Daniel Figeys
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dfigeys.bsky.social
Daniel Figeys
@dfigeys.bsky.social
340 followers 700 following 28 posts
Precision-function-based microbiome trials.
Ex vivo microbiome assays.
Microbiome–xenobiotic interactions.
Meta-omics analyses
Posts Replies Media Videos
dfigeys.bsky.social
Functional redundancy matters: the more overlapping microbial functions you have, the more resilient your #microbiome. We showed a strong negative correlation between redundancy loss and increase in #antimicrobial resistance protein upon #drug treatment of microbiomes.
@quadraminstitute.bsky.social
October 29, 2025 at 10:22 AM
dfigeys.bsky.social
Interestingly, #drugs for the nervous system (antidepressants/antipsychotics) stand out: #SSRI/ #SNRI/ #TCA push the gut #microbiome into alternate states, lowering functional redundancy(lower capacity to respond) and ramping up antimicrobial-resistance proteins.
@quadraminstitute.bsky.social
dfigeys.bsky.social Daniel Figeys @dfigeys.bsky.social · 16d
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.

rdcu.be/eMmcT
October 27, 2025 at 7:32 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
1 in 5 people in the UK are estimated to be deficient in #vitaminD during winter and spring 📉

Our ViTaL-D Study aims to understand whether tomatoes biofortified through gene-editing tomatoes to be high in vitamin D leads to higher levels of active vitamin D in the blood 🍅

➡️ buff.ly/SIsELo6
A landscape shot of the rooftops of Norwich, with the Cathedral in the centre. In the foreground are trees without their leaves.
October 26, 2025 at 4:03 PM
dfigeys.bsky.social
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.

rdcu.be/eMmcT
October 26, 2025 at 7:09 AM
dfigeys.bsky.social
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social

rdcu.be/eMmcT
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...
rdcu.be
October 24, 2025 at 4:20 PM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
We were delighted to welcome Sir Ian Chapman the new CEO of @ukri.org , together with BBSRC representatives, to Norwich Research Park today hear about our world leading bioscience.

Discover more about our research at the Quadram Institute
➡️ buff.ly/NZYHB2r
October 23, 2025 at 4:15 PM
Reposted by Daniel Figeys
erictopol.bsky.social
Exposure to sugar early in life: a natural experiment among >63,000 @uk_biobank participants: rationing of sugar was associated with less cardiovascular risk in adulthood www.bmj.com/content/391/...
Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes: natural experiment study
Objective To examine whether exposure to sugar rationing during early life is associated with a reduction in the risk of cardiovascular outcomes in adulthood. Design Natural experiment study. Settin...
www.bmj.com
October 23, 2025 at 12:44 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
“This study is particularly important to me as it took place during my post doc years at the @uniofeastanglia.bsky.social and it has been a source of inspiration for my current research line, as a newly appointed Early Career Fellow at the Quadram Institute."

💬 Dr Serena Monaco
New technique to speed up the design of drugs targeting proteins in the cell membrane - Quadram Institute
An team has developed a new technique that will speed up the design of drugs targeting ion channels, a type of cell membrane protein
buff.ly
October 2, 2025 at 8:37 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
“Vitamin D deficiency represents a significant public health concern, especially during the winter months with significant deficiency across the UK population."

💬 Professor Martin Warren, our Chief Scientific Officer
Vitamin D3 concentrations are lowered by common vitamin D supplement - Quadram Institute
Taking vitamin D2 might be lowering the body's levels of the more efficient form of vitamin D, vitamin D3, according to new research
buff.ly
September 22, 2025 at 8:11 AM
Reposted by Daniel Figeys
erlangen.bsky.social
Maternal emulsifier consumption alters the offspring microbiota leading to long-lasting diseases susceptibility
www.nature.com/articles/s41...
Consumption of food additives during pregnancy alters offspring gut microbiota and increases inflammatory disease risk
medicalxpress.com/news/2025-09...
Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility - Nature Communications
Here, Delaroque et al. show that maternal intake of dietary emulsifiers alters offspring microbiota early in life, which, associated with perturbation of goblet cell function, promotes increased susce...
www.nature.com
September 22, 2025 at 1:54 AM
dfigeys.bsky.social
This is an exciting position that will shape the direction of how we target the gut microbiome. Come join my lab at the Quadram Institute.
quadraminstitute.bsky.social Quadram Institute @quadraminstitute.bsky.social · Sep 15
🆕 Vacancy! We're looking for a Senior Research Scientist to advance precision prebiotic microbiome intervention trials to study the interactions of prebiotics, drugs and other xenobiotics on the gut microbiome.

💷 £45,450 to £56,750
🗓️ Apply by 2 October 2025
➡️ buff.ly/BQKamDW
A social media card with a digital illustration of the gut microbiome and the text "Senior Research Scientist, to advance prevision prebiotic microbiome intervention trials and study the interactions of prebiotics, drugs and other xenobiotics"
September 17, 2025 at 10:07 AM
dfigeys.bsky.social
Interested in compound- microbiome interactions, and how they affect health? Join my lab at the Quadram Institute.
quadraminstitute.bsky.social Quadram Institute @quadraminstitute.bsky.social · Sep 15
🆕 Vacancy! We're looking for a Research Scientist (Xenobiotics) to investigate xenobiotic–microbiome interactions and understand the variation in responses across different individual microbiomes.

