Nicholas Carlson
@docmumbles.bsky.social
Nephrologist | Trialist @Rigshospitalet Copenhagen, Denmark | Board member Danish Society of Nephrology https://nephrology.dk | Lead investigator www.danward.dk | Building APT-Kidney: an Adaptive Platform Trial for Kidney Research | #renalism #nephrology
Reposted by Nicholas Carlson
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
September 26, 2025 at 9:37 AM
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Reposted by Nicholas Carlson
Appraise for the interim analysis of the #VISIONARY trial in IgAN at #ERA25
June 6, 2025 at 9:33 AM
Appraise for the interim analysis of the #VISIONARY trial in IgAN at #ERA25
Reposted by Nicholas Carlson
Great #ACHIEVE ment by @lastwalsh.bsky.social and colleagues presented at the #ERA25. An important study that will hopefully be published accordingly.
June 6, 2025 at 10:13 AM
Great #ACHIEVE ment by @lastwalsh.bsky.social and colleagues presented at the #ERA25. An important study that will hopefully be published accordingly.
Reposted by Nicholas Carlson
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
#ERA25 #MedSky #Nephrology
June 5, 2025 at 9:45 AM
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
#ERA25 #MedSky #Nephrology
Reposted by Nicholas Carlson
just learned this & mind blown 🤯
CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)
BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)
in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC
CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)
BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)
in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC
April 14, 2025 at 3:01 PM
just learned this & mind blown 🤯
CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)
BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)
in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC
CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)
BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)
in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC
Reposted by Nicholas Carlson
Also published today
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
February 7, 2025 at 9:56 AM
Also published today
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
Reposted by Nicholas Carlson
Reposted by Nicholas Carlson
New From PD Dr Sparks and Colleagues Dr Java in JASN
Post-transplant Thrombotic Microangiopathy
pubmed.ncbi.nlm.nih....
Post-transplant Thrombotic Microangiopathy
pubmed.ncbi.nlm.nih....
February 1, 2025 at 6:35 PM
New From PD Dr Sparks and Colleagues Dr Java in JASN
Post-transplant Thrombotic Microangiopathy
pubmed.ncbi.nlm.nih....
Post-transplant Thrombotic Microangiopathy
pubmed.ncbi.nlm.nih....
Reposted by Nicholas Carlson
🆕 Antibody identified in podocytopathies 🫘after Anti nephrin Ab⭐
Anti Slit diaphragm Ab ‼️‼️‼️
The heterogeneity in response to immunosuppression is understandable now!
#Nephsky
Anti Slit diaphragm Ab ‼️‼️‼️
The heterogeneity in response to immunosuppression is understandable now!
#Nephsky
November 24, 2024 at 8:43 AM
🆕 Antibody identified in podocytopathies 🫘after Anti nephrin Ab⭐
Anti Slit diaphragm Ab ‼️‼️‼️
The heterogeneity in response to immunosuppression is understandable now!
#Nephsky
Anti Slit diaphragm Ab ‼️‼️‼️
The heterogeneity in response to immunosuppression is understandable now!
#Nephsky
Reposted by Nicholas Carlson
20 years after their initial MPA model, Xiao, Falk & Jennette publish a groundbreaking paper (doi.org/10.1016/j.ki...). They introduce 3 new mouse models for #ANCA #vasculitis, using anti-MPO abs with different stimuli to mimic MPA, GPA, and EGPA phenotypes. 🧵1/5
Redirecting
doi.org
November 22, 2024 at 7:45 PM
20 years after their initial MPA model, Xiao, Falk & Jennette publish a groundbreaking paper (doi.org/10.1016/j.ki...). They introduce 3 new mouse models for #ANCA #vasculitis, using anti-MPO abs with different stimuli to mimic MPA, GPA, and EGPA phenotypes. 🧵1/5
Reposted by Nicholas Carlson
🧵 My first ever #Skytorial #MedSky #NephSky
🤩Cool study from #AHA24, published in @jamacurrent.bsky.social
📌The premise: HFpEF is characterized by increased left ventricular (LV) chamber pressures
🚀🧑🚀But what happens if 0 gravity (0G)?
jamanetwork.com/journals/jam...
🤩Cool study from #AHA24, published in @jamacurrent.bsky.social
📌The premise: HFpEF is characterized by increased left ventricular (LV) chamber pressures
🚀🧑🚀But what happens if 0 gravity (0G)?
jamanetwork.com/journals/jam...
Heart Failure in Zero Gravity—External Constraint and Cardiac Hemodynamics
In this case series study, pulmonary artery systolic, diastolic, and mean pressures of 2 participants with obesity and heart failure with preserved ejection fraction were measured at zero gravity duri...
jamanetwork.com
November 17, 2024 at 4:46 AM
🧵 My first ever #Skytorial #MedSky #NephSky
🤩Cool study from #AHA24, published in @jamacurrent.bsky.social
📌The premise: HFpEF is characterized by increased left ventricular (LV) chamber pressures
🚀🧑🚀But what happens if 0 gravity (0G)?
jamanetwork.com/journals/jam...
