Eustaquio Lab
@eustaquiolab.bsky.social
We study natural products (secondary metabolites) from bacteria using genomics, reverse genetics, and synthetic biology approaches.
University of Illinois at Chicago
eustaquio.lab.uic.edu
University of Illinois at Chicago
eustaquio.lab.uic.edu
Pinned
Eustaquio Lab
@eustaquiolab.bsky.social
· Dec 10
Discovery of megapolipeptins by genome mining of a Burkholderiales bacteria collection
Burkholderiales bacteria have emerged as a promising source of structurally diverse natural products that are expected to play important ecological and industrial roles. This order ranks in the top th...
pubs.rsc.org
Interested in genome mining for natural product discovery? Check out our recent paper in collaboration with the Linington lab pubs.rsc.org/en/content/a...
Reposted by Eustaquio Lab
And we have a webpage!
Still in the works! But still share please!
We’ll be happy to host you next year in Mexico!
Sitios.quimica.unam.mx/unidad/sisal/manapro
Still in the works! But still share please!
We’ll be happy to host you next year in Mexico!
Sitios.quimica.unam.mx/unidad/sisal/manapro
XVIII MaNaPro
Sitios.quimica.unam.mx
November 14, 2025 at 1:54 AM
And we have a webpage!
Still in the works! But still share please!
We’ll be happy to host you next year in Mexico!
Sitios.quimica.unam.mx/unidad/sisal/manapro
Still in the works! But still share please!
We’ll be happy to host you next year in Mexico!
Sitios.quimica.unam.mx/unidad/sisal/manapro
Reposted by Eustaquio Lab
🚨There is less than one week left to nominate for the 2026 @natprodreports.rsc.org Emerging Investigator Lectureship! Don't miss the opportunity to recognise a rising star in the field #chemsky #secmet #natprod
⏳Nominations close 19 October
Details on how to nominate🔽
www.rsc.org/standards-an...
⏳Nominations close 19 October
Details on how to nominate🔽
www.rsc.org/standards-an...
October 13, 2025 at 8:24 AM
🚨There is less than one week left to nominate for the 2026 @natprodreports.rsc.org Emerging Investigator Lectureship! Don't miss the opportunity to recognise a rising star in the field #chemsky #secmet #natprod
⏳Nominations close 19 October
Details on how to nominate🔽
www.rsc.org/standards-an...
⏳Nominations close 19 October
Details on how to nominate🔽
www.rsc.org/standards-an...
Reposted by Eustaquio Lab
Be sure to read this review, part of our Industrial Perspective themed collection, by Stefano Donadio & co. from NAICONS Srl discussing the trends in metabolite discovery from Actinomycetes #secmet #natprod
Find it in full below👇
Find it in full below👇
Trends in metabolite discovery from Actinomycetes
Covering: 2013 to 2023 In this review, we analyzed the scientific literature of the period 2013–2023 that reported novel specialized metabolites from the Actinomycetes, one of the most prolific…
pubs.rsc.org
September 26, 2025 at 11:56 AM
Reposted by Eustaquio Lab
Reposted by Eustaquio Lab
ICYMI: Nominations for the 2026 @natprodreports.rsc.org Emerging Investigator Lectureship are currently open! #chemsky #secmet #naturalproducts #synbio 🧪
⌛Deadline for nominations is 19 October 2025
Details on how to nominate can be found on our website here▶️rsc.li/npr-lectureship
⌛Deadline for nominations is 19 October 2025
Details on how to nominate can be found on our website here▶️rsc.li/npr-lectureship
September 24, 2025 at 2:08 PM
ICYMI: Nominations for the 2026 @natprodreports.rsc.org Emerging Investigator Lectureship are currently open! #chemsky #secmet #naturalproducts #synbio 🧪
⌛Deadline for nominations is 19 October 2025
Details on how to nominate can be found on our website here▶️rsc.li/npr-lectureship
⌛Deadline for nominations is 19 October 2025
Details on how to nominate can be found on our website here▶️rsc.li/npr-lectureship
Reposted by Eustaquio Lab
We are proud to be able to offer this as an OpenAccess article!
pmc.ncbi.nlm.nih.gov/articles/PMC.... Thank you to #NaturalProductReports for helping us.
#SecMet
pmc.ncbi.nlm.nih.gov/articles/PMC.... Thank you to #NaturalProductReports for helping us.
#SecMet
September 16, 2025 at 6:01 PM
Reposted by Eustaquio Lab
“principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches”👇🏼
#Perspective in @natcomms.nature.com
#Perspective in @natcomms.nature.com
I am really excited to see this article on basic experimental design principles published. Definitely will be mandatory reading for incoming graduate students in my lab. Maggie Wagner who led this article did an amazing job with the illustrations of basic principles www.nature.com/articles/s41...
