@davidmorizet.bsky.social
Reposted
📣 Publication in @nature.com
A new class of molecules capable of killing #cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, @cnrs.fr and @inserm.fr
Read publication 👉 www.nature.com/articles/s41...
A new class of molecules capable of killing #cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, @cnrs.fr and @inserm.fr
Read publication 👉 www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 7, 2025 at 4:18 PM
📣 Publication in @nature.com
A new class of molecules capable of killing #cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, @cnrs.fr and @inserm.fr
Read publication 👉 www.nature.com/articles/s41...
A new class of molecules capable of killing #cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, @cnrs.fr and @inserm.fr
Read publication 👉 www.nature.com/articles/s41...
Reposted
All of our neural dynamics tools, software, protocols, datasets, and even hardware plans are now available in one convenient place!
Check it out and let us know what you'd like to see next: www.allenneuraldynamics.org/tools
🧠📈
Check it out and let us know what you'd like to see next: www.allenneuraldynamics.org/tools
🧠📈
Open Tools | Allen Institute for Neural Dynamics
We are doing science in the open. Our data and tools are openly available to the community.
www.allenneuraldynamics.org
May 5, 2025 at 11:48 PM
All of our neural dynamics tools, software, protocols, datasets, and even hardware plans are now available in one convenient place!
Check it out and let us know what you'd like to see next: www.allenneuraldynamics.org/tools
🧠📈
Check it out and let us know what you'd like to see next: www.allenneuraldynamics.org/tools
🧠📈
Reposted
Very cool study from Ikuo Suzuki lab, comparing temporal patterning in mouse and rat cerebral cortex.
Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes.
www.biorxiv.org/content/bior...
Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes.
www.biorxiv.org/content/bior...
www.biorxiv.org
May 1, 2025 at 1:42 PM
Very cool study from Ikuo Suzuki lab, comparing temporal patterning in mouse and rat cerebral cortex.
Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes.
www.biorxiv.org/content/bior...
Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes.
www.biorxiv.org/content/bior...
Reposted
It’s out! The first paper from my postdoc – and first from the @bhadurilab.bsky.social – is now live @natneuro.nature.com . 🧠✨
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Parallel meta-analyses of the human cortex in development (seven datasets) and adulthood (16 datasets) generated over 500 gene co-expression networks that can describe mechanisms of cortical development, centering on peak stages of neurogenesis 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex - Nature Neuroscience
Nano et al. introduce a pipeline to generate meta-atlases of the human brain from existing single-cell datasets and extract gene modules linked to cell fate specification. Perturbing these programs in...
www.nature.com
May 2, 2025 at 12:39 AM
It’s out! The first paper from my postdoc – and first from the @bhadurilab.bsky.social – is now live @natneuro.nature.com . 🧠✨
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Reposted
It was already discussed in the @empirepoduk.bsky.social but here again: changing the Eurocentric narrative about the history of science – why multiculturalism matters theconversation.com/changing-the...
Changing the Eurocentric narrative about the history of science – why multiculturalism matters
The West’s Eurocentric version of scientific history omits some of the most important events that shaped modern thinking.
theconversation.com
April 11, 2025 at 9:07 AM
It was already discussed in the @empirepoduk.bsky.social but here again: changing the Eurocentric narrative about the history of science – why multiculturalism matters theconversation.com/changing-the...
Reposted
Happy to share my new article on how morphological diversification proceeds during evolutionary radiations: "The diffused evolutionary dynamics of morphological novelty" www.pnas.org/doi/10.1073/... 🧵 1/12
The diffused evolutionary dynamics of morphological novelty | PNAS
Rates of evolution are fundamental to understand the processes that shaped the history
of life. The predominant view holds that high rates of pheno...
www.pnas.org
May 2, 2025 at 8:46 AM
Happy to share my new article on how morphological diversification proceeds during evolutionary radiations: "The diffused evolutionary dynamics of morphological novelty" www.pnas.org/doi/10.1073/... 🧵 1/12
Reposted
GlycoCaging, a targeted drug delivery system using plant oligosaccharide glycoconjugates, enables microbiota-activated colonic drug release, reducing off-target effects while maintaining drug efficacy in inflammatory bowel disease #NBThighlight www.science.org/doi/10.1126/...
Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting
The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a t...
www.science.org
May 5, 2025 at 2:41 PM
GlycoCaging, a targeted drug delivery system using plant oligosaccharide glycoconjugates, enables microbiota-activated colonic drug release, reducing off-target effects while maintaining drug efficacy in inflammatory bowel disease #NBThighlight www.science.org/doi/10.1126/...
Reposted
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits
Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...
www.biorxiv.org
May 5, 2025 at 3:40 PM
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
May 5, 2025 at 10:00 AM
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
Reposted
Karla Flores had a tumor strangling her spinal cord near the base of her skull. Doctors weighed whether they should attempt a high-risk surgery that had never been done before.
Surgeons bid for medical first: Removing spinal tumor through patient’s eye
Karla Flores had a tumor strangling her spinal cord near the base of her skull. Doctors weighed whether they should attempt a high-risk surgery that had never been done before.
www.washingtonpost.com
May 4, 2025 at 4:43 PM
Karla Flores had a tumor strangling her spinal cord near the base of her skull. Doctors weighed whether they should attempt a high-risk surgery that had never been done before.
Reposted
🧠 New preprint! Our meta-analysis of scRNA-seq data (37 donors, GWs 8–26) maps ECM dynamics in human cortical development, linking many genes to NDDs.
📄 Read more:https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
#Neuroscience #scRNAseq #ECM #Neurodevelopment #Preprint #metaanalysis
📄 Read more:https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
#Neuroscience #scRNAseq #ECM #Neurodevelopment #Preprint #metaanalysis
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis
Human cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM). ECM plays ...
www.biorxiv.org
February 25, 2025 at 4:14 PM
🧠 New preprint! Our meta-analysis of scRNA-seq data (37 donors, GWs 8–26) maps ECM dynamics in human cortical development, linking many genes to NDDs.
📄 Read more:https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
#Neuroscience #scRNAseq #ECM #Neurodevelopment #Preprint #metaanalysis
📄 Read more:https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
#Neuroscience #scRNAseq #ECM #Neurodevelopment #Preprint #metaanalysis
Reposted
What if LLMs could “read” & “write” biology? 🤔
Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝
🔗 Blog: research.google/blog/teachin...
🔗 Preprint: biorxiv.org/content/10.1...
Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝
🔗 Blog: research.google/blog/teachin...
🔗 Preprint: biorxiv.org/content/10.1...
Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis
research.google
April 18, 2025 at 2:14 PM
What if LLMs could “read” & “write” biology? 🤔
Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝
🔗 Blog: research.google/blog/teachin...
🔗 Preprint: biorxiv.org/content/10.1...
Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝
🔗 Blog: research.google/blog/teachin...
🔗 Preprint: biorxiv.org/content/10.1...
Reposted
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications
Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...
www.nature.com
February 11, 2025 at 11:29 AM
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...