Alessandro Gozzi
@gozziale.bsky.social
Senior scientist at Istituto Italiano di Tecnologia (Rovereto, Italy)
🧠 🐁 Functional Neuroimaging, Brain (dys)connectivity and Autism
ERC Grantee
www.gozzilab.it
🧠 🐁 Functional Neuroimaging, Brain (dys)connectivity and Autism
ERC Grantee
www.gozzilab.it
Pinned
Can we use brain scans to identify biologically distinct "autisms"? And If so, how?
In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions!
Find out more here 👇👇
www.biorxiv.org/content/10.1...
Thread below 🧵 1/n
In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions!
Find out more here 👇👇
www.biorxiv.org/content/10.1...
Thread below 🧵 1/n
Reposted by Alessandro Gozzi
Mind over matter, matter over mind?
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
October 28, 2025 at 6:52 AM
Mind over matter, matter over mind?
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
Reposted by Alessandro Gozzi
1/6 Excited to share our new Nature Protocols article led by Tatiana Shnitko: “Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during fMRI”, a step-by-step guide for simultaneous FSCV + fMRI.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2025 at 2:15 PM
1/6 Excited to share our new Nature Protocols article led by Tatiana Shnitko: “Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during fMRI”, a step-by-step guide for simultaneous FSCV + fMRI.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alessandro Gozzi
Our paper on improving statistical reporting in psychology is now online 🎉
As a part of this paper, we also created the Transparent Statistical Reporting in Psychology checklist, which researchers can use to improve their statistical reporting practices
www.nature.com/articles/s44...
As a part of this paper, we also created the Transparent Statistical Reporting in Psychology checklist, which researchers can use to improve their statistical reporting practices
www.nature.com/articles/s44...
November 14, 2025 at 8:43 PM
Our paper on improving statistical reporting in psychology is now online 🎉
As a part of this paper, we also created the Transparent Statistical Reporting in Psychology checklist, which researchers can use to improve their statistical reporting practices
www.nature.com/articles/s44...
As a part of this paper, we also created the Transparent Statistical Reporting in Psychology checklist, which researchers can use to improve their statistical reporting practices
www.nature.com/articles/s44...
Reposted by Alessandro Gozzi
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 13, 2025 at 4:10 PM
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Reposted by Alessandro Gozzi
🚨New review paper ! Lovely to reconnect with Sheraz Khan around what we think is a timely review of the state of knowledge about brain electrophysiological markers of early/late Alzheimer’s disease pathophysiology, and what's left to discover.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies
We conducted a review of the electrophysiological manifestations of Alzheimer's disease (AD) as captured by electroencephalography (EEG) and magnetoencephalography (MEG), with a focus on tracking th...
alz-journals.onlinelibrary.wiley.com
November 13, 2025 at 5:36 PM
🚨New review paper ! Lovely to reconnect with Sheraz Khan around what we think is a timely review of the state of knowledge about brain electrophysiological markers of early/late Alzheimer’s disease pathophysiology, and what's left to discover.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Alessandro Gozzi
14 months after submission, our article “Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI" is now out in @natmethods.nature.com . You can read it here rdcu.be/ePJo6
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI
Nature Methods - Stimulus-modulated approach to steady state (SASS) is an acquisition scheme for event-related fMRI that generates data with high temporal signal-to-noise ratios interspaced with...
rdcu.be
November 13, 2025 at 12:23 PM
14 months after submission, our article “Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI" is now out in @natmethods.nature.com . You can read it here rdcu.be/ePJo6
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
Reposted by Alessandro Gozzi
Understanding consciousness is one of the greatest scientific challenges of the 21st century, made urgent by rapid advances in AI. Join this #FrontiersForum webinar to explore our Frontiers in Science article on a new phase of consciousness science ➡️ fro.ntiers.in/x64CgqQpPXb
fro.ntiers.in
November 12, 2025 at 4:23 AM
Understanding consciousness is one of the greatest scientific challenges of the 21st century, made urgent by rapid advances in AI. Join this #FrontiersForum webinar to explore our Frontiers in Science article on a new phase of consciousness science ➡️ fro.ntiers.in/x64CgqQpPXb
Reposted by Alessandro Gozzi
New paper in Imaging Neuroscience by Chirag Mehra, Jonathan O’Muircheartaigh, et al:
Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers
doi.org/10.1162/IMAG...
Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers
doi.org/10.1162/IMAG...
November 12, 2025 at 6:14 AM
New paper in Imaging Neuroscience by Chirag Mehra, Jonathan O’Muircheartaigh, et al:
Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers
doi.org/10.1162/IMAG...
Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers
doi.org/10.1162/IMAG...
Reposted by Alessandro Gozzi
Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prediction of neural activity in connectome-constrained recurrent networks - Nature Neuroscience
The authors show that connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictio...
www.nature.com
November 10, 2025 at 10:12 PM
Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alessandro Gozzi
ICYMI @ohbmofficial.bsky.social 2025 keynotes are now online! Here's mine: "Towards a universal taxonomy of functional brain networks" 🧠 www.youtube.com/watch?v=ZW9J...
