Eric Paulissen
@ericpaulissen.bsky.social
Postdoc in the Crump lab. Interested in vertebrate body plans and stem cell biology.
Reposted by Eric Paulissen
🎄 Day 1 of the 24 Days of Development ✨🧬
This study shows how different fixation methods (PFA vs. TCA) change what researchers can visualize in chicken embryos using HCR or IHC. 🔍🐣🔬 doi.org/10.1016/j.yd...
This study shows how different fixation methods (PFA vs. TCA) change what researchers can visualize in chicken embryos using HCR or IHC. 🔍🐣🔬 doi.org/10.1016/j.yd...
December 1, 2025 at 3:04 PM
🎄 Day 1 of the 24 Days of Development ✨🧬
This study shows how different fixation methods (PFA vs. TCA) change what researchers can visualize in chicken embryos using HCR or IHC. 🔍🐣🔬 doi.org/10.1016/j.yd...
This study shows how different fixation methods (PFA vs. TCA) change what researchers can visualize in chicken embryos using HCR or IHC. 🔍🐣🔬 doi.org/10.1016/j.yd...
Reposted by Eric Paulissen
Midline tissue formation in zebrafish development
This Research Highlight showcases the work from Robert Morabito, Benjamin Martin (@blmartin.bsky.social) and colleagues @stonybrooku.bsky.social :
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Robert Morabito, Benjamin Martin (@blmartin.bsky.social) and colleagues @stonybrooku.bsky.social :
journals.biologists.com/dev/article/...
November 21, 2025 at 12:40 PM
Midline tissue formation in zebrafish development
This Research Highlight showcases the work from Robert Morabito, Benjamin Martin (@blmartin.bsky.social) and colleagues @stonybrooku.bsky.social :
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Robert Morabito, Benjamin Martin (@blmartin.bsky.social) and colleagues @stonybrooku.bsky.social :
journals.biologists.com/dev/article/...
Reposted by Eric Paulissen
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
A quadratic paradigm describes the relationship between phenotype severity and variation - Nature Communications
Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...
www.nature.com
October 15, 2025 at 9:24 AM
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Reposted by Eric Paulissen
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Reposted by Eric Paulissen
A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
September 15, 2025 at 8:17 PM
A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
Reposted by Eric Paulissen
A giant in molecular biology and virology has passed. RIP David Baltimore.
www.nytimes.com/2025/09/07/s...
www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 8, 2025 at 2:02 AM
A giant in molecular biology and virology has passed. RIP David Baltimore.
www.nytimes.com/2025/09/07/s...
www.nytimes.com/2025/09/07/s...
Reposted by Eric Paulissen
#DBfeature
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
September 2, 2025 at 11:24 AM
#DBfeature
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
Reposted by Eric Paulissen
Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...
An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish
Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...
www.biorxiv.org
April 21, 2025 at 1:47 PM
Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...
Reposted by Eric Paulissen
Congratulations to Gage Crump, professor and vice-chair of the Department of Stem Cell Biology and Regenerative Medicine and Stem Cell Research @keck.usc.edu on receiving the 2025 USC Provost Mentoring Award! @crumplab.bsky.social @stemcell.keck.usc.edu stemcell.keck.usc.edu/gage-crump-r...
April 7, 2025 at 2:35 PM
Congratulations to Gage Crump, professor and vice-chair of the Department of Stem Cell Biology and Regenerative Medicine and Stem Cell Research @keck.usc.edu on receiving the 2025 USC Provost Mentoring Award! @crumplab.bsky.social @stemcell.keck.usc.edu stemcell.keck.usc.edu/gage-crump-r...
Reposted by Eric Paulissen
Congratulations to Camilla Teng, for winning the "Platform presentation SDB prize" for post-docs at the Northwest SDB meeting, which sounds like it was a fantastic meeting! Camilla will be on the faculty job market soon, so look out for her! @socdevbio.bsky.social @ctbatucsf.bsky.social
March 28, 2025 at 4:32 PM
Congratulations to Camilla Teng, for winning the "Platform presentation SDB prize" for post-docs at the Northwest SDB meeting, which sounds like it was a fantastic meeting! Camilla will be on the faculty job market soon, so look out for her! @socdevbio.bsky.social @ctbatucsf.bsky.social
Reposted by Eric Paulissen
The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41...
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Repurposing of a gill gene regulatory program for outer ear evolution - Nature
Nature - Repurposing of a gill gene regulatory program for outer ear evolution
www.nature.com
January 9, 2025 at 4:48 PM
The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41...
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Reposted by Eric Paulissen
Time to recycle this xmas brittle star HCR ⭐
Happy holidays all!! ❄️🎁🎄
Stay tuned for some more brittle star data coming soon 😎
#fluorescence #microscopy #HCR #holidays #imaging
Happy holidays all!! ❄️🎁🎄
Stay tuned for some more brittle star data coming soon 😎
#fluorescence #microscopy #HCR #holidays #imaging
December 24, 2024 at 2:59 PM
Time to recycle this xmas brittle star HCR ⭐
Happy holidays all!! ❄️🎁🎄
Stay tuned for some more brittle star data coming soon 😎
#fluorescence #microscopy #HCR #holidays #imaging
Happy holidays all!! ❄️🎁🎄
Stay tuned for some more brittle star data coming soon 😎
#fluorescence #microscopy #HCR #holidays #imaging
Reposted by Eric Paulissen
How can some vertebrates naturally recover from deafness?
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
December 13, 2024 at 4:58 PM
How can some vertebrates naturally recover from deafness?
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
Reposted by Eric Paulissen
Congratulations to newly minted PhD Tuo Shi. Some exciting news from Tuo is imminent. Stay tuned!
December 12, 2024 at 3:35 AM
Congratulations to newly minted PhD Tuo Shi. Some exciting news from Tuo is imminent. Stay tuned!
Reposted by Eric Paulissen
This from Liberali and Schier (2024) @priscaliberali.bsky.social @schierlab.bsky.social is just some of the things basic research in Developmental Biology alone has allowed since 1974. Fund basic research. Push back against anti-science nonsense pubmed.ncbi.nlm.nih.gov/38906136/
December 2, 2024 at 8:10 PM
This from Liberali and Schier (2024) @priscaliberali.bsky.social @schierlab.bsky.social is just some of the things basic research in Developmental Biology alone has allowed since 1974. Fund basic research. Push back against anti-science nonsense pubmed.ncbi.nlm.nih.gov/38906136/
Reposted by Eric Paulissen
Looking for something fun to read? Here’s a #popsci piece I did on the crazy history of cilia and left/right patterning in embryos. Remember #devbiolwriteclub Bluesky Boot Camp starts Monday Dec. 2! Please RS (re-skeet?)
nautil.us/the-anatomic...
nautil.us/the-anatomic...
The Anatomical Quirk That Saved Dr. No
A wild tale of how scientists unraveled embryology's most fascinating mystery.
nautil.us
November 27, 2024 at 5:07 PM
Looking for something fun to read? Here’s a #popsci piece I did on the crazy history of cilia and left/right patterning in embryos. Remember #devbiolwriteclub Bluesky Boot Camp starts Monday Dec. 2! Please RS (re-skeet?)
nautil.us/the-anatomic...
nautil.us/the-anatomic...