Jarrod Dudakov
@dudakov-lab.bsky.social
Immunology with a touch of regenerative medicine (or is it the other way around?). Thymus enthusiast at Fred Hutch (previously seen around Monash Uni & Sloan Kettering Institute) 🇦🇺 in 🇺🇸
Reposted by Jarrod Dudakov
Intrathymic progenitor cell transplantation restores T cell development through ILC3-TEC crosstalk https://www.biorxiv.org/content/10.1101/2025.11.10.687563v1
November 12, 2025 at 2:15 AM
Intrathymic progenitor cell transplantation restores T cell development through ILC3-TEC crosstalk https://www.biorxiv.org/content/10.1101/2025.11.10.687563v1
Reposted by Jarrod Dudakov
T cell fate is dictated by different antigen presenting cells in response to dietary versus gut epithelial self-antigen https://www.biorxiv.org/content/10.1101/2025.11.06.687030v1
November 8, 2025 at 4:16 AM
T cell fate is dictated by different antigen presenting cells in response to dietary versus gut epithelial self-antigen https://www.biorxiv.org/content/10.1101/2025.11.06.687030v1
Reposted by Jarrod Dudakov
I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocomp…
www.sciencedirect.com
November 5, 2025 at 9:16 PM
I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...
Reposted by Jarrod Dudakov
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Jarrod Dudakov
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells @jem.org
rupress.org/jem/article-...
rupress.org/jem/article-...
October 23, 2025 at 5:20 PM
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells @jem.org
rupress.org/jem/article-...
rupress.org/jem/article-...
Reposted by Jarrod Dudakov
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice
Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...
rdcu.be
October 22, 2025 at 1:10 PM
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
Coming out of retirement for just one last epic score.
October 19, 2025 at 2:43 PM
Coming out of retirement for just one last epic score.
Reposted by Jarrod Dudakov
Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.
urldefense.com
October 17, 2025 at 12:22 PM
Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1
Finally some press that this policy goes way beyond the tech sector - which does dominate H1B numbers - but is also crucial for medicine and research too. Death by a thousand open wounds.
“Most of these positions aren’t positions for which we can hire domestically,” (Dr. Martin ) said, pointing to, for example, America’s shortage of anesthesiologists'
Trump’s H-1B Visa Fee Could Strain Universities and Schools
www.nytimes.com
October 8, 2025 at 1:56 PM
Finally some press that this policy goes way beyond the tech sector - which does dominate H1B numbers - but is also crucial for medicine and research too. Death by a thousand open wounds.
Reposted by Jarrod Dudakov
Secondary lymphoid organ endothelial cells prime alloreactive CD4+ T cells to trigger acute graft-versus-host disease https://www.biorxiv.org/content/10.1101/2025.10.07.677751v1
October 8, 2025 at 4:19 AM
Secondary lymphoid organ endothelial cells prime alloreactive CD4+ T cells to trigger acute graft-versus-host disease https://www.biorxiv.org/content/10.1101/2025.10.07.677751v1
Great primer. Also great to see peripheral tolerance recognized, but I will note you can’t get tregs without central tolerance and the thymus! Miller snubbed again!
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 1:52 PM
Great primer. Also great to see peripheral tolerance recognized, but I will note you can’t get tregs without central tolerance and the thymus! Miller snubbed again!
Reposted by Jarrod Dudakov
Review @cp-trendsimmuno.bsky.social Decoding immune aging at single-cell resolution
cell.com/trends/immun...
cell.com/trends/immun...
September 27, 2025 at 5:57 PM
Review @cp-trendsimmuno.bsky.social Decoding immune aging at single-cell resolution
cell.com/trends/immun...
cell.com/trends/immun...
Reposted by Jarrod Dudakov
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging
Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.
www.nature.com
September 26, 2025 at 3:00 AM
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Amazing. (I really hope we don’t find out this is AI)
I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
September 25, 2025 at 1:42 AM
Amazing. (I really hope we don’t find out this is AI)
Reposted by Jarrod Dudakov
Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.
September 20, 2025 at 4:09 AM
Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.
Yes, please! Will be trying this out soon. (Well, someone in the lab will be trying this soon!).
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 4:50 PM
Yes, please! Will be trying this out soon. (Well, someone in the lab will be trying this soon!).
