Matt Doyle
@doylemt1.bsky.social
🇦🇺 Senior Lecturer at @sydneyuni.bsky.social and former NIHer. Research: Bacterial outer membrane biogenesis - membrane protein folding - protein translocation across membranes - novel antibiotics. He/him.
Pinned
Matt Doyle
@doylemt1.bsky.social
· Nov 21
The patatin-like protein PlpD forms structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane - Nature Communications
The Omp85 superfamily is a widely distributed class of outer membrane proteins found in Gram-negative bacteria, mitochondria and chloroplasts. Here the authors show that PlpD has a different structure...
www.nature.com
Because I'm new here I want to share two recent papers from my students to show the science we are interested in. 🦠🧫 #Microsky
1) Sarah Hanson's work on a new homodimer found across many Gram-negatives that modifies lipids in the outer membrane:
www.nature.com/articles/s41...
1) Sarah Hanson's work on a new homodimer found across many Gram-negatives that modifies lipids in the outer membrane:
www.nature.com/articles/s41...
Reposted by Matt Doyle
Congrats to #USYD's A/Prof Yu Heng Lau for landing a $958,564 ARC Discovery grant to develop tiny protein cages to improve how plants use carbon, water & nutrients + boost crop yields. Sydney Analytical + Sydney Mass Spectrometry look forward to continuing our collaboration.
@yuhenglau.bsky.social
@yuhenglau.bsky.social
November 12, 2025 at 1:13 AM
Congrats to #USYD's A/Prof Yu Heng Lau for landing a $958,564 ARC Discovery grant to develop tiny protein cages to improve how plants use carbon, water & nutrients + boost crop yields. Sydney Analytical + Sydney Mass Spectrometry look forward to continuing our collaboration.
@yuhenglau.bsky.social
@yuhenglau.bsky.social
Reposted by Matt Doyle
Between 2018–2023, antibiotic resistance increased in over 40% of the pathogen–antibiotic combinations monitored, with an average annual rise of 5–15%.
Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u
Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u
October 15, 2025 at 8:00 AM
Between 2018–2023, antibiotic resistance increased in over 40% of the pathogen–antibiotic combinations monitored, with an average annual rise of 5–15%.
Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u
Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u
Reposted by Matt Doyle
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology
Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.
doi.org
October 2, 2025 at 6:20 AM
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
Reposted by Matt Doyle
Thanks for coming Doyle lab! It was great to have you here.
October 1, 2025 at 8:06 AM
Thanks for coming Doyle lab! It was great to have you here.
Reposted by Matt Doyle
Congratulations to all our poster and speaker prize winners!! 🏆🏆🏆
October 1, 2025 at 2:54 AM
Congratulations to all our poster and speaker prize winners!! 🏆🏆🏆
Reposted by Matt Doyle
And that's a wrap! A huge shout out goes to our conference chair Michael Landsberg @dr-berger.bsky.social and the rest of the organizing committee for putting together such a vibrant #ASBMB2025! See you all at #ComBio2026!
October 1, 2025 at 3:23 AM
And that's a wrap! A huge shout out goes to our conference chair Michael Landsberg @dr-berger.bsky.social and the rest of the organizing committee for putting together such a vibrant #ASBMB2025! See you all at #ComBio2026!
Very proud of both my students @itzfredz.bsky.social (Alfred Hartojo) and @alanaheisenhuth.bsky.social (Alanah Eisenhuth) for presenting their research at ASBMB2025. Also congrats to Alfred for his poster prize! 👏🏆
October 1, 2025 at 3:59 AM
Very proud of both my students @itzfredz.bsky.social (Alfred Hartojo) and @alanaheisenhuth.bsky.social (Alanah Eisenhuth) for presenting their research at ASBMB2025. Also congrats to Alfred for his poster prize! 👏🏆
Reposted by Matt Doyle
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 9:29 AM
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
Reposted by Matt Doyle
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 8:46 AM
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
Reposted by Matt Doyle
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 2, 2025 at 3:01 PM
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Reposted by Matt Doyle
PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research.
