🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...

📣 Two week left to apply! 👇

Apply in the link below or, if you have specific questions, reach out!

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!

We are looking for a #postdoc to discover cell-autonomous innate immune antiviral factors in mammals, based on newly-identified defense of prokaryotes!
#EvoCure #comparativeImmunology #virology
Please share
@inserm.fr @ciri-lyon.bsky.social @cnrsbiologie.bsky.social
ciri.ens-lyon.fr/teams/lp2l/j...

Exciting to see our paper now published 🙌
www.science.org/doi/10.1126/...

In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems

CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems

Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...

Super happy to see this work finally out in @naturecomms.bsky.social! Great team effort revealing how single-stranded DNA binding protein RPA interacts with the DNA polymerases in the archaeal replisome 🧵(1/4)
www.nature.com/articles/s41...
@sauguet-lab.bsky.social @pasteur.fr

🧬 Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 👉 https://www.sisb2025.conferences-pasteur.org/home

Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇

If you want to help us update DefenseFinder, you can add all the systems we could have missed on this table (suggestion sheet): docs.google.com/spreadsheets...
You can also see which systems are already included in the next version of DefenseFinder

👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder.

We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things.

Please answer wt preprints/papers with new systems or mail/git them to us. 🙏

What is the diversity of antiphage systems out there ?

We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.

Leb by E. Mordret.
www.biorxiv.org/content/10.1...

Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...

Out in NAR, AntiDefenseFinder & our "systematic" analysis of inhibitors of antiphage systems wt Bondy-Denomy lab led by @ftesson.bsky.social and E. Huiting.

Not so "systematic" as very few known, fun stuff on MGE, antidefense islands and cool phages exaptations!

academic.oup.com/nar/advance-...

Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬.
Excited to welcome these amazing speakers at Institut Pasteur.
Registration will open beginning of November. Abstract deadline February 28. Stay tuned.
Co-organized by @soreklab.bsky.social P. Kranzusch

Out in Nature Microbiology, we predicted phage-bacteria interactions in E. coli species using only genomic information.

Adsorption, not defense systems, is the main driver at this scale (relevant for a phage therapy context), leading to tailored cocktails!

www.nature.com/articles/s41...
🧵👇