Doug Kojetin
@dougkojetin.bsky.social
Structural biology, biophysics, biochemistry, molecular and cellular pharmacology | nuclear receptors | NMR | Vanderbilt University, Department of Biochemistry | kojetinlab.org
Pinned
Doug Kojetin
@dougkojetin.bsky.social
· Dec 13
PPAR Binding Strikes Again
www.science.org
Many thanks to @dereklowe.bsky.social for highlighting our recent study in @elife.bsky.social on synthetic ligand cobinding to the #nuclearreceptor PPARγ! I'm a long-time reader of the Blog, so this is quite a treat to be featured (in a positive light)! www.science.org/content/blog...
Happy to serve! 🧲 #NMR
Thank you to the members of the MagLab's User Committee who were in town this week to provide feedback to lab leadership on our proposal process, capabilities, performance, and key initiatives to ensure they best align with user needs.
November 6, 2025 at 8:22 PM
Happy to serve! 🧲 #NMR
Reposted by Doug Kojetin
TTPD #7 with @fraserlab.com.
We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations.
wankowiczlab.com/2025/09/27/T...
Spotify: open.spotify.com/episode/0JCB...
We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations.
wankowiczlab.com/2025/09/27/T...
Spotify: open.spotify.com/episode/0JCB...
The Tortured Proteins Department, Episode 7
This is the official web page for the Stephanie Wankowicz Lab at Vanderbilt University.
wankowiczlab.com
September 27, 2025 at 8:00 PM
TTPD #7 with @fraserlab.com.
We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations.
wankowiczlab.com/2025/09/27/T...
Spotify: open.spotify.com/episode/0JCB...
We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations.
wankowiczlab.com/2025/09/27/T...
Spotify: open.spotify.com/episode/0JCB...
Reposted by Doug Kojetin
Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data.
These are plots of funding probability fas a function of percentile score for 9 institutes.
1/7
These are plots of funding probability fas a function of percentile score for 9 institutes.
1/7
September 25, 2025 at 6:56 PM
Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data.
These are plots of funding probability fas a function of percentile score for 9 institutes.
1/7
These are plots of funding probability fas a function of percentile score for 9 institutes.
1/7
Reposted by Doug Kojetin
So that adds up to 340 new R01 that were not funded in this past week alone, due to the multi-year funding mandate. sorry, "strong suggestion".
September 15, 2025 at 6:52 PM
So that adds up to 340 new R01 that were not funded in this past week alone, due to the multi-year funding mandate. sorry, "strong suggestion".
Reposted by Doug Kojetin
I am all for journal caps but $2000 is too low. As @peiferlabunc.bsky.social said, it costs $ to run a journal.
NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at:
osp.od.nih.gov/comment-form....
osp.od.nih.gov/comment-form....
August 12, 2025 at 1:37 AM
I am all for journal caps but $2000 is too low. As @peiferlabunc.bsky.social said, it costs $ to run a journal.
Reposted by Doug Kojetin
Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants.
We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15.
Even if this ends up being temporary, it’s time we don’t have.
We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15.
Even if this ends up being temporary, it’s time we don’t have.
July 30, 2025 at 3:02 AM
Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants.
We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15.
Even if this ends up being temporary, it’s time we don’t have.
We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15.
Even if this ends up being temporary, it’s time we don’t have.
Reposted by Doug Kojetin
I wrote a commentary for the Sun-Sentinel about training as a scientist in South Florida and the role/importance of federal funding for biomedical research. While focused on Florida, it applies broadly. Gift link, feel free to share:
www.sun-sentinel.com/2025/06/14/d...
www.sun-sentinel.com/2025/06/14/d...
Don’t let the light of science dim in the Sunshine State | Opinion
Seth Tomchik received his undergraduate and graduate training in South Florida and went on to run a Scripps Florida lab before moving to the University of Iowa. Federal funding for scientific resea…
www.sun-sentinel.com
July 26, 2025 at 2:49 PM
I wrote a commentary for the Sun-Sentinel about training as a scientist in South Florida and the role/importance of federal funding for biomedical research. While focused on Florida, it applies broadly. Gift link, feel free to share:
www.sun-sentinel.com/2025/06/14/d...
www.sun-sentinel.com/2025/06/14/d...
