Reposted by dan guint⌬ 🇵🇭〽️
Our latest is a serendipitously discovered pair of reactions that can pull either the C2 or C3 carbon out of quinolines by choice of an amine scavenger. A deep mechanistic dive took us some surprising places, in @chemiejisoo.bsky.social's latest.
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes
Divergent synthesis is a powerful strategy that provides simultaneous access to multiple derivatives of a given substrate. However, the emerging developments in skeletal editing have largely delivered...
pubs.acs.org
May 28, 2025 at 2:20 PM
Our latest is a serendipitously discovered pair of reactions that can pull either the C2 or C3 carbon out of quinolines by choice of an amine scavenger. A deep mechanistic dive took us some surprising places, in @chemiejisoo.bsky.social's latest.
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by dan guint⌬ 🇵🇭〽️
Social sanctions are powerful, for ill and for good, and I personally feel like it would be good to make shit like ChatGPT utterly socially unacceptable, like the height of shame to admit using, a subject that slams down an awkward silence when it’s uncritically invoked
“Just calm down and let people enjoy chatgpt.” Sorry, no. I find it creepy that folks are treating a machine that mimics human speech as their friend / therapist. It is feeding you lies. It is destroying your thinking abilities. Shut it off. Talk to other humans. Go outside.
May 11, 2025 at 4:06 PM
Social sanctions are powerful, for ill and for good, and I personally feel like it would be good to make shit like ChatGPT utterly socially unacceptable, like the height of shame to admit using, a subject that slams down an awkward silence when it’s uncritically invoked
Reposted by dan guint⌬ 🇵🇭〽️
Congratulations to Ryan and Moto on the publication of their 1,2-acyl transposition in 2,3-dihdyrobenzofurans in @science.org!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
1,2-Acyl transposition through photochemical skeletal rearrangement of 2,3-dihydrobenzofurans
Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple peripheral positions are therefore highly valuable. In this ...
www.science.org
May 8, 2025 at 11:17 PM
Congratulations to Ryan and Moto on the publication of their 1,2-acyl transposition in 2,3-dihdyrobenzofurans in @science.org!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
okay well i guess i don’t need to read literature tn
April 30, 2025 at 4:19 AM
okay well i guess i don’t need to read literature tn
first day in industry ✅
can’t believe i’m a process chemist
can’t believe i’m a process chemist
April 29, 2025 at 2:40 AM
first day in industry ✅
can’t believe i’m a process chemist
can’t believe i’m a process chemist
officially a bostonian (or whatever they call people who live in cambridge!)
aside from the sweet process gig, i’m now closer to one of my favorite cats in the world, stella 🫶🏼♥️
aside from the sweet process gig, i’m now closer to one of my favorite cats in the world, stella 🫶🏼♥️
April 27, 2025 at 2:16 PM
officially a bostonian (or whatever they call people who live in cambridge!)
aside from the sweet process gig, i’m now closer to one of my favorite cats in the world, stella 🫶🏼♥️
aside from the sweet process gig, i’m now closer to one of my favorite cats in the world, stella 🫶🏼♥️
excited to announce that i’ll be joining the process/hte team at vertex (boston) at the end of april!
crazy to think 4 years ago on this very day, i got into umich, now i get to transition to my dream role in industry 🤠♥️
crazy to think 4 years ago on this very day, i got into umich, now i get to transition to my dream role in industry 🤠♥️
April 3, 2025 at 12:45 AM
excited to announce that i’ll be joining the process/hte team at vertex (boston) at the end of april!
crazy to think 4 years ago on this very day, i got into umich, now i get to transition to my dream role in industry 🤠♥️
crazy to think 4 years ago on this very day, i got into umich, now i get to transition to my dream role in industry 🤠♥️
Reposted by dan guint⌬ 🇵🇭〽️
@narayanlab.bsky.social and @gabegomes.bsky.social designed Catnip--so named because it's "for the biocats"--to make it easier for newbs to use enzymatic reactions in organic synthesis. I had the privilege of hearing them talk about it at #ACSSpring2025 earlier this week!
