Ioana Genescu
@igenescu.bsky.social
Neurodev enthousiast 🧠 | Research Associate MarínLab @devneuro.bsky.social @kingsioppn.bsky.social | Sir Henry Wellcome Postdoctoral Fellow | 🇷🇴🇫🇷🇬🇧
Reposted by Ioana Genescu
📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
October 21, 2025 at 12:54 PM
📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
Reposted by Ioana Genescu
For the first time, researchers have restored some vision to people with a common eye disease by using a prosthetic retinal implant. The treatment could improve the lives of an estimated one million people in the U.S. who lose their vision to the condition if it's approved for broader use.
Vision Restored Using Prosthetic Retinal Implant
The device could help a million people with a severe form of macular degeneration to be able to see enough to read.
nyti.ms
October 20, 2025 at 12:55 PM
For the first time, researchers have restored some vision to people with a common eye disease by using a prosthetic retinal implant. The treatment could improve the lives of an estimated one million people in the U.S. who lose their vision to the condition if it's approved for broader use.
Reposted by Ioana Genescu
We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology.
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
October 10, 2025 at 1:55 PM
We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology.
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
Reposted by Ioana Genescu
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 19, 2025 at 6:04 AM
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Reposted by Ioana Genescu
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 26, 2025 at 8:28 AM
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Reposted by Ioana Genescu
How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.
@crtd-tud.bsky.social @cp-neuron.bsky.social
www.sciencedirect.com/science/arti...
A thread below 👇
@crtd-tud.bsky.social @cp-neuron.bsky.social
www.sciencedirect.com/science/arti...
A thread below 👇
July 23, 2025 at 11:33 AM
How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.
@crtd-tud.bsky.social @cp-neuron.bsky.social
www.sciencedirect.com/science/arti...
A thread below 👇
@crtd-tud.bsky.social @cp-neuron.bsky.social
www.sciencedirect.com/science/arti...
A thread below 👇
Reposted by Ioana Genescu
Excited to share our new preprint on #thalamus development! 🧠 We reveal how sensory and non-sensory circuits are specified in embryogenesis #mutiomics, #spatialtranscriptomics, #lineagetracing. @neuroalc.bsky.social @glb-lab.bsky.social @jplopez-atalaya.bsky.social www.biorxiv.org/content/10.1...
Early lineage divergence segregates sensory and non-sensory thalamic circuits
The thalamus integrates sensory, motor, and associative functions via distinct nuclei, yet the developmental principles driving their specification remain unclear. Here, we generate a spatiotemporal s...
www.biorxiv.org
July 22, 2025 at 8:01 PM
Excited to share our new preprint on #thalamus development! 🧠 We reveal how sensory and non-sensory circuits are specified in embryogenesis #mutiomics, #spatialtranscriptomics, #lineagetracing. @neuroalc.bsky.social @glb-lab.bsky.social @jplopez-atalaya.bsky.social www.biorxiv.org/content/10.1...
Reposted by Ioana Genescu
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
www.biorxiv.org
July 21, 2025 at 7:58 AM
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ioana Genescu
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
Reposted by Ioana Genescu
🚨 New Paper Alert! 🚨
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 15, 2025 at 3:18 PM
🚨 New Paper Alert! 🚨
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
Reposted by Ioana Genescu
12th Dev Brains:
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
July 12, 2025 at 9:53 PM
12th Dev Brains:
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
Reposted by Ioana Genescu
ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on
@addgene.bsky.social
addgene nature.com/articles/s41...
Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social
@addgene.bsky.social
addgene nature.com/articles/s41...
Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social
ATLAS: a rationally designed anterograde transsynaptic tracer - Nature Methods
ATLAS is a tool for circuit tracing, demonstrated here in rodents. It allows anterograde transsynaptic tracing, starting from genetically defined neurons.
nature.com
May 1, 2025 at 2:56 PM
ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on
@addgene.bsky.social
addgene nature.com/articles/s41...
Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social
@addgene.bsky.social
addgene nature.com/articles/s41...
Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social
Reposted by Ioana Genescu
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
www.sciencedirect.com
June 11, 2025 at 11:34 AM
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Reposted by Ioana Genescu
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations
Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...
rdcu.be
May 15, 2025 at 8:26 AM
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Reposted by Ioana Genescu
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
The beginning of a beautiful collaboration 🤩 curious about what the result will be !
Today I started recording these fantastic pyramidal neurons in layer 2/3 of the somatosensory cortex!
New collab with @igenescu.bsky.social.
New collab with @igenescu.bsky.social.
May 15, 2025 at 4:45 PM
The beginning of a beautiful collaboration 🤩 curious about what the result will be !
Reposted by Ioana Genescu
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
May 5, 2025 at 4:52 PM
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
Reposted by Ioana Genescu
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
April 30, 2025 at 3:41 PM
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
Reposted by Ioana Genescu
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
April 17, 2025 at 3:45 PM
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
Reposted by Ioana Genescu
Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D!
Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...
Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...
April 1, 2025 at 11:10 AM
Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D!
Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...
Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...
Reposted by Ioana Genescu
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
March 19, 2025 at 5:31 PM
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
Reposted by Ioana Genescu
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
March 16, 2025 at 10:31 AM
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Reposted by Ioana Genescu
📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
March 10, 2025 at 8:10 AM
📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
Reposted by Ioana Genescu
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
Apply by: February 16th!
January 14, 2025 at 4:58 AM
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
Apply by: February 16th!
Reposted by Ioana Genescu
Scenes from the incredible turnout today at Berkeley's @standupforscience.bsky.social rally. @tedmiguel.bsky.social, @jenniferdoudna.bsky.social, and dozens of researchers, elected officials, and citizens defended science and the jobs, health benefits, and progress it creates for all Americans.
March 8, 2025 at 4:44 AM
Scenes from the incredible turnout today at Berkeley's @standupforscience.bsky.social rally. @tedmiguel.bsky.social, @jenniferdoudna.bsky.social, and dozens of researchers, elected officials, and citizens defended science and the jobs, health benefits, and progress it creates for all Americans.