Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

Excited to share the bulk of my postdocotoral work from the @ditalialab.bsky.social on how cells interpret dynamic morphogen signaling during development! Many thanks to our collaborators & coauthors @shelbyflies.bsky.social, Massimo Vergassola, Jacqueline Janssen, and Anna Chao.

Website and registration will open soon for the West Coast SDB meeting, Aug 14–17 at Cal-Poly SLO! Abstract deadline for talks is July 7. Final deadline for abstracts (posters) and registration is July 31. We will have prizes for best undergrad, grad, and post doc presentations! #wcsdb2025 1/4

I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao!
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?

Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...

New(ish) preprint! 📰What whole-cell patterns emerge from the arrangement, morphologies, and interactions of organelles in the 3D space of the cell? What would we see if we could gather ALL the whole-cell reconstruction data that's out there in one place? www.biorxiv.org/content/10.1...
🧵 1/11

I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

Developmental systems have regions that deform actively or passively from their active neighbors. We use a ring of tissue as a model to investigate this boundary-driven morphogenesis in its biological context, learning something about gastrulation and possibly blastopore geometries in the process!

A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron).

We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.

The Society for Developmental Biology has released a statement on the Unprecedented Disruptions to Biomedical Research in the United States.

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!

www.biorxiv.org/content/10.1...

New preprint from Alex Long, Tim Stearns, Jessica Feldman, Lillian Fritz-Laylin and colleagues! Chytrids are neat, understudied and ecologically important as frog pathogens. Shown here, they also remodel their centrioles during cilia disassembly prior to mitosis:
www.biorxiv.org/content/10.1...

Wishing you all the best for 2025 ! ...and a little late thread on our recent preprint studying how tissue growth is affected by mild induction of apoptosis. Drosophila wing disc readjusts global tissue size by modulating dev. time without local proliferation boost.
www.biorxiv.org/content/10.1...

Can’t wait for all the amazing things to come from the Ramm lab!

Thrilled to announce that in January I will be opening my own lab at the Friedrich Miescher Laboratory @mpi-bio-fml.bsky.social of the Max Planck Society @maxplanck.de in lovely Tübingen, Germany!