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
Chemists create matchmaking app for biocatalysis
Machine learning model Catnip helps chemists find biocatalysts to try in synthesis
cen.acs.org
March 28, 2025 at 5:49 PM
@narayanlab.bsky.social and @gabegomes.bsky.social designed Catnip--so named because it's "for the biocats"--to make it easier for newbs to use enzymatic reactions in organic synthesis. I had the privilege of hearing them talk about it at #ACSSpring2025 earlier this week!
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
contrary to what many people might think, i did NOT name my wifi network “organic chemistry is easy”
March 10, 2025 at 10:09 PM
contrary to what many people might think, i did NOT name my wifi network “organic chemistry is easy”
wdym my 3 years of synthesis/biocat doesn’t make me eligible for an entry level synthesis position in industry 🫠
March 4, 2025 at 6:26 PM
wdym my 3 years of synthesis/biocat doesn’t make me eligible for an entry level synthesis position in industry 🫠
Reposted by dan guint⌬ 🇵🇭〽️
Approx. 5 bullets on what I did this past week:
- singlet or triplet state
- C-H insertion
- cyclopropanation
- ylide formation
- Wolff rearrangement
- singlet or triplet state
- C-H insertion
- cyclopropanation
- ylide formation
- Wolff rearrangement
Approx. 5 bullets on what I did this past week:
-drank a whiskey drink
-drank a vodka drink
-drank a lager drink
-drank a cider drink
-sang a song that reminded of the good times
-sang a song that reminded of the best times
-drank a whiskey drink
-drank a vodka drink
-drank a lager drink
-drank a cider drink
-sang a song that reminded of the good times
-sang a song that reminded of the best times
February 22, 2025 at 11:49 PM
Approx. 5 bullets on what I did this past week:
- singlet or triplet state
- C-H insertion
- cyclopropanation
- ylide formation
- Wolff rearrangement
- singlet or triplet state
- C-H insertion
- cyclopropanation
- ylide formation
- Wolff rearrangement
Reposted by dan guint⌬ 🇵🇭〽️
Don't forget that the lead compound for vertex came from a library developed in collaboration with the Jin Quan Yu lab at Scripps, using CH functionalization
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
February 22, 2025 at 8:09 PM
Don't forget that the lead compound for vertex came from a library developed in collaboration with the Jin Quan Yu lab at Scripps, using CH functionalization
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
first on-site interview: ✅
feels nice to not have to be interviewing from my apartment 😭
feels nice to not have to be interviewing from my apartment 😭
February 11, 2025 at 10:01 PM
first on-site interview: ✅
feels nice to not have to be interviewing from my apartment 😭
feels nice to not have to be interviewing from my apartment 😭
Reposted by dan guint⌬ 🇵🇭〽️
I am teaching my favorite course again this semester:
"Chemical Neuroscience - a Synthetic Approach".
We are posting some materials online, check them out.
www.traunergroup.org/teaching
"Chemical Neuroscience - a Synthetic Approach".
We are posting some materials online, check them out.
www.traunergroup.org/teaching
February 6, 2025 at 5:04 PM
I am teaching my favorite course again this semester:
"Chemical Neuroscience - a Synthetic Approach".
We are posting some materials online, check them out.
www.traunergroup.org/teaching
"Chemical Neuroscience - a Synthetic Approach".
We are posting some materials online, check them out.
www.traunergroup.org/teaching
Reposted by dan guint⌬ 🇵🇭〽️
Reading this book 📕 for the third time, might be a blueprint for how Marc Cuban can help build a news 📰 network with journalists like Jim Acosta, who can tell the TRUTH to POWER 💪💪💪 and lead the RESISTANCE 🙏🙏🙏
February 2, 2025 at 12:45 PM
Reading this book 📕 for the third time, might be a blueprint for how Marc Cuban can help build a news 📰 network with journalists like Jim Acosta, who can tell the TRUTH to POWER 💪💪💪 and lead the RESISTANCE 🙏🙏🙏
Reposted by dan guint⌬ 🇵🇭〽️
Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.
