Ich habe heute im Deutschlandfunk gehört, dass es erste Schätzungen gibt, dass alleine die Kürzung der internationalen Hilfsgelder durch die faschistische Führung der USA, weltweit für ca. 300.000 Todesfälle verantwortlich ist.

Meine Verachtung für diese Massenmörder ist beispiellos.

Manufacturing CAR T cells in the laboratory is expensive and time-consuming.

An in vivo approach could get this powerful therapy to more people
https://go.nature.com/45w5A5w

This is what can be achieved today due to longstanding federal support of academic basic science alongside close partnership of universities, private industry and NIH intramural initiatives. An ecosystem worth not just saving but doubling down on!

innovativegenomics.org/news/first-p...

Another article on Indigenous knowledge perspectives. Oh! this is what DIVERSITY means. "We discuss how Two-Eyed Seeing can bring breadth of knowledge and humility to the development of research and clinical practices for brain health. "
#science #philsci
www.nature.com/articles/s41...

T cell-specific antigens are discovered at high throughput without killing target cells go.nature.com/3L6cuDp
rdcu.be/ekKtU

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases

https://go.nature.com/3RcyzDa

An immigration crackdown in the United States is rattling the global research community, with high-profile detentions and deportations of academics stoking fears even for travellers with valid entry documents

https://go.nature.com/4iMw7PV

Unfortunately, there was another round of FUNDED grants cancelled yesterday. These illegal cuts stop projects that have been in progress for years, interrupt lifesaving research, and destroy the public good of science in the US.

If you were impacted, please share you story with us: fedfreeze.org

Another unvaccinated child dies from measles, a fully preventable disease, and only the second child to die from measles in the US in the past 22 years

In Brief: Gene and cell therapies from Bayer subsidaries AskBio & BlueRock Therapeutics make headway in trials for Parkinson's nature.com/articles/s41...
rdcu.be/ebozG

What is your pace of aging? A new @nature.com feature on molecular clocks by gets into the issues surrounding these tests (can is really can't) nature.com/articles/d41... by @heidiledford.bsky.social

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...

Society, patients and clinicians welcome a much-needed non-opioid pain medication. Vertex’s first-in-class analgesic Journavx could soon be followed by a new generation of addiction-free pain drugs acting at NaV1.8 sodium channels www.nature.com/articles/s41...

LAG3 marks activated but hyporesponsive NK cells. https://www.biorxiv.org/content/10.1101/2024.12.18.629184v1

Poorly validated antibodies fuel the reproducibility crisis.

YCharOS shares a protocol for antibody validation using KO cell lines.
tinyurl.com/NP-article

Read also the N&V.
tinyurl.com/NP-comment

Glad that our study is cited as an example for improving data quality.
tinyurl.com/CSC-Letter

Thrilled to share our new manuscript combining Perturb-seq (pooled CRISPR screens + scRNA-seq readouts) with Cas12a and its unique guide RNA processing ability.

Led by the extremely talented Valentina Snetkova at Genentech :)!