How thoughtful experimental design can empower biologists in the omics era - Nature Communications
Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...
www.nature.com
August 8, 2025 at 7:26 AM
“principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches”👇🏼
#Perspective in @natcomms.nature.com
#Perspective in @natcomms.nature.com
Reposted by Eustaquio Lab
Bring an N95 or KN95 mask if you are headed to ASP this weekend and have asthma/sensitive lungs. The midwest is smothered in smoke from the Canadian wildfires right now.
woody and buzz lightyear from toy story are standing next to each other with the caption smoke everywhere
ALT: woody and buzz lightyear from toy story are standing next to each other with the caption smoke everywhere
media.tenor.com
August 1, 2025 at 10:50 AM
Bring an N95 or KN95 mask if you are headed to ASP this weekend and have asthma/sensitive lungs. The midwest is smothered in smoke from the Canadian wildfires right now.
Reposted by Eustaquio Lab
Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery
Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we disc...
pubs.rsc.org
July 16, 2025 at 2:35 PM
Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Reposted by Eustaquio Lab
Come read about our thoughts on why cyanobacteria are underrepresented in drug discovery and how both synthetic biology and native hosts can help.
This was fun to work on with a great group of people who include @dtdoering.bsky.social @danudwary.secondarymetabolism.com @eustaquiolab.bsky.social
This was fun to work on with a great group of people who include @dtdoering.bsky.social @danudwary.secondarymetabolism.com @eustaquiolab.bsky.social
Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery
Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we disc...
pubs.rsc.org
July 16, 2025 at 10:07 PM
Come read about our thoughts on why cyanobacteria are underrepresented in drug discovery and how both synthetic biology and native hosts can help.
This was fun to work on with a great group of people who include @dtdoering.bsky.social @danudwary.secondarymetabolism.com @eustaquiolab.bsky.social
This was fun to work on with a great group of people who include @dtdoering.bsky.social @danudwary.secondarymetabolism.com @eustaquiolab.bsky.social
Reposted by Eustaquio Lab
Pleased to share our new paper out in 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘊𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯 led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
April 23, 2025 at 1:37 PM
Pleased to share our new paper out in 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘊𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯 led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
Reposted by Eustaquio Lab
🔓Check out this #OpenAccess review by Lindsay Caesar & co. at @unm.edu & James Madison University, part of our Emerging Investigators collection, on natural product discovery from microbial communities in caves & underground mines #natprod #microsky
Read in full here🔽
Read in full here🔽
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery
Covering: 2014 to 2024 Since the dawn of human history, caves have played an intimate role in our existence. From our earliest ancestors seeking shelter from the elements to more recent generations…
pubs.rsc.org
April 3, 2025 at 3:25 PM
🔓Check out this #OpenAccess review by Lindsay Caesar & co. at @unm.edu & James Madison University, part of our Emerging Investigators collection, on natural product discovery from microbial communities in caves & underground mines #natprod #microsky
Read in full here🔽
Read in full here🔽
Reposted by Eustaquio Lab
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Eustaquio Lab
🎉Natural Product Reports was delighted to announce last month that @ntiekfidele.bsky.social is the winner of the 2025 Natural Product Reports Emerging Investigator Lectureship!
Read more about Fidele and his research here🔽
blogs.rsc.org/np/2025/02/0...
#NatProd #ChemSky #PlantScience
Read more about Fidele and his research here🔽
blogs.rsc.org/np/2025/02/0...
#NatProd #ChemSky #PlantScience
March 3, 2025 at 9:45 AM
🎉Natural Product Reports was delighted to announce last month that @ntiekfidele.bsky.social is the winner of the 2025 Natural Product Reports Emerging Investigator Lectureship!
Read more about Fidele and his research here🔽
blogs.rsc.org/np/2025/02/0...
#NatProd #ChemSky #PlantScience
Read more about Fidele and his research here🔽
blogs.rsc.org/np/2025/02/0...
#NatProd #ChemSky #PlantScience
Reposted by Eustaquio Lab
Out today in Angewandte Chemie
Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides
doi.org/10.1002/anie...
Fun collaboration with the Tørring lab
@thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social
Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides
doi.org/10.1002/anie...
Fun collaboration with the Tørring lab
@thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene ...
doi.org
February 21, 2025 at 4:45 PM
Out today in Angewandte Chemie
Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides
doi.org/10.1002/anie...
Fun collaboration with the Tørring lab
@thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social
Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides
doi.org/10.1002/anie...
Fun collaboration with the Tørring lab
@thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social
Drug discovery requires basic research.
Pharma relies on basic research carried out in academia.
How can pharma CEOs remain quiet or worse yet, support the onslaught on basic research?
It is short sighted to say the least!
www.science.org/content/blog...
Pharma relies on basic research carried out in academia.
How can pharma CEOs remain quiet or worse yet, support the onslaught on basic research?