January 29, 2025 at 4:52 PM
Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.
arguably one of my favorite mechanistic sequences in a total synthesis <3
It’s BUSINESS Monday, ok?! A #mechanismmonday problem for y’all, please enjoy - answer tomorrow! And YES, this is a crossover episode (problem is from Denksport 😎) #chemsky
January 22, 2025 at 9:47 PM
arguably one of my favorite mechanistic sequences in a total synthesis <3
first the knowles group and now the yoon group???
skeletal editing is on a ROLL today 🤠
skeletal editing is on a ROLL today 🤠
Friends, I'm pleased to draw your attention to two new preprints today describing complementary heteroatom insertion reactions into saturated carbocycles, one from our group and another from the Knowles laboratory.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
January 22, 2025 at 7:06 PM
first the knowles group and now the yoon group???
skeletal editing is on a ROLL today 🤠
skeletal editing is on a ROLL today 🤠
absolute BANGER of a skeletal editing & PCET paper 😍
Exo-to-endo nitrogen transposition in saturated rings
Authors: Danny Thach, Robert Knowles
DOI: 10.26434/chemrxiv-2025-nlj7m
Authors: Danny Thach, Robert Knowles
DOI: 10.26434/chemrxiv-2025-nlj7m
January 22, 2025 at 4:26 PM
absolute BANGER of a skeletal editing & PCET paper 😍
If you went to college/uni
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. physician-scientist
2. biomedical engineering
3. chemE -> physics -> chem
4. tbd 🫢
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. physician-scientist
2. biomedical engineering
3. chemE -> physics -> chem
4. tbd 🫢
If you went to college/uni
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. Be a Chemist
2. Chemistry
3. Chemistry
4. Chemistry…and posts with really bad puns and #ChemDadJokes
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. Be a Chemist
2. Chemistry
3. Chemistry
4. Chemistry…and posts with really bad puns and #ChemDadJokes
If you went to college/uni
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. Had no idea
2. Had no major in mind when I started
3. Declared chemistry at end of 2nd year
4. I teach college chemistry
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. Had no idea
2. Had no major in mind when I started
3. Declared chemistry at end of 2nd year
4. I teach college chemistry
January 22, 2025 at 8:52 AM
If you went to college/uni
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. physician-scientist
2. biomedical engineering
3. chemE -> physics -> chem
4. tbd 🫢
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?
1. physician-scientist
2. biomedical engineering
3. chemE -> physics -> chem
4. tbd 🫢
“how’s the job search going?”
mass spec position BUT they don’t want chemists and/or people who aim to go to grad school 🫠
mass spec position BUT they don’t want chemists and/or people who aim to go to grad school 🫠
January 14, 2025 at 2:28 AM
“how’s the job search going?”
mass spec position BUT they don’t want chemists and/or people who aim to go to grad school 🫠
mass spec position BUT they don’t want chemists and/or people who aim to go to grad school 🫠
Reposted by dan guint⌬ 🇵🇭〽️
Surviving Your First Week in Medicinal Chemistry
Would like to see more perspectives like this in the journal. Going from an academic lab, esp if focused on synthetic organic chemistry, into industrial medicinal chemistry, really is falling through the looking glass.
Would like to see more perspectives like this in the journal. Going from an academic lab, esp if focused on synthetic organic chemistry, into industrial medicinal chemistry, really is falling through the looking glass.
Surviving Your First Week in Medicinal Chemistry
pubs.acs.org
December 18, 2024 at 12:34 PM
Surviving Your First Week in Medicinal Chemistry
Would like to see more perspectives like this in the journal. Going from an academic lab, esp if focused on synthetic organic chemistry, into industrial medicinal chemistry, really is falling through the looking glass.
Would like to see more perspectives like this in the journal. Going from an academic lab, esp if focused on synthetic organic chemistry, into industrial medicinal chemistry, really is falling through the looking glass.
currently holding space for my favorite protecting group 💚
December 8, 2024 at 6:51 AM
currently holding space for my favorite protecting group 💚
the day-long interview process can be taxing, but it’s really gratifying to know that people can sense my passion & love for chemistry in the way i communicate my research
December 2, 2024 at 8:52 PM
the day-long interview process can be taxing, but it’s really gratifying to know that people can sense my passion & love for chemistry in the way i communicate my research