François Deloche
@fdeloche.bsky.social
Hearing science - peripheral auditory system, cochlear models, computational neuroscience. Postdoc researcher at Macquarie University (Sydney). Alumni of: Purdue, Ghent University. From Paris
Pinned
François Deloche
@fdeloche.bsky.social
· Jun 16
authors.elsevier.com
[PAPER ALERT 🚨] Happy to share our new publication 'Active control of transverse viscoelastic damping in the tectorial membrane: A second mechanism for traveling-wave amplification? '
also presented at the Mechanics of Hearing workshop last year. authors.elsevier.com/a/1lFhQ1M5IZ...
also presented at the Mechanics of Hearing workshop last year. authors.elsevier.com/a/1lFhQ1M5IZ...
Each year amazed by the incredible carving work of Purdue Audiology student Isabella Huddleston 🤩🤩 via x.com/HeinzLab_Pur... #Halloween 🎃👻
October 31, 2025 at 11:14 PM
Each year amazed by the incredible carving work of Purdue Audiology student Isabella Huddleston 🤩🤩 via x.com/HeinzLab_Pur... #Halloween 🎃👻
Reposted by François Deloche
Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine:
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
October 14, 2025 at 11:05 AM
Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine:
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
Reposted by François Deloche
Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology
Arousal as a universal embedding for spatiotemporal brain dynamics - Nature
Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.
www.nature.com
September 24, 2025 at 9:52 PM
Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology
Reposted by François Deloche
New manuscript from the lab!
"Mirror manifolds: partially overlapping neural subspaces for speaking and listening"
Led by superstar grad student Anilu Chavez (not on Bluesky)!
www.biorxiv.org/content/10.1...
"Mirror manifolds: partially overlapping neural subspaces for speaking and listening"
Led by superstar grad student Anilu Chavez (not on Bluesky)!
www.biorxiv.org/content/10.1...
Mirror manifolds: partially overlapping neural subspaces for speaking and listening
Participants in conversations need to associate words their speakers but also retain those words general meanings. For example, someone talking about their hand is not referring to the other speakers ...
www.biorxiv.org
September 22, 2025 at 2:15 PM
New manuscript from the lab!
"Mirror manifolds: partially overlapping neural subspaces for speaking and listening"
Led by superstar grad student Anilu Chavez (not on Bluesky)!
www.biorxiv.org/content/10.1...
"Mirror manifolds: partially overlapping neural subspaces for speaking and listening"
Led by superstar grad student Anilu Chavez (not on Bluesky)!
www.biorxiv.org/content/10.1...
I had the chance to have Stephane Mallat as a teacher. His course connected important ideas in statistical signal processing/machine learning with mathematical concepts. It was very inspiring I know him as a great mentor. His book 'a wavelet tour on signal processing' is a classic IMO :)
#PressRelease 🗞️ The 2025 CNRS Gold Medal has been awarded to Stéphane Mallat, recognised the world over for his research on mathematics applied to signal processing and artificial intelligence.
👉 cnrs.fr/en/press/bet...
#CNRStalents 🏅
👉 cnrs.fr/en/press/bet...
#CNRStalents 🏅
September 11, 2025 at 4:14 PM
I had the chance to have Stephane Mallat as a teacher. His course connected important ideas in statistical signal processing/machine learning with mathematical concepts. It was very inspiring I know him as a great mentor. His book 'a wavelet tour on signal processing' is a classic IMO :)
Reposted by François Deloche
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...
www.rockefeller.edu
August 18, 2025 at 7:59 PM
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
Reposted by François Deloche
Jim Hudspeth has died 💔
I am so sad. He was probably my favorite hearing researcher of all time. Absolute genius and also generous - he spent hours on the phone advising me on my career even tho we barely knew each other.
May his memory be a blessing.
www.ted.com/talks/jim_hu...
I am so sad. He was probably my favorite hearing researcher of all time. Absolute genius and also generous - he spent hours on the phone advising me on my career even tho we barely knew each other.
May his memory be a blessing.
www.ted.com/talks/jim_hu...
Jim Hudspeth: The beautiful, mysterious science of how you hear
Have you ever wondered how your ears work? In this delightful and fascinating talk, biophysicist Jim Hudspeth demonstrates the wonderfully simple yet astonishingly powerful mechanics of hair cells, th...
www.ted.com
August 18, 2025 at 10:27 PM
Jim Hudspeth has died 💔
I am so sad. He was probably my favorite hearing researcher of all time. Absolute genius and also generous - he spent hours on the phone advising me on my career even tho we barely knew each other.
May his memory be a blessing.
www.ted.com/talks/jim_hu...
I am so sad. He was probably my favorite hearing researcher of all time. Absolute genius and also generous - he spent hours on the phone advising me on my career even tho we barely knew each other.
May his memory be a blessing.
www.ted.com/talks/jim_hu...
Reposted by François Deloche
I love this experience-sampling study on the absolute pitch of earworms! It's a really nicely done study conducted in everyday settings. The link to this paper (open access) is provided below. It is also featured in a podcast (tinyurl.com/4ydrw5zp) by the Psychonomic Society. Congrats!
