Elena Kuzmin
@elena-kuzmin.bsky.social
Assistant Professor, Dep. Biology, Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, School of Health, Concordia University | Adjunct Professor, Dep. Human Genetics, Goodman Cancer Institute, McGill University
Pinned
Elena Kuzmin
@elena-kuzmin.bsky.social
· Oct 17
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
Reposted by Elena Kuzmin
❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC).
No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...
No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...
December 3, 2025 at 12:01 AM
❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC).
No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...
No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...
Reposted by Elena Kuzmin
Checkout the latest preprint from the lab - single-cell CIN signatures unlocked! Ongoing HRD improves PARPi sensitivity detection and ongoing NHEJ associates with subclonal diversification in TNBC
📢 New preprint out!
We are thrilled to introduce our framework to track #ongoingCIN by leveraging single-cell genomics and CIN signatures:
www.biorxiv.org/content/10.1...
We are thrilled to introduce our framework to track #ongoingCIN by leveraging single-cell genomics and CIN signatures:
www.biorxiv.org/content/10.1...
Tracking ongoing chromosomal instability using single-cell whole-genome sequencing
Chromosomal instability (CIN) generates aneuploid genomes that are characteristic of most cancers. While bulk genome sequencing reveals historical CIN, it lacks the resolution to identify ongoing CIN ...
www.biorxiv.org
November 28, 2025 at 5:36 PM
Checkout the latest preprint from the lab - single-cell CIN signatures unlocked! Ongoing HRD improves PARPi sensitivity detection and ongoing NHEJ associates with subclonal diversification in TNBC
Reposted by Elena Kuzmin
Thank the @johndoench.bsky.social and Root labs for depositing these deliciously named libraries, and check out our blog post for more:
blog.addgene.org
A Tour of Addgene's Most Popular Pooled Libraries
twp.ai
November 20, 2025 at 5:00 PM
Thank the @johndoench.bsky.social and Root labs for depositing these deliciously named libraries, and check out our blog post for more:
Very excited to co-chair the 2026 Forbeck Forum on Evolution and Modeling of Cancer Genetic Networks and Cell States with @goyallab.bsky.social | Great line-up of speakers, intimate setting and thorough discussions!
www.forbeckforums.org/forums/evolu...
www.forbeckforums.org/forums/evolu...
Evolution and Modeling of Cancer Genetic Networks and Cell States | Forbeck Forums
www.forbeckforums.org
November 12, 2025 at 5:16 PM
Very excited to co-chair the 2026 Forbeck Forum on Evolution and Modeling of Cancer Genetic Networks and Cell States with @goyallab.bsky.social | Great line-up of speakers, intimate setting and thorough discussions!
www.forbeckforums.org/forums/evolu...
www.forbeckforums.org/forums/evolu...
Reposted by Elena Kuzmin
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26
genetics-gsa.org/yeast-2026/
genetics-gsa.org/yeast-2026/
November 7, 2025 at 3:41 PM
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26
genetics-gsa.org/yeast-2026/
genetics-gsa.org/yeast-2026/
Reposted by Elena Kuzmin
Please 🔁! #MASSIV will be held in Vancouver from January 19-22, 2026. 4-day meeting on #synbio x #tissueengineering.
Some trainee-focused events. >50 talks (10 from abstracts), posters, panel & publishing insights sessions.
www.massivconference.com
Abstract deadline: Nov 14
Some trainee-focused events. >50 talks (10 from abstracts), posters, panel & publishing insights sessions.
www.massivconference.com
Abstract deadline: Nov 14
October 25, 2025 at 4:21 PM
Please 🔁! #MASSIV will be held in Vancouver from January 19-22, 2026. 4-day meeting on #synbio x #tissueengineering.
Some trainee-focused events. >50 talks (10 from abstracts), posters, panel & publishing insights sessions.
www.massivconference.com
Abstract deadline: Nov 14
Some trainee-focused events. >50 talks (10 from abstracts), posters, panel & publishing insights sessions.
www.massivconference.com
Abstract deadline: Nov 14
Our department is looking for a Canada Research Chair Tier 2 in Applied Synthetic Biology candidate! Deadline to apply is Dec 5, 2025. Please, repost. www.concordia.ca/jobs/artsci/...