Learn more: youtu.be/senXARXzO20
#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social
Learn more: youtu.be/senXARXzO20
#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social
July 31, 2025 at 12:00 AM
PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research.
Learn more: youtu.be/senXARXzO20
#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social
Learn more: youtu.be/senXARXzO20
#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social
Reposted by Matt Doyle
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
“Revolutionary Science Comes from Unexpected Angles”
magazine.hms.harvard.edu
July 29, 2025 at 4:00 PM
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
Reposted by Matt Doyle
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
July 21, 2025 at 9:56 AM
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
Reposted by Matt Doyle
Introducing Latent-X — our all-atom frontier AI model for protein binder design.
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
July 22, 2025 at 6:21 AM
Introducing Latent-X — our all-atom frontier AI model for protein binder design.
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
Reposted by Matt Doyle
The costs of #antimicrobial resistance 🦠 continue to rise 📈. The Center for Global Development reports that by 2050 #AMR could shrink the global economy by US$1.7T.
Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.
Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.
Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans
Antimicrobial resistance (AMR) is a growing global health crisis that threatens to undo decades of progress in medicine. This tool allows you to explore the potential impact of different interventions...
www.cgdev.org
July 20, 2025 at 9:31 PM
The costs of #antimicrobial resistance 🦠 continue to rise 📈. The Center for Global Development reports that by 2050 #AMR could shrink the global economy by US$1.7T.
Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.
Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.
Excited to be in Adelaide for the MTPconnect Innovation in Antimicrobials event ahead of attending 2025 ASM Conference @aussocmic.bsky.social
July 14, 2025 at 2:00 AM
Excited to be in Adelaide for the MTPconnect Innovation in Antimicrobials event ahead of attending 2025 ASM Conference @aussocmic.bsky.social
Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications
This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...
www.nature.com
July 6, 2025 at 6:54 AM
Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lost in the labyrinth of poorly LLM written "scientific" articles. Bad science writing example excerpt:
"Initially, we delve into the intricacies of […], accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal […] mechanisms."
...boy
"Initially, we delve into the intricacies of […], accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal […] mechanisms."
...boy
July 6, 2025 at 5:27 AM
Lost in the labyrinth of poorly LLM written "scientific" articles. Bad science writing example excerpt:
"Initially, we delve into the intricacies of […], accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal […] mechanisms."
...boy
"Initially, we delve into the intricacies of […], accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal […] mechanisms."
...boy
Reposted by Matt Doyle
Great science looks at big unknowns.
In bacteria, sRNAs control gene expression but ‘how’ they do this at systems level is far from known. @MACSYS is recruiting for courageous PhD students who would learn, know and report how sRNAs deliver systems level phenotypes
macsys.org/monash-phd-s... for
In bacteria, sRNAs control gene expression but ‘how’ they do this at systems level is far from known. @MACSYS is recruiting for courageous PhD students who would learn, know and report how sRNAs deliver systems level phenotypes
macsys.org/monash-phd-s... for
PhD Scholarships at Monash University - MACSYS
Do cutting-edge research at the frontiers of Whole Cell Modelling! The MACSYS Node at Monash University has multiple PhD Scholarships available to work on some exciting projects! $41,753 p.a. stipend ...
macsys.org
May 25, 2025 at 6:29 AM
Great science looks at big unknowns.
In bacteria, sRNAs control gene expression but ‘how’ they do this at systems level is far from known. @MACSYS is recruiting for courageous PhD students who would learn, know and report how sRNAs deliver systems level phenotypes
macsys.org/monash-phd-s... for
In bacteria, sRNAs control gene expression but ‘how’ they do this at systems level is far from known. @MACSYS is recruiting for courageous PhD students who would learn, know and report how sRNAs deliver systems level phenotypes
macsys.org/monash-phd-s... for
Reposted by Matt Doyle
After an unexpectedly long editorial process, our paper describing the structures of the E coli TolAQR and TonB-ExbBD complexes is finally out. The coordinates are to be released on July 9th on the PDB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cryo-EM structures of the E. coli Ton and Tol motor complexes - Nature Communications
The Ton and Tol systems are bacterial energy-transducing complexes that use the proton motive force at the inner membrane to exert force on outer membrane proteins. Here the authors present the high-r...