August 8, 2025 at 4:48 PM
I love this experience-sampling study on the absolute pitch of earworms! It's a really nicely done study conducted in everyday settings. The link to this paper (open access) is provided below. It is also featured in a podcast (tinyurl.com/4ydrw5zp) by the Psychonomic Society. Congrats!
Reposted by François Deloche
🔵 Proud to share our new preprint 🔵
We compared humans and deep neural networks on sound localization 👂📍
Humans robustly localized OOD sounds even without primary interaural cues (ITD & ILD)
Models localized well only in-training distribution sounds, failing on OOD regime
Link & full story 🧵👇
We compared humans and deep neural networks on sound localization 👂📍
Humans robustly localized OOD sounds even without primary interaural cues (ITD & ILD)
Models localized well only in-training distribution sounds, failing on OOD regime
Link & full story 🧵👇
August 9, 2025 at 11:04 AM
🔵 Proud to share our new preprint 🔵
We compared humans and deep neural networks on sound localization 👂📍
Humans robustly localized OOD sounds even without primary interaural cues (ITD & ILD)
Models localized well only in-training distribution sounds, failing on OOD regime
Link & full story 🧵👇
We compared humans and deep neural networks on sound localization 👂📍
Humans robustly localized OOD sounds even without primary interaural cues (ITD & ILD)
Models localized well only in-training distribution sounds, failing on OOD regime
Link & full story 🧵👇
Reposted by François Deloche
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
August 1, 2025 at 10:10 AM
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
Reposted by François Deloche
A major NIH grant to study ways to restore hearing was terminated by the Trump administration bc it was awarded through a DEI initiative—to a researcher who qualified bc of his own hearing loss www.cnn.com/2025/07/29/h... @manorlaboratory.bsky.social
July 29, 2025 at 12:45 PM
A major NIH grant to study ways to restore hearing was terminated by the Trump administration bc it was awarded through a DEI initiative—to a researcher who qualified bc of his own hearing loss www.cnn.com/2025/07/29/h... @manorlaboratory.bsky.social
Reposted by François Deloche
1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
Sensory responses of visual cortical neurons are not prediction errors
Predictive coding is theorized to be a ubiquitous cortical process to explain sensory responses. It asserts that the brain continuously predicts sensory information and imposes those predictions on lo...
www.biorxiv.org
July 11, 2025 at 3:45 PM
1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
👏
A 17-year-old teen refutes a mathematical conjecture proposed 40 years ago
Hannah Cairo has solved the so-called Mizohata-Takeuchi conjecture, a problem in harmonic analysis closely linked to other central results in the field.
english.elpais.com/science-tech...
Hannah Cairo has solved the so-called Mizohata-Takeuchi conjecture, a problem in harmonic analysis closely linked to other central results in the field.
english.elpais.com/science-tech...
A 17-year-old teen refutes a mathematical conjecture proposed 40 years ago
Hannah Cairo has solved the so-called Mizohata-Takeuchi conjecture, a problem in harmonic analysis closely linked to other central results in the field. This fall, she will begin her doctoral studies ...
english.elpais.com
July 2, 2025 at 10:19 PM
👏
Reposted by François Deloche
Howdy! Today's paper spotlight comes from Chun Liang and was published in June. This paper shows that knocking out the ATP gated receptor P2X7 enhances hearing sensitivity but makes noise induced cochlea damage much worse! Adds info to those mysterious type II fibres 🔍 www.pnas.org/doi/10.1073/...
July 2, 2025 at 7:43 AM
Howdy! Today's paper spotlight comes from Chun Liang and was published in June. This paper shows that knocking out the ATP gated receptor P2X7 enhances hearing sensitivity but makes noise induced cochlea damage much worse! Adds info to those mysterious type II fibres 🔍 www.pnas.org/doi/10.1073/...
Reposted by François Deloche
Gene therapy to treat deafness now a success in young adults!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
AAV gene therapy for autosomal recessive deafness 9: a single-arm trial - Nature Medicine
Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 month...
www.nature.com
July 2, 2025 at 1:55 PM
Gene therapy to treat deafness now a success in young adults!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by François Deloche
Delighted to have our newest paper out in #Jneurosci ! We looked at how much a single cell contributes to an auditory-evoked EEG signal. Big thanks to my co-authors Ira Kraemer, Christine Köppl, Catherine Carr and Richard Kempter (all not in Bsky). Here’s how: (1/13)
bsky.app/profile/sfnj...
bsky.app/profile/sfnj...
#JNeurosci: <a href="https://bsky.app/profile/did:plc:2qzyacanl3gck4zou547d34y" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@paulakuokkanen.bsky.social et al. isolated scalp signals from single neurons in the 1st processing stage of the barn owl auditory pathway, finding that single neurons' contributions to the scalp signal were unexpectedly large, and time-locked to the 2nd peak.
vist.ly/3n7ycdj
vist.ly/3n7ycdj
June 28, 2025 at 2:18 PM
Delighted to have our newest paper out in #Jneurosci ! We looked at how much a single cell contributes to an auditory-evoked EEG signal. Big thanks to my co-authors Ira Kraemer, Christine Köppl, Catherine Carr and Richard Kempter (all not in Bsky). Here’s how: (1/13)
bsky.app/profile/sfnj...
bsky.app/profile/sfnj...