🤩Cool study from #AHA24, published in @jamacurrent.bsky.social
📌The premise: HFpEF is characterized by increased left ventricular (LV) chamber pressures
🚀🧑🚀But what happens if 0 gravity (0G)?
jamanetwork.com/journals/jam...
Reposted by Nicholas Carlson
Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
DEFINE_ME
www.ajkd.org
November 17, 2024 at 11:09 AM
Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
Reposted by Nicholas Carlson
Further sprinting towards intensive blood pressure lowering in TD2 👍🏻
Guess what the kidney outcomes look like…
#BROAD RCT presented at #AHA24 and in NEJM 👇
www.nejm.org/doi/full/10....
Guess what the kidney outcomes look like…
#BROAD RCT presented at #AHA24 and in NEJM 👇
www.nejm.org/doi/full/10....
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes | NEJM
Effective targets for systolic blood-pressure control in patients with type 2 diabetes
are unclear. We enrolled patients 50 years of age or older with type 2 diabetes, elevated
systolic blood press...
www.nejm.org
November 16, 2024 at 5:43 PM
Further sprinting towards intensive blood pressure lowering in TD2 👍🏻
Guess what the kidney outcomes look like…
#BROAD RCT presented at #AHA24 and in NEJM 👇
www.nejm.org/doi/full/10....
Guess what the kidney outcomes look like…
#BROAD RCT presented at #AHA24 and in NEJM 👇
www.nejm.org/doi/full/10....
Reposted by Nicholas Carlson
1/14
🤔 Why do we use iodine as an intravenous contrast agent?
The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.
🤔 Why do we use iodine as an intravenous contrast agent?
The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.
November 16, 2024 at 9:28 PM
1/14
🤔 Why do we use iodine as an intravenous contrast agent?
The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.
🤔 Why do we use iodine as an intravenous contrast agent?
The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.
Reposted by Nicholas Carlson
📣Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity 👇👇 #cardiovascular #cardiosky #Obesity #diabetes #GLP-1 #heartfailure
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
www.nejm.org
November 16, 2024 at 3:18 PM
📣Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity 👇👇 #cardiovascular #cardiosky #Obesity #diabetes #GLP-1 #heartfailure
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Nicholas Carlson
Hypochloremia is associated with diuretic resistance. In 👇 study from Yale, hypochloremia was associated with poor diuretic efficiency (defined as mmol of UNa per doubling of loop diuretic dose). Of note - serum sodium was NOT associated with diuretic efficiency #cardiosky
November 15, 2024 at 8:21 PM
Hypochloremia is associated with diuretic resistance. In 👇 study from Yale, hypochloremia was associated with poor diuretic efficiency (defined as mmol of UNa per doubling of loop diuretic dose). Of note - serum sodium was NOT associated with diuretic efficiency #cardiosky
Reposted by Nicholas Carlson
First post on 🦋 #nephsky
Papers from the WEROCK Study on CRRT for AKI in children, young adults #CRRTnotCKRT
1️⃣ Demographics, outcomes- in AJKD; free till 11/30/24 www.ajkd.org/article/S027...
N=980; Significant practice changes in the 20 yrs since ppCRRT; Survival to ICU discharge ⬆️ (64%)
Papers from the WEROCK Study on CRRT for AKI in children, young adults #CRRTnotCKRT
1️⃣ Demographics, outcomes- in AJKD; free till 11/30/24 www.ajkd.org/article/S027...
N=980; Significant practice changes in the 20 yrs since ppCRRT; Survival to ICU discharge ⬆️ (64%)
November 13, 2024 at 3:10 AM
First post on 🦋 #nephsky
Papers from the WEROCK Study on CRRT for AKI in children, young adults #CRRTnotCKRT
1️⃣ Demographics, outcomes- in AJKD; free till 11/30/24 www.ajkd.org/article/S027...
N=980; Significant practice changes in the 20 yrs since ppCRRT; Survival to ICU discharge ⬆️ (64%)
Papers from the WEROCK Study on CRRT for AKI in children, young adults #CRRTnotCKRT
1️⃣ Demographics, outcomes- in AJKD; free till 11/30/24 www.ajkd.org/article/S027...
N=980; Significant practice changes in the 20 yrs since ppCRRT; Survival to ICU discharge ⬆️ (64%)
Reposted by Nicholas Carlson
Wanted to share some thoughts on our recent publication in JAMA Pediatrics "Glomerular Filtration Rate Changes Following UTI in Children With Vesicoureteral Reflux" which we presented at Kidney Week and published simultaneously. jamanetwork.com/journals/jam...
eGFR Changes Following UTI in Children With Vesicoureteral Reflux
This cohort study uses data from the Children With Vesicoureteral Reflux trial to assess estimated glomerular filtration rate (eGFR) changes in participants with vs without recurrent urinary tract inf...
jamanetwork.com
November 13, 2024 at 6:47 PM
Wanted to share some thoughts on our recent publication in JAMA Pediatrics "Glomerular Filtration Rate Changes Following UTI in Children With Vesicoureteral Reflux" which we presented at Kidney Week and published simultaneously. jamanetwork.com/journals/jam...
Reposted by Nicholas Carlson