It is short sighted to say the least!
www.science.org/content/blog...
Pharma CEOS Speaking Up, Damn It
www.science.org
February 20, 2025 at 2:53 PM
Drug discovery requires basic research.
Pharma relies on basic research carried out in academia.
How can pharma CEOs remain quiet or worse yet, support the onslaught on basic research?
It is short sighted to say the least!
www.science.org/content/blog...
Pharma relies on basic research carried out in academia.
How can pharma CEOs remain quiet or worse yet, support the onslaught on basic research?
It is short sighted to say the least!
www.science.org/content/blog...
Reposted by Eustaquio Lab
NIGMS council meeting has been postponed.
This will reverberate.
America's scientific leadership and its innovation economy is under threat.
www.nigms.nih.gov/about/counci...
This will reverberate.
America's scientific leadership and its innovation economy is under threat.
www.nigms.nih.gov/about/counci...
February 6, 2025 at 2:50 PM
NIGMS council meeting has been postponed.
This will reverberate.
America's scientific leadership and its innovation economy is under threat.
www.nigms.nih.gov/about/counci...
This will reverberate.
America's scientific leadership and its innovation economy is under threat.
www.nigms.nih.gov/about/counci...
Reposted by Eustaquio Lab
The overview of AMR that you always wanted (someone else to write) - amazing!
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Antimicrobial resistance: a concise update
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted
and cohesive...
www.thelancet.com
February 5, 2025 at 10:02 AM
The overview of AMR that you always wanted (someone else to write) - amazing!
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Reposted by Eustaquio Lab
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
What's Happening Inside the NIH and NSF
www.science.org
February 4, 2025 at 4:40 PM
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
Reposted by Eustaquio Lab
We're delighted to announce Fidele Ntie-Kang (University of Buea) as the winner of the 2025 Natural Product Reports Emerging Investigator Lectureship! 🎉 Read more about Fidele and his research here: blogs.rsc.org/np/2025/02/0...
#NatProd #PlantScience
#NatProd #PlantScience
February 4, 2025 at 1:38 PM
We're delighted to announce Fidele Ntie-Kang (University of Buea) as the winner of the 2025 Natural Product Reports Emerging Investigator Lectureship! 🎉 Read more about Fidele and his research here: blogs.rsc.org/np/2025/02/0...
#NatProd #PlantScience
#NatProd #PlantScience
Reposted by Eustaquio Lab
www.washingtonpost.com/lifestyle/20... brilliant to see this from Brian Murphy’s lab and their exemplary outreach work
Camarria is already looking forward to her future career.
“I want to be a scientist,” she said.
And Camerria was an author on the published paper pubs.acs.org/doi/10.1021/...
Camarria is already looking forward to her future career.
“I want to be a scientist,” she said.
And Camerria was an author on the published paper pubs.acs.org/doi/10.1021/...
Middle-schooler finds goose poop that has cancer-fighting compound
“My mom, auntie and grandma have all had cancer, so it makes me happy that something I found could help,” said Camarria Williams.
www.washingtonpost.com
January 9, 2025 at 9:45 PM
www.washingtonpost.com/lifestyle/20... brilliant to see this from Brian Murphy’s lab and their exemplary outreach work
Camarria is already looking forward to her future career.
“I want to be a scientist,” she said.
And Camerria was an author on the published paper pubs.acs.org/doi/10.1021/...
Camarria is already looking forward to her future career.
“I want to be a scientist,” she said.
And Camerria was an author on the published paper pubs.acs.org/doi/10.1021/...
Reposted by Eustaquio Lab
Strong showing of @scrippsocean.bsky.social and @ucsdhealthsci.bsky.social alums at the first full day of SIMB #NP2025 meeting @chekanlab.bsky.social
@eustaquiolab.bsky.social Neha Garg Kaity Ryan
@eustaquiolab.bsky.social Neha Garg Kaity Ryan
January 7, 2025 at 12:23 AM
Strong showing of @scrippsocean.bsky.social and @ucsdhealthsci.bsky.social alums at the first full day of SIMB #NP2025 meeting @chekanlab.bsky.social
@eustaquiolab.bsky.social Neha Garg Kaity Ryan
@eustaquiolab.bsky.social Neha Garg Kaity Ryan
Interested in genome mining for natural product discovery? Check out our recent paper in collaboration with the Linington lab pubs.rsc.org/en/content/a...
Discovery of megapolipeptins by genome mining of a Burkholderiales bacteria collection
Burkholderiales bacteria have emerged as a promising source of structurally diverse natural products that are expected to play important ecological and industrial roles. This order ranks in the top th...
pubs.rsc.org
December 10, 2024 at 3:20 PM
Interested in genome mining for natural product discovery? Check out our recent paper in collaboration with the Linington lab pubs.rsc.org/en/content/a...