Frédéric Rieux-Laucat
@frl-lab.bsky.social
The Immunogenetics of Pediatric Autoimmune Diseases Lab @institut Imagine (https://www.institutimagine.org/fr), focuses on Primary Immune Deficiencies and Dysregulations (PIDDs)
#Autoimmunity
#Immunology
#Genetics
#mutations (germline and/or somatic)
#Autoimmunity
#Immunology
#Genetics
#mutations (germline and/or somatic)
Reposted by Frédéric Rieux-Laucat
Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
October 28, 2025 at 3:35 PM
Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
Reposted by Frédéric Rieux-Laucat
Open call for applications for the International PhD PPU-IMAGINE program!
Don’t miss out on 16 different PhD research projects at Institut Imagine!
Deadline: October 20, 2025
For more information: www.institutimagine.org/en/internati...
Don’t miss out on 16 different PhD research projects at Institut Imagine!
Deadline: October 20, 2025
For more information: www.institutimagine.org/en/internati...
September 4, 2025 at 8:27 AM
Open call for applications for the International PhD PPU-IMAGINE program!
Don’t miss out on 16 different PhD research projects at Institut Imagine!
Deadline: October 20, 2025
For more information: www.institutimagine.org/en/internati...
Don’t miss out on 16 different PhD research projects at Institut Imagine!
Deadline: October 20, 2025
For more information: www.institutimagine.org/en/internati...
Reposted by Frédéric Rieux-Laucat
Congratulations @damien-glon.bsky.social !
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...
www.biorxiv.org
May 28, 2025 at 7:24 AM
Congratulations @damien-glon.bsky.social !
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
Reposted by Frédéric Rieux-Laucat
🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...
www.biorxiv.org
May 28, 2025 at 6:17 AM
🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
Reposted by Frédéric Rieux-Laucat
@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 11, 2025 at 9:15 AM
@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
Reposted by Frédéric Rieux-Laucat
Thrilled to share our latest in @jem.org! 🚨
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz
January 15, 2025 at 10:06 PM
Thrilled to share our latest in @jem.org! 🚨
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
Reposted by Frédéric Rieux-Laucat
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
January 15, 2025 at 10:17 PM
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
Reposted by Frédéric Rieux-Laucat
Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz
January 15, 2025 at 7:51 PM
Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz
Reposted by Frédéric Rieux-Laucat
This work was done in @institutimagine.bsky.social in the laboratory of @frl-lab.bsky.social with Bénédicte Neven and collaborators in France and Belgium @casanovalab.bsky.social @anne-puel.bsky.social
Many thanks to all co-authors!
Many thanks to all co-authors!
January 15, 2025 at 10:10 PM
This work was done in @institutimagine.bsky.social in the laboratory of @frl-lab.bsky.social with Bénédicte Neven and collaborators in France and Belgium @casanovalab.bsky.social @anne-puel.bsky.social
Many thanks to all co-authors!
Many thanks to all co-authors!
Reposted by Frédéric Rieux-Laucat
Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells.
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
T cell receptor–centric perspective to multimodal single-cell data analysis
T cell receptor–centric perspective improves single-cell analysis.
doi.org
December 2, 2024 at 8:30 AM
Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells.
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
Reposted by Frédéric Rieux-Laucat
Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence, including a female-specific cytotoxic CD8+ T cell subpopulation @martamele.bsky.social @mariasopenar.bsky.social
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
November 19, 2024 at 5:04 PM
Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence, including a female-specific cytotoxic CD8+ T cell subpopulation @martamele.bsky.social @mariasopenar.bsky.social
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
How can we better explain that vaccination is the unique way to protect our children? And as said a brillant French pediatrician, Pr Robert Debré, long ago, our children are our eternity….
10.3 million cases of measles occurred worldwide last year, up 20% from 2022, primarily because of inadequate immunization coverage.
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...
Surge in worldwide measles cases driven by lack of vaccine coverage, WHO says
The WHO and CDC say there were about 10.3 million cases of measles last year, up 20 percent from 2022. Children are especially susceptible to complications.
www.washingtonpost.com
November 19, 2024 at 8:13 PM
How can we better explain that vaccination is the unique way to protect our children? And as said a brillant French pediatrician, Pr Robert Debré, long ago, our children are our eternity….
Reposted by Frédéric Rieux-Laucat
10.3 million cases of measles occurred worldwide last year, up 20% from 2022, primarily because of inadequate immunization coverage.
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...
Surge in worldwide measles cases driven by lack of vaccine coverage, WHO says
The WHO and CDC say there were about 10.3 million cases of measles last year, up 20 percent from 2022. Children are especially susceptible to complications.
www.washingtonpost.com
November 18, 2024 at 5:15 PM
10.3 million cases of measles occurred worldwide last year, up 20% from 2022, primarily because of inadequate immunization coverage.
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...
Reposted by Frédéric Rieux-Laucat
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
nature.com
November 17, 2024 at 6:57 AM
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...