Hatem Abouguendia
@hatem-abouguendia.bsky.social
Doctoral Researcher in Finland @InFLAMES_Health | Immunometabolism | HCMV | Erasmus MSc in Vaccinology Alumnus | Clinical Pharmacist (Opinions are my own)
Reposted by Hatem Abouguendia
We are hiring two postdoctoral researchers to study the Initiation and Modulation of Immune Responses! Check out at 👉 ats.talentadore.com/apply/kaksi-...
Two Postdoctoral Researchers at the Faculty of Medicine to Study the Initiation and Modulation of Immune Responses
The immunology research group “Leukocyte Traffic and the Immune Response”, led by Professor Marko Salmi, invites applications for two fixed-term postdoctoral researcher positions at the [Faculty of Me...
ats.talentadore.com
November 6, 2025 at 1:50 PM
We are hiring two postdoctoral researchers to study the Initiation and Modulation of Immune Responses! Check out at 👉 ats.talentadore.com/apply/kaksi-...
Reposted by Hatem Abouguendia
Professor Cecilia Soderberg-Naucler, one of MediCity’s group leaders, shares her insights in a recent interview with Aurora online.
Cecilia believes that cancer is something other than the genetic disease it is commonly thought to be. She thinks that the root cause of cancer lies in metabolism.
Cecilia believes that cancer is something other than the genetic disease it is commonly thought to be. She thinks that the root cause of cancer lies in metabolism.
November 6, 2025 at 8:55 PM
Professor Cecilia Soderberg-Naucler, one of MediCity’s group leaders, shares her insights in a recent interview with Aurora online.
Cecilia believes that cancer is something other than the genetic disease it is commonly thought to be. She thinks that the root cause of cancer lies in metabolism.
Cecilia believes that cancer is something other than the genetic disease it is commonly thought to be. She thinks that the root cause of cancer lies in metabolism.
Reposted by Hatem Abouguendia
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry
High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...
currentprotocols.onlinelibrary.wiley.com
September 25, 2025 at 5:06 PM
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Hatem Abouguendia
What could cause the reactivation of Epstein–Barr virus in individuals with long COVID
-Direct virus infection?
-inflammatory mediators?
-metabolic signals?
www.tandfonline.com/...
1/6
-Direct virus infection?
-inflammatory mediators?
-metabolic signals?
www.tandfonline.com/...
1/6
What could cause the reactivation of Epstein–Barr virus in individuals with long COVID
Published in Emerging Microbes & Infections (Vol. 14, No. 1, 2025)
www.tandfonline.com
September 16, 2025 at 9:26 PM
What could cause the reactivation of Epstein–Barr virus in individuals with long COVID
-Direct virus infection?
-inflammatory mediators?
-metabolic signals?
www.tandfonline.com/...
1/6
-Direct virus infection?
-inflammatory mediators?
-metabolic signals?
www.tandfonline.com/...
1/6
Reposted by Hatem Abouguendia
Denmark eliminates 25% book tax to combat declining reading
boingboing.net/2025/08/22/d...
boingboing.net/2025/08/22/d...
Denmark eliminates 25% book tax to combat declining reading skills
Denmark is eliminating its 25% book tax after finding reading skills in steep decline. Culture Minister Engel-Schmidt: "The gift of reading is something we should give to younger generations."
boingboing.net
August 23, 2025 at 10:55 AM
Denmark eliminates 25% book tax to combat declining reading
boingboing.net/2025/08/22/d...
boingboing.net/2025/08/22/d...
Reposted by Hatem Abouguendia
#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology
Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.
www.nature.com
August 23, 2025 at 4:25 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hatem Abouguendia
A beautiful study highlighting the power of untargeted metabolomics:
Imidazole propionate is a driver and therapeutic target in atherosclerosis www.nature.com/articles/s41...
Imidazole propionate is a driver and therapeutic target in atherosclerosis www.nature.com/articles/s41...
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
www.nature.com
July 16, 2025 at 6:42 PM
A beautiful study highlighting the power of untargeted metabolomics:
Imidazole propionate is a driver and therapeutic target in atherosclerosis www.nature.com/articles/s41...
Imidazole propionate is a driver and therapeutic target in atherosclerosis www.nature.com/articles/s41...
Reposted by Hatem Abouguendia
Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study
24 years .... no effect. The aluminium in vaccines has NO negative health effects.
www.acpjournals.org/...
1/3
24 years .... no effect. The aluminium in vaccines has NO negative health effects.
www.acpjournals.org/...
1/3
Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study: Annals of Internal Medicine: Vol 0, No 0
Background: Aluminum is used as an adjuvant in nonlive vaccines administered in early childhood. Concerns persist about potential associations between vaccination with aluminum-adsorbed vaccines an...
www.acpjournals.org
July 15, 2025 at 3:09 PM
Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study
24 years .... no effect. The aluminium in vaccines has NO negative health effects.
www.acpjournals.org/...