Reposted by François Deloche
Does anyone else find it perpetually annoying that what most folks would consider neural "computation" is Marr's "algorithmic" level, while his *computational* level is really just "what's the goal of this thing anyway?" AKA function.
June 26, 2025 at 2:53 AM
Does anyone else find it perpetually annoying that what most folks would consider neural "computation" is Marr's "algorithmic" level, while his *computational* level is really just "what's the goal of this thing anyway?" AKA function.
[PAPER ALERT 🚨] Happy to share our new publication 'Active control of transverse viscoelastic damping in the tectorial membrane: A second mechanism for traveling-wave amplification? '
also presented at the Mechanics of Hearing workshop last year. authors.elsevier.com/a/1lFhQ1M5IZ...
also presented at the Mechanics of Hearing workshop last year. authors.elsevier.com/a/1lFhQ1M5IZ...
authors.elsevier.com
June 16, 2025 at 10:40 AM
[PAPER ALERT 🚨] Happy to share our new publication 'Active control of transverse viscoelastic damping in the tectorial membrane: A second mechanism for traveling-wave amplification? '
also presented at the Mechanics of Hearing workshop last year. authors.elsevier.com/a/1lFhQ1M5IZ...
also presented at the Mechanics of Hearing workshop last year. authors.elsevier.com/a/1lFhQ1M5IZ...
Reposted by François Deloche
Today's #PaperSpotlight comes from Patricia M. Quinones et al, published in April this year. The study mainly used optical coherence tomography (OCT), and interestingly showed that silencing inner hair cells led to larger sound-induced vibrations in the cochlea!
🔗: www.jneurosci.org/content/45/1...
🔗: www.jneurosci.org/content/45/1...
June 5, 2025 at 6:16 PM
Today's #PaperSpotlight comes from Patricia M. Quinones et al, published in April this year. The study mainly used optical coherence tomography (OCT), and interestingly showed that silencing inner hair cells led to larger sound-induced vibrations in the cochlea!
🔗: www.jneurosci.org/content/45/1...
🔗: www.jneurosci.org/content/45/1...
Reposted by François Deloche
👏 Dr. Laurel Carney has been named the 2025 David T. Blackstock Mentorship Award from the Acoustical Society of America (@asa-news.bsky.social)! Honored for her outstanding #mentorship in #acoustics & #hearing research.
🔗 Read more: tinyurl.com/uofrbme-carney-blackstock
#facultyawards #Meliora!
🔗 Read more: tinyurl.com/uofrbme-carney-blackstock
#facultyawards #Meliora!
Laurel Carney Wins ASA Blackstock Mentorship Award
Related Links...
www.hajim.rochester.edu
June 2, 2025 at 8:42 PM
👏 Dr. Laurel Carney has been named the 2025 David T. Blackstock Mentorship Award from the Acoustical Society of America (@asa-news.bsky.social)! Honored for her outstanding #mentorship in #acoustics & #hearing research.
🔗 Read more: tinyurl.com/uofrbme-carney-blackstock
#facultyawards #Meliora!
🔗 Read more: tinyurl.com/uofrbme-carney-blackstock
#facultyawards #Meliora!
Reposted by François Deloche
Yesterday I defended my 'Habilitation à diriger des Recherches'! Thanks to those who attended! And thank you to a wonderful jury: J. Gervain, A. Calcus, I. Chitoran, J.J. Aucouturier, E. Gaudrain, C. Lorenzi.
May 27, 2025 at 4:46 AM
Yesterday I defended my 'Habilitation à diriger des Recherches'! Thanks to those who attended! And thank you to a wonderful jury: J. Gervain, A. Calcus, I. Chitoran, J.J. Aucouturier, E. Gaudrain, C. Lorenzi.
Reposted by François Deloche
Bonjour, nous sommes le
May 25, 2025 at 4:29 AM
Bonjour, nous sommes le
Reposted by François Deloche
Crucially, these language representations evolve with age: while fast phonetic features are already present in the superior temporal gyrus of the youngest individuals, slower word-level representations only emerge in the associative cortices of older individuals.
May 15, 2025 at 12:19 PM
Crucially, these language representations evolve with age: while fast phonetic features are already present in the superior temporal gyrus of the youngest individuals, slower word-level representations only emerge in the associative cortices of older individuals.
Reposted by François Deloche
The Deaf Scientists Pipeline in Rochester, NY offers support for students and researchers from high school to postdoctoral levels. Now, due to NIH funding cuts, this one-of-a-kind initiative has been dismantled. My recent story for @science.org
Crucial training pipeline for Deaf scientists dismantled by NIH funding cuts
The one-of-a-kind initiative offered support from high school to postdoctoral levels
www.science.org
May 7, 2025 at 3:41 PM
The Deaf Scientists Pipeline in Rochester, NY offers support for students and researchers from high school to postdoctoral levels. Now, due to NIH funding cuts, this one-of-a-kind initiative has been dismantled. My recent story for @science.org