Christian Gallardo
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gallardo-seq.bsky.social
Christian Gallardo
@gallardo-seq.bsky.social
1.2K followers 1.2K following 27 posts
Long read sequencing of RNA viruses and their hosts | RNA structure-function | Genomics technology development | Genomics assay R&D | Scripps Research 🎓 | Senior Scientist at @TwistBioscience.com
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Reposted by Christian Gallardo
punkrockscience.bsky.social
I was thinking about this in another thread, but - what *are* the details that would make a show set in a bio/chem lab “realistic”?

- the pipette always needs a tip when used
- some things are *scrupulously* clean, to the point that they’re worn from it
- lab coats need to be dirty (or disposable)
August 28, 2025 at 11:26 PM
Reposted by Christian Gallardo
harmitmalik.bsky.social
It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking.

All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever.

Yay for us!
August 23, 2025 at 4:25 PM
Reposted by Christian Gallardo
atinygreencell.bsky.social
Catching some falling stars
August 23, 2025 at 4:51 PM
Reposted by Christian Gallardo
debnathghosal.bsky.social
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 2, 2025 at 3:01 PM
Reposted by Christian Gallardo
twistbioscience.com
💥 Boom! All gene fragment formats starting at 2 day turnaround time, only 7¢ per base.

Press Release: investors.twistbioscience.com/news-release...

@twistbioscience.com
July 7, 2025 at 1:31 PM
Reposted by Christian Gallardo
gregggonsalves.bsky.social
Who are the functionaries carrying out the destruction of the NIH? The Gang of Four: Memoli, McElroy, Schnabel, Bhattacharya. There are others, but these men play major day-to-day roles, they are the implementers, the enforcers, the true believers. www.thenation.com/article/poli...
Inside the Bloodbath at the NIH
Sources say that a climate of fear has spread throughout the agency as the Trump administration takes a hatchet to its core functions.
www.thenation.com
May 8, 2025 at 10:46 AM
Reposted by Christian Gallardo
jenarna.bsky.social
Check out our recently published paper about identifying RNA modifications from raw Nanopore data: www.nature.com/articles/s42...
Congrats to Jannes, Manja and all the co-authors!
The RMaP challenge of predicting RNA modifications by nanopore sequencing - Communications Chemistry
RNA modifications play critical roles in gene expression regulation, RNA stability, and translation efficiency, however, the detection of RNA modifications by various sequencing approaches may present...
www.nature.com
April 28, 2025 at 2:52 PM
Reposted by Christian Gallardo
febos.bsky.social
Couldn’t wait to share - SQUARNA 2.0 is here, with greatly improved performance in single-sequence RNA secondary structure prediction!
github.com/febos/SQUARNA
Updated preprint is coming soon :)
#SQUARNA #RNA #2D #Structure #Prediction #Bioinformatics #Research #Pseudoknot
April 27, 2025 at 8:57 PM
Reposted by Christian Gallardo
vscooper.micropopbio.org
Important 🧵 if your research depends on genome assemblies from long (PacBio / ONT) reads. As @merenbey.bsky.social says, these may not be the genomes you are looking for. TLDR: the assemblers are wrong and predict too many small circular contigs.
April 28, 2025 at 3:47 PM
Reposted by Christian Gallardo
narjournal.bsky.social
🧬 Happy National DNA Day! 🧬
Today we celebrate the completion of the human genome project (2003) and discovery of the double helix (1953). From genome editing to RNA therapeutics, research into nucleic acids continues to drive scientific breakthroughs #NationalDNADay #NucleicAcids #DNAday2025
April 25, 2025 at 8:02 AM
Reposted by Christian Gallardo
tetherin.bsky.social
The Palantirs were originally made so that the Men of the West could communicate.

But then they were taken over by the Enemy to spread corruption, sow fear, and spread disinformation to destroy the world of Men.

