loeffler

📅 April 17th
⌚ 12:00 pm Pacific Time

Watch on Zoom: ucsf.zoom.us/j/9748140490...

#PediatricTB #Tuberculosis #TBSky
April 14, 2025 at 9:55 PM
djaganath.bsky.social
Check out our new publication on the accuracy of TB treatment decision algorithms for childhood TB in Uganda: journals.plos.org/globalpublic...

#tbsky #tuberculosis #idsky
The Accuracy of the Uganda National Tuberculosis and Leprosy Program diagnostic algorithm and the World Health Organisation treatment decision algorithms for childhood tuberculosis: A retrospective an...
Author summary In this study, we assessed and compared the accuracy of the 2017 Uganda National TB and Leprosy Program (NTLP) algorithm with the 2022 World Health Organization (WHO) Treatment Decision...
journals.plos.org
April 8, 2025 at 8:36 PM
Reposted by Devan Jaganath, MD MPH
taghivscience.bsky.social
#Tuberculosis Research at the National Institutes of Health – Saving Lives, Shrinking Costs, Fueling American Jobs and Innovation www.treatmentactiongroup.org/publication/... #NIH #TB #HIV

@treatmentactiongroup.org
Tuberculosis Research at the National Institutes of Health - Saving Lives, Shrinking Costs, Fueling American Jobs and Innovation – Treatment Action Group
This policy brief describes the crucial role NIH plays in supporting research on new products to prevent, diagnose, and cure TB. This research is especially important at a time when new forms of drug ...
www.treatmentactiongroup.org
April 7, 2025 at 12:05 PM
djaganath.bsky.social
Why should we help? I’ve heard many complex reasons, but ultimately because we can and should. #idsky #tuberculosis #hiv
Opinion | Musk Said No One Has Died Since Aid Was Cut. That Isn’t True. (Gift Article)
A journey through the front lines of global poverty shows that when the world’s richest men slash aid for the world’s poorest children, the result is sickness, starvation and death.
www.nytimes.com
March 15, 2025 at 6:40 PM
Reposted by Devan Jaganath, MD MPH
madhupai.bsky.social
Abandoned in the Middle of Clinical Trials, Because of a Trump Order

www.nytimes.com/2025/02/06/h...
Dozens of Clinical Trials Have Been Frozen in Response to Trump’s USAID Order
The stop-work order on U.S.A.I.D.-funded research has left thousands of people with experimental drugs and devices in their bodies, with no access to monitoring or care.
www.nytimes.com
February 7, 2025 at 12:12 AM
djaganath.bsky.social
We cannot let the amazing progress we have made be lost; #idsky #pedsky #tuberculosis
January 30, 2025 at 5:39 PM
Reposted by Devan Jaganath, MD MPH
tomsandora.bsky.social
Here’s the link to the new HHS campaign to combat misinformation about vaccines, which are the greatest miracle of modern medicine (and vaccines are one of the few cost-saving health interventions we have). #IDSky www.hhs.gov/letsgetreal
www.hhs.gov
December 23, 2024 at 1:37 PM
djaganath.bsky.social
Congrats to the TB-CHAMP and VQUIN teams on their landmark work to guide treatment of MDR-TB exposure. This also shows we can conduct parallel and coordinated child and adult studies to advance care for all.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
#idsky #pedsidsky #tuberculosis
December 20, 2024 at 11:49 PM