Reposted by Doug Kojetin
In France, we are very grateful for the support of @cnrs.fr and #Infranalytics that allows us to access the 1.2 GHz spectrometer in Lille for free (upon selection of proposals of course).
National Gateway Ultrahigh Field NMR Center gateway-nmr.osu.edu #NMRchat #NMR 🧲
External Academic: $25/hr
Industry: $200/hr
External Academic: $25/hr
Industry: $200/hr
National Gateway Ultrahigh Field NMR Facility | Ohio State
gateway-nmr.osu.edu
May 17, 2025 at 7:12 PM
In France, we are very grateful for the support of @cnrs.fr and #Infranalytics that allows us to access the 1.2 GHz spectrometer in Lille for free (upon selection of proposals of course).
Reposted by Doug Kojetin
Anyone have a lead on replacement syringes for Malvern VP-ITC instruments? They no longer sell them, and they want me to upgrade to the PEAQ system. Unfortunately, we have a PEAQ-ITC, and it doesn't work with the concentrations needed for nanoparticle experiments. #chemsky #biophysics #ITC
May 14, 2025 at 3:46 PM
Anyone have a lead on replacement syringes for Malvern VP-ITC instruments? They no longer sell them, and they want me to upgrade to the PEAQ system. Unfortunately, we have a PEAQ-ITC, and it doesn't work with the concentrations needed for nanoparticle experiments. #chemsky #biophysics #ITC
Reposted by Doug Kojetin
Basic science saves lives and fuels the economy, which is why I’m advocating for:
➡️NIH & NSF to spend FY25 funds
➡️$51.3B for NIH, $9.9B in FY26
➡️Restoration of many canceled NIH & NSF grants
Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123....
#ScienceServesUsAll #ASBMBAdvocates
➡️NIH & NSF to spend FY25 funds
➡️$51.3B for NIH, $9.9B in FY26
➡️Restoration of many canceled NIH & NSF grants
Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123....
#ScienceServesUsAll #ASBMBAdvocates
Urge Congress to re-establish the U.S. as the Leader in Innovation
American Society For Biochemistry And Molecular Biology
asbmb.quorum.us
May 14, 2025 at 7:11 PM
Basic science saves lives and fuels the economy, which is why I’m advocating for:
➡️NIH & NSF to spend FY25 funds
➡️$51.3B for NIH, $9.9B in FY26
➡️Restoration of many canceled NIH & NSF grants
Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123....
#ScienceServesUsAll #ASBMBAdvocates
➡️NIH & NSF to spend FY25 funds
➡️$51.3B for NIH, $9.9B in FY26
➡️Restoration of many canceled NIH & NSF grants
Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123....
#ScienceServesUsAll #ASBMBAdvocates
Reposted by Doug Kojetin
No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...
No-cost extensions of NIH grants are no longer automatically approved
The no-cost extension (NCE) allows the recipient of a NIH grant to continue to spend on the project after the original award interval has expired. This NIH website explains the way NCE used to work…
drugmonkey.wordpress.com
May 9, 2025 at 8:22 PM
No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...
Reposted by Doug Kojetin
Heavy water isn’t water. That goes for protein NMR experiments and for a lot else besides:
Heavy Water in Your NMR Experiments, And Elsewhere
www.science.org
May 9, 2025 at 4:18 PM
Heavy water isn’t water. That goes for protein NMR experiments and for a lot else besides:
Reposted by Doug Kojetin
Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation"
bit.ly/43P7xJG
@vubasicsciences.bsky.social @vanderbilt.edu
bit.ly/43P7xJG
@vubasicsciences.bsky.social @vanderbilt.edu
April 11, 2025 at 5:36 PM
Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation"
bit.ly/43P7xJG
@vubasicsciences.bsky.social @vanderbilt.edu
bit.ly/43P7xJG
@vubasicsciences.bsky.social @vanderbilt.edu
Reposted by Doug Kojetin
NIH adds about 100 billion/yr to the economy
This needs to be framed beyond academia, as most on the right want to see it suffer.
This needs to be framed for how devastating this will be for the economy, at all levels (local/state/fed) as these budgets send billions across the country in people’s salaries/etc.
