Wendy Xin
@droligo.bsky.social
🇨🇦 neuroscientist, postdoc at UCSF · NINDS K99 fellow · oligodendrocytes & myelin | synapses & circuits · PhD Johns Hopkins/NIDA, BSc UofT · she/her
www.oligodendrocyte.org
www.oligodendrocyte.org
Pinned
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Reposted by Wendy Xin
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
October 29, 2025 at 2:57 PM
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Reposted by Wendy Xin
If you’re interested in the roles of glia in stroke and TBI, kick off #SfN2025 with a minisymposium on Saturday afternoon in room 6B!
@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!
@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!
November 14, 2025 at 8:07 PM
If you’re interested in the roles of glia in stroke and TBI, kick off #SfN2025 with a minisymposium on Saturday afternoon in room 6B!
@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!
@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!
Reposted by Wendy Xin
The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out!
www.raajgowrishankarlab.org
www.raajgowrishankarlab.org
Gowrishankar Lab
www.raajgowrishankarlab.org
November 12, 2025 at 10:23 PM
The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out!
www.raajgowrishankarlab.org
www.raajgowrishankarlab.org
Reposted by Wendy Xin
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Wendy Xin
In How to Change a Memory, neuroscientist @okaysteve.bsky.social shares his disarmingly personal account of the new science of memory manipulation.
🎧️📔 The #audiobook, read by the author himself, is out now!
Add it to your #audio library: press.princeton.edu/books/audio/...
🎧️📔 The #audiobook, read by the author himself, is out now!
Add it to your #audio library: press.princeton.edu/books/audio/...
November 4, 2025 at 8:46 PM
In How to Change a Memory, neuroscientist @okaysteve.bsky.social shares his disarmingly personal account of the new science of memory manipulation.
🎧️📔 The #audiobook, read by the author himself, is out now!
Add it to your #audio library: press.princeton.edu/books/audio/...
🎧️📔 The #audiobook, read by the author himself, is out now!
Add it to your #audio library: press.princeton.edu/books/audio/...
Reposted by Wendy Xin
Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
November 4, 2025 at 4:25 PM
Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
Reposted by Wendy Xin
Reposted by Wendy Xin
Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...
Retinal glia regulate development of the circadian photoentrainment circuit
Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to th…
www.sciencedirect.com
October 29, 2025 at 2:27 PM
Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...
Reposted by Wendy Xin
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
Molecular mechanisms mediating engram ensemble retrievability state in mice
Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…
www.sciencedirect.com
October 30, 2025 at 3:32 PM
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
October 29, 2025 at 2:57 PM
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Reposted by Wendy Xin
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200
Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.
www.nature.com
October 28, 2025 at 10:06 PM
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
Reposted by Wendy Xin
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:32 PM
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Reposted by Wendy Xin
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
authors.elsevier.com
October 22, 2025 at 6:50 PM
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Reposted by Wendy Xin
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
OASIS: in vivo AAV-mediated transduction and genome editing of adult oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.10.20.683551v1
October 21, 2025 at 11:58 PM
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
Reposted by Wendy Xin
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
October 15, 2025 at 4:11 PM
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
Reposted by Wendy Xin
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
October 10, 2025 at 11:13 PM
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair!
(see also - gorgeous astrocytes for fluorescence Friday)
www.sciencedirect.com/science/arti...
(see also - gorgeous astrocytes for fluorescence Friday)
www.sciencedirect.com/science/arti...
October 10, 2025 at 5:42 PM
Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair!
(see also - gorgeous astrocytes for fluorescence Friday)
www.sciencedirect.com/science/arti...
(see also - gorgeous astrocytes for fluorescence Friday)
www.sciencedirect.com/science/arti...
Reposted by Wendy Xin
Come join us at @westernu.ca: Chair, Department of Medical Biophysics: www.uwo.ca/facultyrelat...
www.uwo.ca
October 10, 2025 at 2:56 AM
Come join us at @westernu.ca: Chair, Department of Medical Biophysics: www.uwo.ca/facultyrelat...
Reposted by Wendy Xin
PhD / Postdoc in Neuroscience – University of Montreal - Seeking a highly motivated PhD student or Postdoctoral Fellow to join an exciting collaborative project between the laboratories of Dr. Antonio Nanci and Dr. Ravi Rungta at the Université de Montréal. can-acn.org/phd-postdoc-...
October 7, 2025 at 8:30 PM
PhD / Postdoc in Neuroscience – University of Montreal - Seeking a highly motivated PhD student or Postdoctoral Fellow to join an exciting collaborative project between the laboratories of Dr. Antonio Nanci and Dr. Ravi Rungta at the Université de Montréal. can-acn.org/phd-postdoc-...
Patch clamp friends, anyone have experience with the Digidata HumSilencer feature? Does it do anything?
October 3, 2025 at 7:54 PM
Patch clamp friends, anyone have experience with the Digidata HumSilencer feature? Does it do anything?
Reposted by Wendy Xin
Interview with @pegmccarthy.bsky.social on the *evidence* related to Tylenol and pregnancy
nam.edu/news-and-ins...
nam.edu/news-and-ins...
Autism and Tylenol: Exploring the Evidence on Acetaminophen in Pregnancy - NAM
Margaret McCarthy discusses the genetics of autism, how to interpret associations with Tylenol (acetaminophen) use in health studies, and why medical guidance matters.
nam.edu
September 26, 2025 at 1:12 AM
Interview with @pegmccarthy.bsky.social on the *evidence* related to Tylenol and pregnancy
nam.edu/news-and-ins...
nam.edu/news-and-ins...
Reposted by Wendy Xin
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
September 12, 2025 at 1:21 PM
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
Reposted by Wendy Xin
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...
www.biorxiv.org
September 3, 2025 at 11:51 AM
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Wendy Xin
We are looking for a new coordinator to join the Education & Engagement team at @alleninstitute.org! This person will support the full breadth of our efforts here in the program, including administrative support, participant communications, helping with field trips, and much more. 1/2
August 28, 2025 at 5:10 PM
We are looking for a new coordinator to join the Education & Engagement team at @alleninstitute.org! This person will support the full breadth of our efforts here in the program, including administrative support, participant communications, helping with field trips, and much more. 1/2
Reposted by Wendy Xin
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)
Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex
The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...
www.biorxiv.org
August 19, 2025 at 4:22 PM
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)