OHBM 2025 | Keynote | Lucina Uddin | Towards a universal taxonomy of functional brain networks
YouTube video by Organization for Human Brain Mapping
www.youtube.com
November 5, 2025 at 7:21 PM
ICYMI @ohbmofficial.bsky.social 2025 keynotes are now online! Here's mine: "Towards a universal taxonomy of functional brain networks" 🧠 www.youtube.com/watch?v=ZW9J...
Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...
👇👇
www.thetransmitter.org/spectrum/ram...
Ramping up cortical activity in early life sparks autism-like behaviors in mice
The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.
www.thetransmitter.org
November 4, 2025 at 10:59 AM
Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...
👇👇
www.thetransmitter.org/spectrum/ram...
Reposted by Alessandro Gozzi
Our School is recruiting! Come and join a great team
@MonashUni
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
@MonashUni
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
Job Search
careers.pageuppeople.com
November 4, 2025 at 12:08 AM
Our School is recruiting! Come and join a great team
@MonashUni
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
@MonashUni
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
Reposted by Alessandro Gozzi
Preprint is now published: doi.org/10.1002/hbm....
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
November 4, 2025 at 12:32 AM
Preprint is now published: doi.org/10.1002/hbm....
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Reposted by Alessandro Gozzi
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Applications for MCSA are up 64%! 50% now come from outside the EU. Trump effect?
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
MSCA Postdoctoral Fellowships 2025 receives record number of 17,058 proposals
This year’s annual MSCA Postdoctoral Fellowships call has attracted considerable interest from the research community with 17,058 proposals submitted.
marie-sklodowska-curie-actions.ec.europa.eu
November 3, 2025 at 8:24 AM
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Reposted by Alessandro Gozzi
Talking about spooky stuff…try to do awake mouse fMRI.
Oh, you want it spookier? Try to add simultaneous Ca2+ imaging.
Now, do it all again, longitudinally….
So proud to finally have this out!!!
🐭 🧠 🧲
Go read…if you dare!! 👻
www.biorxiv.org/content/10.1...
Oh, you want it spookier? Try to add simultaneous Ca2+ imaging.
Now, do it all again, longitudinally….
So proud to finally have this out!!!
🐭 🧠 🧲
Go read…if you dare!! 👻
www.biorxiv.org/content/10.1...
Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice
Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most neuroimaging studies in rodents use anesthes...
www.biorxiv.org
October 31, 2025 at 1:52 PM
Talking about spooky stuff…try to do awake mouse fMRI.
Oh, you want it spookier? Try to add simultaneous Ca2+ imaging.
Now, do it all again, longitudinally….
So proud to finally have this out!!!
🐭 🧠 🧲
Go read…if you dare!! 👻
www.biorxiv.org/content/10.1...
Oh, you want it spookier? Try to add simultaneous Ca2+ imaging.
Now, do it all again, longitudinally….
So proud to finally have this out!!!
🐭 🧠 🧲
Go read…if you dare!! 👻
www.biorxiv.org/content/10.1...
Reposted by Alessandro Gozzi
🆕 New open neuroimaging dataset released!
I’m happy to share that our Naturalistic Neuroimaging Database (NNDb3T+) is now publicly available! NNDb3T+ captures rich, multimodal brain activity in a naturalistic setting with 40 participants and over 160 hours of scanning!
I’m happy to share that our Naturalistic Neuroimaging Database (NNDb3T+) is now publicly available! NNDb3T+ captures rich, multimodal brain activity in a naturalistic setting with 40 participants and over 160 hours of scanning!
October 27, 2025 at 7:04 PM
🆕 New open neuroimaging dataset released!
I’m happy to share that our Naturalistic Neuroimaging Database (NNDb3T+) is now publicly available! NNDb3T+ captures rich, multimodal brain activity in a naturalistic setting with 40 participants and over 160 hours of scanning!
I’m happy to share that our Naturalistic Neuroimaging Database (NNDb3T+) is now publicly available! NNDb3T+ captures rich, multimodal brain activity in a naturalistic setting with 40 participants and over 160 hours of scanning!
Reposted by Alessandro Gozzi
Reposted by Alessandro Gozzi
Join the School 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐢𝐭𝐲 𝐢𝐧 𝐌𝐞𝐧𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡🧠👇
Fantastic lineup of speakers: @clbockting.bsky.social, Eero Castrén, @francescacirulli.bsky.social, Ashley Cooper, Marilyn Gatica, Agustin Ibanez, @satupalva.bsky.social, @pessoabrain.bsky.social, @ribeirocarlitos.bsky.social, Marten Scheffer
Fantastic lineup of speakers: @clbockting.bsky.social, Eero Castrén, @francescacirulli.bsky.social, Ashley Cooper, Marilyn Gatica, Agustin Ibanez, @satupalva.bsky.social, @pessoabrain.bsky.social, @ribeirocarlitos.bsky.social, Marten Scheffer
Interested in the complexity of the brain and the mind? 🧠
Join the School 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐢𝐭𝐲 𝐢𝐧 𝐌𝐞𝐧𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡
📌 Erice, Sicily
📅 26 April–1 May 2026
An #interdisciplinary dialogue on how #mental_states emerge from the #dynamics of 𝐧𝐞𝐮𝐫𝐚𝐥 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐬 and 𝐜𝐨𝐧𝐭𝐞𝐱𝐭𝐮𝐚𝐥 𝐟𝐚𝐜𝐭𝐨𝐫𝐬
centromajorana.it/mentalhealth...