Canada Research Chair Tier II in Applied Synthetic Biology | Faculty of Arts and Science - Concordia University
The Department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure track faculty position and Tier II Canada Research Chair (CRC) in Applied Synthet...
www.concordia.ca
October 22, 2025 at 5:11 PM
Our department is looking for a Canada Research Chair Tier 2 in Applied Synthetic Biology candidate! Deadline to apply is Dec 5, 2025. Please, repost. www.concordia.ca/jobs/artsci/...
Reposted by Elena Kuzmin
Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
October 18, 2025 at 5:50 PM
Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Reposted by Elena Kuzmin
Excited to share my first first-author preprint!
This work would not have been possible without the support and guidance of my supervisor Dr. Elena Kuzmin, as well as my lab mates (past and present) and our collaborators.
This work would not have been possible without the support and guidance of my supervisor Dr. Elena Kuzmin, as well as my lab mates (past and present) and our collaborators.
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
October 17, 2025 at 10:35 PM
Excited to share my first first-author preprint!
This work would not have been possible without the support and guidance of my supervisor Dr. Elena Kuzmin, as well as my lab mates (past and present) and our collaborators.
This work would not have been possible without the support and guidance of my supervisor Dr. Elena Kuzmin, as well as my lab mates (past and present) and our collaborators.
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
October 17, 2025 at 5:55 PM
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
Reposted by Elena Kuzmin
In #G3journal, @elena-kuzmin.bsky.social et al. present PARPAL database, a valuable resource for #yeast researchers to understand the retention and evolution of paralogs. A phenomics screen further shows how proteins respond to paralog deletion by localization & abundance changes. buff.ly/oM97WyH
September 10, 2025 at 10:01 PM
In #G3journal, @elena-kuzmin.bsky.social et al. present PARPAL database, a valuable resource for #yeast researchers to understand the retention and evolution of paralogs. A phenomics screen further shows how proteins respond to paralog deletion by localization & abundance changes. buff.ly/oM97WyH
Our manuscript on the PARPAL database is out in G3! We share our phenomics screen on how proteins respond to their paralog deletion by localization & abundance changes and integrate other datasets with collab @guilbourque.bsky.social @leopoldparts.bsky.social doi.org/10.1093/g3jo...
July 24, 2025 at 9:11 PM
Our manuscript on the PARPAL database is out in G3! We share our phenomics screen on how proteins respond to their paralog deletion by localization & abundance changes and integrate other datasets with collab @guilbourque.bsky.social @leopoldparts.bsky.social doi.org/10.1093/g3jo...
Reposted by Elena Kuzmin
At long last, Rosalind's paper on comparing methods for paralog synthetic lethality is online:
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens - Genome Biology
Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CR...
genomebiology.biomedcentral.com
July 2, 2025 at 1:05 PM
At long last, Rosalind's paper on comparing methods for paralog synthetic lethality is online:
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Our manuscript on how single-cell imaging of protein dynamics of paralogs reveals sources of gene retention is out in iScience with a great team of collaborators @leopoldparts.bsky.social @guilbourque.bsky.social www.cell.com/iscience/ful...
June 19, 2025 at 3:35 PM
Our manuscript on how single-cell imaging of protein dynamics of paralogs reveals sources of gene retention is out in iScience with a great team of collaborators @leopoldparts.bsky.social @guilbourque.bsky.social www.cell.com/iscience/ful...
Reposted by Elena Kuzmin
Please check out our new approach to modeling somatic mutation signatures.
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
Damage and Misrepair Signatures: Compact Representations of Pan-cancer Mutational Processes
Mutational signatures of single-base substitutions (SBSs) characterize somatic mutation processes which contribute to cancer development and progression. However, current mutational signatures do not ...
www.biorxiv.org
June 3, 2025 at 12:34 AM
Please check out our new approach to modeling somatic mutation signatures.
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
Reposted by Elena Kuzmin
Join us for the 2025 SynBio7.0 conference in Toronto, June 1-3!
SynBio is Canada's largest academic synthetic biology conference.
