Chhabi Govind, PhD
@govindlab.bsky.social
Professor, Oakland University, MICHIGAN.
Visiting Faculty@ LSI, UMich (Klionsky lab).
| Chromatin |Transcription |Autophagy | Yeast | Genomics |🧪
Visiting Faculty@ LSI, UMich (Klionsky lab).
| Chromatin |Transcription |Autophagy | Yeast | Genomics |🧪
Reposted by Chhabi Govind, PhD
DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
Shawky et al. show that DDX3X selectively promotes or represses mRNA translation in a stress-dependent manner. This bidirectional regulation involves position-specific binding to the mRNA 5′ UTR and early coding region, reflecting distinct mechanisms, including initiation control during 48S scanning and translational repression associated with ac4C post-transcriptional modification.
dlvr.it
November 9, 2025 at 3:31 PM
Reposted by Chhabi Govind, PhD
Cap-binding protein eIF4E links protein synthesis to metabolic regulation. When depleted, cells adapt by upregulating amino acid catabolism and biosynthesis. Read how this regulation helps maintain balance during stress. #CellBiology #ProteinSynthesis #yeast www.yeastgenome.org/reference/38...
November 7, 2025 at 5:18 PM
Cap-binding protein eIF4E links protein synthesis to metabolic regulation. When depleted, cells adapt by upregulating amino acid catabolism and biosynthesis. Read how this regulation helps maintain balance during stress. #CellBiology #ProteinSynthesis #yeast www.yeastgenome.org/reference/38...
Reposted by Chhabi Govind, PhD
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
November 6, 2025 at 4:20 PM
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
Reposted by Chhabi Govind, PhD
A structural and regulatory framework for Atg9-containing vesicle formation and their Atg1-dependent remodelling during autophagy initiation https://www.biorxiv.org/content/10.1101/2025.11.06.685569v1
November 7, 2025 at 3:46 AM
A structural and regulatory framework for Atg9-containing vesicle formation and their Atg1-dependent remodelling during autophagy initiation https://www.biorxiv.org/content/10.1101/2025.11.06.685569v1
Reposted by Chhabi Govind, PhD
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Reposted by Chhabi Govind, PhD
Nuclear auxin signalling induces autophagy for developmental reprogramming https://www.biorxiv.org/content/10.1101/2025.11.04.686542v1
November 5, 2025 at 10:02 PM
Nuclear auxin signalling induces autophagy for developmental reprogramming https://www.biorxiv.org/content/10.1101/2025.11.04.686542v1
Reposted by Chhabi Govind, PhD
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Chhabi Govind, PhD
Very excited to share our work published in Nature Comms last week! Here we describe a range of cool things that can be done once you have the power to control deposition of H3K4me3…
rdcu.be/eNEf4
A short thread:
rdcu.be/eNEf4
A short thread:
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis
Nature Communications - Binenbaum et al. demonstrate that precise CRISPR-based targeting of a key chromatin mark (H3K4me3) can switch on genes, boost disease resistance, and unlock meiotic...
rdcu.be
November 5, 2025 at 9:30 PM
Very excited to share our work published in Nature Comms last week! Here we describe a range of cool things that can be done once you have the power to control deposition of H3K4me3…
rdcu.be/eNEf4
A short thread:
rdcu.be/eNEf4
A short thread:
Reposted by Chhabi Govind, PhD
India won the Women’s Cricket World Cup for the first time with a 52-run victory over South Africa on Sunday.
India wins Women’s Cricket World Cup for first time with 52-run victory over South Africa
India has won the Women’s Cricket World Cup for the first time with a 52-run victory over South Africa on Sunday.
bit.ly
November 2, 2025 at 6:42 PM
India won the Women’s Cricket World Cup for the first time with a 52-run victory over South Africa on Sunday.
Reposted by Chhabi Govind, PhD
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation https://www.biorxiv.org/content/10.1101/2025.10.31.685944v1
November 1, 2025 at 5:30 PM
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation https://www.biorxiv.org/content/10.1101/2025.10.31.685944v1
Reposted by Chhabi Govind, PhD
My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants
The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.
www.nature.com
October 31, 2025 at 1:57 PM
My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
Reposted by Chhabi Govind, PhD
Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1 https://www.biorxiv.org/content/10.1101/2025.10.29.685279v1
October 30, 2025 at 10:32 AM
Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1 https://www.biorxiv.org/content/10.1101/2025.10.29.685279v1
Reposted by Chhabi Govind, PhD
My quote of the day
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
October 30, 2025 at 11:10 AM
My quote of the day
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Reposted by Chhabi Govind, PhD
The UNC Department of Biology is seeking a Director of Biology Teaching Labs, a key leadership role overseeing our undergraduate laboratory program. 1/n
Learn more and apply here: unc.peopleadmin.com/postings/308...
Learn more and apply here: unc.peopleadmin.com/postings/308...