Join the School 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐢𝐭𝐲 𝐢𝐧 𝐌𝐞𝐧𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡
📌 Erice, Sicily
📅 26 April–1 May 2026
An #interdisciplinary dialogue on how #mental_states emerge from the #dynamics of 𝐧𝐞𝐮𝐫𝐚𝐥 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐬 and 𝐜𝐨𝐧𝐭𝐞𝐱𝐭𝐮𝐚𝐥 𝐟𝐚𝐜𝐭𝐨𝐫𝐬
centromajorana.it/mentalhealth...
October 23, 2025 at 10:42 AM
Join the School 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐢𝐭𝐲 𝐢𝐧 𝐌𝐞𝐧𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡🧠👇
Fantastic lineup of speakers: @clbockting.bsky.social, Eero Castrén, @francescacirulli.bsky.social, Ashley Cooper, Marilyn Gatica, Agustin Ibanez, @satupalva.bsky.social, @pessoabrain.bsky.social, @ribeirocarlitos.bsky.social, Marten Scheffer
Fantastic lineup of speakers: @clbockting.bsky.social, Eero Castrén, @francescacirulli.bsky.social, Ashley Cooper, Marilyn Gatica, Agustin Ibanez, @satupalva.bsky.social, @pessoabrain.bsky.social, @ribeirocarlitos.bsky.social, Marten Scheffer
Reposted by Alessandro Gozzi
🔥🔥 NOOSA Brain Workshop 2026 🔥🔥
Less than 3 weeks left to secure register with accomodation for the Noosa Brain Workshop Feb 23-26, 2026.
Places are filling fast - sign up before November 10!
Details: tinyurl.com/5capskbj
Less than 3 weeks left to secure register with accomodation for the Noosa Brain Workshop Feb 23-26, 2026.
Places are filling fast - sign up before November 10!
Details: tinyurl.com/5capskbj
October 20, 2025 at 9:48 PM
🔥🔥 NOOSA Brain Workshop 2026 🔥🔥
Less than 3 weeks left to secure register with accomodation for the Noosa Brain Workshop Feb 23-26, 2026.
Places are filling fast - sign up before November 10!
Details: tinyurl.com/5capskbj
Less than 3 weeks left to secure register with accomodation for the Noosa Brain Workshop Feb 23-26, 2026.
Places are filling fast - sign up before November 10!
Details: tinyurl.com/5capskbj
Reposted by Alessandro Gozzi
Is science getting too competitive?
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
October 19, 2025 at 3:55 PM
Is science getting too competitive?
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
Reposted by Alessandro Gozzi
Why do brain networks vary? Do these differences shape behavior? If every 🧠 is unique, how can we detect common features of brain organization?
@rodbraga.bsky.social and I dig in, in @annualreviews.bsky.social (ahead of print):
go.illinois.edu/Gratton2025-...
#neuroskyence #psychscisky #MedSky
🧵👇
@rodbraga.bsky.social and I dig in, in @annualreviews.bsky.social (ahead of print):
go.illinois.edu/Gratton2025-...
#neuroskyence #psychscisky #MedSky
🧵👇
Dense Phenotyping of Human Brain Network Organization Using Precision fMRI
The advent of noninvasive imaging methods like functional magnetic resonance imaging (fMRI) transformed cognitive neuroscience, providing insights into large-scale brain networks and their link to cog...
go.illinois.edu
October 16, 2025 at 3:00 PM
Why do brain networks vary? Do these differences shape behavior? If every 🧠 is unique, how can we detect common features of brain organization?
@rodbraga.bsky.social and I dig in, in @annualreviews.bsky.social (ahead of print):
go.illinois.edu/Gratton2025-...
#neuroskyence #psychscisky #MedSky
🧵👇
@rodbraga.bsky.social and I dig in, in @annualreviews.bsky.social (ahead of print):
go.illinois.edu/Gratton2025-...
#neuroskyence #psychscisky #MedSky
🧵👇
Reposted by Alessandro Gozzi
Colombo et al., Plos Biology, "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans"
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...
journals.plos.org
October 16, 2025 at 6:13 PM
Colombo et al., Plos Biology, "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans"
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Alessandro Gozzi
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Alessandro Gozzi
Delighted to see this out in @NeuroCellPress!!!
Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
www.cell.com/neuron/fullt...
Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
www.cell.com/neuron/fullt...
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic
markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory
state. Novel DARGs with...
www.cell.com
October 10, 2025 at 2:59 PM
Delighted to see this out in @NeuroCellPress!!!
Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
www.cell.com/neuron/fullt...
Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
www.cell.com/neuron/fullt...
Reposted by Alessandro Gozzi
Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
September 30, 2025 at 7:39 PM
Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications!
doi.org/10.1038/s414...
doi.org/10.1038/s414...