💷 £37,500 to £45,350
🗓️ Apply by 2 October 2025
➡️ buff.ly/8abEye5
A social card with an illustration of a molecules like forms, forming a person in part of the image, plus the text "Research Scientist (Xenobiotics) to investigate xenobiotic-microbiome interactions and understand variation across different individual microbiomes. Salary: £37,500 to £43,350, Contract length: 2.5 Years, Apply by 2 October 2025
September 16, 2025 at 9:57 AM
dfigeys.bsky.social
Interested in healthy aging and the microbiome? Join my lab to explore how ex vivo microbiome assays can guide personalized interventions that modulate specific microbiome-derived metabolites critical for health.
quadraminstitute.bsky.social Quadram Institute @quadraminstitute.bsky.social · Sep 16
🆕 Vacancy! We're looking for a Research Scientist (Clinical Microbiome) to advance precision prebiotic microbiome intervention trials aimed at promoting healthy ageing.

💷 £37,500 to £45,350
🗓️ Apply by 2 October 2025
➡️ buff.ly/KGl7eiG
A photo of someone pipetting in the lab and the text "Research Scientist (Clinical Microbiome) to advance precision prebiotic microbiome intervention trials aimed at promoting trials aimed at promoting healthy ageing, Salary: £37,500 to £43,350, Contract length: 2.5 years, Apply by 2 October"
September 16, 2025 at 9:52 AM
Reposted by Daniel Figeys
bugsinyourguts.bsky.social
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities.

forms.office.com/pages/respon...
September 13, 2025 at 6:31 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
🆕 Vacancy! We’re looking for a Chief Scientific Officer to support the development of the institute’s scientific strategy and scientific leadership of the institute.

💷 Competitive
🗓️ Apply by 12 October 2025
➡️ buff.ly/mKUhD3K
A social card with an image of the Quadram Institute labs and the sentence "To support the development of the institute's scientific strategy and scientific leadership of the institute. Salary: Competitive, Contract length: indefinite, apply by 12 October 2025
September 12, 2025 at 2:00 PM
dfigeys.bsky.social
Thank you @microbiomevif.bsky.social for inviting me. Very insightful questions. Looking forward to follow up.
September 10, 2025 at 4:56 AM
Reposted by Daniel Figeys
microbiomevif.bsky.social
@dfigeys.bsky.social speaks on:

"Life gut microbiome cryopreservation and assays"

@microbiotavault.bsky.social
September 9, 2025 at 1:52 PM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
We were pleased to welcome Dr Yogesh Shouche, Director of SKAN Research Trust, to the Quadram Institute this week to discuss ongoing and future research collaborations.

Read more about our collaboration with the Bengaluru-based not-for-profit medical research trust🌏
➡️ buff.ly/TTa3VJj
Professor Arjan Narbad, Dr Yogesh Shouche, Professor Daniel Figeys and Professor Mark Webber
September 4, 2025 at 9:01 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
“Obesity affects 30% of children by Year 6,” says Dr Emma Webb, a Consultant Pediatrician at @nnuh.bsky.social

Read how Emma is working with @narbadlab.bsky.social to gather data on the gut microbiome in childhood obesity
➡️ buff.ly/MgSiiLR
September 3, 2025 at 7:02 PM
dfigeys.bsky.social
Peptides in sync.

Sun et al. analysed peptide abundance correlations across hundreds of #metaproteomic samples from drug‑treated human gut microbiomes. Correlation maps showed that peptides from the same microbial genome clustered together. Why is this interesting?
www.nature.com/articles/s41...
Peptide abundance correlations in metaproteomics enhance taxonomic and functional analysis of the human gut microbiome - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Peptide abundance correlations in metaproteomics enhance taxonomic and functional analysis of the human gut microbiome
www.nature.com
August 22, 2025 at 6:14 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
"We welcome the new National Food Strategy’s focus on health. A stronger focus on the nutritional quality of food in the UK is badly needed to tackle pressing public health challenges.”

💬 Professor Martin Warren, our Chief Scientific Officer

Read more about our health research
➡️ buff.ly/6u65ztG
A photo of Professor Martin Warren with an image of plant based foods and the text, ""We welcome the new National Food Strategy’s focus on health. The UK currently has the shortest healthy lifespan in Western Europe and obesity rates have doubled since the 1990s. A stronger focus on the nutritional quality of food in the UK is badly needed to tackle these pressing public health challenges.”
July 16, 2025 at 3:38 PM
Reposted by Daniel Figeys
stcmicrobeblog.bsky.social
and here is the link to the paper > www.nature.com/articles/s41...
Non-antibiotics disrupt colonization resistance against enteropathogens - Nature
Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.
www.nature.com
July 18, 2025 at 8:29 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
We were pleased to welcome @ukri.org and BBSRC to the Norwich Research Park today, which included a tour of our Clinical Research Facility Kitchen to chat about our collaborative work with the @johninnescentre.bsky.social on vitamin D 🔬

Read more about our research
➡️ buff.ly/f8mEx9J
The Quadram Institute Human Studies team with the Head of UKRI Quadram Institute Professor Daniel Figeys with PhD student Brenda Mionki talking to UKRI and BBSRC representatives The human studies team talking to UKRI and BBSRC representatives
July 14, 2025 at 3:50 PM
Reposted by Daniel Figeys
natureportfolio.nature.com
The findings of a study in Nature Microbiology show the high bioaccumulation capacity of gut bacteria for PFAS, commonly known as forever chemicals. go.nature.com/4le7Svk #microbiome #medsky 🧪
This is figure 3, which is FIB-SIMS imaging shows intracellular bioaccumulation of PFAS by E. coli ∆tolC.
July 11, 2025 at 1:52 AM
Reposted by Daniel Figeys
quadraminstitute.bsky.social
“I’m delighted to announce @buscainolab.bsky.social ’s appointment as one of our new research group leaders. We look forward to Alessia joining the Quadram team in the autumn.”

💬 @dfigeys.bsky.social

Read more➡️ buff.ly/8AvXvxp
July 9, 2025 at 10:01 AM