Director of Biology Teaching Labs
The Director of Biology Teaching Labs provides leadership and direction in the management of the Biology Department's undergraduate laboratories and will be responsible for the undergraduate laborator...
unc.peopleadmin.com
October 27, 2025 at 2:12 PM
The UNC Department of Biology is seeking a Director of Biology Teaching Labs, a key leadership role overseeing our undergraduate laboratory program. 1/n
Learn more and apply here: unc.peopleadmin.com/postings/308...
Learn more and apply here: unc.peopleadmin.com/postings/308...
Reposted by Chhabi Govind, PhD
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 25, 2025 at 1:11 PM
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted by Chhabi Govind, PhD
What makes PhD students happy? Good supervision - Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research www.nature.com/articles/d41... #mentoring #phd #gradschool #commonsense #true #education #meded
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
www.nature.com
October 24, 2025 at 3:36 PM
What makes PhD students happy? Good supervision - Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research www.nature.com/articles/d41... #mentoring #phd #gradschool #commonsense #true #education #meded
Reposted by Chhabi Govind, PhD
Excited to highlight this fantastic integrative lysosomal cryoET proteomics collab with the Moiseenkova-Bell lab (@isbupenn.bsky.social)“Visualization of lysosomal membrane proteins by cryo electron tomography”. Congrats to Bridget, Vera and the whole team. www.nature.com/articles/s41...
Visualization of lysosomal membrane proteins by cryo electron tomography - Nature Communications
Lysosomes are vital for cellular health and linked to many diseases. Here, authors use cryo-ET to image intact lysosomes and resolve lysosomal protein structures, providing a platform to advance the s...
www.nature.com
October 20, 2025 at 5:33 PM
Excited to highlight this fantastic integrative lysosomal cryoET proteomics collab with the Moiseenkova-Bell lab (@isbupenn.bsky.social)“Visualization of lysosomal membrane proteins by cryo electron tomography”. Congrats to Bridget, Vera and the whole team. www.nature.com/articles/s41...
Reposted by Chhabi Govind, PhD
So...
I am hearing from a couple of sources about warnings that citing grants in publications may be used to target investigators for association with "DEI" or other unmentionables.
I am trying to get better information.
I am hearing from a couple of sources about warnings that citing grants in publications may be used to target investigators for association with "DEI" or other unmentionables.
I am trying to get better information.
a man in a suit and tie is sitting at a table with a microphone in front of him .
ALT: a man in a suit and tie is sitting at a table with a microphone in front of him .
media.tenor.com
October 21, 2025 at 12:42 PM
So...
I am hearing from a couple of sources about warnings that citing grants in publications may be used to target investigators for association with "DEI" or other unmentionables.
I am trying to get better information.
I am hearing from a couple of sources about warnings that citing grants in publications may be used to target investigators for association with "DEI" or other unmentionables.
I am trying to get better information.
Appears that ERA Commons is down!
October 21, 2025 at 10:31 AM
Appears that ERA Commons is down!
Reposted by Chhabi Govind, PhD
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
2026 Autophagy in Stress, Development and Disease Conference GRC
The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
October 17, 2025 at 7:26 PM
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
Reposted by Chhabi Govind, PhD
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Reposted by Chhabi Govind, PhD
Well this is deliciously imprecise. IAR notice in NIH’s eRA Commons. Since they know who is and is not a gov employee, they could omit this for peer reviewers if they didn’t mean us. I’m pretty sure they don’t mean non-gov but WHO KNOWS!?!?!
October 12, 2025 at 6:22 PM
Well this is deliciously imprecise. IAR notice in NIH’s eRA Commons. Since they know who is and is not a gov employee, they could omit this for peer reviewers if they didn’t mean us. I’m pretty sure they don’t mean non-gov but WHO KNOWS!?!?!
Reposted by Chhabi Govind, PhD
UK Autophagy members please have a look at website-we will be updating regularly with meeting information
autophagyuk389582434.wordpress.com
autophagyuk389582434.wordpress.com
Autophagy UK Network
Visit the post for more.
autophagyuk389582434.wordpress.com
October 12, 2025 at 10:32 AM
UK Autophagy members please have a look at website-we will be updating regularly with meeting information
autophagyuk389582434.wordpress.com
autophagyuk389582434.wordpress.com
Reposted by Chhabi Govind, PhD
FLIM Playground: An interactive, end-to-end graphical user interface for analyzing single-cell fluorescence lifetime data by Rupsa Datta and team: www.biorxiv.org/content/10.1...
October 9, 2025 at 10:40 AM
FLIM Playground: An interactive, end-to-end graphical user interface for analyzing single-cell fluorescence lifetime data by Rupsa Datta and team: www.biorxiv.org/content/10.1...
Reposted by Chhabi Govind, PhD
Explore emerging research with field leaders @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26 www.keystonesymposia.org/conferences/...
Autophagy: Mechanisms to Therapy | Keystone Symposia
Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!
keysym.us
October 9, 2025 at 4:52 AM
Explore emerging research with field leaders @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26 www.keystonesymposia.org/conferences/...