Reposted by Jarrod Dudakov
@biorxivpreprint.bsky.social efineptakin alfa (NT-I7), a long-acting form of IL-7, induce beneficial stem-like CD8 T cell-supporting tertiary lymphoid structures enriched for PD-L1 in murine lung tumor model
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
September 19, 2025 at 3:29 AM
@biorxivpreprint.bsky.social efineptakin alfa (NT-I7), a long-acting form of IL-7, induce beneficial stem-like CD8 T cell-supporting tertiary lymphoid structures enriched for PD-L1 in murine lung tumor model
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
Great piece. Now extrapolate across the other 26 institutes and every disease/biological process you can conceive.
“It will take decades to recover from this, if we ever do.” America’s cancer research system, which has helped save millions of lives and is in one of its most productive moments, is under threat by the Trump administration.
Trump Is Shutting Down the War On Cancer
America’s cancer research system, which has helped save millions of lives, is under threat in one of its most productive moments.
nyti.ms
September 14, 2025 at 4:21 PM
Great piece. Now extrapolate across the other 26 institutes and every disease/biological process you can conceive.
Reposted by Jarrod Dudakov
Inflammatory memory of stem cells: implications for hematologic diseases buff.ly/QBUFcjd #hemesky
September 14, 2025 at 4:01 PM
Inflammatory memory of stem cells: implications for hematologic diseases buff.ly/QBUFcjd #hemesky
Reposted by Jarrod Dudakov
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
www.science.org
September 12, 2025 at 9:54 PM
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jarrod Dudakov
ASH applauds the House and Senate Appropriations Committees for rejecting proposed NIH cuts but urges Congress to also protect critical CDC programs supporting individuals with blood disorders.
🔗 https://bit.ly/41PqLNv
#Fight4Hematology #ResearchSavesLives #HemeSky
🔗 https://bit.ly/41PqLNv
#Fight4Hematology #ResearchSavesLives #HemeSky
September 11, 2025 at 8:15 PM
ASH applauds the House and Senate Appropriations Committees for rejecting proposed NIH cuts but urges Congress to also protect critical CDC programs supporting individuals with blood disorders.
🔗 https://bit.ly/41PqLNv
#Fight4Hematology #ResearchSavesLives #HemeSky
🔗 https://bit.ly/41PqLNv
#Fight4Hematology #ResearchSavesLives #HemeSky
Reposted by Jarrod Dudakov
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
www.nature.com/articles/s41...
@natimmunol.nature.com @dudakov-lab.bsky.social @fredhutch.bsky.social
www.nature.com/articles/s41...
@natimmunol.nature.com @dudakov-lab.bsky.social @fredhutch.bsky.social
September 11, 2025 at 5:13 PM
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
www.nature.com/articles/s41...
@natimmunol.nature.com @dudakov-lab.bsky.social @fredhutch.bsky.social
www.nature.com/articles/s41...
@natimmunol.nature.com @dudakov-lab.bsky.social @fredhutch.bsky.social
It gives me great pleasure to present the latest from our lab, outlining a curious cellular and molecular pathway that limits thymic regeneration after acute insult. www.nature.com/articles/s41...
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration - Nature Immunology
The thymus is sensitive to acute insults including infection, as well as to injury from chemotherapy and myeloablative conditioning before hematopoietic cell transplantation. Here, Granadier et al. de...
www.nature.com
September 11, 2025 at 8:59 PM
It gives me great pleasure to present the latest from our lab, outlining a curious cellular and molecular pathway that limits thymic regeneration after acute insult. www.nature.com/articles/s41...
Reposted by Jarrod Dudakov
Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion. New study from Pratibha Bhalla, Nicolai van Oers and colleagues (UT Southwestern Medical Center): rupress.org/jhi/article/...
See a short video summary 🎥 youtu.be/8M7qQELxQ8g
See a short video summary 🎥 youtu.be/8M7qQELxQ8g
Minoxidil restore thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion
Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion
Original paper: doi.org/10.70962/jhi.20250143
Video summary by Pratibha Bhalla (The University…
youtu.be
September 11, 2025 at 7:30 PM
Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion. New study from Pratibha Bhalla, Nicolai van Oers and colleagues (UT Southwestern Medical Center): rupress.org/jhi/article/...
See a short video summary 🎥 youtu.be/8M7qQELxQ8g
See a short video summary 🎥 youtu.be/8M7qQELxQ8g