Kudos to Peter Thiel for choosing the most accurate name for his company.
April 22, 2025 at 6:06 PM
Reposted by Christian Gallardo
nikobowie.bsky.social
BREAKING: On Friday, the federal government issued new demands of Harvard University. The university's lawyers just responded: back off.
April 14, 2025 VIA ELECTRONIC MAIL Josh Gruenbaum Commissioner of the Federal Acquisition Service General Services Administration Sean R. Keveney Acting General Counsel U.S. Department of Health & Human Services Thomas E. Wheeler Acting General Counsel U.S. Department of Education Dear Messrs. Gruenbaum, Keveney, and Wheeler: We represent Harvard University. We are writing in response to your letter dated April 11, 2025, addressed to Dr. Alan Garber, Harvard’s President, and Penny Pritzker, Senior Fellow of the Harvard Corporation. Harvard is committed to fighting antisemitism and other forms of bigotry in its community. Antisemitism and discrimination of any kind not only are abhorrent and antithetical to Harvard’s values but also threaten its academic mission. To that end, Harvard has made, and will continue to make, lasting and robust structural, policy, and programmatic changes to ensure that the university is a welcoming and supportive learning environment for all students and continues to abide in all respects with federal law across its academic programs and operations, while fostering open inquiry in a pluralistic community free from intimidation and open to challenging orthodoxies, whatever their source. Over the past 15 months, Harvard has undertaken substantial policy and programmatic measures. It has made changes to its campus use policies; adopted new accountability procedures; imposed meaningful discipline for those who violate university policies; enhanced programs designed to address bias and promote ideological diversity and civil discourse; hired staff to support these programs and support students; changed partnerships; dedicated resources to combat hate and bias; and enhanced safety and security measures. As a result, Harvard is in a very different place today from where it was a year ago. These efforts, and additional measures the university will be taking against antisemitism, not only are the right thing to do but also are critical to strength… recognized by the Supreme Court. The government’s terms also circumvent Harvard’s statutory rights by requiring unsupported and disruptive remedies for alleged harms that the government has not proven through mandatory processes established by Congress and required by law. No less objectionable is the condition, first made explicit in the letter of March 31, 2025, that Harvard accede to these terms or risk the loss of billions of dollars in federal funding critical to vital research and innovation that has saved and improved lives and allowed Harvard to play a central role in making our country’s scientific, medical, and other research communities the standard-bearers for the world. These demands extend not only to Harvard but to separately incorporated and independently operated medical and research hospitals engaging in life-saving work on behalf of their patients. The university will not surrender its independence or relinquish its constitutional rights. Neither Harvard nor any other private university can allow itself to be taken over by the federal government. Accordingly, Harvard will not accept the government’s terms as an agreement in principle. Harvard remains open to dialogue about what the university has done, and is planning to do, to improve the experience of every member of its community. But Harvard is not prepared to agree to demands that go beyond the lawful authority of this or any administration. William A. Burck Robert K. Hur Quinn Emanuel Urquhart & Sullivan, LLP 1300 I Street NW Suite 900 Suite 900 Washington, DC 20005 King & Spalding LLP 1700 Pennsylvania Avenue NW Washington, DC 20006
April 14, 2025 at 5:16 PM
gallardo-seq.bsky.social
This is not a drill…
We are witnessing the destruction of science in America | Paul Darren Bieniasz
If we stay on this administration’s course, future life-saving medicines may never be invented
www.theguardian.com
April 10, 2025 at 7:11 AM
Reposted by Christian Gallardo
onestpress.onestnetwork.com
Leavitt confirmed that the WH is working on deporting US citizens to El Salvador
April 8, 2025 at 6:02 PM
Reposted by Christian Gallardo
longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/lon...
GitHub - yangao07/longcallD: A local-haplotagging-based small and structural variant caller
A local-haplotagging-based small and structural variant caller - yangao07/longcallD
github.com
March 24, 2025 at 4:53 PM
Reposted by Christian Gallardo
harmitmalik.bsky.social
When the occasion demands the Machiavellianism of a McConnell but all you have to offer is the ‘make nice’ of a Schumer

Like I’ve said before… Disney characters who don’t know they’re trapped in a Tarantino film
March 14, 2025 at 12:47 AM
Reposted by Christian Gallardo
alexwild.bsky.social
This is the formal end of the Democratic Party on the national stage. There is no constituency for an opposition party that doesn’t oppose.
npr.org NPR @npr.org · Mar 13
UPDATE: Senate Minority Leader Chuck Schumer, D-NY, said he plans to vote for a Republican bill to fund the government through September, paving the way for other Democrats to join him.
Senate Democrats signal plans to advance GOP bill to avoid a government shutdown
Senate Minority Leader Chuck Schumer, D-NY, said he plans to vote for a Republican bill to fund the government through September, paving the way for other Democrats to join him.
www.npr.org
March 13, 2025 at 11:31 PM
Reposted by Christian Gallardo
chrislhayes.bsky.social
The institutional Democratic Party is guided by an almost pathological level of conflict avoidance in almost every direction. “What can we do to make the least number of people mad?” is just a bankrupt way to operate.
March 13, 2025 at 10:23 PM
Reposted by Christian Gallardo
jonathancohn.bsky.social
Where is the lie?

theonion.com/democrats-si...
Democrats Sick Of Being Blamed For Cowardice On Issues They Actually Just Don’t Care About
WASHINGTON—Having thus far caved on eliminating the filibuster, advancing an adequate climate change agenda, and protecting voting rights, congressional Democrats told reporters Wednesday they were si...
theonion.com
March 13, 2025 at 11:15 PM
Reposted by Christian Gallardo
drugmonkey.bsky.social
“You aren’t kissing Dear Leader’s ass enough” is a helluva foreign policy.
February 28, 2025 at 6:23 PM
Reposted by Christian Gallardo
sbagen.bsky.social
Read every word of this article to see what the Trump folks are doing to the good civil servants at NIH -- and to the important work that protects all of our health. www.theatlantic.com/health/archi...
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
www.theatlantic.com
February 27, 2025 at 4:48 PM
Reposted by Christian Gallardo
bencollins.bsky.social
Five alarm fire.

www.politico.com/news/2025/02...
February 26, 2025 at 8:31 PM
Reposted by Christian Gallardo
xkcd.com
RNA xkcd.com/3056
February 26, 2025 at 2:58 PM
Reposted by Christian Gallardo
harmitmalik.bsky.social
Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT

apple.news/APlQhGHRrSfy...
Graduate student admissions paused and cut back as universities react to Trump orders on research — STAT
Acceptances for biomedical graduate students and postdoctoral scholars are being cut back at some universities and medical centers across the country as many grapple with the potential impact of the T...
apple.news
February 20, 2025 at 2:04 AM