Gemma Noviello
@gemnov.bsky.social
Researcher in Epigenetics, CRISPRing around. MSCA Postdoctoral Fellow at EMBL Rome (Hackett lab). Before: Max Planck for Molecular Genetics (Ph.D.), Exeter Uni, Pasteur Institute, Sapienza Uni - Pessimismo dell' intelligenza/Ottimismo della volontà.
Reposted by Gemma Noviello
"Children’s toymaker FoloToy says it’s pulling its AI-powered teddy bear “Kumma” after a safety group found that the cuddly companion was giving wildly inappropriate and even dangerous responses, including tips on how to find and light matches, and detailed explanations about sexual kinks"
AI-Powered Stuffed Animal Pulled From Market After Disturbing Interactions With Children
FoloToy says it's suspended sales of its AI-powered teddy bear after researchers found it gave wildly inappropriate and dangerous answers.
futurism.com
November 17, 2025 at 10:52 AM
"Children’s toymaker FoloToy says it’s pulling its AI-powered teddy bear “Kumma” after a safety group found that the cuddly companion was giving wildly inappropriate and even dangerous responses, including tips on how to find and light matches, and detailed explanations about sexual kinks"
Reposted by Gemma Noviello
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
C-boy's a legend!
November 10, 2025 at 9:06 AM
C-boy's a legend!
Reposted by Gemma Noviello
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 7, 2025 at 7:58 PM
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Reposted by Gemma Noviello
A List of Things Said to Have Been Ruined by Women
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November 6, 2025 at 8:43 PM
A List of Things Said to Have Been Ruined by Women
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Super interesting science here 👇🏽
🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.
👉 www.molgen.mpg.de/5099133/schu...
👉 www.molgen.mpg.de/5099133/schu...
November 4, 2025 at 2:25 PM
Super interesting science here 👇🏽
Reposted by Gemma Noviello
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 10:04 AM
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
Yesterday I gave a talk titled "Dividi et impera: Flow-Cytometry for FACS-based CRISPR screens and beyond" during the Flow Cytometry course organised by @embl.org & EMBLRome facilities. It was nice connecting w/ other users & the specialists from the facilities to hear the latest. FC & #FACS rock 🌈
October 30, 2025 at 6:11 PM
Reposted by Gemma Noviello
For the record, Melissa's main targets of Jamaica, Haiti, Cuba, and the Bahamas account for, respectively, 0.016%, 0.0089%, 0.064%, and 0.0038% of the global annual total of CO2 emissions.
October 28, 2025 at 8:31 PM
For the record, Melissa's main targets of Jamaica, Haiti, Cuba, and the Bahamas account for, respectively, 0.016%, 0.0089%, 0.064%, and 0.0038% of the global annual total of CO2 emissions.
Yesterday we hosted @graeffjohannes.bsky.social , first speaker of the seminar series organised by and for @embl.org Rome fellows. It was a fantastic #neuro #epigenetics talk (our 2 favourite things). #EMBL #EMBLRome
October 25, 2025 at 3:55 PM
Yesterday we hosted @graeffjohannes.bsky.social , first speaker of the seminar series organised by and for @embl.org Rome fellows. It was a fantastic #neuro #epigenetics talk (our 2 favourite things). #EMBL #EMBLRome
Reposted by Gemma Noviello
Remember this one? “Humans aren’t very efficient movers—until you put us on a bicycle, when we become some of the most energy-efficient land travelers in the animal kingdom.” Via Scientific American @sciam.bsky.social #CityMakingMath
The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike
A famous graphic, now updated, compares locomotion in the animal kingdom
www.scientificamerican.com
October 16, 2025 at 11:24 PM
Remember this one? “Humans aren’t very efficient movers—until you put us on a bicycle, when we become some of the most energy-efficient land travelers in the animal kingdom.” Via Scientific American @sciam.bsky.social #CityMakingMath
Reposted by Gemma Noviello
🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
August 1, 2025 at 8:13 AM
🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
Happy to see this insightful and rigorous work published in its final form! Congrats to all authors and in particular to super hard-working first author @tschwammle.bsky.social and to @eddaschulz.bsky.social for the brilliant guidance.
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:36 PM
Happy to see this insightful and rigorous work published in its final form! Congrats to all authors and in particular to super hard-working first author @tschwammle.bsky.social and to @eddaschulz.bsky.social for the brilliant guidance.
Reposted by Gemma Noviello
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
September 27, 2025 at 9:46 AM
Reposted by Gemma Noviello
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
September 25, 2025 at 9:20 PM
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Gemma Noviello
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
Reposted by Gemma Noviello
A quick guide on "How to fall downstairs":
Step 1
Step 6
Step 8, 9, 10, 11.
Step 1
Step 6
Step 8, 9, 10, 11.
September 23, 2025 at 5:59 AM
A quick guide on "How to fall downstairs":
Step 1
Step 6
Step 8, 9, 10, 11.
Step 1
Step 6
Step 8, 9, 10, 11.
Reposted by Gemma Noviello
Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE
September 18, 2025 at 4:34 PM
Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE
Reposted by Gemma Noviello
this exists it is called thinking
September 20, 2025 at 12:15 PM
this exists it is called thinking
Beautiful story about chromatin modifiers orchestrating cell states by fine-tuning gene expression from @jzylicz.bsky.social lab. Congrats to all, especially 1st author Nikos Stamidis !
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
September 18, 2025 at 10:08 AM
Beautiful story about chromatin modifiers orchestrating cell states by fine-tuning gene expression from @jzylicz.bsky.social lab. Congrats to all, especially 1st author Nikos Stamidis !
A Bronx Tale, 1993
September 10, 2025 at 6:52 AM
A Bronx Tale, 1993
Reposted by Gemma Noviello
One of my kids thought I was making like a bad @theonion.com joke when I told him that their slogan used to be “don’t be evil” but then they got rid of it.
ICYMI: Google removes net zero goal from website.
Google quietly removes net-zero carbon goal from website amid rapid power-hungry AI data center buildout — industry-first sustainability pledge moved to background amidst AI energy crisis
Google's goal to be net-zero in carbon emissions by 2030 is still apparently company policy, it's just not broadcasting it anymore
www.tomshardware.com
September 8, 2025 at 11:26 AM
One of my kids thought I was making like a bad @theonion.com joke when I told him that their slogan used to be “don’t be evil” but then they got rid of it.
Congrats to all winners! A quick consideration as 🇮🇹 researcher. Italians get 11,5% of all StG (55/478, 2nd top after DE): Italian scientists are top level! Italy itself gets 6.2% of all grants (30/378, jumping to 7th after DE, UK, NL, FR, CH, BE). Italy, why do you like to seed but not to harvest?
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 1:15 PM
Congrats to all winners! A quick consideration as 🇮🇹 researcher. Italians get 11,5% of all StG (55/478, 2nd top after DE): Italian scientists are top level! Italy itself gets 6.2% of all grants (30/378, jumping to 7th after DE, UK, NL, FR, CH, BE). Italy, why do you like to seed but not to harvest?
Reposted by Gemma Noviello
📢 Recruitment for the EMBL International PhD Programme is officially open!
At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!
bit.ly/47mmiFF
At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!
bit.ly/47mmiFF
September 1, 2025 at 9:07 AM
📢 Recruitment for the EMBL International PhD Programme is officially open!
At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!
bit.ly/47mmiFF
At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!
bit.ly/47mmiFF