1/3
24 years .... no effect. The aluminium in vaccines has NO negative health effects.
www.acpjournals.org/...
1/3
Sometime, you don’t even need seahorse to know your hypothesis on metabolic rewiring is working..
Warburg effect in action!
Warburg effect in action!
May 6, 2025 at 7:37 PM
Sometime, you don’t even need seahorse to know your hypothesis on metabolic rewiring is working..
Warburg effect in action!
Warburg effect in action!
CMV co-evolved with human. It is a master regulator of immunity and knows about our biology more than we do.
www.nature.com/articles/s41...
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...
www.nature.com
April 23, 2025 at 6:38 PM
CMV co-evolved with human. It is a master regulator of immunity and knows about our biology more than we do.
Reposted by Hatem Abouguendia
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...
www.biorxiv.org
April 19, 2025 at 6:42 AM
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
Reposted by Hatem Abouguendia
Join this event for PhD students and postdocs in the amazing wilderness of Northern Finland! Reg. dl Thu 10th Apr. Spa hotel Rokua with plenty of saunas and pools and other fun. 😎 Network and learn about mitochondria! @mitoworld.bsky.social @richterlab.bsky.social @ki.se @cecad.bsky.social
Mitochondria Summer School
ssl.eventilla.com
April 7, 2025 at 8:05 AM
Join this event for PhD students and postdocs in the amazing wilderness of Northern Finland! Reg. dl Thu 10th Apr. Spa hotel Rokua with plenty of saunas and pools and other fun. 😎 Network and learn about mitochondria! @mitoworld.bsky.social @richterlab.bsky.social @ki.se @cecad.bsky.social
Reposted by Hatem Abouguendia
We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
April 4, 2025 at 10:14 PM
We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
Reposted by Hatem Abouguendia
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
www.nature.com
March 26, 2025 at 5:33 PM
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
Reposted by Hatem Abouguendia
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
March 13, 2025 at 6:43 AM
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
Reposted by Hatem Abouguendia
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Any recommendations for resources to learn phosphoproteomics analysis?
January 30, 2025 at 4:36 PM
Any recommendations for resources to learn phosphoproteomics analysis?
I ordered an antibody 2 months and half ago .. Today I receive it, just one day before I start my holiday 🌚
January 30, 2025 at 4:17 PM
I ordered an antibody 2 months and half ago .. Today I receive it, just one day before I start my holiday 🌚
Isn’t it disappointing when you see an article that has an experiment you always wanted to do but never did?! Or is it exciting that your hypothesis came true?
January 28, 2025 at 7:44 PM
Isn’t it disappointing when you see an article that has an experiment you always wanted to do but never did?! Or is it exciting that your hypothesis came true?
Reposted by Hatem Abouguendia
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Cancer cells ‘poison’ the immune system with tainted mitochondria
Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.
www.nature.com
January 23, 2025 at 6:41 PM
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Reposted by Hatem Abouguendia
An hour a week, if well planned and strategically directed, lets you #explore, discard and engage with multiple career options, so you can pick the #career you are most interested in. Early markers let you sell yourself as purposeful, even when you hadn't decided on a #goal. Good luck!🤞4/4
January 19, 2025 at 9:08 AM
Reposted by Hatem Abouguendia
📣 This year's #ENII @efis-immunology.bsky.social @eurjimmunol.bsky.social summer school on Advanced Immunology is happening in Alghero, IT - directly reachable via Brussels airport.
Early registration is open & more information can be found here:
www.enii.org
#ImmunoSky
Early registration is open & more information can be found here:
www.enii.org
#ImmunoSky
January 20, 2025 at 8:35 AM
📣 This year's #ENII @efis-immunology.bsky.social @eurjimmunol.bsky.social summer school on Advanced Immunology is happening in Alghero, IT - directly reachable via Brussels airport.
Early registration is open & more information can be found here:
www.enii.org
#ImmunoSky
Early registration is open & more information can be found here:
www.enii.org
#ImmunoSky
Reposted by Hatem Abouguendia
Huh. There are flowers in Ethiopia that native nectar-foraging wolves pollinate! 🦊😋🌻🍊
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa
Click on the article title to read more.
esajournals.onlinelibrary.wiley.com
January 11, 2025 at 4:36 PM
Huh. There are flowers in Ethiopia that native nectar-foraging wolves pollinate! 🦊😋🌻🍊
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Hatem Abouguendia
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we a...
www.biorxiv.org
January 10, 2025 at 7:45 AM
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
Reposted by Hatem Abouguendia
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 https://www.biorxiv.org/content/10.1101/2024.11.14.622799v1
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 https://www.biorxiv.org/content/10.1101/2024.11.14.622799v1
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruse
www.biorxiv.org
November 17, 2024 at 5:15 AM
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 https://www.biorxiv.org/content/10.1101/2024.11.14.622799v1