@fucccp.bsky.social
Full article: Non-coding RNAs regulate autophagy in kidney disease: friend or foe? www.tandfonline.com/doi/full/10....
Non-coding RNAs regulate autophagy in kidney disease: friend or foe?
Macroautophagy/autophagy is a conserved cellular process that degrades misfolded proteins and damaged organelles to regulate cell survival and division. Normal levels of autophagy are observed in h...
www.tandfonline.com
November 3, 2025 at 11:46 AM
Full article: Non-coding RNAs regulate autophagy in kidney disease: friend or foe? www.tandfonline.com/doi/full/10....
Full article: CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells www.tandfonline.com/doi/full/10....
CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells
Acute kidney injury (AKI) is characterized by the dysfunction of renal tubular epithelial cells (TECs), often leading to renal fibrosis. Mitochondrial impairment is a common hallmark across various...
www.tandfonline.com
November 3, 2025 at 11:36 AM
Full article: CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells www.tandfonline.com/doi/full/10....
Reposted
A pacemaker is a small, implantable electronic device that helps regulate the heartbeat.
This JAMA Patient Page describes the body’s heart rhythm and the role of electronic pacemaker devices in maintaining heart rhythm for patients with certain conditions.
https://ja.ma/3HqMxjg
This JAMA Patient Page describes the body’s heart rhythm and the role of electronic pacemaker devices in maintaining heart rhythm for patients with certain conditions.
https://ja.ma/3HqMxjg
June 5, 2025 at 4:00 PM
A pacemaker is a small, implantable electronic device that helps regulate the heartbeat.
This JAMA Patient Page describes the body’s heart rhythm and the role of electronic pacemaker devices in maintaining heart rhythm for patients with certain conditions.
https://ja.ma/3HqMxjg
This JAMA Patient Page describes the body’s heart rhythm and the role of electronic pacemaker devices in maintaining heart rhythm for patients with certain conditions.
https://ja.ma/3HqMxjg
Reposted
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
#ERA25 #MedSky #Nephrology
June 5, 2025 at 9:45 AM
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
#ERA25 #MedSky #Nephrology
Reposted
T0e: #NephJC
In CKD, ⬇️renal clearance 👉 metformin accumulation
Metformin inhibits mitochondrial complex I& gluconeogenesis, ⬆️ pyruvate 👉 shifting metabolism toward lactate production
⚠️👉 LATIC ACIDOSIS
www.aging-us.com/art...
pubmed.ncbi.nlm.nih....
In CKD, ⬇️renal clearance 👉 metformin accumulation
Metformin inhibits mitochondrial complex I& gluconeogenesis, ⬆️ pyruvate 👉 shifting metabolism toward lactate production
⚠️👉 LATIC ACIDOSIS
www.aging-us.com/art...
pubmed.ncbi.nlm.nih....
April 16, 2025 at 1:12 AM
T0e: #NephJC
In CKD, ⬇️renal clearance 👉 metformin accumulation
Metformin inhibits mitochondrial complex I& gluconeogenesis, ⬆️ pyruvate 👉 shifting metabolism toward lactate production
⚠️👉 LATIC ACIDOSIS
www.aging-us.com/art...
pubmed.ncbi.nlm.nih....
In CKD, ⬇️renal clearance 👉 metformin accumulation
Metformin inhibits mitochondrial complex I& gluconeogenesis, ⬆️ pyruvate 👉 shifting metabolism toward lactate production
⚠️👉 LATIC ACIDOSIS
www.aging-us.com/art...
pubmed.ncbi.nlm.nih....
Reposted
Reposted
You may not understand why, but the healthcare insurance and PBM contracts YOU have signed for Tesla, SpaceX , @X, along with CEOs of other big companies , have more impact on healthcare costs and quality of care in this country, than anything you can do with DOGE
December 5, 2024 at 9:59 PM
You may not understand why, but the healthcare insurance and PBM contracts YOU have signed for Tesla, SpaceX , @X, along with CEOs of other big companies , have more impact on healthcare costs and quality of care in this country, than anything you can do with DOGE
Reposted
Compared with continuing metformin, stopping it was associated with a lower 3 yr survival (63.7% versus 70.5%; HR=1.26) while incidence of MACE was similar.
The contd use of metformin may be appropriate when eGFR falls <30 ml/min. RCT is needed to confirm these findings
www.ajkd.org/article/S027...
The contd use of metformin may be appropriate when eGFR falls <30 ml/min. RCT is needed to confirm these findings
www.ajkd.org/article/S027...
November 25, 2024 at 2:07 PM
Compared with continuing metformin, stopping it was associated with a lower 3 yr survival (63.7% versus 70.5%; HR=1.26) while incidence of MACE was similar.
The contd use of metformin may be appropriate when eGFR falls <30 ml/min. RCT is needed to confirm these findings
www.ajkd.org/article/S027...
The contd use of metformin may be appropriate when eGFR falls <30 ml/min. RCT is needed to confirm these findings
www.ajkd.org/article/S027...
Reposted
No more red yellow green stop light colours anymore in the tables and figures because of Red Green colour blindness in the tables and tools (finally because one of the authors had RG colour blindness)
November 22, 2024 at 2:22 PM
No more red yellow green stop light colours anymore in the tables and figures because of Red Green colour blindness in the tables and tools (finally because one of the authors had RG colour blindness)
Reposted
None of the trials initiated at GFR below 20 which ties the gl writers hand
(Though flozins not stopped below 20)
Now DAPA-advanced CKD presented at #KidneyWk which started at GFRs 10-30 suggest slowing GFR >> GFR dip (paper not published yet)
RENAL LIFECYCLES awaited!
(Though flozins not stopped below 20)
Now DAPA-advanced CKD presented at #KidneyWk which started at GFRs 10-30 suggest slowing GFR >> GFR dip (paper not published yet)
RENAL LIFECYCLES awaited!
November 25, 2024 at 11:57 AM
None of the trials initiated at GFR below 20 which ties the gl writers hand
(Though flozins not stopped below 20)
Now DAPA-advanced CKD presented at #KidneyWk which started at GFRs 10-30 suggest slowing GFR >> GFR dip (paper not published yet)
RENAL LIFECYCLES awaited!
(Though flozins not stopped below 20)
Now DAPA-advanced CKD presented at #KidneyWk which started at GFRs 10-30 suggest slowing GFR >> GFR dip (paper not published yet)
RENAL LIFECYCLES awaited!