This needs to be framed for how devastating this will be for the economy, at all levels (local/state/fed) as these budgets send billions across the country in people’s salaries/etc.
Budget released today:
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
May 2, 2025 at 6:34 PM
NIH adds about 100 billion/yr to the economy
Reposted by Doug Kojetin
Budget released today:
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
May 2, 2025 at 4:39 PM
Budget released today:
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
Reposted by Doug Kojetin
Burnette lab graduate student, Zach Sanchez, won the Steve Hann Outstanding Graduate Student Award! He then gave a fun talk on blebbisomes! You can read about his work here:
nature.com/articles/s41...
@vubasicsciences.bsky.social
nature.com/articles/s41...
@vubasicsciences.bsky.social
April 28, 2025 at 12:12 AM
Burnette lab graduate student, Zach Sanchez, won the Steve Hann Outstanding Graduate Student Award! He then gave a fun talk on blebbisomes! You can read about his work here:
nature.com/articles/s41...
@vubasicsciences.bsky.social
nature.com/articles/s41...
@vubasicsciences.bsky.social
Reposted by Doug Kojetin
TV watching recommendations
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
April 27, 2025 at 10:19 AM
TV watching recommendations
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/
Advances in uncovering the mechanisms of macromolecular conformational entropy - PubMed
During protein folding, proteins transition from a disordered polymer into a globular structure, markedly decreasing their conformational degrees of freedom, leading to a substantial reduction in entr...
pubmed.ncbi.nlm.nih.gov
April 25, 2025 at 2:48 PM
Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/
Reposted by Doug Kojetin
Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra"
Paper: biorxiv.org/content/10.1...
Sign up on our website for zoom links!
Paper: biorxiv.org/content/10.1...
Sign up on our website for zoom links!
Learning millisecond protein dynamics from what is missing in NMR spectra
Many proteins’ biological functions rely on interconversions between multiple conformations occurring at micro-to millisecond (µs-ms) timescales. A lack of standardized, large-scale experimental data ...
biorxiv.org
April 22, 2025 at 9:08 PM
Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra"
Paper: biorxiv.org/content/10.1...
Sign up on our website for zoom links!
Paper: biorxiv.org/content/10.1...
Sign up on our website for zoom links!
Reposted by Doug Kojetin
Some new language appeared in the HHS Grants Policy Statement last week.
It doesn't apply to NIH grants (yet)
1/n
It doesn't apply to NIH grants (yet)
1/n
a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .
ALT: a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .
media.tenor.com
April 20, 2025 at 6:59 PM
Some new language appeared in the HHS Grants Policy Statement last week.
It doesn't apply to NIH grants (yet)
1/n
It doesn't apply to NIH grants (yet)
1/n
Reposted by Doug Kojetin
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
April 20, 2025 at 2:34 PM
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
Reposted by Doug Kojetin
Peer networks are so important. We built @nrimpact.bsky.social for this reason, and while we did not anticipate *waves hands wildly* when we put the group together in 2019, the 46 faculty in our group lean on each other in times of personal and professional challenges.
www.nrimpact.com
www.nrimpact.com
April 19, 2025 at 11:21 PM
Peer networks are so important. We built @nrimpact.bsky.social for this reason, and while we did not anticipate *waves hands wildly* when we put the group together in 2019, the 46 faculty in our group lean on each other in times of personal and professional challenges.
www.nrimpact.com
www.nrimpact.com
Reposted by Doug Kojetin
Congrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab."
April 18, 2025 at 4:35 PM
Congrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab."
Reposted by Doug Kojetin
The Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below).
open.spotify.com/show/10PHVou...
open.spotify.com/show/10PHVou...
Episode 2: Cool Science Among Continued Uncertainty by The Tortured Proteins Department
We chatted about the continued chaos of science infrastructure and dived into some cool science from recent meetings Jaime and Stephanie attended. We introduce two new segments: preprints and how to d...
creators.spotify.com
April 15, 2025 at 3:24 PM
The Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below).
open.spotify.com/show/10PHVou...
open.spotify.com/show/10PHVou...
Reposted by Doug Kojetin
Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.social
Conformational Ensemble
conformationalensembles.github.io
March 31, 2025 at 1:41 PM
Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.social