More details on our website! synbio7.vercel.app
SynBio is Canada's largest academic synthetic biology conference.
More details on our website! synbio7.vercel.app
April 23, 2025 at 3:43 PM
Join us for the 2025 SynBio7.0 conference in Toronto, June 1-3!
SynBio is Canada's largest academic synthetic biology conference.
More details on our website! synbio7.vercel.app
SynBio is Canada's largest academic synthetic biology conference.
More details on our website! synbio7.vercel.app
Reposted by Elena Kuzmin
Last call for a postdoc position in single cell analysis/perturb-seq with @nikashakiba.bsky.social at UBC in beautiful Vancouver Canada!
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
March 20, 2025 at 9:40 PM
Last call for a postdoc position in single cell analysis/perturb-seq with @nikashakiba.bsky.social at UBC in beautiful Vancouver Canada!
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
Reposted by Elena Kuzmin
The Early Bird Registration & Submission Deadline is approaching: March 28, 2025!
🔗 Register now
premc.org/yeast2025/re...
Don’t wait until the last minute, spots are limited and allocated on a first-come, first-served basis
🌟 the list of Outstanding Invited Speakers
premc.org/yeast2025/in...
🔗 Register now
premc.org/yeast2025/re...
Don’t wait until the last minute, spots are limited and allocated on a first-come, first-served basis
🌟 the list of Outstanding Invited Speakers
premc.org/yeast2025/in...
March 10, 2025 at 2:07 PM
The Early Bird Registration & Submission Deadline is approaching: March 28, 2025!
🔗 Register now
premc.org/yeast2025/re...
Don’t wait until the last minute, spots are limited and allocated on a first-come, first-served basis
🌟 the list of Outstanding Invited Speakers
premc.org/yeast2025/in...
🔗 Register now
premc.org/yeast2025/re...
Don’t wait until the last minute, spots are limited and allocated on a first-come, first-served basis
🌟 the list of Outstanding Invited Speakers
premc.org/yeast2025/in...
Reposted by Elena Kuzmin
Just add sorbitol!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Enhancing Yeast Transformation: Achieving up to a Tenfold Increase Through a Single Adjustment in the Lithium Acetate–Polyethylene Glycol Method
In red are the proposed improvements to the classical yeast transformation protocol.
onlinelibrary.wiley.com
March 17, 2025 at 11:23 AM
Just add sorbitol!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Great study to have been involved in!
Benchmarking macaque brain gene expression for horizontal and vertical translation | www.science.org/doi/10.1126/...
How useful is macaque brain gene expression for asking questions about macaque protein abundance and human gene expression? Andrea Luppi explores ⤵️
How useful is macaque brain gene expression for asking questions about macaque protein abundance and human gene expression? Andrea Luppi explores ⤵️
March 17, 2025 at 4:59 PM
Great study to have been involved in!
Very excited to share our preprint on the PARPAL web data portal capturing how proteins change their subcellular localization and abundance due to their paralog deletion w/ collab @leopoldparts.bsky.social @guilbourque.bsky.social www.biorxiv.org/content/10.1...
March 17, 2025 at 4:48 PM
Very excited to share our preprint on the PARPAL web data portal capturing how proteins change their subcellular localization and abundance due to their paralog deletion w/ collab @leopoldparts.bsky.social @guilbourque.bsky.social www.biorxiv.org/content/10.1...
Reposted by Elena Kuzmin
Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1...
So what did we find?
So what did we find?
The modifiers that cause changes in gene essentiality
www.biorxiv.org
March 9, 2025 at 2:45 PM
Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1...
So what did we find?
So what did we find?
We are hiring a Tier II Canada Research Chair (CRC) in Synthetic Biology and Biomanufacturing at Concordia University. Please, repost. www.concordia.ca/artsci/about...
Canada Research Chair (CRC) Tier II in Synthetic Biology and Biomanufacturing - Concordia University
The department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure-track faculty position with the opportunity to apply for a Tier II Canada Researc...
www.concordia.ca
March 6, 2025 at 3:55 AM
We are hiring a Tier II Canada Research Chair (CRC) in Synthetic Biology and Biomanufacturing at Concordia University. Please, repost. www.concordia.ca/artsci/about...