George Finney
@georgeefinney.bsky.social
Post-doc @pallettlab.bsky.social, Institute of Immunity and Transplantation, UCL • investigating stromal-T cell communication in liver fibrosis • he/him • #immunology
Reposted by George Finney
Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more!
www.nature.com/nrgastro/vol...
www.nature.com/nrgastro/vol...
November 25, 2025 at 9:01 AM
Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more!
www.nature.com/nrgastro/vol...
www.nature.com/nrgastro/vol...
Reposted by George Finney
A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪
November 19, 2025 at 2:17 PM
A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪
Reposted by George Finney
Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
November 10, 2025 at 5:01 PM
Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
Reposted by George Finney
Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Memory CD8+ T cells can undergo TCR-dependent or -independent activation. Here, Lee et al. show that IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions. Furthermore, they validate a bystander activation gene set induced by IL-15 and decreased upon TCR stimulation.
dlvr.it
October 31, 2025 at 7:55 PM
Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Reposted by George Finney
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 31, 2025 at 8:47 PM
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by George Finney
Halloween costumes to scare scientists (by @twisteddoodles.bsky.social) 🧪
October 31, 2025 at 1:24 PM
Halloween costumes to scare scientists (by @twisteddoodles.bsky.social) 🧪
Reposted by George Finney
Kyoto University scientists converted ordinary T cells into stable regulatory T cells that can suppress autoimmune disease in mice.
This approach may enable personalized, targeted cell therapy for inflammatory diseases.
www.science.org/doi/10.1126/...
This approach may enable personalized, targeted cell therapy for inflammatory diseases.
www.science.org/doi/10.1126/...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
www.science.org
October 28, 2025 at 2:06 AM
Kyoto University scientists converted ordinary T cells into stable regulatory T cells that can suppress autoimmune disease in mice.
This approach may enable personalized, targeted cell therapy for inflammatory diseases.
www.science.org/doi/10.1126/...
This approach may enable personalized, targeted cell therapy for inflammatory diseases.
www.science.org/doi/10.1126/...
Reposted by George Finney
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by George Finney
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
www.nature.com
October 27, 2025 at 3:40 PM
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
I'm incredibly honoured to be presenting my research on CD8 TRM in liver fibrosis within the ‘Immune interactions in tissues’ session at @britsocimm.bsky.social Congress 2025!
Added to this, I’m also excited to be selected to share this work as part of the Bright Sparks Postdoc session 🥳
Added to this, I’m also excited to be selected to share this work as part of the Bright Sparks Postdoc session 🥳
October 22, 2025 at 11:06 AM
I'm incredibly honoured to be presenting my research on CD8 TRM in liver fibrosis within the ‘Immune interactions in tissues’ session at @britsocimm.bsky.social Congress 2025!
Added to this, I’m also excited to be selected to share this work as part of the Bright Sparks Postdoc session 🥳
Added to this, I’m also excited to be selected to share this work as part of the Bright Sparks Postdoc session 🥳
Reposted by George Finney
Reposted by George Finney
Yang, Farber and colleagues @columbiamed.bsky.social show how lung tissue resident memory T cells optimize protection through IL-10 production which regulates #macrophage-mediated #inflammation in the lungs. rupress.org/jem/article/...
#InnateImmunity #MucosalImmunology
#InnateImmunity #MucosalImmunology
October 13, 2025 at 7:30 PM
Yang, Farber and colleagues @columbiamed.bsky.social show how lung tissue resident memory T cells optimize protection through IL-10 production which regulates #macrophage-mediated #inflammation in the lungs. rupress.org/jem/article/...
#InnateImmunity #MucosalImmunology
#InnateImmunity #MucosalImmunology
Reposted by George Finney
Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...
mRNA initiation and termination are spatially coordinated
Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...
www.science.org
October 10, 2025 at 6:14 PM
Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...
Reposted by George Finney
More coming on what this means but this was one of those stories that took almost a decade to come together but was well worth the time. Also check out a companion piece on @biorxiv by Patrick Brennan!
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 9, 2025 at 2:38 AM
More coming on what this means but this was one of those stories that took almost a decade to come together but was well worth the time. Also check out a companion piece on @biorxiv by Patrick Brennan!
Reposted by George Finney
Our iconic immune cell badges are back for #BSI25, and you get to choose the next design! 🎨🧫
Vote now and help decide which badge will join the line-up in Liverpool 👇
Cast your vote here🔗: https://bit.ly/46DtHzy
Vote now and help decide which badge will join the line-up in Liverpool 👇
Cast your vote here🔗: https://bit.ly/46DtHzy
October 8, 2025 at 8:45 AM
Our iconic immune cell badges are back for #BSI25, and you get to choose the next design! 🎨🧫
Vote now and help decide which badge will join the line-up in Liverpool 👇
Cast your vote here🔗: https://bit.ly/46DtHzy
Vote now and help decide which badge will join the line-up in Liverpool 👇
Cast your vote here🔗: https://bit.ly/46DtHzy
Reposted by George Finney
Pre-division TCF1 drop determines long-term CD8 T cell fates @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:21 PM
Pre-division TCF1 drop determines long-term CD8 T cell fates @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by George Finney
Without an understanding of immune tolerance, organ transplantation will not be possible. Also, their discoveries opened avenues for cancer and auto immune disease therapies.
Congratulations to these year's awardees of the nobel prize in physiology or medicine.
bit.ly/4mC0Gc5
Congratulations to these year's awardees of the nobel prize in physiology or medicine.
bit.ly/4mC0Gc5
October 6, 2025 at 11:05 AM
Without an understanding of immune tolerance, organ transplantation will not be possible. Also, their discoveries opened avenues for cancer and auto immune disease therapies.
Congratulations to these year's awardees of the nobel prize in physiology or medicine.
bit.ly/4mC0Gc5
Congratulations to these year's awardees of the nobel prize in physiology or medicine.
bit.ly/4mC0Gc5
Reposted by George Finney
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
October 6, 2025 at 3:37 PM
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
Reposted by George Finney
October 1, 2025 at 5:35 PM
Reposted by George Finney
Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
September 22, 2025 at 4:52 PM
Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
New online! Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.
www.nature.com
September 22, 2025 at 4:11 PM
🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
Reposted by George Finney
Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!
Nuclear polarization to the immune synapse facilitates an early transcriptional burst
Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.
www.science.org
September 19, 2025 at 8:54 PM
Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!
Reposted by George Finney
A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection @jclinical-invest.bsky.social @nationwidekids.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
September 16, 2025 at 5:02 PM
A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection @jclinical-invest.bsky.social @nationwidekids.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by George Finney
Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset @biorxivpreprint.bsky.social @nidcr.bsky.social #NCI www.biorxiv.org/content/10.1...
September 17, 2025 at 1:42 AM
Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset @biorxivpreprint.bsky.social @nidcr.bsky.social #NCI www.biorxiv.org/content/10.1...
Reposted by George Finney
CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
September 15, 2025 at 4:54 PM
CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...