Jarrod Dudakov
@dudakov-lab.bsky.social
Immunology with a touch of regenerative medicine (or is it the other way around?). Thymus enthusiast at Fred Hutch (previously seen around Monash Uni & Sloan Kettering Institute) 🇦🇺 in 🇺🇸
Coming out of retirement for just one last epic score.
October 19, 2025 at 2:43 PM
Coming out of retirement for just one last epic score.
Amazing that one guy in Portland could start a movement.
October 18, 2025 at 8:45 PM
Amazing that one guy in Portland could start a movement.
Moreover, despite the increase in IFNg, we also found that thymic epithelial cells (TECs) actually decreased their MHCI expression after damage, making them vulnerable to NK-mediated killing. Given the central importance of TECs for all thymic function, their killing after damage inhibits repair.
September 11, 2025 at 8:59 PM
Moreover, despite the increase in IFNg, we also found that thymic epithelial cells (TECs) actually decreased their MHCI expression after damage, making them vulnerable to NK-mediated killing. Given the central importance of TECs for all thymic function, their killing after damage inhibits repair.
But to our surprise, although upregulated in response to IL-18, this inhibitory effect was not mediated by IFNg. Instead, both perforin and granzyme could limit thymic regeneration, but only perforin was regulated by IL-18.
September 11, 2025 at 8:59 PM
But to our surprise, although upregulated in response to IL-18, this inhibitory effect was not mediated by IFNg. Instead, both perforin and granzyme could limit thymic regeneration, but only perforin was regulated by IL-18.
Using a slew of mouse strains and assays including imaging, single-cell sequencing, parabiosis, and more, David found that IL-18 released by hematopoietic (DC/macrophage) and non-hematopoietic (mesothelial) cells activated NK cells (but not ILC1) limiting repair via their cytotoxic function.
September 11, 2025 at 8:59 PM
Using a slew of mouse strains and assays including imaging, single-cell sequencing, parabiosis, and more, David found that IL-18 released by hematopoietic (DC/macrophage) and non-hematopoietic (mesothelial) cells activated NK cells (but not ILC1) limiting repair via their cytotoxic function.
David found that indeed there was an activation of pro-inflammatory IL-1 and IL-18, and that this was not just a feature of ionizing radiation-induced injury but was a common response across a range of damage modalities including corticosteroid stress, LPS, and cytoreductive chemotherapy.
September 11, 2025 at 8:59 PM
David found that indeed there was an activation of pro-inflammatory IL-1 and IL-18, and that this was not just a feature of ionizing radiation-induced injury but was a common response across a range of damage modalities including corticosteroid stress, LPS, and cytoreductive chemotherapy.
This has been a really fun one, not least of which because it was driven by our first bona fide graduate student, an incredibly talented MSTP student @david-granadier.bsky.social.
September 11, 2025 at 8:59 PM
This has been a really fun one, not least of which because it was driven by our first bona fide graduate student, an incredibly talented MSTP student @david-granadier.bsky.social.
How on Earth is he still referred to as a vaccine skeptic? I think we are well beyond that now. www.nytimes.com/2025/06/09/h...
June 10, 2025 at 12:06 AM
How on Earth is he still referred to as a vaccine skeptic? I think we are well beyond that now. www.nytimes.com/2025/06/09/h...
Great piece and highlights what we need to be making clearer.
June 3, 2025 at 6:19 PM
Great piece and highlights what we need to be making clearer.
Add one Governor to the cause!
March 7, 2025 at 8:46 PM
Add one Governor to the cause!
Geared up for today’s rally!
March 7, 2025 at 4:03 PM
Geared up for today’s rally!
This rings very true for me and my science awakening really. Realizing that this work we had published added a small (probably very small) but meaningful contribution to a chain of knowledge stretching back through human history was one of the most powerful - almost religious - experiences I’ve had.
February 9, 2025 at 3:07 AM
This rings very true for me and my science awakening really. Realizing that this work we had published added a small (probably very small) but meaningful contribution to a chain of knowledge stretching back through human history was one of the most powerful - almost religious - experiences I’ve had.
January 28, 2025 at 1:09 AM
Interested in T cells and where they come from? Then now is the perfect opportunity to register for ThymUS (www.thymusmeeting.org). Don't miss out on what is shaping up to be a fantastic meting in gorgeous Kauai.
January 3, 2025 at 5:14 PM
Interested in T cells and where they come from? Then now is the perfect opportunity to register for ThymUS (www.thymusmeeting.org). Don't miss out on what is shaping up to be a fantastic meting in gorgeous Kauai.
Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice in Chains.
November 19, 2024 at 4:27 AM
Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice in Chains.
Happy Halloween from the Dudakov Lab Muppets!
November 1, 2023 at 1:39 AM
Happy Halloween from the Dudakov Lab Muppets!
Wonderful day at Mayo Clinic Arizona visiting Drs. Lancaster, Maharlooei, Borges da Silva and other superstars. 🔥Immunology program they have built in the desert - and I'm told only a balmy 98 degrees today!
September 15, 2023 at 3:38 AM
Wonderful day at Mayo Clinic Arizona visiting Drs. Lancaster, Maharlooei, Borges da Silva and other superstars. 🔥Immunology program they have built in the desert - and I'm told only a balmy 98 degrees today!