www.nature.com
July 1, 2025 at 3:03 PM
After an unexpectedly long editorial process, our paper describing the structures of the E coli TolAQR and TonB-ExbBD complexes is finally out. The coordinates are to be released on July 9th on the PDB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Matt Doyle
It is a very short list of cities in which you can visit three world class research universities on three consecutive days without switching hotels.
Tomorrow, Sydney University. Wednesday, UNSW. Thursday, Macquarie University.
Tomorrow, Sydney University. Wednesday, UNSW. Thursday, Macquarie University.
June 23, 2025 at 12:42 PM
It is a very short list of cities in which you can visit three world class research universities on three consecutive days without switching hotels.
Tomorrow, Sydney University. Wednesday, UNSW. Thursday, Macquarie University.
Tomorrow, Sydney University. Wednesday, UNSW. Thursday, Macquarie University.
Reposted by Matt Doyle
Feeling very humbled by receiving this award and equally excited to attend ASM in Adelaide this year! 🎉
🎉 Congratulations to the winners of the 2025 Early Career Microbiologist Award!
🏆 Winner: Dr Hannah Brown @hannjbrown.bsky.social
🏆 Runner-Up: Dr Binod Rayamajhee
We’re proud to support the next generation of microbiology leaders and can’t wait to see where their research takes them!
🏆 Winner: Dr Hannah Brown @hannjbrown.bsky.social
🏆 Runner-Up: Dr Binod Rayamajhee
We’re proud to support the next generation of microbiology leaders and can’t wait to see where their research takes them!
June 23, 2025 at 8:54 AM
Feeling very humbled by receiving this award and equally excited to attend ASM in Adelaide this year! 🎉
Reposted by Matt Doyle
JAMS June Monthly is next week🥳
📅 Tuesday 24th June, 2024
📍 The Rose, Chippendale (LOCATION CHANGE!)
Can't wait to see you all at this new location! Come for the microbes, stay for the mates 🍻
#microbiolgy #JAMSmicro #science #seminar #networking #biology #research
@doylemt1.bsky.social
📅 Tuesday 24th June, 2024
📍 The Rose, Chippendale (LOCATION CHANGE!)
Can't wait to see you all at this new location! Come for the microbes, stay for the mates 🍻
#microbiolgy #JAMSmicro #science #seminar #networking #biology #research
@doylemt1.bsky.social
June 18, 2025 at 7:19 AM
JAMS June Monthly is next week🥳
📅 Tuesday 24th June, 2024
📍 The Rose, Chippendale (LOCATION CHANGE!)
Can't wait to see you all at this new location! Come for the microbes, stay for the mates 🍻
#microbiolgy #JAMSmicro #science #seminar #networking #biology #research
@doylemt1.bsky.social
📅 Tuesday 24th June, 2024
📍 The Rose, Chippendale (LOCATION CHANGE!)
Can't wait to see you all at this new location! Come for the microbes, stay for the mates 🍻
#microbiolgy #JAMSmicro #science #seminar #networking #biology #research
@doylemt1.bsky.social
Reposted by Matt Doyle
Super excited to share our latest work revealing impt of protein-lipid interactions for the pri fn of the Tol-Pal complex in maintaining outer memb lipid homeostasis in E. coli! Huge discovery by Nadege Lim in collab @pstansfeld.bsky.social @robincorey.bsky.social 1/7
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 17, 2025 at 11:03 AM
Super excited to share our latest work revealing impt of protein-lipid interactions for the pri fn of the Tol-Pal complex in maintaining outer memb lipid homeostasis in E. coli! Huge discovery by Nadege Lim in collab @pstansfeld.bsky.social @robincorey.bsky.social 1/7
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...