Quentin Riller
@quentinriller.bsky.social
MD, internal medicine and clinical immunology resident @APHP. PhD immunology, post-doc in Frédéric Rieux-Laucat's lab, Imagine Insitute, Necker Paris #SingleCell #Rstats
Congratulations @damien-glon.bsky.social !
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...
www.biorxiv.org
May 28, 2025 at 7:24 AM
Congratulations @damien-glon.bsky.social !
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥
🔥🔥
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates https://www.biorxiv.org/content/10.1101/2025.05.21.655319v1
May 27, 2025 at 5:10 PM
🔥🔥
🎉 Excited to share the publication of our study in @bloodjournal.bsky.social , highlighted by an accompanying editorial!
📄 Article: doi.org/10.1182/bloo...
🖋 Editorial: doi.org/10.1182/bloo...
📄 Article: doi.org/10.1182/bloo...
🖋 Editorial: doi.org/10.1182/bloo...
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doi-org.proxy.insermbiblio.inist.fr
May 24, 2025 at 8:36 AM
🎉 Excited to share the publication of our study in @bloodjournal.bsky.social , highlighted by an accompanying editorial!
📄 Article: doi.org/10.1182/bloo...
🖋 Editorial: doi.org/10.1182/bloo...
📄 Article: doi.org/10.1182/bloo...
🖋 Editorial: doi.org/10.1182/bloo...
Reposted by Quentin Riller
Graft failure remains challenging, with CI of grade 2 to 4 acute GVHD, but not grade 3 to 4, being significantly higher after PTCY. buff.ly/7VcLjgd #hemesky #transplantation
May 23, 2025 at 5:02 PM
Graft failure remains challenging, with CI of grade 2 to 4 acute GVHD, but not grade 3 to 4, being significantly higher after PTCY. buff.ly/7VcLjgd #hemesky #transplantation
Reposted by Quentin Riller
@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 11, 2025 at 9:15 AM
@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
Reposted by Quentin Riller
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
January 15, 2025 at 10:17 PM
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
Thrilled to share our latest in @jem.org! 🚨
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz
January 15, 2025 at 10:06 PM
Thrilled to share our latest in @jem.org! 🚨
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology